Atp5mc1l2 (ATP synthase membrane subunit c locus 1 like 2) - Rat Genome Database

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Gene: Atp5mc1l2 (ATP synthase membrane subunit c locus 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Atp5mc1l2 (Ensembl: RGD1559629)
Name: ATP synthase membrane subunit c locus 1 like 2 (Ensembl:similar to H+ ATP synthase)
RGD ID: 1559629
Description: Predicted to enable lipid binding activity and proton transmembrane transporter activity. Predicted to be involved in proton transmembrane transport; PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH Cuprizon; fipronil.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07064224.1; ATP synthase F(0) complex subunit C1, mitochondrial-like; LOC366614; RGD1559629; similar to H+ ATP synthase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8672,381,081 - 72,381,479 (+)NCBIGRCr8
mRatBN7.2666,654,187 - 66,654,763 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl666,654,294 - 66,654,692 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0669,950,129 - 69,951,013 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl669,950,500 - 69,950,898 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0679,512,128 - 79,512,526 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4669,197,171 - 69,197,569 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera665,581,850 - 65,582,734 (+)NCBICelera
Cytogenetic Map6q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Cuprizon  (EXP)
fipronil  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Atp5mc1l2
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:34
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000049500
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63207442872227641Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63330954981132889Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)63443413777102317Rat
1354632Scl29Serum cholesterol level QTL 293.74blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)63509870971636405Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)63523041780230417Rat
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)63878398983783989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)63878398983783989Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
4889848Pur25Proteinuria QTL 25140.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)65672856290198260Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)66304056271636266Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000049500   ⟹   ENSRNOP00000048392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl666,654,294 - 66,654,692 (+)Ensembl
RefSeq Acc Id: XM_039113178   ⟹   XP_038969106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8672,381,081 - 72,381,479 (+)NCBI
mRatBN7.2666,654,187 - 66,654,763 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038969106 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000048392
  ENSRNOP00000048392.3
Reference Protein Sequences
RefSeq Acc Id: XP_038969106   ⟸   XM_039113178
- UniProtKB: D3Z869 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000048392   ⟸   ENSRNOT00000049500
Protein Domains
V-ATPase proteolipid subunit C-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z869-F1-model_v2 AlphaFold D3Z869 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559629 AgrOrtholog
BioCyc Gene G2FUF-37627 BioCyc
Ensembl Genes ENSRNOG00000031317 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049500.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.20.10 UniProtKB/TrEMBL
InterPro ATP_synth_F0_csu UniProtKB/TrEMBL
  ATP_synth_F0_csu_sf UniProtKB/TrEMBL
  ATPase_proteolipid_c-like_dom UniProtKB/TrEMBL
  F/V-ATP_Csub_sf UniProtKB/TrEMBL
NCBI Gene 366614 ENTREZGENE
PANTHER ATP SYNTHASE F(0) COMPLEX SUBUNIT C1, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR10031 UniProtKB/TrEMBL
Pfam ATP-synt_C UniProtKB/TrEMBL
PhenoGen Atp5mc1l2 PhenoGen
PRINTS ATPASEC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031317 RatGTEx
Superfamily-SCOP SSF81333 UniProtKB/TrEMBL
UniProt D3Z869 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Atp5mc1l2  ATP synthase membrane subunit c locus 1 like 2  RGD1559629  similar to H+ ATP synthase  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1559629  similar to H+ ATP synthase  AABR07064224.1    Data merged from RGD:15003874 737654 PROVISIONAL
2019-11-08 AABR07064224.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1559629  similar to H+ ATP synthase   RGD1559629_predicted  similar to H+ ATP synthase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559629_predicted  similar to H+ ATP synthase (predicted)  LOC366614  similar to H+ ATP synthase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC366614  similar to H+ ATP synthase      Symbol and Name status set to provisional 70820 PROVISIONAL