RAPGEFL1 (Rap guanine nucleotide exchange factor like 1) - Rat Genome Database

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Gene: RAPGEFL1 (Rap guanine nucleotide exchange factor like 1) Sus scrofa
Analyze
Symbol: RAPGEFL1
Name: Rap guanine nucleotide exchange factor like 1
RGD ID: 14269715
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); INVOLVED IN Ras protein signal transduction (inferred); small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH familial cold autoinflammatory syndrome 2 (ortholog); hypertrophic cardiomyopathy 25 (ortholog); prostate cancer (ortholog); FOUND IN plasma membrane (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: rap guanine nucleotide exchange factor-like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,181,849 - 22,195,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,180,928 - 22,195,841 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,546,729 - 22,561,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RAPGEFL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1222,181,849 - 22,195,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11222,180,928 - 22,195,841 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,546,729 - 22,561,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEFL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,177,010 - 40,195,650 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,177,010 - 40,195,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371738,333,263 - 38,351,902 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,591,394 - 35,605,426 (+)NCBINCBI36Build 36hg18NCBI36
Build 341735,588,138 - 35,605,426NCBI
Celera1734,994,758 - 35,012,421 (+)NCBICelera
Cytogenetic Map17q21.1NCBI
HuRef1734,127,434 - 34,145,100 (+)NCBIHuRef
CHM1_11738,569,927 - 38,587,592 (+)NCBICHM1_1
T2T-CHM13v2.01741,040,889 - 41,059,520 (+)NCBIT2T-CHM13v2.0
Rapgefl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391198,727,611 - 98,744,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1198,727,611 - 98,744,523 (+)EnsemblGRCm39 Ensembl
GRCm381198,836,785 - 98,853,009 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,836,785 - 98,853,697 (+)EnsemblGRCm38mm10GRCm38
MGSCv371198,698,099 - 98,714,319 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361198,653,244 - 98,669,095 (+)NCBIMGSCv36mm8
Celera11108,491,920 - 108,508,404 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.7NCBI
Rapgefl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,289,980 - 84,306,614 (+)NCBIGRCr8
mRatBN7.21083,793,711 - 83,810,373 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1083,793,694 - 83,810,371 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01086,749,220 - 86,765,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1086,763,117 - 86,765,675 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,545,478 - 86,561,332 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41087,607,651 - 87,620,668 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1082,541,374 - 82,554,813 (+)NCBICelera
Cytogenetic Map10q31NCBI
Rapgefl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,809,630 - 14,816,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,802,094 - 14,818,096 (+)NCBIChiLan1.0ChiLan1.0
RAPGEFL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,759,538 - 24,777,374 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,654,350 - 26,672,187 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01717,093,714 - 17,111,187 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11717,315,114 - 17,335,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1717,315,114 - 17,335,258 (-)Ensemblpanpan1.1panPan2
RAPGEFL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,385,970 - 22,399,584 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,387,786 - 22,394,887 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,846,496 - 21,871,864 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,166,995 - 23,192,372 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,167,166 - 23,192,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,940,814 - 21,966,167 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0922,199,543 - 22,224,894 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0922,324,485 - 22,349,849 (-)NCBIUU_Cfam_GSD_1.0
Rapgefl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,779,660 - 21,793,695 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,281,433 - 15,296,636 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,281,462 - 15,295,479 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEFL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,978,561 - 65,995,738 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607736,883,727 - 36,901,319 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgefl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,036,543 - 3,045,595 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,036,245 - 3,045,610 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RAPGEFL1
338 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 9 4 3 5 2 23 2 2 1
Below cutoff 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000019029   ⟹   ENSSSCP00000018524
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,181,849 - 22,195,840 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000089004   ⟹   ENSSSCP00000060367
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1222,181,849 - 22,195,837 (-)Ensembl
RefSeq Acc Id: XM_003131487   ⟹   XP_003131535
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,180,928 - 22,195,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013979506   ⟹   XP_013834960
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,180,928 - 22,195,841 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002337115
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,180,928 - 22,195,841 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002337116
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11222,180,928 - 22,195,841 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003131535   ⟸   XM_003131487
- Peptide Label: isoform X2
- UniProtKB: F1RXC6 (UniProtKB/TrEMBL),   A0A4X1UBR4 (UniProtKB/TrEMBL),   A0A8D1NS41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013834960   ⟸   XM_013979506
- Peptide Label: isoform X1
- UniProtKB: A0A8D1NS41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000018524   ⟸   ENSSSCT00000019029
RefSeq Acc Id: ENSSSCP00000060367   ⟸   ENSSSCT00000089004
Protein Domains
Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017478 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025035941 UniProtKB/TrEMBL
  ENSSSCG00030035067 UniProtKB/TrEMBL
  ENSSSCG00035048434 UniProtKB/TrEMBL
  ENSSSCG00040004264 UniProtKB/TrEMBL
  ENSSSCG00045034800 UniProtKB/TrEMBL
  ENSSSCG00050074353 UniProtKB/TrEMBL
  ENSSSCG00055002115 UniProtKB/TrEMBL
  ENSSSCG00060075185 UniProtKB/TrEMBL
  ENSSSCG00065003775 UniProtKB/TrEMBL
  ENSSSCG00070016127 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019029 ENTREZGENE
  ENSSSCT00000019029.4 UniProtKB/TrEMBL
  ENSSSCT00000089004.2 UniProtKB/TrEMBL
  ENSSSCT00025049020.1 UniProtKB/TrEMBL
  ENSSSCT00030048749.1 UniProtKB/TrEMBL
  ENSSSCT00035064548.1 UniProtKB/TrEMBL
  ENSSSCT00040005571.1 UniProtKB/TrEMBL
  ENSSSCT00045059831.1 UniProtKB/TrEMBL
  ENSSSCT00050101788.1 UniProtKB/TrEMBL
  ENSSSCT00055004074.1 UniProtKB/TrEMBL
  ENSSSCT00060102984.1 UniProtKB/TrEMBL
  ENSSSCT00065005165.1 UniProtKB/TrEMBL
  ENSSSCT00070031659.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro Ras-like_GEF UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report ssc:100525075 UniProtKB/TrEMBL
NCBI Gene RAPGEFL1 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1 UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
PROSITE RASGEF_CAT UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
Superfamily-SCOP SSF48366 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A4X1UBR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QQ02_PIG UniProtKB/TrEMBL
  A0A8D1NS41 ENTREZGENE, UniProtKB/TrEMBL
  F1RXC6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92095 ENTREZGENE