Spef1 (sperm flagellar 1) - Rat Genome Database

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Gene: Spef1 (sperm flagellar 1) Mus musculus
Analyze
Symbol: Spef1
Name: sperm flagellar 1
RGD ID: 1552440
MGI Page MGI
Description: Enables microtubule binding activity. Involved in axonemal central apparatus assembly; cilium movement; and negative regulation of microtubule depolymerization. Located in 9+2 motile cilium; axonemal central apparatus; and ciliary tip. Is expressed in several structures, including central nervous system; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human SPEF1 (sperm flagellar 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4931426K16Rik; calponin-homology and microtubule-associated protein; Clamp; sperm flagellar protein 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,012,181 - 131,016,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,012,181 - 131,029,202 (-)EnsemblGRCm39 Ensembl
GRCm382131,170,261 - 131,174,810 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,170,261 - 131,187,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,995,997 - 131,000,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,995,997 - 131,000,546 (-)NCBIMGSCv36mm8
Celera2132,394,333 - 132,398,883 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15979255   PMID:16141072   PMID:16141073   PMID:16206169   PMID:21267068   PMID:21873635  
PMID:24194600   PMID:27626380   PMID:30535028  


Genomics

Comparative Map Data
Spef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,012,181 - 131,016,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,012,181 - 131,029,202 (-)EnsemblGRCm39 Ensembl
GRCm382131,170,261 - 131,174,810 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,170,261 - 131,187,282 (-)EnsemblGRCm38mm10GRCm38
MGSCv372130,995,997 - 131,000,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,995,997 - 131,000,546 (-)NCBIMGSCv36mm8
Celera2132,394,333 - 132,398,883 (-)NCBICelera
Cytogenetic Map2F1NCBI
cM Map263.28NCBI
SPEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,777,504 - 3,781,448 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl203,777,504 - 3,781,448 (-)EnsemblGRCh38hg38GRCh38
GRCh37203,758,151 - 3,762,095 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,706,151 - 3,710,102 (-)NCBINCBI36Build 36hg18NCBI36
Build 34203,706,151 - 3,710,061NCBI
Celera203,820,021 - 3,823,972 (-)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,706,709 - 3,710,657 (-)NCBIHuRef
CHM1_1203,758,467 - 3,762,413 (-)NCBICHM1_1
T2T-CHM13v2.0203,808,445 - 3,812,388 (-)NCBIT2T-CHM13v2.0
Spef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83138,843,679 - 138,849,762 (-)NCBIGRCr8
mRatBN7.23118,390,659 - 118,396,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,390,575 - 118,394,531 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,285,004 - 122,288,862 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03130,884,350 - 130,888,228 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03128,541,107 - 128,544,963 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03123,712,907 - 123,720,787 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,714,564 - 123,718,432 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,212,953 - 130,219,185 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,877,343 - 118,881,211 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,782,916 - 118,786,719 (-)NCBI
Celera3117,198,821 - 117,202,689 (-)NCBICelera
Cytogenetic Map3q36NCBI
Spef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,620,593 - 14,626,049 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,620,593 - 14,626,049 (-)NCBIChiLan1.0ChiLan1.0
SPEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2214,739,651 - 4,744,508 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1204,736,476 - 4,742,474 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0203,858,548 - 3,863,150 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1203,615,358 - 3,619,390 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,615,358 - 3,619,390 (-)Ensemblpanpan1.1panPan2
SPEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,572,457 - 17,580,006 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,574,741 - 17,578,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,402,172 - 17,408,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,991,277 - 17,997,400 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,993,220 - 17,998,605 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,586,132 - 17,593,665 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,697,226 - 17,703,348 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02418,024,874 - 18,031,001 (+)NCBIUU_Cfam_GSD_1.0
Spef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,486,052 - 166,492,305 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,919,913 - 14,922,995 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648514,917,352 - 14,923,669 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,934,856 - 31,938,463 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,934,856 - 31,938,463 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,264,818 - 36,271,217 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,462,933 - 34,467,575 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,462,896 - 34,466,923 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660719,986,035 - 9,990,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,862,872 - 4,866,783 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,861,992 - 4,868,261 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spef1
122 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1379
Count of miRNA genes:490
Interacting mature miRNAs:600
Transcripts:ENSMUST00000028801, ENSMUST00000110218, ENSMUST00000127987
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126041920135441920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1558989Gnf4_mgrowth and fatness 4 (mouse)Not determined2128173704132714157Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse

Markers in Region
UniSTS:234526  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,171,419 - 131,171,628UniSTSGRCm38
MGSCv372130,997,155 - 130,997,364UniSTSGRCm37
Celera2132,395,491 - 132,395,700UniSTS
Cytogenetic Map2F3UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000028801   ⟹   ENSMUSP00000028801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,012,181 - 131,029,202 (-)Ensembl
GRCm38.p6 Ensembl2131,170,261 - 131,187,282 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110218   ⟹   ENSMUSP00000105847
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,012,236 - 131,017,121 (-)Ensembl
GRCm38.p6 Ensembl2131,170,316 - 131,175,201 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127987   ⟹   ENSMUSP00000114178
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,013,531 - 131,016,573 (-)Ensembl
GRCm38.p6 Ensembl2131,171,611 - 131,174,653 (-)Ensembl
RefSeq Acc Id: NM_027641   ⟹   NP_081917
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,012,181 - 131,016,730 (-)NCBI
GRCm382131,170,261 - 131,174,810 (-)NCBI
MGSCv372130,995,997 - 131,000,546 (-)RGD
Celera2132,394,333 - 132,398,883 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_081917 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH06046 (Get FASTA)   NCBI Sequence Viewer  
  AAX56299 (Get FASTA)   NCBI Sequence Viewer  
  BAC32928 (Get FASTA)   NCBI Sequence Viewer  
  BAC33121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000028801.2
  ENSMUSP00000105847
  ENSMUSP00000105847.3
  ENSMUSP00000114178.2
GenBank Protein Q99JL1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_081917   ⟸   NM_027641
- UniProtKB: Q543S5 (UniProtKB/Swiss-Prot),   A2ANS9 (UniProtKB/Swiss-Prot),   Q9D4J8 (UniProtKB/Swiss-Prot),   Q99JL1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000105847   ⟸   ENSMUST00000110218
RefSeq Acc Id: ENSMUSP00000114178   ⟸   ENSMUST00000127987
RefSeq Acc Id: ENSMUSP00000028801   ⟸   ENSMUST00000028801
Protein Domains
Calponin-homology (CH)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99JL1-F1-model_v2 AlphaFold Q99JL1 1-234 view protein structure

Promoters
RGD ID:6831009
Promoter ID:MM_KWN:31790
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000089510,   NM_007682,   OTTMUST00000037802,   OTTMUST00000037803
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362131,000,391 - 131,006,042 (-)MPROMDB
RGD ID:6878794
Promoter ID:EPDNEW_M2848
Type:initiation region
Name:Spef1_1
Description:Mus musculus sperm flagellar 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382131,174,772 - 131,174,832EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3513546 AgrOrtholog
Ensembl Genes ENSMUSG00000027329 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000028801.8 UniProtKB/Swiss-Prot
  ENSMUST00000110218 ENTREZGENE
  ENSMUST00000110218.9 UniProtKB/Swiss-Prot
  ENSMUST00000127987.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70997 UniProtKB/Swiss-Prot
MGD MGI:3513546 ENTREZGENE
NCBI Gene 70997 ENTREZGENE
PANTHER SPERM FLAGELLAR PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPERMATOGENESIS-ASSOCIATED 4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spef1 PhenoGen
PROSITE PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2ANS9 ENTREZGENE
  F6ZW13_MOUSE UniProtKB/TrEMBL
  Q543S5 ENTREZGENE
  Q99JL1 ENTREZGENE
  Q9D4J8 ENTREZGENE
  SPEF1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A2ANS9 UniProtKB/Swiss-Prot
  Q543S5 UniProtKB/Swiss-Prot
  Q9D4J8 UniProtKB/Swiss-Prot