Tmem269 (transmembrane protein 269) - Rat Genome Database

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Gene: Tmem269 (transmembrane protein 269) Mus musculus
Analyze
Symbol: Tmem269
Name: transmembrane protein 269
RGD ID: 1557285
MGI Page MGI
Description: Predicted to be located in membrane. Orthologous to human TMEM269 (transmembrane protein 269).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 4930538K18Rik; hypothetical protein LOC75180; RIKEN cDNA 4930538K18 gene; RP23-344D2.8; uncharacterized protein LOC75180
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,062,209 - 119,075,754 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,062,252 - 119,075,414 (-)EnsemblGRCm39 Ensembl
GRCm384119,205,012 - 119,218,557 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,205,055 - 119,218,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,877,660 - 118,890,822 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364118,702,987 - 118,716,149 (-)NCBIMGSCv36mm8
Celera4117,932,722 - 117,946,092 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15782199   PMID:16141072   PMID:16141073  


Genomics

Comparative Map Data
Tmem269
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394119,062,209 - 119,075,754 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4119,062,252 - 119,075,414 (-)EnsemblGRCm39 Ensembl
GRCm384119,205,012 - 119,218,557 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,205,055 - 119,218,217 (-)EnsemblGRCm38mm10GRCm38
MGSCv374118,877,660 - 118,890,822 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364118,702,987 - 118,716,149 (-)NCBIMGSCv36mm8
Celera4117,932,722 - 117,946,092 (-)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.34NCBI
TMEM269
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,784,991 - 42,800,827 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,784,991 - 42,816,619 (+)EnsemblGRCh38hg38GRCh38
GRCh37143,250,662 - 43,266,498 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,023,313 - 43,036,263 (+)NCBINCBI36Build 36hg18NCBI36
Celera141,532,657 - 41,545,603 (+)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,373,603 - 41,383,843 (+)NCBIHuRef
CHM1_1143,370,464 - 43,380,704 (+)NCBICHM1_1
T2T-CHM13v2.0142,655,481 - 42,671,316 (+)NCBIT2T-CHM13v2.0
Tmem269
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,102,637 - 138,121,078 (-)NCBIGRCr8
mRatBN7.25132,817,324 - 132,836,360 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,817,324 - 132,829,977 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,544,906 - 135,557,627 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,301,370 - 137,314,091 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,321,956 - 137,334,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,254,946 - 138,272,589 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,254,946 - 138,267,601 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05142,065,488 - 142,077,506 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,791,752 - 139,804,009 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5131,342,931 - 131,355,580 (-)NCBICelera
Cytogenetic Map5q36NCBI
Tmem269
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,312,984 - 2,324,917 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,312,276 - 2,327,745 (+)NCBIChiLan1.0ChiLan1.0
TMEM269
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21184,012,449 - 184,030,655 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11183,147,853 - 183,172,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,083,698 - 42,099,145 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,461,122 - 43,476,625 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,461,122 - 43,474,572 (+)Ensemblpanpan1.1panPan2
TMEM269
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115571,044 - 586,077 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15571,455 - 581,835 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15826,694 - 841,727 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015653,234 - 668,300 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15653,640 - 664,039 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115562,787 - 577,793 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015624,191 - 639,265 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015639,316 - 654,345 (-)NCBIUU_Cfam_GSD_1.0
Tmem269
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,281,914 - 58,298,504 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647424,113,465 - 24,123,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM269
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12090,115,840 - 90,150,599 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603326,764,690 - 26,776,660 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem269
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248922,013,977 - 2,032,558 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem269
441 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:145
Interacting mature miRNAs:148
Transcripts:ENSMUST00000030394
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
1300689Dob1_mDietary obesity 1 (mouse)Body weight4101574601123127211Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
13208565Bmiq6_mbody mass index QTL 6 (mouse)4110857197125893793Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115030777129465915Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301996Mmtg2_mmodifier of mammary tumor growth 2 (mouse)Not determined4116270979124055180Mouse
4141330Iva1_misovaleric acid smelling 1 (mouse)Not determined117071971120723203Mouse
12904006Cfq1_mconditioned fear QTL 1 (mouse)4117177646120107755Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
12903992Opfaq6_mopen field activity QTL 6 (mouse)4119064995121366497Mouse

