SRD5A2 (steroid 5 alpha-reductase 2)

Gene: SRD5A2 (steroid 5 alpha-reductase 2) Sus scrofa

Analyze

Symbol:

SRD5A2

Name:

steroid 5 alpha-reductase 2

RGD ID:

14205943

Description:

ENCODES a protein that exhibits 3-oxo-5-alpha-steroid 4-dehydrogenase activity (ortholog); amide binding (ortholog); testosterone dehydrogenase [NAD(P)] activity (ortholog); INVOLVED IN androgen biosynthetic process (ortholog); androgen metabolic process (ortholog); biphenyl metabolic process (ortholog); PARTICIPATES IN testosterone biosynthetic pathway; ASSOCIATED WITH alopecia (ortholog); autism spectrum disorder (ortholog); Autoinflammation with Infantile Enterocolitis (ortholog); FOUND IN cell body fiber (ortholog); neuronal cell body (ortholog); INTERACTS WITH ammonia

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; S5AR 2; SR type 2; ST5AR2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	107,840,200 - 107,918,350 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	107,840,200 - 107,918,351 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	114,644,279 - 114,657,350 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alopecia (ISO)

autism spectrum disorder (ISO)

Autoinflammation with Infantile Enterocolitis (ISO)

breast carcinoma (ISO)

diabetes mellitus (ISO)

Endometrial Neoplasms (ISO)

endometriosis (ISO)

familial cold autoinflammatory syndrome 4 (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 4 (ISO)

hyperprolactinemia (ISO)

hypogonadism (ISO)

hypospadias (ISO)

Penis Agenesis (ISO)

prostate cancer (ISO)

prostatic hypertrophy (ISO)

Prostatic Neoplasms (ISO)

Pseudovaginal Perineoscrotal Hypospadias (ISO)

xanthinuria (ISO)

xanthinuria type II (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

ammonia (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen biosynthetic process (IEA,ISO)

androgen metabolic process (ISO)

biphenyl metabolic process (ISO)

bone development (ISO)

brassinosteroid biosynthetic process (IEA)

cell differentiation (IEA)

dibenzo-p-dioxin metabolic process (ISO)

female genitalia development (ISO)

hippocampus development (ISO)

hypothalamus development (ISO)

lipid metabolic process (IEA)

male genitalia development (ISO)

male gonad development (ISO)

phthalate metabolic process (ISO)

response to biphenyl (ISO)

response to follicle-stimulating hormone (ISO)

response to nutrient levels (ISO)

response to organic cyclic compound (ISO)

response to peptide hormone (ISO)

response to steroid hormone (ISO)

response to testosterone (ISO)

response to xenobiotic stimulus (ISO)

sex differentiation (IEA)

steroid biosynthetic process (IBA,ISO)

steroid catabolic process (ISO)

steroid metabolic process (IEA)

testosterone biosynthetic process (ISS)

Cellular Component

cell body fiber (ISO)

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

intracellular membrane-bounded organelle (IEA)

membrane (IEA)

neuronal cell body (ISO)

Molecular Function

3-oxo-5-alpha-steroid 4-dehydrogenase activity (IBA,IEA,ISO)

3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity (IEA)

amide binding (ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-CH group of donors (IEA)

protein binding (ISO)

steroid dehydrogenase activity (IEA)

testosterone dehydrogenase [NAD(P)] activity (ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

testosterone biosynthetic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SRD5A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	107,840,200 - 107,918,350 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	107,840,200 - 107,918,351 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	114,644,279 - 114,657,350 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRD5A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	31,522,480 - 31,663,009 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	31,522,480 - 31,580,938 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	31,747,550 - 31,806,007 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	31,603,160 - 31,659,544 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	31,661,306 - 31,717,691	NCBI
Celera	2	31,590,884 - 31,647,296 (-)	NCBI		Celera
Cytogenetic Map	2	p23.1	NCBI
HuRef	2	31,485,637 - 31,542,001 (-)	NCBI		HuRef
CHM1_1	2	31,678,089 - 31,734,473 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	31,567,195 - 31,707,768 (-)	NCBI		T2T-CHM13v2.0

