Magea8 (MAGE family member A8) - Rat Genome Database

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Gene: Magea8 (MAGE family member A8) Mus musculus
Analyze
Symbol: Magea8
Name: MAGE family member A8
RGD ID: 1557882
MGI Page MGI
Description: Predicted to enable caspase binding activity and histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; endoplasmic reticulum; and nuclear body. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; heart; liver; and reproductive system. Orthologous to several human genes including MAGEA10 (MAGE family member A10).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Mage-; Mage-a8; melanoma antigen family A, 8; melanoma antigen, family A, 8
RGD Orthologs
Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Magea9-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X153,768,771 - 153,778,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX153,768,771 - 153,778,846 (-)EnsemblGRCm39 Ensembl
GRCm38X154,985,775 - 154,995,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX154,985,775 - 154,995,850 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X151,420,318 - 151,430,393 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X150,326,489 - 150,336,566 (-)NCBIMGSCv36mm8
CeleraX138,309,077 - 138,319,152 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX72.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9933564   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11454705   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:21873635   PMID:31143371  
PMID:31149633  


Genomics

Comparative Map Data
Magea8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X153,768,771 - 153,778,846 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX153,768,771 - 153,778,846 (-)EnsemblGRCm39 Ensembl
GRCm38X154,985,775 - 154,995,850 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX154,985,775 - 154,995,850 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X151,420,318 - 151,430,393 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X150,326,489 - 150,336,566 (-)NCBIMGSCv36mm8
CeleraX138,309,077 - 138,319,152 (-)NCBICelera
Cytogenetic MapXF3NCBI
cM MapX72.38NCBI
Magea8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X43,686,835 - 43,695,013 (+)NCBIGRCr8
mRatBN7.2X39,858,662 - 39,866,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX39,865,466 - 39,866,428 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0X43,172,001 - 43,184,700 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX43,183,381 - 43,184,313 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X43,475,445 - 43,487,279 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X61,298,619 - 61,299,581 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX40,472,078 - 40,475,325 (+)NCBICelera
Cytogenetic MapXq21NCBI

Variants

.
Variants in Magea8
225 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:102
Interacting mature miRNAs:103
Transcripts:ENSMUST00000070141
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302000Pgia25_mproteoglycan induced arthritis 2 (mouse)Not determinedX144474380169476592Mouse
1301209Cia19_mcollagen induced arthritis 19 (mouse)Not determinedX120993165160213038Mouse
1357823Spha3_msperm head anomaly 3 (mouse)Not determinedX102055848162758941Mouse
1558900Bw3_mbody weight QTL 3 (mouse)Not determinedX133540040165298595Mouse
10401118Pgia39_mproteoglycan induced arthritis 39 (mouse)Not determinedX144474380169476592Mouse
10412164Cmv2_mcytomegalovirus resistance 2 (mouse)Not determinedX125685149159685269Mouse
13824981Svwq2_mseminal vesicle weight QTL 2 (mouse)X128900749153782996Mouse
12738421Lfibq17_mliver fibrosis QTL 17 (mouse)X148148453164945064Mouse

Markers in Region
G65194  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF3UniSTS
cM MapX UniSTS
Magea1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXF3UniSTS
cM MapX66.16UniSTS
cM MapX66.1UniSTS
cM MapX66.11UniSTS
cM MapX66.15UniSTS
cM MapX66.13UniSTS
UniSTS:484939  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X154,986,149 - 154,987,111UniSTSGRCm38
MGSCv37X151,420,692 - 151,421,654UniSTSGRCm37
CeleraX138,309,451 - 138,310,413UniSTS
Cytogenetic MapXF3UniSTS
cM MapX66.16UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000070141   ⟹   ENSMUSP00000066341
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX153,768,771 - 153,778,846 (-)Ensembl
GRCm38.p6 EnsemblX154,985,775 - 154,995,850 (-)Ensembl
RefSeq Acc Id: NM_020020   ⟹   NP_064404
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X153,768,771 - 153,778,846 (-)NCBI
GRCm38X154,985,775 - 154,995,850 (-)ENTREZGENE
MGSCv37X151,420,318 - 151,430,393 (-)RGD
CeleraX138,309,077 - 138,319,152 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006528728   ⟹   XP_006528791
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X153,768,771 - 153,778,830 (-)NCBI
GRCm38X154,985,775 - 154,995,834 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_064404 (Get FASTA)   NCBI Sequence Viewer  
  XP_006528791 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI19511 (Get FASTA)   NCBI Sequence Viewer  
  BAE26460 (Get FASTA)   NCBI Sequence Viewer  
  CAA06586 (Get FASTA)   NCBI Sequence Viewer  
  EDL40855 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000066341
  ENSMUSP00000066341.7
Reference Protein Sequences
RefSeq Acc Id: NP_064404   ⟸   NM_020020
- UniProtKB: O89012 (UniProtKB/TrEMBL),   O89007 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006528791   ⟸   XM_006528728
- Peptide Label: isoform X1
- UniProtKB: O89012 (UniProtKB/TrEMBL),   O89007 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000066341   ⟸   ENSMUST00000070141
Protein Domains
MAGE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89012-F1-model_v2 AlphaFold O89012 1-320 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333827 AgrOrtholog
Ensembl Genes ENSMUSG00000059539
  ENSMUSG00000079350 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070141 ENTREZGENE
  ENSMUST00000070141.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.1200 UniProtKB/TrEMBL
  1.10.10.1210 UniProtKB/TrEMBL
InterPro MAGE UniProtKB/TrEMBL
  MAGE UniProtKB/TrEMBL
  MAGE_WH1 UniProtKB/TrEMBL
  MAGE_WH2 UniProtKB/TrEMBL
KEGG Report mmu:17144 UniProtKB/TrEMBL
MGD MGI:1333827 ENTREZGENE
NCBI Gene 17144 ENTREZGENE
PANTHER MAGE FAMILY MEMBER A1-RELATED UniProtKB/TrEMBL
  PTHR11736 UniProtKB/TrEMBL
Pfam MAGE UniProtKB/TrEMBL
PhenoGen Magea8 PhenoGen
PROSITE MAGE UniProtKB/TrEMBL
SMART MAGE UniProtKB/TrEMBL
UniProt O89007 ENTREZGENE, UniProtKB/TrEMBL
  O89012 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-09-01 Magea8  MAGE family member A8  Magea8  melanoma antigen, family A, 8  Symbol and/or name change 5135510 APPROVED