Serpina3j (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J) - Rat Genome Database

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Gene: Serpina3j (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J) Rattus norvegicus
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Symbol: Serpina3j
Name: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J
RGD ID: 1595900
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in response to cytokine. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3); INTERACTS WITH bisphenol A (ortholog); ozone (ortholog); pirinixic acid (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC299277; serine protease inhibitor A3B-like; similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,884,420 - 128,900,135 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,876,923 - 128,914,465 (-)EnsemblGRCr8
mRatBN7.26123,119,647 - 123,135,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,120,387 - 123,136,416 (-)EnsemblmRatBN7.2
Rnor_6.06127,871,895 - 127,888,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,872,666 - 127,886,540 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.06137,083,644 - 137,109,552 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,253,388 - 128,269,951 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,563,978 - 120,616,558 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (ISO)
ozone  (ISO)
pirinixic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Serpina3j
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86128,884,420 - 128,900,135 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6128,876,923 - 128,914,465 (-)EnsemblGRCr8
mRatBN7.26123,119,647 - 123,135,364 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6123,120,387 - 123,136,416 (-)EnsemblmRatBN7.2
Rnor_6.06127,871,895 - 127,888,287 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6127,872,666 - 127,886,540 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.06137,083,644 - 137,109,552 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46128,253,388 - 128,269,951 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6120,563,978 - 120,616,558 (-)NCBICelera
Cytogenetic Map6q32NCBI
Serpina3j
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912104,266,981 - 104,286,845 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12104,280,812 - 104,286,984 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812104,300,722 - 104,320,586 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12104,314,553 - 104,320,725 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv3712105,552,780 - 105,558,796 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612104,715,620 - 104,720,978 (+)NCBIMGSCv36mm8
Celera12105,539,658 - 105,545,673 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1253.92NCBI

Variants

.
Variants in Serpina3j
91 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:137
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000057298
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat

Markers in Region
D6Rat8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86128,868,519 - 128,868,669 (+)Marker Load Pipeline
mRatBN7.26123,103,746 - 123,103,896 (+)MAPPERmRatBN7.2
Rnor_6.06127,856,026 - 127,856,175NCBIRnor6.0
Rnor_5.06137,067,010 - 137,067,159UniSTSRnor5.0
RGSC_v3.46128,236,540 - 128,236,956RGDRGSC3.4
RGSC_v3.46128,236,748 - 128,236,897UniSTSRGSC3.4
Celera6120,585,930 - 120,586,079UniSTS
RGSC_v3.16128,240,495 - 128,240,644RGD
RH 3.4 Map6819.0UniSTS
RH 3.4 Map6819.0RGD
RH 2.0 Map61135.3RGD
SHRSP x BN Map677.2698RGD
FHH x ACI Map681.67RGD
Cytogenetic Map6q32UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 2 26 38 486 103 118 13 60 37 57 27 290 139 13 463 99 239 59 5 5

Sequence


Ensembl Acc Id: ENSRNOT00000057298   ⟹   ENSRNOP00000054117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,876,923 - 128,914,465 (-)Ensembl
mRatBN7.2 Ensembl6123,120,387 - 123,136,416 (-)Ensembl
Rnor_6.0 Ensembl6127,872,666 - 127,886,540 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082680   ⟹   ENSRNOP00000074930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6128,876,942 - 128,912,171 (-)Ensembl
RefSeq Acc Id: XM_008764902   ⟹   XP_008763124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86128,884,420 - 128,900,135 (-)NCBI
mRatBN7.26123,119,647 - 123,135,364 (-)NCBI
Rnor_6.06127,871,895 - 127,888,287 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008763124 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054117
  ENSRNOP00000054117.4
  ENSRNOP00000074930.3
RefSeq Acc Id: XP_008763124   ⟸   XM_008764902
- UniProtKB: D4A4U8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054117   ⟸   ENSRNOT00000057298
Ensembl Acc Id: ENSRNOP00000074930   ⟸   ENSRNOT00000082680
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A4U8-F1-model_v2 AlphaFold D4A4U8 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595900 AgrOrtholog
BioCyc Gene G2FUF-36390 BioCyc
Ensembl Genes ENSRNOG00000037743 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057298 ENTREZGENE
  ENSRNOT00000057298.4 UniProtKB/TrEMBL
  ENSRNOT00000082680.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:299277 UniProtKB/TrEMBL
NCBI Gene 299277 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  SERINE (OR CYSTEINE) PEPTIDASE INHIBITOR, CLADE A (ALPHA-1 ANTIPROTEINASE, ANTITRYPSIN), MEMBER 3J-RELATED UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpina3j PhenoGen
RatGTEx ENSRNOG00000037743 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A0G2K9B1_RAT UniProtKB/TrEMBL
  D4A4U8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-26 Serpina3j  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J  LOC299277  similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B  Name and Symbol changed 629549 APPROVED
2006-11-20 LOC299277  similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B      Symbol and Name status set to provisional 70820 PROVISIONAL