KAT2A (lysine acetyltransferase 2A) - Rat Genome Database

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Pathways
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Gene: KAT2A (lysine acetyltransferase 2A) Sus scrofa
Analyze
Symbol: KAT2A
Name: lysine acetyltransferase 2A
RGD ID: 14277013
Description: ENCODES a protein that exhibits chromatin binding (ortholog); protein phosphatase binding (ortholog); INVOLVED IN alpha-tubulin acetylation (ortholog); cellular response to nerve growth factor stimulus (ortholog); cellular response to tumor necrosis factor (ortholog); PARTICIPATES IN histone modification pathway; p53 signaling pathway; RNA polymerase II transcription initiation pathway; ASSOCIATED WITH hepatitis B (ortholog); lung non-small cell carcinoma (ortholog); neural tube defect (ortholog); FOUND IN ATAC complex (ortholog); chromatin (ortholog); oxoglutarate dehydrogenase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GCN5L2; general control of amino-acid synthesis 5-like 2; histone acetyltransferase KAT2A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,638,497 - 20,647,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,638,493 - 20,647,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,928,657 - 20,937,624 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-tubulin acetylation  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
chromatin remodeling  (IBA,IEA)
fibroblast proliferation  (IEA,ISO)
gluconeogenesis  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
intracellular distribution of mitochondria  (ISO)
long-term memory  (IEA)
metencephalon development  (IEA,ISO)
midbrain development  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of centriole replication  (IEA)
negative regulation of gluconeogenesis  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA)
nervous system development  (IEA,ISO)
neural tube closure  (IEA,ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell projection organization  (ISO)
positive regulation of cytokine production  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of gluconeogenesis  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IEA)
protein modification process  (ISO)
regulation of bone development  (IEA)
regulation of cartilage development  (IEA)
regulation of cell cycle  (IEA)
regulation of cell division  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of embryonic development  (IEA)
regulation of gene expression  (IEA)
regulation of protein stability  (IEA,ISO)
regulation of regulatory T cell differentiation  (IEA)
regulation of stem cell population maintenance  (IEA)
regulation of synaptic plasticity  (IEA)
regulation of T cell activation  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
regulation of tubulin deacetylation  (IEA)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
somitogenesis  (IEA,ISO)
telencephalon development  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KAT2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,638,497 - 20,647,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,638,493 - 20,647,464 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,928,657 - 20,937,624 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KAT2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,113,111 - 42,121,367 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,113,111 - 42,121,367 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,265,129 - 40,273,385 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,518,655 - 37,526,908 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,518,656 - 37,526,872NCBI
Celera1736,920,167 - 36,928,419 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,030,209 - 36,038,464 (-)NCBIHuRef
CHM1_11740,500,904 - 40,509,157 (-)NCBICHM1_1
T2T-CHM13v2.01742,969,613 - 42,977,870 (-)NCBIT2T-CHM13v2.0
Kat2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,595,572 - 100,603,293 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,595,572 - 100,603,291 (-)EnsemblGRCm39 Ensembl
GRCm3811100,704,746 - 100,712,485 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,704,746 - 100,712,465 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,566,062 - 100,573,768 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,520,838 - 100,528,544 (-)NCBIMGSCv36mm8
Celera11111,321,247 - 111,328,954 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.53NCBI
Kat2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,132,535 - 86,140,877 (-)NCBIGRCr8
mRatBN7.21085,632,216 - 85,640,561 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,632,216 - 85,640,166 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,668,667 - 90,676,617 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,147,250 - 90,155,439 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,540,459 - 85,548,409 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,611,586 - 88,619,558 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,611,586 - 88,619,537 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,405,799 - 88,413,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,642,002 - 89,649,953 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,656,393 - 89,664,314 (-)NCBI
Celera1084,347,901 - 84,355,851 (-)NCBICelera
Cytogenetic Map10q31NCBI
Kat2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,191,186 - 16,197,574 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,192,228 - 16,197,103 (-)NCBIChiLan1.0ChiLan1.0
KAT2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,862,494 - 22,870,902 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,752,604 - 24,761,009 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,194,414 - 15,202,818 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,416,075 - 15,424,197 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,416,075 - 15,424,197 (+)Ensemblpanpan1.1panPan2
