RGD Reference Report - Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals. - Rat Genome Database

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Localization of 5-HT1A and 5-HT2A positive cells in the brainstems of control age-matched and Alzheimer individuals.

Authors: Yeung, LY  Kung, HF  Yew, DT 
Citation: Yeung LY, etal., Age (Dordr). 2010 Dec;32(4):483-95. Epub 2010 May 28.
RGD ID: 5683632
Pubmed: PMID:20508993   (View Abstract at PubMed)
PMCID: PMC2980600   (View Article at PubMed Central)
DOI: DOI:10.1007/s11357-010-9152-x   (Journal Full-text)

Serotonin receptor 1A and 2A positive cells in postmortem brainstems were demonstrated via immunohistochemistry in eight control age-matched elderly individuals and eight Alzheimer patients. The 5-HT1A positive cells were found in substantia nigra, pontile nucleus, and vagal as well as dorsal raphe nucleus, while 5-HT2A receptor positive cells were found in motor, sensory and spinal trigeminal nuclei, pontile nucleus, substantia nigra, and nucleus solitarius. A comparison in density of positive cells per unit area was made between control age-matched and Alzheimer individuals. Statistically significant differences (p

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 5683632 RGD 
Alzheimer's disease  ISOHTR1A (Homo sapiens)5683632; 5683632 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Htr1a  (5-hydroxytryptamine receptor 1A)

Genes (Mus musculus)
Htr1a  (5-hydroxytryptamine (serotonin) receptor 1A)

Genes (Homo sapiens)
HTR1A  (5-hydroxytryptamine receptor 1A)


Additional Information