Defa15 (defensin, alpha, 15) - Rat Genome Database

Name: Defa15
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Defa15 (defensin, alpha, 15) Mus musculus

Analyze

No known orthologs.

Symbol:

Defa15

Name:

defensin, alpha, 15

RGD ID:

1612765

MGI Page

MGI

Description:

Predicted to enable pore-forming activity and protein homodimerization activity. Predicted to be involved in cellular response to lipopolysaccharide; defense response to other organism; and disruption of plasma membrane integrity in another organism. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in midbody and secretory granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA5 (defensin alpha 5).

Type:

protein-coding

Previously known as:

alpha-defensin 15; alpha-defensin, 15; Defcr1; Defcr15; defensin related cryptdin 15; defensin-related cryptdin-15

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	DEFA6 (defensin alpha 6)	HGNC	Panther
Homo sapiens (human):	DEFA3 (defensin alpha 3)	HGNC	Panther
Homo sapiens (human):	DEFA5 (defensin alpha 5)	HGNC	Panther
Homo sapiens (human):	DEFA1 (defensin alpha 1)	HGNC	Panther
Homo sapiens (human):	DEFA4 (defensin alpha 4)	HGNC	Panther
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Defa24 (defensin alpha 24)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	DEFA6 (defensin alpha 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA3 (defensin alpha 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA5 (defensin alpha 5)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA1 (defensin alpha 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)
Homo sapiens (human):	DEFA1B (defensin alpha 1B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoInspector\|PANTHER)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

NCBI Annotation Information:

Genome Annotation Status: not in current annotation release

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Cytogenetic Map	8		NCBI

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

sodium arsenate (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antibacterial humoral response (IBA)

antimicrobial humoral immune response mediated by antimicrobial peptide (IBA)

cellular response to lipopolysaccharide (IBA)

defense response (IEA)

defense response to bacterium (IEA)

defense response to Gram-negative bacterium (IBA)

defense response to Gram-positive bacterium (IBA)

disruption of plasma membrane integrity in another organism (IBA)

innate immune response in mucosa (IBA)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,ISO)

intracellular membrane-bounded organelle (ISO)

midbody (ISO)

secretory granule (ISO)

Molecular Function

pore-forming activity (ISO)

protein homodimerization activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7927786	PMID:8188287	PMID:20003482	PMID:21873635

Genomics

Expression

Sequence

Nucleotide Sequences


GenBank Nucleotide	U03065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Protein Sequences


GenBank Protein	AAA57182	(Get FASTA)	NCBI Sequence Viewer
	P50713	(Get FASTA)	NCBI Sequence Viewer

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P50713-F1-model_v2	AlphaFold	P50713	1-93	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:99586	AgrOrtholog
InterPro	Alpha-defensin	UniProtKB/Swiss-Prot
	Alpha-defensin_pro	UniProtKB/Swiss-Prot
	Defensin_beta/alpha	UniProtKB/Swiss-Prot
	Defensin_propep	UniProtKB/Swiss-Prot
MGD	MGI:99586	ENTREZGENE
NCBI Gene	13234	ENTREZGENE
PANTHER	ALPHA-DEFENSIN 1-RELATED	UniProtKB/Swiss-Prot
	PTHR11876	UniProtKB/Swiss-Prot
Pfam	Defensin_1	UniProtKB/Swiss-Prot
	Defensin_propep	UniProtKB/Swiss-Prot
PhenoGen	Defa15	PhenoGen
PIRSF	Alpha-defensin	UniProtKB/Swiss-Prot
PROSITE	DEFENSIN	UniProtKB/Swiss-Prot
SMART	Defensin_propep	UniProtKB/Swiss-Prot
	DEFSN	UniProtKB/Swiss-Prot
Superfamily-SCOP	Defensin-like	UniProtKB/Swiss-Prot
UniProt	DFA15_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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