Markers in Region
AI450326  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384119,219,905 - 119,220,043UniSTSGRCm38
MGSCv374118,892,510 - 118,892,648UniSTSGRCm37
Celera4117,947,781 - 117,947,919UniSTS
Whitehead/MRC_RH41552.77UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000030394   ⟹   ENSMUSP00000030394
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4119,062,304 - 119,075,414 (-)Ensembl
GRCm38.p6 Ensembl4119,205,107 - 119,218,217 (-)Ensembl
RefSeq Acc Id: ENSMUST00000212054   ⟹   ENSMUSP00000148286
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4119,062,252 - 119,075,414 (-)Ensembl
GRCm38.p6 Ensembl4119,205,055 - 119,218,217 (-)Ensembl
RefSeq Acc Id: NM_029198   ⟹   NP_083474
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394119,062,252 - 119,075,414 (-)NCBI
GRCm384119,205,055 - 119,218,217 (-)NCBI
MGSCv374118,877,660 - 118,890,822 (-)RGD
Celera4117,932,722 - 117,946,092 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006503455   ⟹   XP_006503518
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394119,062,713 - 119,075,754 (-)NCBI
GRCm384119,205,516 - 119,218,557 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006503456   ⟹   XP_006503519
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394119,062,209 - 119,075,754 (-)NCBI
GRCm384119,205,012 - 119,218,557 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011240628   ⟹   XP_011238930
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394119,062,713 - 119,074,302 (-)NCBI
GRCm384119,205,516 - 119,217,104 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030253868   ⟹   XP_030109728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394119,062,209 - 119,075,754 (-)NCBI
GRCm384119,205,012 - 119,218,557 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036164511   ⟹   XP_036020404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394119,062,713 - 119,075,754 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_083474   ⟸   NM_029198
- UniProtKB: Q9D4Y8 (UniProtKB/TrEMBL),   Q80ZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503518   ⟸   XM_006503455
- Peptide Label: isoform X2
- UniProtKB: Q80ZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006503519   ⟸   XM_006503456
- Peptide Label: isoform X3
- UniProtKB: Q80ZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238930   ⟸   XM_011240628
- Peptide Label: isoform X2
- UniProtKB: Q80ZQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030109728   ⟸   XM_030253868
- Peptide Label: isoform X4
- UniProtKB: F6SIZ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000148286   ⟸   ENSMUST00000212054
RefSeq Acc Id: ENSMUSP00000030394   ⟸   ENSMUST00000030394
RefSeq Acc Id: XP_036020404   ⟸   XM_036164511
- Peptide Label: isoform X1
- UniProtKB: Q9D4Y8 (UniProtKB/Swiss-Prot),   Q80ZQ6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D4Y8-F1-model_v2 AlphaFold Q9D4Y8 1-254 view protein structure

Promoters
RGD ID:6834701
Promoter ID:MM_KWN:39347
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:NM_029198
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364118,891,571 - 118,892,071 (-)MPROMDB
RGD ID:6884440
Promoter ID:EPDNEW_M5671
Type:multiple initiation site
Name:Tmem269_1
Description:Mus musculus transmembrane protein 269 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384119,218,175 - 119,218,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922430 AgrOrtholog
Ensembl Genes ENSMUSG00000028642 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000030394 ENTREZGENE
  ENSMUST00000030394.3 UniProtKB/TrEMBL
  ENSMUST00000212054 ENTREZGENE
  ENSMUST00000212054.2 UniProtKB/Swiss-Prot
KEGG Report mmu:75180 UniProtKB/Swiss-Prot
MGD MGI:1922430 ENTREZGENE
NCBI Gene 75180 ENTREZGENE
PhenoGen Tmem269 PhenoGen
UniProt F6SIZ7 ENTREZGENE, UniProtKB/TrEMBL
  Q80ZQ6 ENTREZGENE, UniProtKB/TrEMBL
  Q9D4Y8 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-12-27 Tmem269  transmembrane protein 269  4930538K18Rik  RIKEN cDNA 4930538K18 gene  Symbol and/or name change 5135510 APPROVED