Mir26a-1 (microRNA 26a-1) - Rat Genome Database

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Pathways
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Gene: Mir26a-1 (microRNA 26a-1) Mus musculus
Analyze
Symbol: Mir26a-1
Name: microRNA 26a-1
RGD ID: 1607668
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to mechanical stimulus; long-term synaptic potentiation; and negative regulation of macromolecule metabolic process. Located in extracellular exosome. Part of RISC complex. Is expressed in several structures, including brain and lung. Orthologous to human MIR26A1 (microRNA 26a-1).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: Mir; miR-26a; mir-26a-1; Mirn2; Mirn26a; Mirn26a-1
RGD Orthologs
Human
Rat
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,860,864 - 118,860,953 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,860,864 - 118,860,953 (+)EnsemblGRCm39 Ensembl
GRCm389119,031,796 - 119,031,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,031,796 - 119,031,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv379118,940,914 - 118,941,003 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9119,499,693 - 119,499,782 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to lipopolysaccharide  (IDA)
cellular response to mechanical stimulus  (IDA)
embryo implantation  (IDA)
long-term synaptic potentiation  (IEP)
miRNA-mediated post-transcriptional gene silencing  (IDA,ISO)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of cell cycle G1/S phase transition  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of G1/S transition of mitotic cell cycle  (IDA,ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of MAPK cascade  (ISO)
negative regulation of protein phosphorylation  (IDA)
negative regulation of vascular associated smooth muscle cell differentiation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
response to bacterium  (IEP)
response to wounding  (IEP)
transforming growth factor beta receptor signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:15538371   PMID:15845075   PMID:16369549   PMID:16381832   PMID:16766679   PMID:17369397   PMID:17604727   PMID:18281287   PMID:18452032   PMID:18556655   PMID:18713946  
PMID:18762567   PMID:19524505   PMID:19559694   PMID:19701194   PMID:20215419   PMID:20413612   PMID:20739651   PMID:20857419   PMID:21037258   PMID:21267068   PMID:21718763   PMID:21822254  
PMID:21903578   PMID:22210897   PMID:22367207   PMID:22496754   PMID:22673513   PMID:23028144   PMID:23254997   PMID:23543060   PMID:24047927   PMID:24114270   PMID:24205035   PMID:24328779  
PMID:24594795   PMID:25329154   PMID:25362566   PMID:25395662   PMID:25518928   PMID:25728641   PMID:25766405   PMID:25801675   PMID:25808510   PMID:25858512   PMID:25865461   PMID:25907560  
PMID:25959411   PMID:25961460   PMID:26050992   PMID:26063197   PMID:26107166   PMID:26247736   PMID:26313916   PMID:26320674   PMID:26376347   PMID:26776318   PMID:26787543   PMID:26818545  
PMID:27040676   PMID:27377869   PMID:27939580   PMID:28174206   PMID:28337265   PMID:28558034   PMID:28622289   PMID:29191656   PMID:29436664   PMID:29515367   PMID:29952219   PMID:30024304  
PMID:30703362   PMID:30718039   PMID:31210329   PMID:31338931   PMID:31364731   PMID:31474996   PMID:31488578   PMID:31512556   PMID:31593640   PMID:31887787   PMID:31964775   PMID:32092075  
PMID:32286945   PMID:32433053   PMID:32567701   PMID:32580945   PMID:32588686   PMID:32865120   PMID:33096414   PMID:33179083   PMID:33667597   PMID:33959794   PMID:33993982   PMID:34058933  
PMID:34261477   PMID:34311651   PMID:34370360   PMID:34555985   PMID:34582059   PMID:34714511   PMID:35083625   PMID:35133054   PMID:35957809   PMID:36049464   PMID:36252394   PMID:36524378  
PMID:36611831   PMID:36948295   PMID:37003368   PMID:38164021  


Genomics

Comparative Map Data
Mir26a-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399118,860,864 - 118,860,953 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9118,860,864 - 118,860,953 (+)EnsemblGRCm39 Ensembl
GRCm389119,031,796 - 119,031,885 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,031,796 - 119,031,885 (+)EnsemblGRCm38mm10GRCm38
MGSCv379118,940,914 - 118,941,003 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera9119,499,693 - 119,499,782 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.32NCBI
MIR26A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38337,969,404 - 37,969,480 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl337,969,404 - 37,969,480 (+)EnsemblGRCh38hg38GRCh38
GRCh37338,010,895 - 38,010,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36337,985,898 - 37,985,974 (+)NCBINCBI36Build 36hg18NCBI36
Celera337,945,267 - 37,945,343 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef337,953,581 - 37,953,657 (+)NCBIHuRef
CHM1_1337,962,544 - 37,962,620 (+)NCBICHM1_1
T2T-CHM13v2.0337,973,584 - 37,973,660 (+)NCBIT2T-CHM13v2.0
Mir26a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88127,633,048 - 127,633,137 (+)NCBIGRCr8
mRatBN7.28118,755,289 - 118,755,378 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8118,755,289 - 118,755,378 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8124,356,957 - 124,357,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,555,905 - 122,555,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,388,622 - 120,388,711 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08127,714,441 - 127,714,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8127,714,441 - 127,714,530 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08126,931,592 - 126,931,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8117,928,870 - 117,928,959 (+)NCBICelera
Cytogenetic Map8q32NCBI
MIR26A-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1237,747,073 - 7,747,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl237,747,064 - 7,747,140 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha237,788,996 - 7,789,056 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,036,042 - 8,036,102 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,036,033 - 8,036,109 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1237,850,472 - 7,850,532 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0237,991,571 - 7,991,631 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0237,983,727 - 7,983,787 (+)NCBIUU_Cfam_GSD_1.0

Variants

.
Variants in Mir26a-1
4 total Variants
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8908
Count of gene targets:4577
Count of transcripts:6871
Interacting mature miRNAs:mmu-miR-26a-1-3p
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986107600120107729Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9100889929124359700Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989289476123289595Mouse
1301484Bwq6_mbody weight (mouse)Not determined993591658124359700Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993591658124359700Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986121898120118690Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103118511124359700Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9101829255124359700Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963239711120191934Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9101829255124359700Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991518283124359700Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63239711120191934Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63239711120191934Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103118511124359700Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986625682120625682Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989162124123162124Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991560372124359700Mouse
12910770Splic1_mspleen iron content 1 (mouse)991291078124359700Mouse
12910772Lvic6_mliver iron content 6 (mouse)991291078124359700Mouse
12910773Splic3_mspleen iron content 3 (mouse)991291078124359700Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991560372124359700Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991560372124359700Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103118511124359700Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987677199121677199Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996746658124359700Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991518283124359700Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991518283124359700Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991518283124359700Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991518283124359700Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991518283124359700Mouse
14746992Manh67_mmandible shape 67 (mouse)993865836124359700Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989440541123440541Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083579
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl9118,860,864 - 118,860,953 (+)Ensembl
GRCm38.p6 Ensembl9119,031,796 - 119,031,885 (+)Ensembl
RefSeq Acc Id: NR_029742
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399118,860,864 - 118,860,953 (+)NCBI
GRCm389119,031,796 - 119,031,885 (+)ENTREZGENE
MGSCv379118,940,914 - 118,941,003 (+)RGD
Celera9119,499,693 - 119,499,782 (+)RGD
cM Map9 ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676900 AgrOrtholog
Ensembl Genes ENSMUSG00000065513 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083579 ENTREZGENE
MGD MGI:2676900 ENTREZGENE
miRBase MI0000573 ENTREZGENE
NCBI Gene 387218 ENTREZGENE
PhenoGen Mir26a-1 PhenoGen
RNAcentral URS00000C0D3F RNACentral
  URS000019B0F7 RNACentral
  URS000075D9C9 RNACentral