Miga1 (mitoguardin 1) - Rat Genome Database

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Gene: Miga1 (mitoguardin 1) Rattus norvegicus
Analyze
Symbol: Miga1
Name: mitoguardin 1
RGD ID: 1559958
Description: Predicted to enable protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in mitochondrial fusion. Predicted to be located in mitochondrion and plasma membrane. Orthologous to human MIGA1 (mitoguardin 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; amphetamine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Fam73a; family with sequence similarity 73, member A; LOC362058; mitoguardin-1; RGD1559958; similar to RIKEN cDNA C030011O14 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,884,071 - 243,939,059 (-)NCBIGRCr8
mRatBN7.22241,224,118 - 241,279,174 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2241,226,015 - 241,279,106 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02257,490,729 - 257,546,846 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2257,493,875 - 257,546,799 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02276,167,480 - 276,223,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42250,803,495 - 250,852,993 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2233,158,543 - 233,212,583 (-)NCBICelera
Cytogenetic Map2q45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IEA,ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:26711011  


Genomics

Comparative Map Data
Miga1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,884,071 - 243,939,059 (-)NCBIGRCr8
mRatBN7.22241,224,118 - 241,279,174 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2241,226,015 - 241,279,106 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02257,490,729 - 257,546,846 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2257,493,875 - 257,546,799 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02276,167,480 - 276,223,312 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42250,803,495 - 250,852,993 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2233,158,543 - 233,212,583 (-)NCBICelera
Cytogenetic Map2q45NCBI
MIGA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,779,649 - 77,879,540 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,779,624 - 77,879,540 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,245,334 - 78,345,225 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,017,897 - 78,116,680 (+)NCBINCBI36Build 36hg18NCBI36
Celera176,484,888 - 76,583,132 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef176,376,932 - 76,476,864 (+)NCBIHuRef
CHM1_1178,361,154 - 78,461,631 (+)NCBICHM1_1
T2T-CHM13v2.0177,618,463 - 77,718,372 (+)NCBIT2T-CHM13v2.0
Miga1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393151,979,096 - 152,046,073 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3151,979,486 - 152,046,044 (-)EnsemblGRCm39 Ensembl
GRCm383152,273,459 - 152,340,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3152,273,849 - 152,340,407 (-)EnsemblGRCm38mm10GRCm38
MGSCv373151,936,423 - 152,003,371 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363152,211,235 - 152,277,776 (-)NCBIMGSCv36mm8
Celera3158,751,339 - 158,808,485 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map377.1NCBI
Miga1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542315,321,627 - 15,388,057 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542315,321,656 - 15,406,359 (-)NCBIChiLan1.0ChiLan1.0
MIGA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21149,012,726 - 149,109,352 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,175,127 - 148,272,111 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0176,999,588 - 77,095,686 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,084,279 - 79,178,604 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,084,279 - 79,178,604 (+)Ensemblpanpan1.1panPan2
MIGA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1669,019,898 - 69,107,024 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl668,964,187 - 69,107,009 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha671,678,072 - 71,765,154 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0669,606,353 - 69,693,495 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl669,606,354 - 69,693,575 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1669,112,863 - 69,199,692 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0669,057,435 - 69,144,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0669,543,012 - 69,630,621 (-)NCBIUU_Cfam_GSD_1.0
Miga1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505889,089,904 - 89,162,670 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365714,600,170 - 4,673,390 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365714,599,938 - 4,673,414 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIGA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6135,423,423 - 135,512,701 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16135,423,409 - 135,512,567 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26125,603,727 - 125,679,381 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIGA1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12055,299,395 - 55,399,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2055,294,436 - 55,399,972 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603362,122,596 - 62,215,630 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Miga1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474219,353,859 - 19,435,604 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474219,353,949 - 19,435,601 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Miga1
195 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
RH133536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22241,272,746 - 241,272,930 (+)MAPPERmRatBN7.2
Rnor_6.02257,542,331 - 257,542,514NCBIRnor6.0
Rnor_5.02276,218,790 - 276,218,973UniSTSRnor5.0
RGSC_v3.42250,848,006 - 250,848,189UniSTSRGSC3.4
Celera2233,206,224 - 233,206,407UniSTS
RH 3.4 Map21647.91UniSTS
Cytogenetic Map2q45UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 8 2 6 2 74 21 30 2
Low 3 33 40 30 13 30 8 11 14 11 9 8
Below cutoff 8 8 8

