Foxd1 (forkhead box D1) - Rat Genome Database

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Gene: Foxd1 (forkhead box D1) Mus musculus
Analyze
Symbol: Foxd1
Name: forkhead box D1
RGD ID: 1551715
MGI Page MGI
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including kidney development; luteinizing hormone secretion; and regulation of gene expression. Acts upstream of or within axon guidance; branching involved in ureteric bud morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; metanephros; nervous system; and sensory organ. Orthologous to human FOXD1 (forkhead box D1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI385632; BF-2; brain factor 2; forkhead box protein D1; FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4); forkhead-related protein FKHL8; forkhead-related transcription factor 4; FREA; FREAC-4; FREAC4; HFH-BF-2; Hfh10; Hfhbf2; HNF-3/forkhead homolog, brain factor 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,490,753 - 98,493,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,490,750 - 98,495,813 (+)EnsemblGRCm39 Ensembl
GRCm381398,354,245 - 98,356,705 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,354,242 - 98,359,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv371399,124,200 - 99,126,660 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,454,412 - 99,456,849 (+)NCBIMGSCv36mm8
Celera13102,010,574 - 102,012,702 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1351.96NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family. Clevidence DE, etal., Proc Natl Acad Sci U S A 1993 May 1;90(9):3948-52.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. MGD IEA MGD IEA
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7789972   PMID:7815060   PMID:7957066   PMID:8666231   PMID:9118797   PMID:9232602   PMID:9510020   PMID:9811586   PMID:9851982   PMID:9886035   PMID:10021334   PMID:10349636  
PMID:10373304   PMID:10498272   PMID:10572052   PMID:11042159   PMID:11076861   PMID:11138002   PMID:11217851   PMID:11493536   PMID:11507767   PMID:11562352   PMID:11943768   PMID:12060755  
PMID:12223410   PMID:12412011   PMID:12466851   PMID:12591246   PMID:12619136   PMID:12631064   PMID:13678594   PMID:14681479   PMID:15107405   PMID:15162516   PMID:15201220   PMID:15509772  
PMID:15618518   PMID:15634693   PMID:16049112   PMID:16141072   PMID:16141073   PMID:16319116   PMID:16511601   PMID:16585573   PMID:16602821   PMID:16783635   PMID:16818446   PMID:16942767  
PMID:17036046   PMID:17107998   PMID:17452023   PMID:17826763   PMID:18094027   PMID:18287559   PMID:18371453   PMID:18776146   PMID:18835385   PMID:19004857   PMID:19036983   PMID:19060336  
PMID:19281780   PMID:19474326   PMID:19521555   PMID:19542358   PMID:19591821   PMID:19741018   PMID:19793891   PMID:19898483   PMID:20008127   PMID:20059953   PMID:20152829   PMID:20436479  
PMID:20843830   PMID:21035938   PMID:21128305   PMID:21267068   PMID:21303848   PMID:21350013   PMID:21490208   PMID:21613322   PMID:21852398   PMID:21858105   PMID:21873635   PMID:21931791  
PMID:22008794   PMID:22102609   PMID:22282599   PMID:22510988   PMID:22511595   PMID:23262027   PMID:23284914   PMID:23487309   PMID:23555292   PMID:23678105   PMID:23685333   PMID:23720040  
PMID:23823180   PMID:23924232   PMID:23974041   PMID:24099863   PMID:24146773   PMID:24226518   PMID:24284212   PMID:24353058   PMID:24440154   PMID:24496101   PMID:24505489   PMID:24732380  
PMID:25053437   PMID:25358792   PMID:25505333   PMID:25651362   PMID:25758227   PMID:25803581   PMID:26071365   PMID:26116176   PMID:26116661   PMID:26116666   PMID:26138478   PMID:26141512  
PMID:26246508   PMID:26253404   PMID:26256211   PMID:26438731   PMID:26511275   PMID:26726812   PMID:26731474   PMID:26776520   PMID:26956838   PMID:27088801   PMID:27165825   PMID:27335372  
PMID:27582005   PMID:27628903   PMID:27642633   PMID:27779900   PMID:27805902   PMID:27869651   PMID:27957530   PMID:28028137   PMID:28069742   PMID:28286175   PMID:28439006   PMID:28506991  
PMID:28527294   PMID:28535371   PMID:28539333   PMID:28665931   PMID:28701517   PMID:28729440   PMID:28794157   PMID:28847002   PMID:29031500   PMID:29109083   PMID:29284139   PMID:29357412  
PMID:29449449   PMID:29459093   PMID:29592525   PMID:29596840   PMID:29667914   PMID:29679559   PMID:29705331   PMID:29945868   PMID:30063881   PMID:30124871   PMID:30158529   PMID:30377232  
PMID:30516471   PMID:30545632   PMID:30595537   PMID:30661985   PMID:30810761   PMID:30830875   PMID:30943054   PMID:30969804   PMID:31042081   PMID:31102349   PMID:31142573   PMID:31364375  
PMID:31405951   PMID:31405952   PMID:31705443   PMID:31907354   PMID:32040930   PMID:32154933   PMID:32324134   PMID:32541007   PMID:32561725   PMID:32586976   PMID:32715478   PMID:32868762  
PMID:33006313   PMID:33302058   PMID:33479483   PMID:33522480   PMID:33898467   PMID:34031962   PMID:34070742   PMID:34732708   PMID:34878095   PMID:35037469   PMID:35105870   PMID:35247391  
PMID:35263586   PMID:35451473   PMID:35796804   PMID:35830813   PMID:35918150   PMID:36196625   PMID:36335435   PMID:36445780   PMID:36477539   PMID:36527791   PMID:36652050   PMID:36920028  
PMID:36960826   PMID:37227110   PMID:37524711   PMID:37727504   PMID:37823339   PMID:38092733   PMID:38177914   PMID:38424240  