Srd5a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	74,321,886 - 74,354,855 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	74,323,950 - 74,354,911 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	74,014,891 - 74,047,860 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	74,016,955 - 74,047,916 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	74,367,046 - 74,397,256 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	73,922,606 - 73,952,814 (-)	NCBI		MGSCv36	mm8
Celera	17	78,309,438 - 78,339,442 (-)	NCBI		Celera
Cytogenetic Map	17	E2	NCBI
cM Map	17	45.39	NCBI

Srd5a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	27,178,089 - 27,217,588 (+)	NCBI		GRCr8
mRatBN7.2	6	21,426,225 - 21,465,727 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	21,426,215 - 21,462,112 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	21,755,011 - 21,794,514 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	22,070,851 - 22,110,348 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	21,551,287 - 21,590,788 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	25,279,635 - 25,315,501 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	25,279,626 - 25,315,511 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	35,127,532 - 35,163,398 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	21,453,521 - 21,489,408 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	21,456,473 - 21,492,397 (+)	NCBI
Celera	6	20,976,906 - 21,012,848 (+)	NCBI		Celera
Cytogenetic Map	6	q13	NCBI

Srd5a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955441	10,443 - 95,743 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955441	12,149 - 95,733 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRD5A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	94,913,580 - 94,967,170 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	94,917,555 - 94,971,145 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	31,542,646 - 31,597,394 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	31,610,487 - 31,665,718 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	31,610,487 - 31,665,718 (-)	Ensembl	panpan1.1		panPan2

SRD5A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	25,017,113 - 25,056,156 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	25,017,113 - 25,056,544 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	24,811,155 - 24,850,233 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	25,580,015 - 25,620,097 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	25,580,843 - 25,620,171 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	24,887,475 - 24,926,628 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	24,946,476 - 24,985,654 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	25,049,043 - 25,087,911 (-)	NCBI		UU_Cfam_GSD_1.0

Srd5a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	69,130,023 - 69,175,570 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	1,663,911 - 1,708,502 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	1,663,999 - 1,708,530 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRD5A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	75,915,495 - 75,971,280 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	75,917,260 - 75,970,365 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	36,088,943 - 36,288,753 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srd5a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	13,253,729 - 13,321,448 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	13,254,998 - 13,321,360 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SRD5A2
1669 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	hemolymphoid system	nervous system	reproductive system
High
Medium				2
Low
Below cutoff	1	1	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_213988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021085840	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021085841	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF008440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU928283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GFLN01120035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSSCT00000009325 ⟹ ENSSSCP00000009087

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	3	107,840,200 - 107,918,350 (+)	Ensembl

RefSeq Acc Id:

NM_213988 ⟹ NP_999153

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	107,840,200 - 107,918,351 (+)	NCBI

Sequence:

show sequence

TCTCTGCTCTGTCGGAAGCCACTGGCGGGGAATACGGCGCGATGCCTGTTCGCTGCCAGCAGAG
CCCGGTGCTGGCGGGCAGCGCCACTTTGGCTGCCCTGGGGGCACTGGCCCTGTACTTCGCGGAG
CCCTCTGGCTACGGGAAGTACACGGAGAGCCTGACGCCCGCGGCTATCCGCCTGCCAGCCCGTG
CCGCCTGGTTCCTGCAGGAGCTGCCCTCCTTCGTGGTGCCCGCGGGGATCCTCGCCGGGCAGCC
CCGTTCTCTCTTCGGCCCGCCTGCGACTGTGCTTCTGGGCCTCTTCTGCGCACATTACTTCCAC
AGGACATTTGTTTACTCACTGCTCACTAGAGGGAGGCCTTTTCCAGTTGTATTCCTTTTCAGAG
GCTTTGTCTTCTGCATGGGAAATGGACTCCTTCAAGGCTACTATCTGGTTTACTGTGCCGAATA
CCCTGCTGAGTGGTACACAGACATACGGTTTAGCCTAGGTGTGTTCTTATTTATTTTGGGCATG
GGAATCAACATTCACAGCGACTATATATTGCGCCAGCTCAGGAAGCCTGGAGAAGTCATCTATA
AGATTCCACAAGGTGGCTTGTTCACGTACGTTTCTGGAGCCAATTTCCTTGGTGAGATCATTGA
ATGGATCGGCTATGCCTTGGCCACTTGGTCCCTTCCAGCACTTGCATTTGCATTTTTCTCGCTT
TGTTTCCTTGGGCTGCGAGCTTTTCACCATCATAGGTTCTACGTCAAGATGTTTGAGGACTACC
CCAAGTCTCGAAAAGCCCTTATTCCATTTATCTTTTAAAGAAACCAAATAAAAAAAGGAACAAA
GTCCCCACAATCTTGTTGAAGAACCTTCAAGCTGCGGAACCTGTAACTTTTCAAGTCCCACTGT
GTATGTGTAATAATCAGCCTCTGGTGTTCTGGCAGGTGGCCTGAGGATTCTGCACGGGACCCCT
TAGTGTTTCCTCGAACCCTCTCTGCGGGTCTCTATCCTGATTTCCTATTAAAACTTCCACAAGG
TCTGCTTTTATGCAGAGGTATCTGTTTCTTAGCTCTTCCTCCTAGAAAGTGTATACTTCCCTTT
GTATTTTTTTCTCTGAATGGCCCAAGTCCATGTGACTTTATATCTATGCTGTGTCAGTATAAGA
CAGCTCTGTATTTGAGAGTGTTTTGAGTTGAGGGCAGTGCTTACGGAATTTATTTAAGGTACAC
AGTTAACACTTATGCAGACCAGCAGAGATTTAAATTGTAAAGCTGCACAGACCCAGAGCAAATC
TCCTCCGAAATGAAAACCCTGTCATATCTTCCTTTTCCTCAGTTAATTATGAAAGATGTAACAA
GAATAAGTTGACTCTTCAAGGAGGCGTCTTCTCTTCATATGGCTGAAAATGCAGTGATGCATTG
ACTCCGTTTCAAATCTGTGCGGTCTTAGTGCCTCTGTCTTCCTGAAGATTTCACAGTCCCTGTT
AGAGATATAGTCTAACGTAGAAAACTGGGGTGGGTTTTTGCTGAAGGTCAGGTTTTAACAACCA
AGAAGTCATGACTCTGGTTGCCTACCGAGGGAGAGTGAAAATGGGTTGCGTAAACACCCTACAA
CACCCTCTTTTCTCGGAAACCAGCGGATACATTGAAACAATGAAAGTGTCAGATAATGGAAATT
GCCAAGTAAGAGCATGTGCTGGTGCCCCAAGGAGACAGATACCATGACTGAAGCATCTCAGAAG
CAACCCTTCCCTTCTGGAGTTTCTGCTTCACAGTCCTCAGGATCTGATCAAGAAGGAGTTCTCC
TAGGAGCGCCTTGAACTTCAGTCCTCAAAAGTCCTGGGGGCAGAGGCTGAAAACTGCAACCAGA
GGGATGCCTCTGGGCAGAAACCTGTTTTCTTTGACTCGACAGTGTTTCACACATAGTTTTTTTT
TTGTTTTGTTTTATGTTCAGAGTTTCCAAAATTTAAAAATTAGGTAATTTCTACACTTTCTAGT
TTTCTTAAAAAAGTCGGAGGATCTGGGCCTGTAGAACCTGCTAAGAACTGGGACTGATCAGCTG
ATACACACGAGCATTTGCAACTTTGAAGAGGCGGGGTCGTATGAGTGCTGAGACTTTGGACTCT
CTAAAGAAGGGGTTGAACACTCATAATCAGAATGAACAACAGTATTTGTCTCTGTAGGCCCAGG
TTGGGTTGGTAATATTTAACAAAGCCTTTTGAGAAATGAGCNCCAGTTTTATCAGCTGCAGTGC
TAAGTCCAGGAATTAACTGTATAAGACATATAGGACACTCAAAATATCTGAAGACGATGTCAAT
CACTGAAAAATACAGACTGTAATCATATAAATACATGTTTTGCTGTTTATTAAATGCCTCTCAT
ATCATGGATGTTAAATAATTTTTTTGAATTAAAAGATCCCAGAATGCAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_021085840 ⟹ XP_020941499