Sequence


RefSeq Acc Id: ENSRNOT00000089370   ⟹   ENSRNOP00000072364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,226,015 - 241,279,106 (-)Ensembl
Rnor_6.0 Ensembl2257,493,875 - 257,546,799 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090367   ⟹   ENSRNOP00000072602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,226,015 - 241,279,023 (-)Ensembl
Rnor_6.0 Ensembl2257,493,875 - 257,546,799 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095768   ⟹   ENSRNOP00000090920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2241,226,015 - 241,279,023 (-)Ensembl
RefSeq Acc Id: XM_039103882   ⟹   XP_038959810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,884,071 - 243,939,059 (-)NCBI
mRatBN7.22241,224,118 - 241,279,174 (-)NCBI
RefSeq Acc Id: XM_039103883   ⟹   XP_038959811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,884,071 - 243,938,914 (-)NCBI
mRatBN7.22241,224,118 - 241,278,971 (-)NCBI
RefSeq Acc Id: XM_039103884   ⟹   XP_038959812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,884,071 - 243,939,059 (-)NCBI
mRatBN7.22241,224,118 - 241,279,174 (-)NCBI
RefSeq Acc Id: XM_039103885   ⟹   XP_038959813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,884,071 - 243,939,059 (-)NCBI
mRatBN7.22241,224,118 - 241,279,174 (-)NCBI
RefSeq Acc Id: XM_039103886   ⟹   XP_038959814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,884,071 - 243,939,059 (-)NCBI
mRatBN7.22241,224,118 - 241,279,174 (-)NCBI
RefSeq Acc Id: XM_039103889   ⟹   XP_038959817
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,923,416 - 243,939,059 (-)NCBI
mRatBN7.22241,262,566 - 241,279,174 (-)NCBI
RefSeq Acc Id: XM_063282752   ⟹   XP_063138822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,884,071 - 243,938,948 (-)NCBI
RefSeq Acc Id: XM_063282753   ⟹   XP_063138823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,884,071 - 243,938,957 (-)NCBI
RefSeq Acc Id: XM_063282754   ⟹   XP_063138824
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,923,416 - 243,938,916 (-)NCBI
RefSeq Acc Id: XM_063282755   ⟹   XP_063138825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82243,923,416 - 243,938,938 (-)NCBI
RefSeq Acc Id: ENSRNOP00000072602   ⟸   ENSRNOT00000090367
RefSeq Acc Id: ENSRNOP00000072364   ⟸   ENSRNOT00000089370
RefSeq Acc Id: XP_038959814   ⟸   XM_039103886
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ADJ1 (UniProtKB/TrEMBL),   A6HWL1 (UniProtKB/TrEMBL),   D4A5P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959813   ⟸   XM_039103885
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K2T2 (UniProtKB/TrEMBL),   A6HWL1 (UniProtKB/TrEMBL),   D4A5P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959812   ⟸   XM_039103884
- Peptide Label: isoform X2
- UniProtKB: A6HWL1 (UniProtKB/TrEMBL),   D4A5P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959810   ⟸   XM_039103882
- Peptide Label: isoform X1
- UniProtKB: A6HWL1 (UniProtKB/TrEMBL),   D4A5P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959811   ⟸   XM_039103883
- Peptide Label: isoform X1
- UniProtKB: A6HWL1 (UniProtKB/TrEMBL),   D4A5P3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959817   ⟸   XM_039103889
- Peptide Label: isoform X6
RefSeq Acc Id: ENSRNOP00000090920   ⟸   ENSRNOT00000095768
RefSeq Acc Id: XP_063138823   ⟸   XM_063282753
- Peptide Label: isoform X4
- UniProtKB: A0A8I6ADJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138822   ⟸   XM_063282752
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K2T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138825   ⟸   XM_063282755
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063138824   ⟸   XM_063282754
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2T2-F1-model_v2 AlphaFold A0A0G2K2T2 1-600 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559958 AgrOrtholog
BioCyc Gene G2FUF-50803 BioCyc
Ensembl Genes ENSRNOG00000056332 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089370.2 UniProtKB/TrEMBL
  ENSRNOT00000090367.2 UniProtKB/TrEMBL
  ENSRNOT00000095768.1 UniProtKB/TrEMBL
InterPro DUF2217 UniProtKB/TrEMBL
NCBI Gene 362058 ENTREZGENE
PANTHER MITOGUARDIN 1 UniProtKB/TrEMBL
  PTHR21508 UniProtKB/TrEMBL
Pfam DUF2217 UniProtKB/TrEMBL
PhenoGen Miga1 PhenoGen
RatGTEx ENSRNOG00000056332 RatGTEx
UniProt A0A0G2K2T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADJ1 ENTREZGENE, UniProtKB/TrEMBL
  A6HWL1 ENTREZGENE, UniProtKB/TrEMBL
  D4A5P3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-29 Miga1  mitoguardin 1  Fam73a  family with sequence similarity 73, member A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-11 Fam73a  family with sequence similarity 73, member A  RGD1559958  similar to RIKEN cDNA C030011O14 gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1559958  similar to RIKEN cDNA C030011O14 gene   RGD1559958_predicted  similar to RIKEN cDNA C030011O14 gene (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559958_predicted  similar to RIKEN cDNA C030011O14 gene (predicted)  LOC362058  similar to RIKEN cDNA C030011O14 gene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC362058  similar to RIKEN cDNA C030011O14 gene      Symbol and Name status set to provisional 70820 PROVISIONAL