LIPJ (lipase family member J) - Rat Genome Database

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Gene: LIPJ (lipase family member J) Homo sapiens
Analyze
Symbol: LIPJ
Name: lipase family member J
RGD ID: 1603579
HGNC Page HGNC:21773
Description: Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be active in intracellular membrane-bounded organelle.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bA425M17.2; FLJ11218; lipase J; lipase member J; lipase, family member J; lipase-like abhydrolase domain-containing protein 1; lipase-like, ab-hydrolase domain containing 1; LIPL1
RGD Orthologs
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381088,582,907 - 88,623,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1088,586,753 - 88,606,976 (+)EnsemblGRCh38hg38GRCh38
GRCh371090,342,664 - 90,366,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,336,499 - 90,356,712 (+)NCBINCBI36Build 36hg18NCBI36
Celera1084,093,334 - 84,113,548 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1083,981,090 - 84,001,299 (+)NCBIHuRef
CHM1_11090,628,595 - 90,648,809 (+)NCBICHM1_1
T2T-CHM13v2.01089,466,981 - 89,507,284 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14702039   PMID:21873635  


Genomics

Comparative Map Data
LIPJ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381088,582,907 - 88,623,184 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1088,586,753 - 88,606,976 (+)EnsemblGRCh38hg38GRCh38
GRCh371090,342,664 - 90,366,733 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,336,499 - 90,356,712 (+)NCBINCBI36Build 36hg18NCBI36
Celera1084,093,334 - 84,113,548 (+)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1083,981,090 - 84,001,299 (+)NCBIHuRef
CHM1_11090,628,595 - 90,648,809 (+)NCBICHM1_1
T2T-CHM13v2.01089,466,981 - 89,507,284 (+)NCBIT2T-CHM13v2.0
Lipj
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,776,650 - 240,789,997 (-)NCBIGRCr8
mRatBN7.21231,363,526 - 231,376,784 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1231,363,646 - 231,376,784 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01252,154,610 - 252,167,791 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,154,616 - 252,167,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,377,521 - 259,390,575 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,694,841 - 237,708,819 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1228,477,188 - 228,490,290 (-)NCBICelera
Cytogenetic Map1q52NCBI
Lipj
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554254,337,718 - 4,365,841 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554254,337,718 - 4,368,577 (-)NCBIChiLan1.0ChiLan1.0
LIPJ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28100,596,654 - 100,624,400 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110100,601,969 - 100,629,715 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01085,307,536 - 85,330,911 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11088,816,492 - 88,832,860 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1088,816,492 - 88,832,860 (+)Ensemblpanpan1.1panPan2
LIPJ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12638,419,821 - 38,441,234 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2638,424,721 - 38,588,175 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2638,232,759 - 38,258,116 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02640,004,034 - 40,025,430 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12637,840,192 - 37,865,672 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02637,435,626 - 37,460,870 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02638,705,616 - 38,730,906 (+)NCBIUU_Cfam_GSD_1.0
Lipj
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721378,139,052 - 78,159,785 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936735633,135 - 654,218 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIPJ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,032,074 - 82,052,232 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl982,035,967 - 82,052,166 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604842,709,571 - 42,729,649 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in LIPJ
15 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q23.31(chr10:88439108-88978831)x3 copy number gain See cases [RCV000050707] Chr10:88439108..88978831 [GRCh38]
Chr10:90198865..90738588 [GRCh37]
Chr10:90188845..90728568 [NCBI36]
Chr10:10q23.31		 uncertain significance
GRCh38/hg38 10q23.2-23.31(chr10:86727432-89201768)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052561]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052561]|See cases [RCV000052561] Chr10:86727432..89201768 [GRCh38]
Chr10:88487189..90961525 [GRCh37]
Chr10:88477169..90951505 [NCBI36]
Chr10:10q23.2-23.31		 pathogenic
GRCh38/hg38 10q23.1-23.31(chr10:84434981-89150802)x3 copy number gain See cases [RCV000053559] Chr10:84434981..89150802 [GRCh38]
Chr10:86194737..90910559 [GRCh37]
Chr10:86184717..90900539 [NCBI36]
Chr10:10q23.1-23.31		 pathogenic
NM_001010939.2(LIPJ):c.98C>T (p.Pro33Leu) single nucleotide variant Malignant melanoma [RCV000069072] Chr10:88591466 [GRCh38]
Chr10:90351223 [GRCh37]
Chr10:90341203 [NCBI36]
Chr10:10q23.31		 not provided
GRCh37/hg19 10q23.1-23.31(chr10:86766571-92609514)x1 copy number loss See cases [RCV000447104] Chr10:86766571..92609514 [GRCh37]
Chr10:10q23.1-23.31		 pathogenic
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1		 pathogenic|drug response
GRCh37/hg19 10q23.2-23.31(chr10:88615516-92032083)x3 copy number gain See cases [RCV000448638] Chr10:88615516..92032083 [GRCh37]
Chr10:10q23.2-23.31		 uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NM_001010939.3(LIPJ):c.302C>T (p.Thr101Met) single nucleotide variant not specified [RCV004286568] Chr10:88594117 [GRCh38]
Chr10:90353874 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3		 drug response
GRCh38/hg38 10q23.31(chr10:87830830-88617225)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626428] Chr10:87830830..88617225 [GRCh38]
Chr10:89590587..90376982 [GRCh37]
Chr10:10q23.31		 drug response
GRCh37/hg19 10q23.1-23.32(chr10:83379241-93219169)x1 copy number loss not provided [RCV000683284] Chr10:83379241..93219169 [GRCh37]
Chr10:10q23.1-23.32		 pathogenic
GRCh37/hg19 10q21.3-23.32(chr10:69040366-93194993)x3 copy number gain not provided [RCV000683289] Chr10:69040366..93194993 [GRCh37]
Chr10:10q21.3-23.32		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
NC_000010.11:g.(?_87552082)_(88768928_?)del deletion PTEN hamartoma tumor syndrome [RCV001033358] Chr10:89311839..90528685 [GRCh37]
Chr10:10q23.2-23.31		 pathogenic
NM_001010939.3(LIPJ):c.152T>G (p.Leu51Trp) single nucleotide variant not specified [RCV004311778] Chr10:88593967 [GRCh38]
Chr10:90353724 [GRCh37]
Chr10:10q23.31		 uncertain significance
NC_000010.11:g.(?_87863161)_(88948936_?)del deletion PTEN hamartoma tumor syndrome [RCV001032107] Chr10:89622918..90708693 [GRCh37]
Chr10:10q23.31		 pathogenic
GRCh37/hg19 10q23.1-23.32(chr10:82595472-93542416)x1 copy number loss not provided [RCV002472429] Chr10:82595472..93542416 [GRCh37]
Chr10:10q23.1-23.32		 pathogenic
GRCh37/hg19 10q23.31-23.33(chr10:89823147-96056941)x1 copy number loss not provided [RCV002472645] Chr10:89823147..96056941 [GRCh37]
Chr10:10q23.31-23.33		 pathogenic
NM_001031709.3(RNLS):c.111G>C (p.Glu37Asp) single nucleotide variant Stage 5 chronic kidney disease [RCV001789711]|not provided [RCV001655053] Chr10:88583080 [GRCh38]
Chr10:90342837 [GRCh37]
Chr10:10q23.31		 association|benign
NR_172141.1(LIPJ):n.735A>G single nucleotide variant not provided [RCV001637812] Chr10:88583641 [GRCh38]
Chr10:90343398 [GRCh37]
Chr10:10q23.31		 benign
NC_000010.11:g.(88598737_88635623)_(88635843_88649818)del deletion Juvenile polyposis syndrome [RCV001254852] Chr10:88635623..88635843 [GRCh38]
Chr10:10q23.31		 pathogenic
GRCh37/hg19 10q23.2-23.31(chr10:88685387-92144296)x1 copy number loss not provided [RCV001258457] Chr10:88685387..92144296 [GRCh37]
Chr10:10q23.2-23.31		 pathogenic
GRCh37/hg19 10q23.31(chr10:90122675-90771228)x3 copy number gain not provided [RCV001258458] Chr10:90122675..90771228 [GRCh37]
Chr10:10q23.31		 uncertain significance
NR_172141.1(LIPJ):n.589T>A single nucleotide variant not provided [RCV001757392] Chr10:88583495 [GRCh38]
Chr10:90343252 [GRCh37]
Chr10:10q23.31		 likely benign
NR_172141.1(LIPJ):n.455G>A single nucleotide variant not provided [RCV001753081] Chr10:88583361 [GRCh38]
Chr10:90343118 [GRCh37]
Chr10:10q23.31		 likely benign
NC_000010.10:g.(?_89514444)_(90537999_?)del deletion PTEN hamartoma tumor syndrome [RCV003111000] Chr10:89514444..90537999 [GRCh37]
Chr10:10q23.31		 pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3		 pathogenic
GRCh37/hg19 10q23.1-23.31(chr10:83533660-91913077)x1 copy number loss See cases [RCV002287561] Chr10:83533660..91913077 [GRCh37]
Chr10:10q23.1-23.31		 pathogenic
NM_001010939.3(LIPJ):c.427G>T (p.Gly143Cys) single nucleotide variant not specified [RCV004127345] Chr10:88594764 [GRCh38]
Chr10:90354521 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.968T>C (p.Leu323Ser) single nucleotide variant not specified [RCV004119874] Chr10:88606774 [GRCh38]
Chr10:90366531 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.632G>A (p.Gly211Asp) single nucleotide variant not specified [RCV004147762] Chr10:88596845 [GRCh38]
Chr10:90356602 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.780G>T (p.Met260Ile) single nucleotide variant not specified [RCV004115624] Chr10:88602632 [GRCh38]
Chr10:90362389 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.614C>T (p.Ser205Leu) single nucleotide variant not specified [RCV004212849] Chr10:88596827 [GRCh38]
Chr10:90356584 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10p13-q26.3(chr10:12829206-135427143) copy number loss Distal 10q deletion syndrome [RCV003319583] Chr10:12829206..135427143 [GRCh37]
Chr10:10p13-q26.3		 pathogenic
GRCh37/hg19 10p14-q26.3(chr10:11138692-135427143) copy number gain Distal trisomy 10q [RCV003319593] Chr10:11138692..135427143 [GRCh37]
Chr10:10p14-q26.3		 pathogenic
NM_001010939.3(LIPJ):c.667A>G (p.Ile223Val) single nucleotide variant not specified [RCV004342179] Chr10:88596880 [GRCh38]
Chr10:90356637 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q11.21-24.2(chr10:42709645-100834951)x3 copy number gain not provided [RCV003484798] Chr10:42709645..100834951 [GRCh37]
Chr10:10q11.21-24.2		 pathogenic
NM_001031709.3(RNLS):c.32T>G (p.Met11Arg) single nucleotide variant not provided [RCV003668405] Chr10:88583159 [GRCh38]
Chr10:90342916 [GRCh37]
Chr10:10q23.31		 uncertain significance
GRCh37/hg19 10q23.31-23.32(chr10:89950990-92959893)x3 copy number gain not specified [RCV003986875] Chr10:89950990..92959893 [GRCh37]
Chr10:10q23.31-23.32		 uncertain significance
GRCh37/hg19 10q23.2-23.32(chr10:88121043-93641582)x1 copy number loss not specified [RCV003986869] Chr10:88121043..93641582 [GRCh37]
Chr10:10q23.2-23.32		 pathogenic
NM_001010939.3(LIPJ):c.209G>A (p.Ser70Asn) single nucleotide variant not specified [RCV004407433] Chr10:88594024 [GRCh38]
Chr10:90353781 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.71G>A (p.Gly24Asp) single nucleotide variant not specified [RCV004341771] Chr10:88591439 [GRCh38]
Chr10:90351196 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001031709.3(RNLS):c.55C>G (p.Leu19Val) single nucleotide variant not specified [RCV004446846] Chr10:88583136 [GRCh38]
Chr10:90342893 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.265G>A (p.Gly89Arg) single nucleotide variant not specified [RCV004407434] Chr10:88594080 [GRCh38]
Chr10:90353837 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.43G>A (p.Glu15Lys) single nucleotide variant not specified [RCV004407436] Chr10:88591411 [GRCh38]
Chr10:90351168 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.116A>G (p.Asn39Ser) single nucleotide variant not specified [RCV004407431] Chr10:88591484 [GRCh38]
