Fbxo45 (F-box protein 45) - Rat Genome Database

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Gene: Fbxo45 (F-box protein 45) Mus musculus
Analyze
Symbol: Fbxo45
Name: F-box protein 45
RGD ID: 1553097
MGI Page MGI
Description: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; and regulation of synaptic vesicle exocytosis. Acts upstream of or within nervous system development. Located in postsynaptic density. Is active in glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Is expressed in nervous system. Orthologous to human FBXO45 (F-box protein 45).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2610017J04Rik; AI463119; BC026799; F-box only protein 45; F-box/SPRY domain-containing protein 1; mFbxo45; MGC19444; MGC90920
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,048,930 - 32,065,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,048,930 - 32,065,976 (-)EnsemblGRCm39 Ensembl
GRCm381632,230,112 - 32,247,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,230,112 - 32,247,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371632,230,198 - 32,247,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,149,859 - 32,166,772 (-)NCBIMGSCv36mm8
Celera1632,715,107 - 32,732,068 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.45NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, etal., Genes Dev 2004 Nov 1;18(21):2573-80.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:15489334   PMID:16141072   PMID:16141073   PMID:19398581   PMID:19996097   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:22798074   PMID:24992930   PMID:25143387   PMID:28671696   PMID:30976085   PMID:31138677   PMID:32341084   PMID:34779401   PMID:36127399   PMID:36853700  


Genomics

Comparative Map Data
Fbxo45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391632,048,930 - 32,065,843 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1632,048,930 - 32,065,976 (-)EnsemblGRCm39 Ensembl
GRCm381632,230,112 - 32,247,025 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,230,112 - 32,247,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371632,230,198 - 32,247,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361632,149,859 - 32,166,772 (-)NCBIMGSCv36mm8
Celera1632,715,107 - 32,732,068 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.45NCBI
FBXO45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,568,660 - 196,589,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,568,611 - 196,589,059 (+)EnsemblGRCh38hg38GRCh38
GRCh373196,295,531 - 196,315,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,780,122 - 197,800,327 (+)NCBINCBI36Build 36hg18NCBI36
Build 343197,783,791 - 197,802,466NCBI
Celera3194,877,764 - 194,897,967 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,593,160 - 193,613,379 (+)NCBIHuRef
CHM1_13196,266,979 - 196,287,198 (+)NCBICHM1_1
T2T-CHM13v2.03199,287,944 - 199,308,337 (+)NCBIT2T-CHM13v2.0
Fbxo45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,056,457 - 82,072,080 (+)NCBIGRCr8
mRatBN7.21168,551,430 - 68,567,053 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,551,122 - 68,566,800 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,388,476 - 77,404,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,045,869 - 70,061,479 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,077,586 - 69,093,209 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01171,795,977 - 71,811,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,796,282 - 71,808,498 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01174,880,648 - 74,895,982 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,371,195 - 70,383,880 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,428,688 - 70,441,225 (+)NCBI
Celera1167,975,427 - 67,990,188 (+)NCBICelera
Cytogenetic Map11q22NCBI
Fbxo45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,714,608 - 12,726,113 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542012,714,749 - 12,727,600 (+)NCBIChiLan1.0ChiLan1.0
FBXO45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,439,690 - 194,459,794 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,444,409 - 194,464,513 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03193,913,712 - 193,934,123 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1 Ensembl3203,856,374 - 203,876,537 (+)Ensemblpanpan1.1panPan2
FBXO45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,627,762 - 29,642,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,635,831 - 29,639,189 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3329,651,560 - 29,665,781 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03329,871,003 - 29,885,256 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3329,871,003 - 29,882,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,648,407 - 29,662,988 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,703,925 - 29,718,166 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,326,269 - 30,340,520 (+)NCBIUU_Cfam_GSD_1.0
Fbxo45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,707,234 - 124,722,319 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367841,162,950 - 1,179,068 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367841,162,950 - 1,177,407 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,545,417 - 133,560,499 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,544,915 - 133,560,687 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FBXO45
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,632,389 - 90,647,431 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,629,330 - 90,647,191 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,423,743 - 64,444,887 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo45
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473061,667,177 - 61,684,162 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo45
421 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1157
Count of miRNA genes:632
Interacting mature miRNAs:813
Transcripts:ENSMUST00000042732
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
25394537Skmw83_mskeletal muscle weight 83, soleus (mouse)163130446533189707Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163140250136540273Mouse

Markers in Region
AI463119  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,230,364 - 32,230,480UniSTSGRCm38
MGSCv371632,230,450 - 32,230,566UniSTSGRCm37
Celera1632,715,359 - 32,715,475UniSTS
Cytogenetic Map16B2UniSTS
Whitehead/MRC_RH16316.39UniSTS
UniSTS:237483  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,234,254 - 32,234,472UniSTSGRCm38
MGSCv371632,234,340 - 32,234,558UniSTSGRCm37
Celera1632,719,248 - 32,719,466UniSTS
Cytogenetic Map16B2UniSTS
UniSTS:237485  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381632,230,207 - 32,230,388UniSTSGRCm38
MGSCv371632,230,293 - 32,230,474UniSTSGRCm37
Celera1632,715,202 - 32,715,383UniSTS
Cytogenetic Map16B2UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042732   ⟹   ENSMUSP00000040168
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1632,048,930 - 32,065,976 (-)Ensembl
GRCm38.p6 Ensembl1632,230,112 - 32,247,158 (-)Ensembl
RefSeq Acc Id: NM_173439   ⟹   NP_775615
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391632,048,930 - 32,065,843 (-)NCBI
GRCm381632,230,112 - 32,247,025 (-)ENTREZGENE
MGSCv371632,230,198 - 32,247,111 (-)RGD
Celera1632,715,107 - 32,732,068 (-)RGD
cM Map16 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_775615 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH26799 (Get FASTA)   NCBI Sequence Viewer  
  AAH88738 (Get FASTA)   NCBI Sequence Viewer  
  AAH98203 (Get FASTA)   NCBI Sequence Viewer  
  EDK97777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000040168
  ENSMUSP00000040168.6
GenBank Protein Q8K3B1 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_775615   ⟸   NM_173439
- UniProtKB: Q5M7B1 (UniProtKB/Swiss-Prot),   Q8K3B1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000040168   ⟸   ENSMUST00000042732
Protein Domains
B30.2/SPRY   F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K3B1-F1-model_v2 AlphaFold Q8K3B1 1-286 view protein structure

Promoters
RGD ID:6827049
Promoter ID:MM_KWN:20750
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000063466,   OTTMUST00000063467,   OTTMUST00000063468,   OTTMUST00000063469
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361632,247,074 - 32,247,574 (-)MPROMDB
RGD ID:8685976
Promoter ID:EPDNEW_M21019
Type:multiple initiation site
Name:Fbxo45_1
Description:Mus musculus F-box protein 45 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381632,247,117 - 32,247,177EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2447775 AgrOrtholog
Ensembl Genes ENSMUSG00000035764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042732 ENTREZGENE
  ENSMUST00000042732.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot
  2.60.120.920 UniProtKB/Swiss-Prot
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  F-box-like_dom_sf UniProtKB/Swiss-Prot
  F-box_dom UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
  SPRY_FBXO45 UniProtKB/Swiss-Prot
KEGG Report mmu:268882 UniProtKB/Swiss-Prot
MGD MGI:2447775 ENTREZGENE
NCBI Gene 268882 ENTREZGENE
PANTHER F-BOX/SPRY DOMAIN-CONTAINING PROTEIN 1 UniProtKB/Swiss-Prot
  SPRY DOMAIN CONTAINING SOCS BOX PROTEIN UniProtKB/Swiss-Prot
Pfam F-box-like UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
PhenoGen Fbxo45 PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot
  FBOX UniProtKB/Swiss-Prot
SMART FBOX UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
  SSF81383 UniProtKB/Swiss-Prot
UniProt FBSP1_MOUSE UniProtKB/Swiss-Prot
  Q5M7B1 ENTREZGENE
  Q8K3B1 ENTREZGENE
UniProt Secondary Q5M7B1 UniProtKB/Swiss-Prot