Serpinb1b (serine (or cysteine) peptidase inhibitor, clade B, member 1b) - Rat Genome Database

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Gene: Serpinb1b (serine (or cysteine) peptidase inhibitor, clade B, member 1b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Serpinb1b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 1b
RGD ID: 1560658
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of interleukin-1 beta production. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1); PARTICIPATES IN Entamoebiasis pathway.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leukocyte elastase inhibitor A-like; LOC102553010; LOC306891; RGD1560658; similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,528,880 - 31,538,119 (-)NCBIGRCr8
mRatBN7.21731,320,135 - 31,329,151 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,320,556 - 31,327,935 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01732,550,351 - 32,559,423 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,550,801 - 32,558,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01734,442,596 - 34,451,533 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41737,679,496 - 37,686,875 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1730,882,641 - 30,891,578 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Serpinb1b
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000022681
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system
High
Medium
Low 1
Below cutoff 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022681   ⟹   ENSRNOP00000022680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1731,320,556 - 31,327,935 (-)Ensembl
Rnor_6.0 Ensembl1732,550,801 - 32,558,180 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000070876   ⟹   ENSRNOP00000067865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1732,009,809 - 32,015,071 (-)Ensembl
RefSeq Acc Id: XM_039096351   ⟹   XP_038952279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,528,880 - 31,538,119 (-)NCBI
mRatBN7.21731,320,135 - 31,329,132 (-)NCBI
RefSeq Acc Id: XM_039096352   ⟹   XP_038952280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,528,886 - 31,536,696 (-)NCBI
mRatBN7.21731,320,135 - 31,329,151 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038952279 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952280 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022680
  ENSRNOP00000022680.8
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000022680   ⟸   ENSRNOT00000022681
RefSeq Acc Id: XP_038952280   ⟸   XM_039096352
- Peptide Label: isoform X2
- UniProtKB: F8WGA3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038952279   ⟸   XM_039096351
- Peptide Label: isoform X1
- UniProtKB: A6J7I6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000067865   ⟸   ENSRNOT00000070876
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RE01-F1-model_v2 AlphaFold M0RE01 1-323 view protein structure
AF-F8WGA3-F1-model_v2 AlphaFold F8WGA3 1-378 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1560658 AgrOrtholog
BioCyc Gene G2FUF-9584 BioCyc
Ensembl Genes ENSRNOG00000034229 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000048358 Ensembl
Ensembl Transcript ENSRNOT00000022681.8 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
NCBI Gene 306891 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  PTHR11461:SF180 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb1b PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000034229 RatGTEx
  ENSRNOG00000048358 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A6J7I6 ENTREZGENE, UniProtKB/TrEMBL
  F8WGA3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Serpinb1b  serine (or cysteine) peptidase inhibitor, clade B, member 1b  LOC102553010  leukocyte elastase inhibitor A-like  Data merged from RGD:7739348 737654 PROVISIONAL
2013-12-18 LOC102553010  leukocyte elastase inhibitor A-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2010-04-23 Serpinb1b  serine (or cysteine) peptidase inhibitor, clade B, member 1b  RGD1560658  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1560658  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b   RGD1560658_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1560658_predicted  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b (predicted)  LOC306891  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306891  similar to serine (or cysteine) proteinase inhibitor, clade B, member 1b      Symbol and Name status set to provisional 70820 PROVISIONAL