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	107,840,224 - 107,918,307 (+)	NCBI

Sequence:

show sequence

CGGGGAATACGGCGCGATGCCTGTTCGCTGCCAGCAGAGCCCGGTGCTGGCGGGCAGCGCCACT
TTGGCTGCCCTGGGGGCACTGGCCCTGTACTTCGCGGAGCCCTCTGGCTACGGGAAGTACACGG
AGAGCCTGACGCCCGCGGCTATCCGCCTGCCAGCCCGTGCCGCCTGGTTCCTGCAGGAGCTGCC
CTCCTTCGTGGTGCCCGCGGGGATCCTCGCCGGGCAGCCCCGTTCTCTCTTCGGCCCGCCTGCG
ACTGTGCTTCTGGGCCTCTTCTGCGCACATTACTTCCACAGGACATTTGTTTACTCACTGCTCA
CTAGAGGGAGGCCTTTTCCAGTTGTATTCCTTTTCAGAGGCTTTGTCTTCTGCATGGGAAATGG
ACTCCTTCAAGGCTACTATCTGGTTTACTGTGCCGAATACCCTGCTGAGTGGTACACAGACATA
CGGTTTAGCCTAGGTGTGTTCTTATTTATTTTGGGCATGGGAATCAACATTCACAGCGACTATA
TATTGCGCCAGCTCAGGAAGCCTGGAGAAGTCATCTATAAGATTCCACAAGGTGGCTTGTTCAC
GTACGTTTCTGGAGCCAATTTCCTTGGTTCTACGTCAAGATGTTTGAGGACTACCCCAAGTCTC
GAAAAGCCCTTATTCCATTTATCTTTTAAAGAAACCAAATAAAAAAGGAACAAAGTCCCCACAA
TCTTGTTGAAGAACCATCAAGCTGCGGAACCTGTAACTTTTCAAGTCCCACTGTGTATGTGTAA
TAATCAGCCTCTGGTGTTCTGGCAGGTGGCCCGAGGATTCTGCACGGGACCCCTTAGTGTTTCT
TCGAACCCTCTCTGCGGGTCCCTATCCTGATTTCCTATTAAAACTTCCACAAGGTCTGCTTTTA
TGCAGAGGTATCTGTTTCTTAGCTCTTCCTCCTAGAAAGTGTAAACTTCCCTTTGTATTTTTTT
CTCTGAATGGCCCAAGTCCATGTGACTTTATATCTATGCTGTGTCAGTATAAGACAGCTCTGTA
TCTGAGAGTGTTTTGAGTTGAGGGCAGTGCTTACGGAATTTATTTAAGGTACACATTTAACACC
TATGCAGACCAGCAGAGATTTAAATTGTAAAGCTGCACAGACCCAGAGCAAATCTCCTCCGAAA
TGAAAGCCCTGTCATATCTTCCTTTTCCTCAGTTAATTATGAAAGATGTGACAAGAATAAGTTG
ACTCTTCAAGGAGGCGTCTTCTCTTCATATGGCTGAAAATGCAGTGATGCATTGACCCTGTTTC
AAATCTGTGCGGTCTTAGTGCCTCTGTCTTCCTGAAGATTTCACAGTCCCTGTTAGAGATATAG
TCTAATGTAGAAAACTGGGGTGGGTTTTTGCTGAAGGTCAGGTTTTAACAACCAAGAAGTCATG
ACTCTGGTTGCCTACAGAGAGAGAGTGAAAATGGGTTGTGTAAACACCCTACAACACCCTCTTT
TCTTGGAAACCAGCGATACATTGAAACAATGAAAGTGTCAGATAATGGAAATTGCCAAGTAAGA
GCATGTGCTGGTGCCCCAAGGAGACAGATACCATGACTGAAGCATCTCAGAAGCAACCCTTCCC
TTCTAGAGTTTCTGCTTCACAGTCCTCAGGATCTGATCAAGAAGGAGTTCTCCTAGGAGCGCCT
TGAACTTCAGTCCTCAAAAGTCCTGGGGGCAGAGGCTGAAAACTGCAACCAGAGGGATGCCTCT
GGGCAGAAACCTGTTTTCTTTGACTCAACAGTGTTTCACACATAGTTTTTTTTTTGTTTTGTTT
TATGTTCAGAGTTTCCAAAATTTAAAAATTAGGTAATTTCTACACTTTCTAGTTTTCTTAAAAA
AGTCGAAGGATCTGGGCCTGTAGAACCTGCTAAGAACTGGGACTGATCAGCTGATACACACGAG
CATTTGCAACTTTGAAGAGGCGGGGTCGTATGAGTGCTGAGACTTTGGACTCTCTAAAGAAGGG
GTTGAACACTCATAATCAGAATGAACAACAGTATTTGTCTCTGTAGGCCCAGGTTGGGTTGGTA
ATATTTAACAAAGCCCTTTGAGAAATGAGCACCAGTTTTATCAGCTGCAGTGCTAAGTCCAGGA
ATTAACTGTATAAGACACATAGGACACTCAAAATATCTGAAGACGATGTCAATCACTGAAAAAT
ACAGACTGTAATCATATAAATACATGTTTTGCTGTTTATTAAATGCCTCTCATATCA

