Nacad (NAC alpha domain containing) - Rat Genome Database

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Gene: Nacad (NAC alpha domain containing) Rattus norvegicus
Analyze
Symbol: Nacad
Name: NAC alpha domain containing
RGD ID: 1559824
Description: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Orthologous to human NACAD (NAC alpha domain containing); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC289786; LOC289786; NAC-alpha domain-containing protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,679,215 - 85,688,742 (-)NCBIGRCr8
mRatBN7.21481,465,299 - 81,473,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,465,299 - 81,473,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,866,587 - 85,875,069 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,106,390 - 87,114,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,555,986 - 83,564,468 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,860,607 - 86,868,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,860,608 - 86,868,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,494,051 - 80,502,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,354,263 - 87,363,221 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1480,347,050 - 80,355,532 (-)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548  


Genomics

Comparative Map Data
Nacad
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81485,679,215 - 85,688,742 (-)NCBIGRCr8
mRatBN7.21481,465,299 - 81,473,866 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1481,465,299 - 81,473,781 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1485,866,587 - 85,875,069 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,106,390 - 87,114,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01483,555,986 - 83,564,468 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01486,860,607 - 86,868,605 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1486,860,608 - 86,868,598 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01480,494,051 - 80,502,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,354,263 - 87,363,221 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1480,347,050 - 80,355,532 (-)NCBICelera
Cytogenetic Map14q21NCBI
NACAD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,080,437 - 45,088,969 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,080,437 - 45,088,969 (-)EnsemblGRCh38hg38GRCh38
GRCh37745,120,036 - 45,128,568 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,067,578 - 45,095,757 (-)NCBINCBI36Build 36hg18NCBI36
Celera745,218,992 - 45,227,329 (-)NCBICelera
Cytogenetic Map7p13NCBI
HuRef745,004,007 - 45,012,344 (-)NCBIHuRef
CHM1_1745,123,853 - 45,132,190 (-)NCBICHM1_1
T2T-CHM13v2.0745,241,246 - 45,249,778 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,159,326 - 45,167,663 (-)NCBI
Nacad
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,547,814 - 6,556,059 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,547,823 - 6,556,053 (-)EnsemblGRCm39 Ensembl
GRCm38116,597,814 - 6,606,059 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,597,823 - 6,606,053 (-)EnsemblGRCm38mm10GRCm38
MGSCv37116,497,826 - 6,506,057 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,497,823 - 6,506,057 (-)NCBIMGSCv36mm8
MGSCv36116,482,285 - 6,490,519 (-)NCBIMGSCv36mm8
Cytogenetic Map11A1NCBI
cM Map114.6NCBI
Nacad
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554567,224,202 - 7,230,660 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554567,224,224 - 7,230,736 (+)NCBIChiLan1.0ChiLan1.0
NACAD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2649,993,705 - 50,003,426 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1798,318,443 - 98,328,164 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0745,794,340 - 45,802,532 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1745,861,001 - 45,869,388 (-)NCBIpanpan1.1PanPan1.1panPan2
NACAD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11610,393,993 - 10,394,424 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha162,610,385 - 2,618,972 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01614,241,933 - 14,250,521 (+)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.01613,875,029 - 13,883,618 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01613,854,540 - 13,863,130 (+)NCBIUU_Cfam_GSD_1.0
Nacad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118100,672,261 - 100,682,284 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647819,884,067 - 19,893,673 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647819,883,992 - 19,893,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NACAD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11850,385,116 - 50,394,787 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21855,216,074 - 55,225,617 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NACAD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12113,594,969 - 13,603,436 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2113,598,304 - 13,605,614 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660628,925,669 - 8,934,341 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nacad
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247407,299,294 - 7,307,056 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nacad
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000044768
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat

Markers in Region
RH129519  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21481,465,561 - 81,465,971 (+)MAPPERmRatBN7.2
Rnor_6.01486,860,870 - 86,861,279NCBIRnor6.0
Rnor_5.01480,494,314 - 80,494,723UniSTSRnor5.0
RGSC_v3.41487,355,015 - 87,355,424UniSTSRGSC3.4
Celera1480,347,313 - 80,347,722UniSTS
RH 3.4 Map14586.4UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 72
Low 3 39 24 8 18 8 7 7 2 27 40 11 7
Below cutoff 27 27 1 27 1 4 8 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087212   ⟹   ENSRNOP00000074030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,465,299 - 81,473,781 (-)Ensembl
Rnor_6.0 Ensembl1486,860,608 - 86,868,598 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102318   ⟹   ENSRNOP00000079182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1481,465,299 - 81,473,781 (-)Ensembl
RefSeq Acc Id: NM_001100655   ⟹   NP_001094125
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,679,215 - 85,687,697 (-)NCBI
mRatBN7.21481,465,299 - 81,473,781 (-)NCBI
Rnor_6.01486,860,607 - 86,868,605 (-)NCBI
Rnor_5.01480,494,051 - 80,502,042 (-)NCBI
Celera1480,347,050 - 80,355,532 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039091759   ⟹   XP_038947687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81485,679,215 - 85,688,742 (-)NCBI
mRatBN7.21481,465,299 - 81,473,866 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094125 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947687 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91311 (Get FASTA)   NCBI Sequence Viewer  
  EDM00367 (Get FASTA)   NCBI Sequence Viewer  
  EDM00368 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074030.2
  ENSRNOP00000079182
  ENSRNOP00000079182.1
Reference Protein Sequences
RefSeq Acc Id: NP_001094125   ⟸   NM_001100655
- UniProtKB: F1M6E5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074030   ⟸   ENSRNOT00000087212
RefSeq Acc Id: XP_038947687   ⟸   XM_039091759
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZMB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079182   ⟸   ENSRNOT00000102318
Protein Domains
NAC-A/B

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6E5-F1-model_v2 AlphaFold F1M6E5 1-1416 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699481
Promoter ID:EPDNEW_R10003
Type:initiation region
Name:Nacad_1
Description:NAC alpha domain containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01486,868,658 - 86,868,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559824 AgrOrtholog
BioCyc Gene G2FUF-15071 BioCyc
Ensembl Genes ENSRNOG00000053875 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087212.2 UniProtKB/TrEMBL
  ENSRNOT00000102318.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.30 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7311803 IMAGE-MGC_LOAD
InterPro EGD2/NACA UniProtKB/TrEMBL
  NAC-like_UBA UniProtKB/TrEMBL
  NAC_A/B_dom_sf UniProtKB/TrEMBL
  NACAD_UBA UniProtKB/TrEMBL
  Nas_poly-pep-assoc_cplx UniProtKB/TrEMBL
MGC_CLONE MGC:109270 IMAGE-MGC_LOAD
NCBI Gene 289786 ENTREZGENE
PANTHER NAC-ALPHA DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PTHR21713 UniProtKB/TrEMBL
Pfam HYPK_UBA UniProtKB/TrEMBL
  NAC UniProtKB/TrEMBL
PhenoGen Nacad PhenoGen
PROSITE NAC_AB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053875 RatGTEx
SMART NAC UniProtKB/TrEMBL
UniProt A0A8I5ZMB0 ENTREZGENE, UniProtKB/TrEMBL
  F1M6E5 ENTREZGENE, UniProtKB/TrEMBL
  Q5BJV5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Nacad  NAC alpha domain containing  LOC289786  hypothetical protein LOC289786  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC289786  hypothetical protein LOC289786      Symbol and Name status set to provisional 70820 PROVISIONAL