Chr10:90351241 [GRCh37]
Chr10:10q23.31		 uncertain significance
NM_001010939.3(LIPJ):c.203A>G (p.Asn68Ser) single nucleotide variant not specified [RCV004407432] Chr10:88594018 [GRCh38]
Chr10:90353775 [GRCh37]
Chr10:10q23.31		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:162
Interacting mature miRNAs:166
Transcripts:ENST00000371939, ENST00000526923, ENST00000531458
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 81
Low 149 40 275 4 56 1 249 97 558 3 424 288 3 42 210
Below cutoff 1808 1941 1208 468 1156 320 3492 1550 2698 243 745 939 150 1069 2291

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001010939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005269542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006717635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011539320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017015740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024447826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047424642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047424643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054364875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054364876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054364877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054364878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054364879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054364880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054364881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK090891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC042900 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000371939   ⟹   ENSP00000361007
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1088,586,762 - 88,606,976 (+)Ensembl
RefSeq Acc Id: ENST00000526923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1088,586,753 - 88,594,312 (+)Ensembl
RefSeq Acc Id: ENST00000531458   ⟹   ENSP00000434211
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1088,594,746 - 88,606,823 (+)Ensembl
RefSeq Acc Id: NM_001010939   ⟹   NP_001010939
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,586,762 - 88,606,976 (+)NCBI
GRCh371090,346,519 - 90,366,733 (+)RGD
Build 361090,336,499 - 90,356,712 (+)NCBI Archive
Celera1084,093,334 - 84,113,548 (+)RGD
HuRef1083,981,090 - 84,001,299 (+)ENTREZGENE
CHM1_11090,628,595 - 90,648,809 (+)NCBI
T2T-CHM13v2.01089,470,836 - 89,491,045 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001394640   ⟹   NP_001381569
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,586,762 - 88,606,976 (+)NCBI
T2T-CHM13v2.01089,470,836 - 89,491,045 (+)NCBI
Sequence:
RefSeq Acc Id: NR_172141
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,582,907 - 88,606,976 (+)NCBI
T2T-CHM13v2.01089,466,981 - 89,491,045 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005269542   ⟹   XP_005269599
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,591,411 - 88,606,976 (+)NCBI
GRCh371090,346,519 - 90,366,733 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006717635   ⟹   XP_006717698
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,582,907 - 88,606,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539315   ⟹   XP_011537617
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,586,823 - 88,606,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539318   ⟹   XP_011537620
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,595,002 - 88,606,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011539319   ⟹   XP_011537621
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,591,411 - 88,606,976 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047424642   ⟹   XP_047280598
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,586,762 - 88,623,184 (+)NCBI
RefSeq Acc Id: XM_047424643   ⟹   XP_047280599
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381088,586,762 - 88,623,161 (+)NCBI
RefSeq Acc Id: XM_054364875   ⟹   XP_054220850