hide sequence

RefSeq Acc Id:

XM_021085841 ⟹ XP_020941500

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	107,840,224 - 107,918,307 (+)	NCBI

Sequence:

show sequence

CGGGGAATACGGCGCGATGCCTGTTCGCTGCCAGCAGAGCCCGGTGCTGGCGGGCAGCGCCACT
TTGGCTGCCCTGGGGGCACTGGCCCTGTACTTCGCGGAGCCCTCTGGCTACGGGAAGTACACGG
AGAGCCTGACGCCCGCGGCTATCCGCCTGCCAGCCCGTGCCGCCTGGTTCCTGCAGGAGCTGCC
CTCCTTCGTGGTGCCCGCGGGGATCCTCGCCGGGCAGCCCCGTTCTCTCTTCGGCCCGCCTGCG
ACTGTGCTTCTGGGCCTCTTCTGCGCACATTACTTCCACAGGACATTTGTTTACTCACTGCTCA
CTAGAGGGAGGCCTTTTCCAGTTGTATTCCTTTTCAGAGGCTTTGTCTTCTGCATGGGAAATGG
ACTCCTTCAAGGCTACTATCTGGTTTACTGTGCCGAATACCCTGCTGAGTGGTACACAGACATA
CGGTTTAGCCTAGGTGTGTTCTTATTTATTTTGGGCATGGGAATCAACATTCACAGCGACTATA
TATTGCGCCAGCTCAGGAAGCCTGGAGAAGTCATCTATAAGATTCCACAAGGTTCTACGTCAAG
ATGTTTGAGGACTACCCCAAGTCTCGAAAAGCCCTTATTCCATTTATCTTTTAAAGAAACCAAA
TAAAAAAGGAACAAAGTCCCCACAATCTTGTTGAAGAACCATCAAGCTGCGGAACCTGTAACTT
TTCAAGTCCCACTGTGTATGTGTAATAATCAGCCTCTGGTGTTCTGGCAGGTGGCCCGAGGATT
CTGCACGGGACCCCTTAGTGTTTCTTCGAACCCTCTCTGCGGGTCCCTATCCTGATTTCCTATT
AAAACTTCCACAAGGTCTGCTTTTATGCAGAGGTATCTGTTTCTTAGCTCTTCCTCCTAGAAAG
TGTAAACTTCCCTTTGTATTTTTTTCTCTGAATGGCCCAAGTCCATGTGACTTTATATCTATGC
TGTGTCAGTATAAGACAGCTCTGTATCTGAGAGTGTTTTGAGTTGAGGGCAGTGCTTACGGAAT
TTATTTAAGGTACACATTTAACACCTATGCAGACCAGCAGAGATTTAAATTGTAAAGCTGCACA
GACCCAGAGCAAATCTCCTCCGAAATGAAAGCCCTGTCATATCTTCCTTTTCCTCAGTTAATTA
TGAAAGATGTGACAAGAATAAGTTGACTCTTCAAGGAGGCGTCTTCTCTTCATATGGCTGAAAA
TGCAGTGATGCATTGACCCTGTTTCAAATCTGTGCGGTCTTAGTGCCTCTGTCTTCCTGAAGAT
TTCACAGTCCCTGTTAGAGATATAGTCTAATGTAGAAAACTGGGGTGGGTTTTTGCTGAAGGTC
