Zfp566 (zinc finger protein 566) - Rat Genome Database

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Gene: Zfp566 (zinc finger protein 566) Mus musculus
Analyze
Symbol: Zfp566
Name: zinc finger protein 566
RGD ID: 1558411
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF566 (zinc finger protein 566).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2700043M03Rik; mszf4
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,776,762 - 29,789,935 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl729,776,762 - 29,789,952 (-)EnsemblGRCm39 Ensembl
GRCm38730,077,337 - 30,090,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,077,337 - 30,090,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37730,862,356 - 30,875,529 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36729,786,097 - 29,799,157 (-)NCBIMGSCv36mm8
Celera724,666,835 - 24,677,312 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:9630514   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:16141072   PMID:16141073   PMID:17967808  
PMID:18287559   PMID:18799693   PMID:20059953   PMID:20412781   PMID:21873635  


Genomics

Comparative Map Data
Zfp566
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,776,762 - 29,789,935 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl729,776,762 - 29,789,952 (-)EnsemblGRCm39 Ensembl
GRCm38730,077,337 - 30,090,510 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,077,337 - 30,090,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37730,862,356 - 30,875,529 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36729,786,097 - 29,799,157 (-)NCBIMGSCv36mm8
Celera724,666,835 - 24,677,312 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.26NCBI
ZNF566
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,445,119 - 36,489,561 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,445,119 - 36,489,902 (-)EnsemblGRCh38hg38GRCh38
GRCh371936,936,021 - 36,980,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,630,418 - 41,672,177 (-)NCBINCBI36Build 36hg18NCBI36
Build 341941,630,417 - 41,672,177NCBI
Celera1933,720,996 - 33,765,440 (-)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,404,358 - 33,448,689 (-)NCBIHuRef
CHM1_11936,936,423 - 36,981,054 (-)NCBICHM1_1
T2T-CHM13v2.01939,120,063 - 39,164,789 (-)NCBIT2T-CHM13v2.0
Zfp566
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,445,850 - 94,461,215 (-)NCBIGRCr8
mRatBN7.2185,318,449 - 85,342,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,318,452 - 85,333,161 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx190,728,302 - 90,745,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,199,528 - 99,214,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,486,537 - 92,503,759 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,407,903 - 88,413,209 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,415,257 - 88,428,685 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,569,289 - 89,574,595 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4185,114,488 - 85,127,961 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera179,693,348 - 79,707,486 (-)NCBICelera
Cytogenetic Map1q21NCBI
ZNF566
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,589,016 - 42,633,717 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,470,932 - 44,515,328 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01933,405,783 - 33,450,357 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11943,312,332 - 43,356,927 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1943,312,332 - 43,356,927 (+)Ensemblpanpan1.1panPan2
ZNF566
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,092,785 - 116,123,483 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,037,736 - 116,123,414 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1115,502,276 - 115,531,558 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01116,697,909 - 116,727,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1116,641,325 - 116,726,698 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,267,842 - 116,297,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01115,886,435 - 115,915,699 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01116,937,938 - 116,967,416 (-)NCBIUU_Cfam_GSD_1.0
ZNF566
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,894,275 - 45,928,201 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1645,893,983 - 45,927,775 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2641,336,114 - 41,413,028 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF566
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1631,307,236 - 31,347,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl631,307,608 - 31,332,205 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660739,105,449 - 9,150,425 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp566
504 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:247
Count of miRNA genes:225
Interacting mature miRNAs:237
Transcripts:ENSMUST00000088785, ENSMUST00000182248
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71872879439674033Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72730579836842367Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse

Markers in Region
UniSTS:235644  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38730,077,365 - 30,077,600UniSTSGRCm38
MGSCv37730,862,384 - 30,862,619UniSTSGRCm37
Celera724,666,862 - 24,667,099UniSTS
Cytogenetic Map7B1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000088785   ⟹   ENSMUSP00000086164
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl729,776,762 - 29,789,952 (-)Ensembl
GRCm38.p6 Ensembl730,077,337 - 30,090,527 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182248
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl729,780,497 - 29,789,888 (-)Ensembl
GRCm38.p6 Ensembl730,081,072 - 30,090,463 (-)Ensembl
RefSeq Acc Id: NM_152814   ⟹   NP_690027
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39729,776,762 - 29,789,935 (-)NCBI
GRCm38730,077,337 - 30,090,510 (-)ENTREZGENE
MGSCv37730,862,356 - 30,875,529 (-)RGD
Celera724,666,835 - 24,677,312 (-)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_690027 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH19790 (Get FASTA)   NCBI Sequence Viewer  
  BAA31365 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000086164
  ENSMUSP00000086164.5
Reference Protein Sequences
RefSeq Acc Id: NP_690027   ⟸   NM_152814
- UniProtKB: Q8VCI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000086164   ⟸   ENSMUST00000088785
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCI1-F1-model_v2 AlphaFold Q8VCI1 1-386 view protein structure

Promoters
RGD ID:6892578
Promoter ID:EPDNEW_M9736
Type:initiation region
Name:Zfp566_1
Description:Mus musculus zinc finger protein 566 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38730,090,427 - 30,090,487EPDNEW
RGD ID:6842463
Promoter ID:MM_KWN:49766
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000072617,   ENSMUST00000078563,   NM_152814,   UC009GDB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36730,875,164 - 30,875,664 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919806 AgrOrtholog
Ensembl Genes ENSMUSG00000078768 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000088785 ENTREZGENE
  ENSMUST00000088785.6 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report mmu:72556 UniProtKB/TrEMBL
MGD MGI:1919806 ENTREZGENE
NCBI Gene 72556 ENTREZGENE
PANTHER KRAB DOMAIN C2H2 ZINC FINGER UniProtKB/TrEMBL
  ZINC FINGER AND SCAN DOMAIN-CONTAINING UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 566 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 726 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp566 PhenoGen
PRINTS ZINCFINGER UniProtKB/TrEMBL
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt O88215_MOUSE UniProtKB/TrEMBL
  Q8VCI1 ENTREZGENE, UniProtKB/TrEMBL