Mir449a (microRNA 449a) - Rat Genome Database

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Gene: Mir449a (microRNA 449a) Mus musculus
Analyze
Symbol: Mir449a
Name: microRNA 449a
RGD ID: 1608186
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; embryonic brain development; and motile cilium assembly. Is expressed in brain; future hindbrain roof plate; heart ventricle; and olfactory epithelium. Orthologous to human MIR449A (microRNA 449a).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-449a; Mirn; Mirn449; Mirn449a; mmu-mir-449
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913113,174,068 - 113,174,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13113,174,068 - 113,174,158 (+)EnsemblGRCm39 Ensembl
GRCm3813113,037,534 - 113,037,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13113,037,534 - 113,037,624 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,827,742 - 113,827,832 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera13117,355,551 - 117,355,641 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.93NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15735639   PMID:16381832   PMID:17369397   PMID:17604727   PMID:18184563   PMID:19056356   PMID:19960022   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20558326   PMID:21037258  
PMID:21088493   PMID:21267068   PMID:21418558   PMID:22570483   PMID:23893957   PMID:24982181   PMID:25329700   PMID:26107383   PMID:27351886   PMID:27707753   PMID:28498403   PMID:28878284  
PMID:28923932   PMID:29162901   PMID:29720725   PMID:29880381   PMID:30015944   PMID:30551487   PMID:30578296   PMID:30659149   PMID:31068677   PMID:31336052   PMID:31345231   PMID:32124967  
PMID:33095425   PMID:33179102   PMID:33645622   PMID:33787491   PMID:35887096   PMID:36781680   PMID:36976763  


Genomics

Comparative Map Data
Mir449a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913113,174,068 - 113,174,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13113,174,068 - 113,174,158 (+)EnsemblGRCm39 Ensembl
GRCm3813113,037,534 - 113,037,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13113,037,534 - 113,037,624 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,827,742 - 113,827,832 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera13117,355,551 - 117,355,641 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.93NCBI
MIR449A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38555,170,532 - 55,170,622 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl555,170,532 - 55,170,622 (-)EnsemblGRCh38hg38GRCh38
GRCh37554,466,360 - 54,466,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36554,502,116 - 54,502,206 (-)NCBINCBI36Build 36hg18NCBI36
Celera551,419,206 - 51,419,296 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef551,439,533 - 51,439,623 (-)NCBIHuRef
CHM1_1554,469,853 - 54,469,943 (-)NCBICHM1_1
T2T-CHM13v2.0555,997,819 - 55,997,909 (-)NCBIT2T-CHM13v2.0
Mir449a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8246,403,910 - 46,404,000 (+)NCBIGRCr8
mRatBN7.2244,670,714 - 44,670,804 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,670,714 - 44,670,804 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx251,781,734 - 51,781,824 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0249,840,092 - 49,840,182 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0244,715,525 - 44,715,615 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0244,897,601 - 44,897,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,897,601 - 44,897,691 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0263,935,154 - 63,935,244 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera240,445,141 - 40,445,231 (+)NCBICelera
Cytogenetic Map2q14NCBI
MIR449A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,541,949 - 42,542,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,541,949 - 42,542,039 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,587,525 - 39,587,615 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,003,982 - 43,004,072 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1240,070,025 - 40,070,115 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,884,585 - 40,884,675 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,707,507 - 41,707,597 (-)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Mir449a
8 total Variants
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:25497
Count of gene targets:11006
Count of transcripts:18755
Interacting mature miRNAs:mmu-miR-449a-3p, mmu-miR-449a-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102602630120883175Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103341617117043216Mouse
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107613580119476372Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110409487119476372Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13113,174,068 - 113,174,158 (+)Ensembl
GRCm38.p6 Ensembl13113,037,534 - 113,037,624 (+)Ensembl
RefSeq Acc Id: NR_029961
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913113,174,068 - 113,174,158 (+)NCBI
GRCm3813113,037,534 - 113,037,624 (+)ENTREZGENE
MGSCv3713113,827,742 - 113,827,832 (+)RGD
Celera13117,355,551 - 117,355,641 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Promoters
RGD ID:8681332
Promoter ID:EPDNEW_M18696
Type:single initiation site
Name:Mir449a_1
Description:Mus musculus microRNA 449a , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813113,037,613 - 113,037,673EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619407 AgrOrtholog
Ensembl Genes ENSMUSG00000065575 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083641 ENTREZGENE
MGD MGI:3619407 ENTREZGENE
miRBase MI0001649 ENTREZGENE
NCBI Gene 723868 ENTREZGENE
PhenoGen Mir449a PhenoGen
RNAcentral URS00001F5B39 RNACentral
  URS000029DF45 RNACentral
  URS000064C3C7 RNACentral