AGGTTTTAACAACCAAGAAGTCATGACTCTGGTTGCCTACAGAGAGAGAGTGAAAATGGGTTGT
GTAAACACCCTACAACACCCTCTTTTCTTGGAAACCAGCGATACATTGAAACAATGAAAGTGTC
AGATAATGGAAATTGCCAAGTAAGAGCATGTGCTGGTGCCCCAAGGAGACAGATACCATGACTG
AAGCATCTCAGAAGCAACCCTTCCCTTCTAGAGTTTCTGCTTCACAGTCCTCAGGATCTGATCA
AGAAGGAGTTCTCCTAGGAGCGCCTTGAACTTCAGTCCTCAAAAGTCCTGGGGGCAGAGGCTGA
AAACTGCAACCAGAGGGATGCCTCTGGGCAGAAACCTGTTTTCTTTGACTCAACAGTGTTTCAC
ACATAGTTTTTTTTTTGTTTTGTTTTATGTTCAGAGTTTCCAAAATTTAAAAATTAGGTAATTT
CTACACTTTCTAGTTTTCTTAAAAAAGTCGAAGGATCTGGGCCTGTAGAACCTGCTAAGAACTG
GGACTGATCAGCTGATACACACGAGCATTTGCAACTTTGAAGAGGCGGGGTCGTATGAGTGCTG
AGACTTTGGACTCTCTAAAGAAGGGGTTGAACACTCATAATCAGAATGAACAACAGTATTTGTC
TCTGTAGGCCCAGGTTGGGTTGGTAATATTTAACAAAGCCCTTTGAGAAATGAGCACCAGTTTT
ATCAGCTGCAGTGCTAAGTCCAGGAATTAACTGTATAAGACACATAGGACACTCAAAATATCTG
AAGACGATGTCAATCACTGAAAAATACAGACTGTAATCATATAAATACATGTTTTGCTGTTTAT
TAAATGCCTCTCATATCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_999153	(Get FASTA)	NCBI Sequence Viewer
	XP_020941499	(Get FASTA)	NCBI Sequence Viewer
	XP_020941500	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB69279	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000009087
	ENSSSCP00000009087.4
	ENSSSCP00000009087.5
	ENSSSCP00025024703.1
	ENSSSCP00030021001.1
	ENSSSCP00035026067.1
	ENSSSCP00040027543.1
	ENSSSCP00045010660.1
	ENSSSCP00055029157.1
	ENSSSCP00060014019.1
	ENSSSCP00065007271.1
	ENSSSCP00070012924.1
GenBank Protein	O18765	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_999153 ⟸ NM_213988

- UniProtKB:

