HTR1A (5-hydroxytryptamine receptor 1A) - Rat Genome Database

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Gene: HTR1A (5-hydroxytryptamine receptor 1A) Sus scrofa
Analyze
Symbol: HTR1A
Name: 5-hydroxytryptamine receptor 1A
RGD ID: 14169346
Description: ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); G-protein alpha-subunit binding (ortholog); serotonin binding (ortholog); INVOLVED IN adenylate cyclase-inhibiting serotonin receptor signaling pathway (ortholog); G protein-coupled serotonin receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); Alzheimer's disease (ortholog); FOUND IN axon hillock (ortholog); GABA-ergic synapse (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1642,478,923 - 42,484,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11642,479,812 - 42,484,365 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21645,547,917 - 45,550,733 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:18653286   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HTR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1642,478,923 - 42,484,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11642,479,812 - 42,484,365 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21645,547,917 - 45,550,733 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HTR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38563,957,874 - 63,962,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl563,957,874 - 63,962,507 (-)EnsemblGRCh38hg38GRCh38
GRCh37563,253,701 - 63,258,272 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36563,292,034 - 63,293,302 (-)NCBINCBI36Build 36hg18NCBI36
Build 34563,292,033 - 63,293,302NCBI
Celera560,253,209 - 60,254,477 (-)NCBICelera
Cytogenetic Map5q12.3NCBI
HuRef560,210,553 - 60,212,797 (-)NCBIHuRef
CHM1_1563,255,560 - 63,257,804 (-)NCBICHM1_1
T2T-CHM13v2.0564,778,009 - 64,782,580 (-)NCBIT2T-CHM13v2.0
Htr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913105,580,040 - 105,584,630 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13105,580,147 - 105,584,630 (+)EnsemblGRCm39 Ensembl
GRCm3813105,443,693 - 105,448,133 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13105,443,639 - 105,448,122 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713106,233,773 - 106,238,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613106,564,148 - 106,568,501 (+)NCBIMGSCv36mm8
Celera13109,835,550 - 109,839,989 (+)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1356.92NCBI
Htr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8238,427,169 - 38,431,733 (+)NCBIGRCr8
mRatBN7.2236,693,462 - 36,698,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl236,694,174 - 36,695,442 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx243,823,087 - 43,824,355 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0241,881,727 - 41,882,995 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0236,737,009 - 36,738,277 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0236,246,628 - 36,247,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl236,246,628 - 36,247,896 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0255,362,662 - 55,363,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4236,434,518 - 36,435,786 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1236,354,886 - 36,356,155 (+)NCBI
Celera232,636,756 - 32,638,024 (+)NCBICelera
RH 3.4 Map2156.5RGD
Cytogenetic Map2q13NCBI
Htr1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554464,913,884 - 4,915,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554464,913,181 - 4,917,726 (+)NCBIChiLan1.0ChiLan1.0
HTR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2449,960,948 - 49,964,784 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1548,114,114 - 48,118,414 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0550,045,266 - 50,049,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1551,691,853 - 51,696,257 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl551,692,416 - 51,693,684 (+)Ensemblpanpan1.1panPan2
HTR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1250,005,277 - 50,006,548 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl250,002,740 - 50,006,548 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha246,962,303 - 46,963,574 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0250,490,014 - 50,491,285 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1247,550,689 - 47,551,960 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0248,341,999 - 48,343,270 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0249,236,031 - 49,237,302 (-)NCBIUU_Cfam_GSD_1.0
Htr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213196,105,986 - 196,110,702 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364805,043,204 - 5,044,472 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364805,042,531 - 5,047,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1460,159,542 - 60,162,947 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl460,159,944 - 60,161,212 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660498,232,890 - 8,758,394 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248155,816,601 - 5,820,864 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248155,817,196 - 5,821,197 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HTR1A
80 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000092660   ⟹   ENSSSCP00000076519
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1642,478,923 - 42,484,304 (-)Ensembl
RefSeq Acc Id: XM_005672476   ⟹   XP_005672533
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11642,479,812 - 42,484,365 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005672533   ⟸   XM_005672476
- UniProtKB: A0A4X1UTF5 (UniProtKB/TrEMBL),   A0A8W4FB22 (UniProtKB/TrEMBL),   A0A8D0P2F3 (UniProtKB/TrEMBL),   A0A8D1EDW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000076519   ⟸   ENSSSCT00000092660
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000054440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005006977 UniProtKB/TrEMBL
  ENSSSCG00015051213 UniProtKB/TrEMBL
  ENSSSCG00025056105 UniProtKB/TrEMBL
  ENSSSCG00030042611 UniProtKB/TrEMBL
  ENSSSCG00035058719 UniProtKB/TrEMBL
  ENSSSCG00040035324 UniProtKB/TrEMBL
  ENSSSCG00045037890 UniProtKB/TrEMBL
  ENSSSCG00050000332 UniProtKB/TrEMBL
  ENSSSCG00055021045 UniProtKB/TrEMBL
  ENSSSCG00060066719 UniProtKB/TrEMBL
  ENSSSCG00065042322 UniProtKB/TrEMBL
  ENSSSCG00070019300 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000092660 ENTREZGENE
  ENSSSCT00000092660.1 UniProtKB/TrEMBL
  ENSSSCT00005010476.1 UniProtKB/TrEMBL
  ENSSSCT00015068134.1 UniProtKB/TrEMBL
  ENSSSCT00025076717.1 UniProtKB/TrEMBL
  ENSSSCT00030059336.1 UniProtKB/TrEMBL
  ENSSSCT00035078593.1 UniProtKB/TrEMBL
  ENSSSCT00040047429.1 UniProtKB/TrEMBL
  ENSSSCT00045065502.1 UniProtKB/TrEMBL
  ENSSSCT00050000347.1 UniProtKB/TrEMBL
  ENSSSCT00055041289.1 UniProtKB/TrEMBL
  ENSSSCT00060091051.1 UniProtKB/TrEMBL
  ENSSSCT00065057856.1 UniProtKB/TrEMBL
  ENSSSCT00070038151.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 5HT1A_rcpt UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:100526081 UniProtKB/TrEMBL
NCBI Gene HTR1A ENTREZGENE
PANTHER ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/TrEMBL
  G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS 5HT1ARECEPTR UniProtKB/TrEMBL
  5HTRECEPTOR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A4X1UTF5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0P2F3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1EDW8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8W4FB22 ENTREZGENE
UniProt Secondary A0A8W4FB22 UniProtKB/TrEMBL
VGNC ID VGNC:111809 ENTREZGENE