Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RPS6KC1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPS6KC1 mRNA | CTD | PMID:22079256 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RPS6KC1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RPS6KC1 mRNA | CTD | PMID:22206623 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RPS6KC1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RPS6KC1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RPS6KC1 (Homo sapiens) | 6480464 | [Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in increased expression of RPS6KC1 mRNA | CTD | PMID:29704546 | 2,4-dinitrotoluene | affects expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | 2 and 4-dinitrotoluene affects the expression of RPS6KC1 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of RPS6KC1 mRNA | CTD | PMID:21346803 | 3,4-methylenedioxymethamphetamine | increases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of RPS6KC1 mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of RPS6KC1 mRNA | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | increases methylation | ISO | RPS6KC1 (Homo sapiens) | 6480464 | bisphenol S results in increased methylation of RPS6KC1 gene | CTD | PMID:31601247 | aflatoxin B1 | increases methylation | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of RPS6KC1 gene | CTD | PMID:27153756 | aristolochic acid A | decreases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of RPS6KC1 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | RPS6KC1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to RPS6KC1 mRNA] | CTD | PMID:32406909 | atrazine | affects methylation | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of RPS6KC1 gene | CTD | PMID:35440735 | benzo[a]pyrene | decreases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of RPS6KC1 mRNA | CTD | PMID:20064835 | benzo[a]pyrene | increases methylation | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of RPS6KC1 promoter | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[a]pyrene diol epoxide I | affects expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:20382639 | bisphenol A | increases expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of RPS6KC1 mRNA | CTD | PMID:25181051 more ... | bortezomib | increases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Bortezomib results in increased expression of RPS6KC1 mRNA | CTD | PMID:20977926 | caffeine | affects phosphorylation | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of RPS6KC1 protein | CTD | PMID:35688186 | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RPS6KC1 gene | CTD | PMID:20938992 | ciglitazone | multiple interactions | ISO | RPS6KC1 (Homo sapiens) | 6480464 | [ciglitazone binds to PPARG protein alternative form] which results in increased expression of RPS6KC1 mRNA | CTD | PMID:16197558 | clofibrate | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of RPS6KC1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RPS6KC1 mRNA] | CTD | PMID:17585979 | cobalt dichloride | increases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of RPS6KC1 mRNA | CTD | PMID:19320972 | coumarin | decreases phosphorylation | ISO | RPS6KC1 (Homo sapiens) | 6480464 | coumarin results in decreased phosphorylation of RPS6KC1 protein | CTD | PMID:35688186 | cyclosporin A | increases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of RPS6KC1 mRNA | CTD | PMID:20106945 | DDT | increases methylation | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | DDT results in increased methylation of RPS6KC1 gene | CTD | PMID:31682807 | dicrotophos | decreases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of RPS6KC1 mRNA | CTD | PMID:28302478 | doxorubicin | decreases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of RPS6KC1 mRNA | CTD | PMID:29803840 | ethanol | multiple interactions | EXP | | 6480464 | Ethanol affects the expression of and affects the splicing of RPS6KC1 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | [1 more ... | CTD | PMID:20938992 and PMID:22206623 | FR900359 | increases phosphorylation | ISO | RPS6KC1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of RPS6KC1 protein | CTD | PMID:37730182 | furan | increases methylation | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | furan results in increased methylation of RPS6KC1 gene | CTD | PMID:22079235 | gallic acid | increases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Gallic Acid results in increased expression of RPS6KC1 mRNA | CTD | PMID:34408198 | gallic acid | decreases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Gallic Acid results in decreased expression of RPS6KC1 mRNA | CTD | PMID:34408198 | glyphosate | affects methylation | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Glyphosate affects the methylation of RPS6KC1 gene | CTD | PMID:35440735 | glyphosate | increases methylation | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Glyphosate results in increased methylation of RPS6KC1 gene | CTD | PMID:31011160 | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of RPS6KC1 gene | CTD | PMID:20938992 | mercury atom | decreases expression | EXP | | 6480464 | Mercury analog results in decreased expression of RPS6KC1 mRNA | CTD | PMID:25056781 | mercury(0) | decreases expression | EXP | | 6480464 | Mercury analog results in decreased expression of RPS6KC1 mRNA | CTD | PMID:25056781 | methoxychlor | affects methylation | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Methoxychlor affects the methylation of RPS6KC1 gene | CTD | PMID:35440735 | N,N-diethyl-m-toluamide | multiple interactions | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of RPS6KC1 gene | CTD | PMID:33148267 | paracetamol | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of RPS6KC1 mRNA and PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RPS6KC1 mRNA] | CTD | PMID:17585979 | paracetamol | decreases expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of RPS6KC1 mRNA | CTD | PMID:33387578 | paracetamol | increases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of RPS6KC1 mRNA | CTD | PMID:22230336 | PCB138 | multiple interactions | EXP | | 6480464 | [2 more ... | CTD | PMID:25510870 | permethrin | multiple interactions | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of RPS6KC1 gene | CTD | PMID:33148267 | potassium chromate | decreases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of RPS6KC1 mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | RPS6KC1 (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of RPS6KC1 mRNA | CTD | PMID:22079256 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of RPS6KC1 mRNA | CTD | PMID:28903501 | resveratrol | multiple interactions | ISO | RPS6KC1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of RPS6KC1 mRNA | CTD | PMID:23557933 | rotenone | decreases expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Rotenone results in decreased expression of RPS6KC1 mRNA | CTD | PMID:19013527 | sodium arsenite | increases methylation | ISO | RPS6KC1 (Homo sapiens) | 6480464 | sodium arsenite results in increased methylation of RPS6KC1 gene | CTD | PMID:24570342 | sunitinib | increases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of RPS6KC1 mRNA | CTD | PMID:31533062 | thioacetamide | increases expression | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of RPS6KC1 mRNA | CTD | PMID:23411599 | trichloroethene | increases methylation | ISO | Rps6kc1 (Rattus norvegicus) | 6480464 | Trichloroethylene results in increased methylation of RPS6KC1 gene | CTD | PMID:27618143 | valproic acid | increases expression | ISO | RPS6KC1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of RPS6KC1 mRNA | CTD | PMID:29154799 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Cellular Component
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Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Cellular Component
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11544199 | PMID:12477932 | PMID:12520002 | PMID:12904583 | PMID:14610273 | PMID:15489334 | PMID:16141072 |
| PMID:16141073 | PMID:16602821 | PMID:18799693 | PMID:21267068 | PMID:21677750 | PMID:21873635 | PMID:25211037 | PMID:31040226 | PMID:36417873 |
Genomics
Comparative Map Data
| Rps6kc1 (Mus musculus - house mouse) |
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| RPS6KC1 (Homo sapiens - human) |
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| Rps6kc1 (Rattus norvegicus - Norway rat) |
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| Rps6kc1 (Chinchilla lanigera - long-tailed chinchilla) |
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| RPS6KC1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| RPS6KC1 (Canis lupus familiaris - dog) |
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| Rps6kc1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| RPS6KC1 (Sus scrofa - pig) |
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| RPS6KC1 (Chlorocebus sabaeus - green monkey) |
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| Rps6kc1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Rps6kc1
4475 total Variants 
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