SFRP2 (secreted frizzled related protein 2) - Rat Genome Database

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Pathways
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Gene: SFRP2 (secreted frizzled related protein 2) Sus scrofa
Analyze
Symbol: SFRP2
Name: secreted frizzled related protein 2
RGD ID: 14121671
Description: ENCODES a protein that exhibits fibronectin binding (ortholog); integrin binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); apoptotic process (ortholog); BMP signaling pathway (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); inflammatory bowel disease (ortholog); FOUND IN collagen-containing extracellular matrix (ortholog); INTERACTS WITH ammonia
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: secreted frizzled-related protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,337,144 - 75,345,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,337,311 - 75,345,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,743,347 - 79,751,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ammonia  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
apoptotic process  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA)
canonical Wnt signaling pathway  (IBA,IEA,ISO)
cardiac left ventricle morphogenesis  (IEA)
cardiac muscle cell apoptotic process  (IEA,ISO)
cartilage development  (IEA,ISO)
cell differentiation  (IEA)
cell-cell signaling  (ISO)
cellular response to X-ray  (IEA)
chondrocyte development  (IEA,ISO)
collagen fibril organization  (IEA,ISO)
convergent extension involved in axis elongation  (IEA,ISO)
development of primary male sexual characteristics  (IEA,ISO)
digestive tract morphogenesis  (IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
hematopoietic stem cell proliferation  (IEA)
male gonad development  (IEA,ISO)
mesodermal cell fate specification  (IEA,ISO)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell apoptotic process  (IEA,ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of dermatome development  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial cell proliferation  (IEA)
negative regulation of epithelial to mesenchymal transition  (IEA)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
negative regulation of mesodermal cell fate specification  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA)
negative regulation of planar cell polarity pathway involved in axis elongation  (IEA,ISO)
negative regulation of Wnt signaling pathway  (IEA)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
non-canonical Wnt signaling pathway  (IBA,IEA)
obsolete cellular response to extracellular stimulus  (IEA)
outflow tract morphogenesis  (IEA)
planar cell polarity pathway involved in axis elongation  (IEA,ISO)
planar cell polarity pathway involved in neural tube closure  (IEA,ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell growth  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of osteoblast differentiation  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
post-anal tail morphogenesis  (IEA,ISO)
regulation of apoptotic process  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of establishment of planar polarity  (IEA,ISO)
regulation of midbrain dopaminergic neuron differentiation  (IEA)
regulation of neuron projection development  (IEA)
regulation of stem cell division  (IEA)
regulation of Wnt signaling pathway  (IEA)
response to nutrient  (ISO)
response to xenobiotic stimulus  (IEA)
sclerotome development  (IEA)
somitogenesis  (IEA,ISO)
stem cell fate specification  (IEA,ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in somitogenesis  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:30032202  