KAT2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,778,434 - 20,787,057 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,779,042 - 20,787,067 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,239,316 - 20,247,945 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,497,151 - 21,505,776 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,497,762 - 21,505,766 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,282,433 - 20,291,051 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,549,548 - 20,558,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,652,594 - 20,661,220 (+)NCBIUU_Cfam_GSD_1.0
Kat2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,114,702 - 20,122,441 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,952,363 - 16,960,489 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649016,952,698 - 16,960,424 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KAT2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,146,146 - 64,154,726 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,146,207 - 64,154,252 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,962,125 - 34,971,363 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kat2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,782,366 - 1,788,951 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,782,367 - 1,787,408 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in KAT2A
261 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 10 4 3 4 2 23 2 3 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000018956   ⟹   ENSSSCP00000018451
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,638,497 - 20,647,461 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042249   ⟹   ENSSSCP00000047074
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1220,638,493 - 20,647,463 (+)Ensembl
RefSeq Acc Id: XM_003131405   ⟹   XP_003131453
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,638,494 - 20,647,464 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005668830   ⟹   XP_005668887
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,638,494 - 20,647,464 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013980959   ⟹   XP_013836413
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,638,493 - 20,647,464 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013980960   ⟹   XP_013836414
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11220,638,493 - 20,647,464 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_013836413   ⟸   XM_013980959
- Peptide Label: isoform X1
- UniProtKB: A0A8D0RQ96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013836414   ⟸   XM_013980960
- Peptide Label: isoform X2
- UniProtKB: A0A4X1U6S0 (UniProtKB/TrEMBL),   F1S0Q0 (UniProtKB/TrEMBL),   A0A8D0RQ96 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005668887   ⟸   XM_005668830
- Peptide Label: isoform X3
- UniProtKB: A0A480VCN1 (UniProtKB/TrEMBL),   A0A8D1DTJ4 (UniProtKB/TrEMBL),   A0A8D0ND80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003131453   ⟸   XM_003131405
- Peptide Label: isoform X4
- UniProtKB: A0A480V2P3 (UniProtKB/TrEMBL),   A0A8D0ND80 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047074   ⟸   ENSSSCT00000042249
RefSeq Acc Id: ENSSSCP00000018451   ⟸   ENSSSCT00000018956
Protein Domains
Bromo   N-acetyltransferase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015032429 UniProtKB/TrEMBL
  ENSSSCG00025033332 UniProtKB/TrEMBL
  ENSSSCG00030067122 UniProtKB/TrEMBL
  ENSSSCG00035019534 UniProtKB/TrEMBL
  ENSSSCG00040020098 UniProtKB/TrEMBL
  ENSSSCG00045038200 UniProtKB/TrEMBL
  ENSSSCG00050068824 UniProtKB/TrEMBL
  ENSSSCG00055029274 UniProtKB/TrEMBL
  ENSSSCG00065006602 UniProtKB/TrEMBL
  ENSSSCG00070014400 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000018956 ENTREZGENE
  ENSSSCT00000018956.5 UniProtKB/TrEMBL
  ENSSSCT00015042966.1 UniProtKB/TrEMBL
  ENSSSCT00025045362.1 UniProtKB/TrEMBL
  ENSSSCT00030093840.1 UniProtKB/TrEMBL
  ENSSSCT00035025307.1 UniProtKB/TrEMBL
  ENSSSCT00040027203.1 UniProtKB/TrEMBL
  ENSSSCT00040027297.1 UniProtKB/TrEMBL
  ENSSSCT00045066144.1 UniProtKB/TrEMBL
  ENSSSCT00050093940.1 UniProtKB/TrEMBL
  ENSSSCT00055058104.1 UniProtKB/TrEMBL
  ENSSSCT00065008876.1 UniProtKB/TrEMBL
  ENSSSCT00070028270.1 UniProtKB/TrEMBL
  ENSSSCT00070028287.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.920.10 UniProtKB/TrEMBL
  3.40.630.30 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  Bromodomain-like_sf UniProtKB/TrEMBL
  Bromodomain_CS UniProtKB/TrEMBL
  GCN5 UniProtKB/TrEMBL
  GCN5/PCAF UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
KEGG Report ssc:100524215 UniProtKB/TrEMBL
NCBI Gene KAT2A ENTREZGENE
PANTHER HISTONE ACETYLTRANSFERASE KAT2A UniProtKB/TrEMBL
  PTHR45750 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
  Bromodomain UniProtKB/TrEMBL
  PCAF_N UniProtKB/TrEMBL
PIRSF Histone_acetylase_PCAF UniProtKB/TrEMBL
PRINTS BROMODOMAIN UniProtKB/TrEMBL
PROSITE BROMODOMAIN_1 UniProtKB/TrEMBL
  BROMODOMAIN_2 UniProtKB/TrEMBL
  GNAT UniProtKB/TrEMBL
SMART BROMO UniProtKB/TrEMBL
Superfamily-SCOP SSF47370 UniProtKB/TrEMBL
  SSF55729 UniProtKB/TrEMBL
UniProt A0A480V2P3 ENTREZGENE, UniProtKB/TrEMBL
  A0A480VCN1 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U417_PIG UniProtKB/TrEMBL
  A0A4X1U6S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0ND80 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0RQ96 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1DTJ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1DUG6_PIG UniProtKB/TrEMBL
  F1S0Q0 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:89303 ENTREZGENE