Cd33 (CD33 molecule) - Rat Genome Database

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Gene: Cd33 (CD33 molecule) Mus musculus
Analyze
Symbol: Cd33
Name: CD33 molecule
RGD ID: 1556894
MGI Page MGI
Description: Predicted to enable protein phosphatase binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Is expressed in central nervous system; genitourinary system; spleen; and submandibular gland. Orthologous to several human genes including CD33 (CD33 molecule).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD33 antigen; gp6; gp67; myeloid cell surface antigen CD33; sialic acid-binding Ig-like lectin 3; Sigle; Siglec-3
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,176,823 - 43,186,679 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,173,640 - 43,193,852 (-)EnsemblGRCm39 Ensembl
GRCm38743,527,399 - 43,537,424 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,524,216 - 43,544,428 (-)EnsemblGRCm38mm10GRCm38
MGSCv37750,782,826 - 50,788,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,396,037 - 43,401,143 (-)NCBIMGSCv36mm8
Celera738,996,297 - 39,002,012 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8193354   PMID:8812484   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11171044   PMID:11217851   PMID:12477932   PMID:12773563   PMID:16141072   PMID:16141073   PMID:17008544  
PMID:20660734   PMID:21267068   PMID:21873635   PMID:23623698   PMID:24194600   PMID:24227736   PMID:25320078   PMID:27626380   PMID:28700664   PMID:30645205   PMID:31301936   PMID:32803224  
PMID:35921817   PMID:36639554  


Genomics

Comparative Map Data
Cd33
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39743,176,823 - 43,186,679 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl743,173,640 - 43,193,852 (-)EnsemblGRCm39 Ensembl
GRCm38743,527,399 - 43,537,424 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl743,524,216 - 43,544,428 (-)EnsemblGRCm38mm10GRCm38
MGSCv37750,782,826 - 50,788,541 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36743,396,037 - 43,401,143 (-)NCBIMGSCv36mm8
Celera738,996,297 - 39,002,012 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map728.25NCBI
CD33
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,211,076 - 51,240,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,225,064 - 51,243,860 (+)EnsemblGRCh38hg38GRCh38
GRCh371951,728,336 - 51,743,271 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,420,147 - 56,435,086 (+)NCBINCBI36Build 36hg18NCBI36
Build 341956,420,174 - 56,435,084NCBI
Celera1948,780,420 - 48,795,363 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,061,383 - 48,076,328 (+)NCBIHuRef
CHM1_11951,730,399 - 51,745,342 (+)NCBICHM1_1
T2T-CHM13v2.01954,304,101 - 54,328,637 (+)NCBIT2T-CHM13v2.0
Cd33
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81103,071,985 - 103,086,687 (-)NCBIGRCr8
mRatBN7.2193,935,418 - 93,940,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl193,930,971 - 93,950,149 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0198,388,811 - 98,403,539 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl198,398,660 - 98,402,968 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0199,475,380 - 99,480,079 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4193,904,033 - 93,910,383 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera188,211,524 - 88,226,240 (-)NCBICelera
Cytogenetic Map1q22NCBI
LOC100983058
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,264,065 - 57,279,033 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,185,554 - 59,200,518 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01948,161,860 - 48,176,824 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11957,049,009 - 57,063,958 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1957,049,009 - 57,063,958 (+)Ensemblpanpan1.1panPan2
LOC100686511
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,722,187 - 105,731,616 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1105,294,588 - 105,304,256 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01106,231,215 - 106,240,879 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11105,903,008 - 105,912,671 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,543,870 - 105,553,532 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01106,339,280 - 106,348,950 (-)NCBIUU_Cfam_GSD_1.0
LOC110261034
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1655,745,864 - 55,778,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CD33
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,149,695 - 44,166,710 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,156,925 - 44,166,487 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,201,799 - 24,213,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Cd33
324 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:946
Count of miRNA genes:352
Interacting mature miRNAs:398
Transcripts:ENSMUST00000004728, ENSMUST00000039861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined7998886743988984Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71030579844305936Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000004728   ⟹   ENSMUSP00000004728
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl743,177,419 - 43,182,525 (-)Ensembl
GRCm38.p6 Ensembl743,527,995 - 43,533,101 (-)Ensembl
RefSeq Acc Id: ENSMUST00000039861   ⟹   ENSMUSP00000045458
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl743,177,798 - 43,193,852 (-)Ensembl
GRCm38.p6 Ensembl743,528,374 - 43,544,428 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205503   ⟹   ENSMUSP00000146225
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl743,173,640 - 43,182,595 (-)Ensembl
GRCm38.p6 Ensembl743,524,216 - 43,533,171 (-)Ensembl
RefSeq Acc Id: ENSMUST00000205687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl743,179,776 - 43,182,511 (-)Ensembl
GRCm38.p6 Ensembl743,530,352 - 43,533,087 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206371   ⟹   ENSMUSP00000145596
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl743,177,950 - 43,182,102 (-)Ensembl
GRCm38.p6 Ensembl743,528,526 - 43,532,678 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206977
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl743,181,463 - 43,182,378 (-)Ensembl
GRCm38.p6 Ensembl743,532,039 - 43,532,954 (-)Ensembl
RefSeq Acc Id: NM_001111058   ⟹   NP_001104528
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39743,176,880 - 43,182,595 (-)NCBI
GRCm38743,527,456 - 43,533,171 (-)NCBI
MGSCv37750,782,826 - 50,788,541 (-)RGD
Celera738,996,297 - 39,002,012 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_021293   ⟹   NP_067268
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39743,176,880 - 43,182,595 (-)NCBI
GRCm38743,527,456 - 43,533,171 (-)NCBI
MGSCv37750,782,826 - 50,788,541 (-)RGD
Celera738,996,297 - 39,002,012 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540590   ⟹   XP_006540653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39743,176,823 - 43,186,679 (-)NCBI
GRCm38743,527,399 - 43,537,424 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_067268   ⟸   NM_021293
- Peptide Label: isoform 2 precursor
- UniProtKB: Q63994 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001104528   ⟸   NM_001111058
- Peptide Label: isoform 1 precursor
- UniProtKB: A2RT59 (UniProtKB/Swiss-Prot),   Q63997 (UniProtKB/Swiss-Prot),   Q63994 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540653   ⟸   XM_006540590
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000145596   ⟸   ENSMUST00000206371
RefSeq Acc Id: ENSMUSP00000146225   ⟸   ENSMUST00000205503
RefSeq Acc Id: ENSMUSP00000045458   ⟸   ENSMUST00000039861
RefSeq Acc Id: ENSMUSP00000004728   ⟸   ENSMUST00000004728
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63994-F1-model_v2 AlphaFold Q63994 1-403 view protein structure

Promoters
RGD ID:8663773
Promoter ID:EPDNEW_M9918
Type:initiation region
Name:Cd33_1
Description:Mus musculus CD33 antigen , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38743,533,102 - 43,533,162EPDNEW
RGD ID:6840808
Promoter ID:MM_KWN:50195
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:NM_001111058,   NM_021293,   UC009GNA.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36750,788,234 - 50,788,734 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99440 AgrOrtholog
Ensembl Genes ENSMUSG00000004609 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004728 ENTREZGENE
  ENSMUST00000004728.12 UniProtKB/Swiss-Prot
  ENSMUST00000039861.7 UniProtKB/Swiss-Prot
  ENSMUST00000205503 ENTREZGENE
  ENSMUST00000205503.2 UniProtKB/Swiss-Prot
  ENSMUST00000206371.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12489 UniProtKB/Swiss-Prot
MGD MGI:99440 ENTREZGENE
NCBI Gene 12489 ENTREZGENE
PANTHER MYELOID CELL SURFACE ANTIGEN CD33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot
PhenoGen Cd33 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RNJ9_MOUSE UniProtKB/TrEMBL
  A2RT59 ENTREZGENE
  CD33_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q63997 ENTREZGENE
UniProt Secondary A2RT59 UniProtKB/Swiss-Prot
  Q63997 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-27 Cd33  CD33 molecule  Cd33  CD33 antigen  Symbol and/or name change 5135510 APPROVED