O18765 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPVRCQQSPVLAGSATLAALGALALYFAEPSGYGKYTESLTPAAIRLPARAAWFLQELPSFVVP
AGILAGQPRSLFGPPATVLLGLFCAHYFHRTFVYSLLTRGRPFPVVFLFRGFVFCMGNGLLQGY
YLVYCAEYPAEWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEVIYKIPQGGLFTYVSGA
NFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYVKMFEDYPKSRKALIPFIF

hide sequence

RefSeq Acc Id:

XP_020941499 ⟸ XM_021085840

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPVRCQQSPVLAGSATLAALGALALYFAEPSGYGKYTESLTPAAIRLPARAAWFLQELPSFVVP
AGILAGQPRSLFGPPATVLLGLFCAHYFHRTFVYSLLTRGRPFPVVFLFRGFVFCMGNGLLQGY
YLVYCAEYPAEWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEVIYKIPQGGLFTYVSGA
NFLGSTSRCLRTTPSLEKPLFHLSFKETK

hide sequence

RefSeq Acc Id:

XP_020941500 ⟸ XM_021085841

- Peptide Label:

isoform X2

- Sequence:

show sequence

MPVRCQQSPVLAGSATLAALGALALYFAEPSGYGKYTESLTPAAIRLPARAAWFLQELPSFVVP
AGILAGQPRSLFGPPATVLLGLFCAHYFHRTFVYSLLTRGRPFPVVFLFRGFVFCMGNGLLQGY
YLVYCAEYPAEWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEVIYKIPQGSTSRCLRTT
PSLEKPLFHLSFKETK

hide sequence

RefSeq Acc Id:

ENSSSCP00000009087 ⟸ ENSSSCT00000009325

Protein Domains

Steroid 5-alpha reductase C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000008521	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSSSCG00025043068	UniProtKB/TrEMBL
	ENSSSCG00030033689	UniProtKB/Swiss-Prot
	ENSSSCG00035048311	UniProtKB/TrEMBL
	ENSSSCG00040048320	UniProtKB/Swiss-Prot
	ENSSSCG00045009063	UniProtKB/Swiss-Prot
	ENSSSCG00055018745	UniProtKB/Swiss-Prot
	ENSSSCG00060024102	UniProtKB/Swiss-Prot
	ENSSSCG00065013419	UniProtKB/TrEMBL
	ENSSSCG00070008083	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000009325	ENTREZGENE
	ENSSSCT00000009325.4	UniProtKB/TrEMBL
	ENSSSCT00000009325.5	UniProtKB/Swiss-Prot
	ENSSSCT00025058365.1	UniProtKB/TrEMBL
	ENSSSCT00030046625.1	UniProtKB/Swiss-Prot
	ENSSSCT00035064367.1	UniProtKB/TrEMBL
	ENSSSCT00040065105.1	UniProtKB/Swiss-Prot
	ENSSSCT00045015342.1	UniProtKB/Swiss-Prot
	ENSSSCT00055036688.1	UniProtKB/Swiss-Prot
	ENSSSCT00060032689.1	UniProtKB/Swiss-Prot
	ENSSSCT00065017843.1	UniProtKB/TrEMBL
	ENSSSCT00070015619.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.120.1630	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	3-oxo-5-alpha-steroid_4-DH	UniProtKB/Swiss-Prot
	3-oxo-5_a-steroid_4-DH_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SRD5A/TECR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	ssc:397048	UniProtKB/Swiss-Prot
NCBI Gene	SRD5A2	ENTREZGENE
PANTHER	3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10556	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Steroid_dh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PIRSF	5_alpha-SR2	UniProtKB/Swiss-Prot
PROSITE	S5A_REDUCTASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A4X1TCJ1_PIG	UniProtKB/TrEMBL
	A0A5S8KL28_PIG	UniProtKB/TrEMBL
	A0A8D1A916_PIG	UniProtKB/TrEMBL
	A0A8D2BZJ0_PIG	UniProtKB/TrEMBL
	O18765	ENTREZGENE, UniProtKB/Swiss-Prot
VGNC ID	VGNC:93449	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations