Mogat2 (monoacylglycerol O-acyltransferase 2) - Rat Genome Database

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Gene: Mogat2 (monoacylglycerol O-acyltransferase 2) Mus musculus
Analyze
Symbol: Mogat2
Name: monoacylglycerol O-acyltransferase 2
RGD ID: 1552612
MGI Page MGI
Description: Enables 2-acylglycerol O-acyltransferase activity and acetyltransferase activity. Involved in triglyceride biosynthetic process. Acts upstream of or within diacylglycerol biosynthetic process and intestinal absorption. Predicted to be located in perinuclear endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; embryo endoderm; liver; metanephros; and yolk sac. Orthologous to human MOGAT2 (monoacylglycerol O-acyltransferase 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-acylglycerol O-acyltransferase 2; acyl CoA:monoacylglycerol acyltransferase 2; acyl-CoA:monoacylglycerol acyltransferase 2; DGAT2; DGAT2L5; diacylglycerol acyltransferase 2-like protein 5; mannoside acetylglucosaminyltransferase 1-like; Mgat; Mgat1l; MGAT2; monoacylglycerol O-acyltransferase 1-like
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,868,291 - 98,887,818 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,868,291 - 98,887,826 (-)EnsemblGRCm39 Ensembl
GRCm38799,219,084 - 99,238,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,219,084 - 99,238,619 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,367,594 - 106,387,121 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,094,276 - 99,113,794 (-)NCBIMGSCv36mm8
Celera799,544,118 - 99,564,053 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.03NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Mouse MP Annotation Import Pipeline RGD automated import pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12576479   PMID:12621063   PMID:12730219   PMID:14681479   PMID:14966132  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:17683524   PMID:18287559   PMID:19049983   PMID:19287392   PMID:19732742   PMID:21386911   PMID:21677750   PMID:21734185   PMID:21873635  
PMID:23536640   PMID:24784138   PMID:25315695   PMID:25535286   PMID:27373844   PMID:27531967   PMID:31837122   PMID:32325033   PMID:36878279  


Genomics

Comparative Map Data
Mogat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,868,291 - 98,887,818 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,868,291 - 98,887,826 (-)EnsemblGRCm39 Ensembl
GRCm38799,219,084 - 99,238,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,219,084 - 99,238,619 (-)EnsemblGRCm38mm10GRCm38
MGSCv377106,367,594 - 106,387,121 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36799,094,276 - 99,113,794 (-)NCBIMGSCv36mm8
Celera799,544,118 - 99,564,053 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.03NCBI
MOGAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,717,838 - 75,732,953 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,717,838 - 75,732,958 (+)EnsemblGRCh38hg38GRCh38
GRCh371175,428,883 - 75,443,998 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,106,582 - 75,119,979 (+)NCBINCBI36Build 36hg18NCBI36
Build 341175,106,581 - 75,119,979NCBI
Celera1172,736,737 - 72,750,141 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1171,725,777 - 71,739,178 (+)NCBIHuRef
CHM1_11175,312,544 - 75,325,943 (+)NCBICHM1_1
T2T-CHM13v2.01175,647,254 - 75,662,376 (+)NCBIT2T-CHM13v2.0
Mogat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,933,964 - 162,957,896 (-)NCBIGRCr8
mRatBN7.21153,521,813 - 153,545,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,521,815 - 153,545,756 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,518,099 - 161,541,955 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,698,250 - 168,722,102 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,571,769 - 161,595,625 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,181,762 - 164,205,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,181,764 - 164,205,222 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,384,255 - 170,407,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,516,531 - 156,540,899 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1151,606,536 - 151,630,273 (-)NCBICelera
Cytogenetic Map1q32NCBI
MOGAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2976,648,353 - 76,662,247 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11177,690,960 - 77,704,853 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,779,443 - 70,792,409 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11174,081,258 - 74,094,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,079,287 - 74,092,710 (+)Ensemblpanpan1.1panPan2
MOGAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,899,620 - 22,954,776 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,899,598 - 22,918,523 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,665,340 - 22,684,045 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02123,102,483 - 23,121,200 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,102,468 - 23,134,598 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12122,901,313 - 22,920,017 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,097,545 - 23,116,256 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,014,964 - 23,033,822 (-)NCBIUU_Cfam_GSD_1.0
Mogat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,864,686 - 62,883,253 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,464,427 - 4,481,509 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,464,453 - 4,482,237 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MOGAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,937,700 - 10,008,913 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.199,937,654 - 9,951,679 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,119,127 - 11,132,973 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MOGAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,935,212 - 66,952,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,935,584 - 66,951,891 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604358,851,042 - 58,867,507 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mogat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,450,300 - 1,468,514 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248171,450,238 - 1,468,503 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mogat2
613 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:484
Count of miRNA genes:346
Interacting mature miRNAs:405
Transcripts:ENSMUST00000064231, ENSMUST00000132343
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745161966118693530Mouse
13208555Lgth10_mbody length 10 (mouse)751649748125599172Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753249748143153737Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)754819589116822815Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)756949748134001729Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)761749748121399223Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)761749748123699223Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)761849748102749207Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765249748126499172Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)76578898699788986Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)76578898699788986Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767290094101290240Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767290094101290240Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767290094101290240Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)767849748105449207Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)767849748119499223Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)767849748124199223Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)767849748124999172Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768365595102365702Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)769949748120499223Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770143137104143379Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772263372106263372Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773049748125699172Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773149748143153737Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)773725965107725965Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)774849748122199223Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)774849748122199223Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775394215109394346Mouse
14746989Manh62_mmandible shape 62 (mouse)775742528109742528Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)778649748136901729Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780551681114551791Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80551681114551791Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)780849748126699172Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781249748124199223Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781449748126499172Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)781849748126499172Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785049208124199223Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785365595112533819Mouse
27226792Feml7_mfemur length 7, 5 week (mouse)78614920898949207Mouse
1301647Elpt_melevated leptin (mouse)Not determined786500186120500329Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787043932121044066Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787043932121044066Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787043932121044066Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787143137119485380Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787249208126499172Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787249208126499172Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)787849208108099207Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791482996125483156Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791482996125483156Mouse
13464255Ifvrq2_minfluenza virus resistance QTL 2 (mouse)792500698106455693Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793391848127392041Mouse
1301478Eae26_msusceptibility to experimental allergic encephalomyelitis 26 (mouse)Not determined798164922132165010Mouse
13524850Asrq7_macoustic startle response 7 (mouse)798394974132394974Mouse