Genomics

Comparative Map Data
SFRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl875,337,144 - 75,345,921 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1875,337,311 - 75,345,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2879,743,347 - 79,751,962 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SFRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384153,780,591 - 153,789,083 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4153,780,591 - 153,789,083 (-)EnsemblGRCh38hg38GRCh38
GRCh374154,701,743 - 154,710,235 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364154,921,192 - 154,929,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 344155,059,346 - 155,067,833NCBI
Celera4152,026,238 - 152,034,728 (-)NCBICelera
Cytogenetic Map4q31.3NCBI
HuRef4150,432,908 - 150,441,398 (-)NCBIHuRef
CHM1_14154,680,045 - 154,688,529 (-)NCBICHM1_1
T2T-CHM13v2.04157,105,099 - 157,113,596 (-)NCBIT2T-CHM13v2.0
Sfrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39383,673,628 - 83,681,621 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl383,673,628 - 83,681,623 (+)EnsemblGRCm39 Ensembl
GRCm38383,765,750 - 83,774,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl383,766,321 - 83,774,316 (+)EnsemblGRCm38mm10GRCm38
MGSCv37383,570,243 - 83,578,236 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36383,852,248 - 83,860,242 (+)NCBIMGSCv36mm8
Celera383,778,926 - 83,786,923 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map337.37NCBI
Sfrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82171,387,536 - 171,395,081 (+)NCBIGRCr8
mRatBN7.22169,089,517 - 169,097,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2169,089,517 - 169,097,063 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2176,277,331 - 176,284,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02174,297,265 - 174,304,827 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02168,898,730 - 168,906,293 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02182,723,732 - 182,731,277 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2182,723,854 - 182,731,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02202,136,233 - 202,143,778 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42175,479,320 - 175,486,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12175,435,856 - 175,436,574 (+)NCBI
Celera2163,105,875 - 163,113,424 (+)NCBICelera
Cytogenetic Map2q34NCBI
Sfrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554718,103,783 - 8,112,321 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554718,103,937 - 8,112,596 (-)NCBIChiLan1.0ChiLan1.0
SFRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23151,668,957 - 151,682,045 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14152,024,677 - 152,032,604 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04146,123,075 - 146,131,543 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14157,944,733 - 157,953,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4157,944,733 - 157,953,258 (-)Ensemblpanpan1.1panPan2
SFRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11551,541,197 - 51,548,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1551,540,500 - 51,548,765 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1551,886,301 - 51,894,431 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01552,226,638 - 52,234,922 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1552,226,643 - 52,235,106 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11551,482,317 - 51,490,435 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01551,588,474 - 51,596,595 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01551,900,564 - 51,908,708 (-)NCBIUU_Cfam_GSD_1.0
Sfrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530138,934,030 - 38,942,739 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936576604,069 - 613,021 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936576604,174 - 612,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17100,336,442 - 100,345,093 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7100,336,119 - 100,345,086 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603779,988,717 - 79,997,279 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248585,052,518 - 5,061,591 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248585,052,736 - 5,061,495 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SFRP2
236 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system
High
Medium 2 1 1
Low 6 2 3 2 1 22 2
Below cutoff 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009861   ⟹   ENSSSCP00000009608
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl875,337,144 - 75,345,921 (+)Ensembl
RefSeq Acc Id: NM_001244395   ⟹   NP_001231324
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1875,337,311 - 75,345,926 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001231324   ⟸   NM_001244395
- Peptide Label: precursor
- UniProtKB: F1RX31 (UniProtKB/TrEMBL),   A0A4X1STF2 (UniProtKB/TrEMBL),   A0A8D0VP35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009608   ⟸   ENSSSCT00000009861
Protein Domains
FZ   NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015075500 UniProtKB/TrEMBL
  ENSSSCG00025046870 UniProtKB/TrEMBL
  ENSSSCG00030014139 UniProtKB/TrEMBL
  ENSSSCG00035019106 UniProtKB/TrEMBL
  ENSSSCG00040074894 UniProtKB/TrEMBL
  ENSSSCG00045004812 UniProtKB/TrEMBL
  ENSSSCG00050005732 UniProtKB/TrEMBL
  ENSSSCG00055011016 UniProtKB/TrEMBL
  ENSSSCG00060039562 UniProtKB/TrEMBL
  ENSSSCG00065060325 UniProtKB/TrEMBL
  ENSSSCG00070003597 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000009861 ENTREZGENE
  ENSSSCT00000009861.5 UniProtKB/TrEMBL
  ENSSSCT00015101743.1 UniProtKB/TrEMBL
  ENSSSCT00025063734.1 UniProtKB/TrEMBL
  ENSSSCT00030019427.1 UniProtKB/TrEMBL
  ENSSSCT00035024714.1 UniProtKB/TrEMBL
  ENSSSCT00040103691.1 UniProtKB/TrEMBL
  ENSSSCT00045007935.1 UniProtKB/TrEMBL
  ENSSSCT00050007763.1 UniProtKB/TrEMBL
  ENSSSCT00055021614.1 UniProtKB/TrEMBL
  ENSSSCT00060053538.1 UniProtKB/TrEMBL
  ENSSSCT00065082632.1 UniProtKB/TrEMBL
  ENSSSCT00070006733.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  SFRP2_CRD UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
KEGG Report ssc:100516027 UniProtKB/TrEMBL
NCBI Gene SFRP2 ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  SECRETED FRIZZLED-RELATED PROTEIN 1 UniProtKB/TrEMBL
Pfam NTR UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PROSITE NTR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART C345C UniProtKB/TrEMBL
  FRI UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/TrEMBL
  SSF63501 UniProtKB/TrEMBL
UniProt A0A4X1STF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0VP35 ENTREZGENE, UniProtKB/TrEMBL
  F1RX31 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:92775 ENTREZGENE