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01089,466,981 - 89,491,045 (+)NCBI
RefSeq Acc Id: XM_054364876   ⟹   XP_054220851
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01089,470,897 - 89,491,045 (+)NCBI
RefSeq Acc Id: XM_054364877   ⟹   XP_054220852
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01089,470,836 - 89,507,284 (+)NCBI
RefSeq Acc Id: XM_054364878   ⟹   XP_054220853
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01089,470,836 - 89,507,261 (+)NCBI
RefSeq Acc Id: XM_054364879   ⟹   XP_054220854
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01089,475,485 - 89,491,045 (+)NCBI
RefSeq Acc Id: XM_054364880   ⟹   XP_054220855
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01089,479,076 - 89,491,045 (+)NCBI
RefSeq Acc Id: XM_054364881   ⟹   XP_054220856
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01089,475,485 - 89,491,045 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001010939   ⟸   NM_001010939
- Peptide Label: isoform 1
- UniProtKB: A8MT98 (UniProtKB/Swiss-Prot),   Q0P671 (UniProtKB/Swiss-Prot),   Q5W064 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005269599   ⟸   XM_005269542
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006717698   ⟸   XM_006717635
- Peptide Label: isoform X1
- UniProtKB: A8MT98 (UniProtKB/Swiss-Prot),   Q0P671 (UniProtKB/Swiss-Prot),   Q5W064 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011537617   ⟸   XM_011539315
- Peptide Label: isoform X1
- UniProtKB: A8MT98 (UniProtKB/Swiss-Prot),   Q0P671 (UniProtKB/Swiss-Prot),   Q5W064 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011537621   ⟸   XM_011539319
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_011537620   ⟸   XM_011539318
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSP00000361007   ⟸   ENST00000371939
RefSeq Acc Id: ENSP00000434211   ⟸   ENST00000531458
RefSeq Acc Id: NP_001381569   ⟸   NM_001394640
- Peptide Label: isoform 2
RefSeq Acc Id: XP_047280598   ⟸   XM_047424642
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047280599   ⟸   XM_047424643
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054220850   ⟸   XM_054364875
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054220852   ⟸   XM_054364877
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054220853   ⟸   XM_054364878
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054220851   ⟸   XM_054364876
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054220854   ⟸   XM_054364879
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054220856   ⟸   XM_054364881
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054220855   ⟸   XM_054364880
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5W064-F1-model_v2 AlphaFold Q5W064 1-366 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:21773 AgrOrtholog
COSMIC LIPJ COSMIC
Ensembl Genes ENSG00000204022 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000371939 ENTREZGENE
  ENST00000371939.7 UniProtKB/Swiss-Prot
  ENST00000531458.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000204022 GTEx
HGNC ID HGNC:21773 ENTREZGENE
Human Proteome Map LIPJ Human Proteome Map
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_lipase UniProtKB/Swiss-Prot
  Lipase_euk UniProtKB/Swiss-Prot
KEGG Report hsa:142910 UniProtKB/Swiss-Prot
NCBI Gene 142910 ENTREZGENE
OMIM 613921 OMIM
PANTHER LIPASE MEMBER J UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LYSOSOMAL ACID LIPASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydro_lipase UniProtKB/Swiss-Prot
PharmGKB PA162394099 PharmGKB
PIRSF Steryl_ester_lip UniProtKB/Swiss-Prot
PROSITE LIPASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8MT98 ENTREZGENE
  H0YDS3_HUMAN UniProtKB/TrEMBL
  LIPJ_HUMAN UniProtKB/Swiss-Prot
  Q0P671 ENTREZGENE
  Q5W064 ENTREZGENE
UniProt Secondary A8MT98 UniProtKB/Swiss-Prot
  Q0P671 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 LIPJ  lipase family member J    lipase, family member J  Symbol and/or name change 5135510 APPROVED