Tmem198b (transmembrane protein 198b) - Rat Genome Database

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Gene: Tmem198b (transmembrane protein 198b) Mus musculus
Analyze
Symbol: Tmem198b
Name: transmembrane protein 198b
RGD ID: 1615833
MGI Page MGI
Description: Predicted to be active in plasma membrane. Orthologous to human TMEM198B (transmembrane protein 198B (pseudogene)).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110012D08Rik; hypothetical protein LOC73827; uncharacterized protein LOC73827
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,633,958 - 128,641,255 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,635,905 - 128,640,239 (-)EnsemblGRCm39 Ensembl
GRCm3810128,798,089 - 128,805,386 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,800,036 - 128,804,370 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,237,092 - 128,241,426 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,202,985 - 128,207,319 (-)NCBIMGSCv36mm8
Celera10131,192,251 - 131,196,585 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18799693  
PMID:20562862   PMID:21873635  


Genomics

Comparative Map Data
Tmem198b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,633,958 - 128,641,255 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,635,905 - 128,640,239 (-)EnsemblGRCm39 Ensembl
GRCm3810128,798,089 - 128,805,386 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,800,036 - 128,804,370 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,237,092 - 128,241,426 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,202,985 - 128,207,319 (-)NCBIMGSCv36mm8
Celera10131,192,251 - 131,196,585 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.16NCBI
TMEM198B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,829,608 - 55,836,246 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,829,608 - 55,836,253 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,832,159 - 55,834,988 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,223,392 - 56,230,030 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,509,658 - 54,516,311 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map12q13.2NCBI
HuRef1253,261,775 - 53,268,413 (+)NCBIHuRef
CHM1_11256,190,172 - 56,196,810 (+)NCBICHM1_1
T2T-CHM13v2.01255,796,254 - 55,802,893 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Tmem198b
178 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1205
Count of miRNA genes:411
Interacting mature miRNAs:446
Transcripts:ENSMUST00000051011, ENSMUST00000139227, ENSMUST00000152966
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099220635130530862Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105179713130530862Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097217101130530862Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397217101130530862Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103243727130530862Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108575094130530862Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108575094130530862Mouse
12911219Frct3b_mfear conditioning traits 3b (mouse)10127675574129466996Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10100986516130530862Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102506908130530862Mouse
12904000Opfaq7_mopen field activity QTL 7 (mouse)10127746318129466375Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097217101130530862Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099220635130530862Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105041304130530862Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105179713130530862Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105041304130530862Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105041304130530862Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108575094130530862Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97758644130530862Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122785970129466996Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097217101130530862Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101497164130530862Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104110021130530862Mouse
14746996Manh69_mmandible shape 69 (mouse)10104763638130530862Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10102902508130530862Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125633671129466375Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099220635130530862Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122785970129466996Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108515907130530862Mouse
12911221Frct3d_mfear conditioning traits 3d (mouse)10127675574129466996Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105179713130530862Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10102847852130530862Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122785970129466996Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097535905130530862Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10100986516130530862Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101497164130530862Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108515907130530862Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108575094130530862Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001358266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001358267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_178066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030245325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC131081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK054166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000051011   ⟹   ENSMUSP00000050451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,635,905 - 128,640,239 (-)Ensembl
GRCm38.p6 Ensembl10128,800,036 - 128,804,370 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139227   ⟹   ENSMUSP00000118082
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,636,710 - 128,639,586 (-)Ensembl
GRCm38.p6 Ensembl10128,800,841 - 128,803,717 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152966
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl10128,635,974 - 128,639,830 (-)Ensembl
GRCm38.p6 Ensembl10128,800,105 - 128,803,961 (-)Ensembl
RefSeq Acc Id: NM_001358266   ⟹   NP_001345195
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,905 - 128,640,316 (-)NCBI
GRCm3810128,800,036 - 128,804,447 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001358267   ⟹   NP_001345196
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,905 - 128,639,836 (-)NCBI
GRCm3810128,800,036 - 128,803,967 (-)NCBI
Sequence:
RefSeq Acc Id: NM_178066   ⟹   NP_835167
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,905 - 128,640,316 (-)NCBI
GRCm3810128,800,036 - 128,804,447 (-)NCBI
MGSCv3710128,237,092 - 128,241,426 (-)RGD
Celera10131,192,251 - 131,196,585 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006514222   ⟹   XP_006514285
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,905 - 128,640,616 (-)NCBI
GRCm3810128,800,036 - 128,804,747 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006514224   ⟹   XP_006514287
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,900 - 128,640,045 (-)NCBI
GRCm3810128,800,030 - 128,804,176 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006514225   ⟹   XP_006514288
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,905 - 128,641,246 (-)NCBI
GRCm3810128,800,036 - 128,805,050 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006514226   ⟹   XP_006514289
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,633,958 - 128,640,354 (-)NCBI
GRCm3810128,798,089 - 128,804,489 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245321   ⟹   XP_030101181
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,905 - 128,641,255 (-)NCBI
GRCm3810128,800,036 - 128,805,386 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245322   ⟹   XP_030101182
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,635,905 - 128,641,243 (-)NCBI
GRCm3810128,800,036 - 128,805,386 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245324   ⟹   XP_030101184
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,633,958 - 128,640,618 (-)NCBI
GRCm3810128,798,089 - 128,804,749 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030245325   ⟹   XP_030101185
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910128,633,958 - 128,641,242 (-)NCBI
GRCm3810128,798,089 - 128,805,373 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_835167   ⟸   NM_178066
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514289   ⟸   XM_006514226
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006514288   ⟸   XM_006514225
- Peptide Label: isoform X1
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514285   ⟸   XM_006514222
- Peptide Label: isoform X1
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006514287   ⟸   XM_006514224
- Peptide Label: isoform X1
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030101185   ⟸   XM_030245325
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030101184   ⟸   XM_030245324
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030101182   ⟸   XM_030245322
- Peptide Label: isoform X1
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030101181   ⟸   XM_030245321
- Peptide Label: isoform X1
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001345195   ⟸   NM_001358266
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001345196   ⟸   NM_001358267
- UniProtKB: Q8CFU0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000118082   ⟸   ENSMUST00000139227
RefSeq Acc Id: ENSMUSP00000050451   ⟸   ENSMUST00000051011
Protein Domains
DUF4203

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CFU0-F1-model_v2 AlphaFold Q8CFU0 1-350 view protein structure

Promoters
RGD ID:6819855
Promoter ID:MM_KWN:6025
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_178066,   OTTMUST00000084407,   OTTMUST00000084408,   UC007HOJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610128,241,056 - 128,242,417 (-)MPROMDB
RGD ID:8673664
Promoter ID:EPDNEW_M14863
Type:multiple initiation site
Name:Tmem198b_2
Description:Mus musculus transmembrane protein 198b , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14864  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,803,967 - 128,804,027EPDNEW
RGD ID:8673666
Promoter ID:EPDNEW_M14864
Type:initiation region
Name:Tmem198b_1
Description:Mus musculus transmembrane protein 198b , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14863  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810128,804,439 - 128,804,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921077 AgrOrtholog
Ensembl Genes ENSMUSG00000047090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000051011 ENTREZGENE
  ENSMUST00000051011.14 UniProtKB/TrEMBL
  ENSMUST00000139227.2 UniProtKB/TrEMBL
InterPro DUF4203 UniProtKB/TrEMBL
  TMEM198 UniProtKB/TrEMBL
MGD MGI:1921077 ENTREZGENE
NCBI Gene 73827 ENTREZGENE
PANTHER PTHR31247 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 198B UniProtKB/TrEMBL
Pfam DUF4203 UniProtKB/TrEMBL
PhenoGen Tmem198b PhenoGen
UniProt D6RJ24_MOUSE UniProtKB/TrEMBL
  Q8CFU0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-12-13 Tmem198b  transmembrane protein 198b  1110012D08Rik  RIKEN cDNA 1110012D08 gene  Symbol and/or name change 5135510 APPROVED