Genomics

Comparative Map Data
Foxd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,490,753 - 98,493,213 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,490,750 - 98,495,813 (+)EnsemblGRCm39 Ensembl
GRCm381398,354,245 - 98,356,705 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,354,242 - 98,359,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv371399,124,200 - 99,126,660 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,454,412 - 99,456,849 (+)NCBIMGSCv36mm8
Celera13102,010,574 - 102,012,702 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1351.96NCBI
FOXD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38573,446,266 - 73,448,777 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl573,444,827 - 73,448,777 (-)EnsemblGRCh38hg38GRCh38
GRCh37572,742,093 - 72,744,602 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36572,777,839 - 72,780,108 (-)NCBINCBI36Build 36hg18NCBI36
Build 34572,777,870 - 72,780,356NCBI
Celera568,637,378 - 68,639,649 (-)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef567,947,569 - 67,949,821 (-)NCBIHuRef
CHM1_1572,174,804 - 72,177,081 (-)NCBICHM1_1
T2T-CHM13v2.0573,927,589 - 73,930,100 (-)NCBIT2T-CHM13v2.0
Foxd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8231,436,802 - 31,439,222 (+)NCBIGRCr8
mRatBN7.2229,702,558 - 29,704,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl229,702,558 - 29,704,978 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx236,759,829 - 36,762,247 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0234,854,175 - 34,856,593 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0229,672,088 - 29,674,506 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0228,460,068 - 28,462,488 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl228,460,068 - 28,462,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0247,560,939 - 47,563,359 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4228,944,067 - 28,945,665 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1228,864,816 - 28,865,119 (+)NCBI
Celera225,739,043 - 25,741,152 (+)NCBICelera
Cytogenetic Map2q12NCBI
Foxd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542527,158,601 - 27,159,447 (+)NCBIChiLan1.0ChiLan1.0
FOXD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2441,869,400 - 41,871,933 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,021,506 - 40,025,581 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0541,867,118 - 41,870,497 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FOXD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha253,266,967 - 53,269,485 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0256,812,484 - 56,814,991 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1253,873,429 - 53,875,972 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,641,541 - 54,644,071 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0255,532,914 - 55,535,465 (-)NCBIUU_Cfam_GSD_1.0
FOXD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl282,607,848 - 82,609,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1282,607,113 - 82,612,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FOXD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1467,790,423 - 67,796,901 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604916,561,007 - 16,563,829 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249052,487,981 - 2,490,068 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Foxd1
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:201
Count of miRNA genes:170
Interacting mature miRNAs:181
Transcripts:ENSMUST00000105098
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1301445Listr2_mlisteriosis resistance 2 (mouse)Not determined1366744601100744746Mouse
1301593Heal8_mwound healing/regeneration 8 (mouse)Not determined1368053999102054119Mouse
14696726Kidrq3_mkidney weight, right QTL 3 (mouse)1368217066102217066Mouse
14747007Mancz11_mmandible centroid size 11 (mouse)1370111284104111284Mouse
4141266Mol3_mmodifier of LPS-response 3 (mouse)Not determined76132600112431103Mouse
12880414V125Dq10_mvitamin D active form serum level QTL 10 (mouse)1378036508112036508Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
4141728Egaq4_mearly growth adjusted QTL 4 (mouse)Not determined87901985112431103Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse

Markers in Region
Foxd1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381398,355,711 - 98,356,568UniSTSGRCm38
MGSCv371399,125,666 - 99,126,523UniSTSGRCm37
Celera13102,011,708 - 102,012,565UniSTS
Cytogenetic Map13D1UniSTS
cM Map1352.0UniSTS
UniSTS:237087  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381398,356,194 - 98,356,351UniSTSGRCm38
MGSCv371399,126,149 - 99,126,306UniSTSGRCm37
Celera13102,012,191 - 102,012,348UniSTS
Cytogenetic Map13D1UniSTS
cM Map1352.0UniSTS
AI385632  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381398,356,120 - 98,356,258UniSTSGRCm38
MGSCv371399,126,075 - 99,126,213UniSTSGRCm37
Celera13102,012,117 - 102,012,255UniSTS
Cytogenetic Map13D1UniSTS
cM Map1352.0UniSTS
Whitehead/MRC_RH13850.54UniSTS
PMC316354P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381398,355,012 - 98,355,281UniSTSGRCm38
GRCm384114,925,550 - 114,925,819UniSTSGRCm38
MGSCv374114,598,155 - 114,598,424UniSTSGRCm37
MGSCv371399,124,967 - 99,125,236UniSTSGRCm37
Celera4113,673,324 - 113,673,593UniSTS
Cytogenetic Map4C7UniSTS
Cytogenetic Map13D1UniSTS
cM Map449.6UniSTS
cM Map1352.0UniSTS
UniSTS:489064  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera13102,010,608 - 102,012,206UniSTS
Cytogenetic Map13D1UniSTS
cM Map1352.0UniSTS
UniSTS:495469  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera13102,010,684 - 102,012,252UniSTS
Cytogenetic Map13D1UniSTS
cM Map1352.0UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000105098   ⟹   ENSMUSP00000100725
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1398,490,750 - 98,495,813 (+)Ensembl
GRCm38.p6 Ensembl1398,354,242 - 98,359,305 (+)Ensembl
RefSeq Acc Id: NM_008242   ⟹   NP_032268
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391398,490,753 - 98,493,213 (+)NCBI
GRCm381398,354,245 - 98,356,705 (+)ENTREZGENE
MGSCv371399,124,200 - 99,126,660 (+)RGD
Celera13102,010,574 - 102,012,702 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_032268 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC42042 (Get FASTA)   NCBI Sequence Viewer  
  BAE21140 (Get FASTA)   NCBI Sequence Viewer  
  BAE24920 (Get FASTA)   NCBI Sequence Viewer  
  BAE25207 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000100725
  ENSMUSP00000100725.4
GenBank Protein Q61345 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_032268   ⟸   NM_008242
- UniProtKB: Q3UQW8 (UniProtKB/Swiss-Prot),   Q61345 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000100725   ⟸   ENSMUST00000105098

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q61345-F1-model_v2 AlphaFold Q61345 1-456 view protein structure

Promoters
RGD ID:8681112
Promoter ID:EPDNEW_M18587
Type:multiple initiation site
Name:Foxd1_1
Description:Mus musculus forkhead box D1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381398,354,243 - 98,354,303EPDNEW
RGD ID:6823910
Promoter ID:MM_KWN:15018
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_008242
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361399,124,116 - 99,126,142 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347463 AgrOrtholog
Ensembl Genes ENSMUSG00000050789
  ENSMUSG00000078302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000105098 ENTREZGENE
  ENSMUST00000105098.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot
InterPro Fork_head_dom UniProtKB/Swiss-Prot
  TF_fork_head_CS_1 UniProtKB/Swiss-Prot
  TF_fork_head_CS_2 UniProtKB/Swiss-Prot
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot
  WH_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report mmu:15229 UniProtKB/Swiss-Prot
MGD MGI:1347463 ENTREZGENE
NCBI Gene 15229 ENTREZGENE
PANTHER FORKHEAD BOX PROTEIN UniProtKB/Swiss-Prot
  FORKHEAD BOX PROTEIN D1 UniProtKB/Swiss-Prot
Pfam Forkhead UniProtKB/Swiss-Prot
PhenoGen Foxd1 PhenoGen
PRINTS FORKHEAD UniProtKB/Swiss-Prot
PROSITE FORK_HEAD_1 UniProtKB/Swiss-Prot
  FORK_HEAD_2 UniProtKB/Swiss-Prot
  FORK_HEAD_3 UniProtKB/Swiss-Prot
SMART SM00339 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot
UniProt FOXD1_MOUSE UniProtKB/Swiss-Prot
  Q3UQ37_MOUSE UniProtKB/TrEMBL
  Q3UQW8 ENTREZGENE
  Q61345 ENTREZGENE
UniProt Secondary Q3UQW8 UniProtKB/Swiss-Prot