Markers in Region
26.MMHAP94FLA5.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38799,219,650 - 99,219,846UniSTSGRCm38
MGSCv377106,368,160 - 106,368,356UniSTSGRCm37
Celera799,544,684 - 99,544,880UniSTS
Cytogenetic Map7E2UniSTS
Whitehead_YAC7 UniSTS
UniSTS:235717  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38799,219,113 - 99,219,312UniSTSGRCm38
MGSCv377106,367,623 - 106,367,822UniSTSGRCm37
Celera799,544,147 - 99,544,346UniSTS
Cytogenetic Map7E2UniSTS
Mogat2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7E2UniSTS
cM Map7 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000064231   ⟹   ENSMUSP00000064041
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,868,291 - 98,887,826 (-)Ensembl
GRCm38.p6 Ensembl799,219,084 - 99,238,619 (-)Ensembl
RefSeq Acc Id: ENSMUST00000132343
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl798,875,784 - 98,887,801 (-)Ensembl
GRCm38.p6 Ensembl799,226,577 - 99,238,594 (-)Ensembl
RefSeq Acc Id: NM_177448   ⟹   NP_803231
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39798,868,291 - 98,887,818 (-)NCBI
GRCm38799,219,084 - 99,238,611 (-)ENTREZGENE
MGSCv377106,367,594 - 106,387,121 (-)RGD
Celera799,544,118 - 99,564,053 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011241737   ⟹   XP_011240039
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39798,868,291 - 98,887,300 (-)NCBI
GRCm38799,219,084 - 99,238,093 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_803231   ⟸   NM_177448
- UniProtKB: Q80W94 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011240039   ⟸   XM_011241737
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000064041   ⟸   ENSMUST00000064231

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80W94-F1-model_v2 AlphaFold Q80W94 1-334 view protein structure

Promoters
RGD ID:8664865
Promoter ID:EPDNEW_M10463
Type:initiation region
Name:Mogat2_1
Description:Mus musculus monoacylglycerol O-acyltransferase 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38799,238,573 - 99,238,633EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2663253 AgrOrtholog
Ensembl Genes ENSMUSG00000052396 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064231 ENTREZGENE
  ENSMUST00000064231.8 UniProtKB/Swiss-Prot
InterPro DAGAT UniProtKB/Swiss-Prot
KEGG Report mmu:233549 UniProtKB/Swiss-Prot
MGD MGI:2663253 ENTREZGENE
NCBI Gene 233549 ENTREZGENE
PANTHER 2-ACYLGLYCEROL O-ACYLTRANSFERASE 2 UniProtKB/Swiss-Prot
  DIACYLGLYCEROL O-ACYLTRANSFERASE UniProtKB/Swiss-Prot
Pfam DAGAT UniProtKB/Swiss-Prot
PhenoGen Mogat2 PhenoGen
UniProt MOGT2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE