TNNC2 (troponin C2, fast skeletal type) - Rat Genome Database

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Gene: TNNC2 (troponin C2, fast skeletal type) Sus scrofa
Analyze
Symbol: TNNC2
Name: troponin C2, fast skeletal type
RGD ID: 14101058
Description: ENCODES a protein that exhibits actin binding (ortholog); INVOLVED IN regulation of muscle contraction (inferred); skeletal muscle contraction (inferred); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH congenital myopathy 15 (ortholog); focal epilepsy (ortholog); T-Cell Immunodeficiency, Recurrent Infections, and Autoimmunity with or without Cardiac Malformations (ortholog); FOUND IN myosin II complex (inferred); troponin complex (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fast skeletal muscle troponin C; troponin C, skeletal muscle
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,024,687 - 48,028,651 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,025,621 - 48,026,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,671,689 - 53,672,831 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:6825863   PMID:14681463   PMID:16870582   PMID:17145712   PMID:19200139   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNNC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1748,024,687 - 48,028,651 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11748,025,621 - 48,026,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21753,671,689 - 53,672,831 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNNC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382045,823,214 - 45,833,306 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2045,823,214 - 45,833,745 (-)EnsemblGRCh38hg38GRCh38
GRCh372044,451,853 - 44,455,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,885,260 - 43,889,360 (-)NCBINCBI36Build 36hg18NCBI36
Build 342043,885,263 - 43,889,360NCBI
Celera2041,162,347 - 41,166,448 (-)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2041,193,614 - 41,197,713 (-)NCBIHuRef
CHM1_12044,354,991 - 44,359,091 (-)NCBICHM1_1
T2T-CHM13v2.02047,559,705 - 47,569,768 (-)NCBIT2T-CHM13v2.0
Tnnc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392164,619,081 - 164,621,654 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2164,619,081 - 164,621,887 (-)EnsemblGRCm39 Ensembl
GRCm382164,777,161 - 164,779,734 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2164,777,161 - 164,779,967 (-)EnsemblGRCm38mm10GRCm38
MGSCv372164,602,661 - 164,605,234 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362164,468,366 - 164,470,939 (-)NCBIMGSCv36mm8
Celera2170,714,468 - 170,717,041 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map285.27NCBI
Tnnc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,932,611 - 173,935,339 (-)NCBIGRCr8
mRatBN7.23153,513,272 - 153,516,033 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3153,513,271 - 153,516,029 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3157,321,952 - 157,324,670 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,820,922 - 165,823,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,564,699 - 163,567,417 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03161,243,607 - 161,246,335 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3161,243,587 - 161,246,351 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03167,429,345 - 167,430,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43155,807,133 - 155,808,219 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13155,713,032 - 155,715,733 (-)NCBI
Celera3152,121,028 - 152,123,756 (-)NCBICelera
Cytogenetic Map3q42NCBI
Tnnc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544511,466,579 - 11,469,123 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544511,466,579 - 11,469,123 (+)NCBIChiLan1.0ChiLan1.0
TNNC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22151,565,060 - 51,575,559 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12051,558,160 - 51,568,463 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02042,162,502 - 42,172,829 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12043,249,725 - 43,260,984 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2043,249,725 - 43,254,134 (-)Ensemblpanpan1.1panPan2
TNNC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12433,136,644 - 33,139,289 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2433,128,290 - 33,163,050 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2432,663,877 - 32,666,541 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02433,847,135 - 33,849,798 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2433,847,144 - 33,849,791 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12433,105,691 - 33,108,351 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02433,220,760 - 33,223,430 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02433,759,900 - 33,762,559 (-)NCBIUU_Cfam_GSD_1.0
Tnnc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640191,742,934 - 191,745,960 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365147,196,536 - 7,199,649 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365147,196,576 - 7,199,603 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNNC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,051,708 - 18,063,108 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,061,492 - 18,062,971 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605066,691,630 - 66,703,067 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TNNC2
38 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system musculoskeletal system nervous system reproductive system respiratory system
High 2
Medium
Low 4 2 1 1
Below cutoff 6 2 3 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000043925   ⟹   ENSSSCP00000038621
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1748,024,687 - 48,026,660 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000055704   ⟹   ENSSSCP00000050173
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1748,025,081 - 48,026,981 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000104921   ⟹   ENSSSCP00000077227
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1748,024,687 - 48,028,651 (-)Ensembl
RefSeq Acc Id: NM_001001862   ⟹   NP_001001862
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11748,025,621 - 48,026,762 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001001862   ⟸   NM_001001862
- UniProtKB: P02587 (UniProtKB/Swiss-Prot),   Q6PVW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000050173   ⟸   ENSSSCT00000055704
RefSeq Acc Id: ENSSSCP00000038621   ⟸   ENSSSCT00000043925
RefSeq Acc Id: ENSSSCP00000077227   ⟸   ENSSSCT00000104921
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007424 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005020081 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000043925.3 UniProtKB/TrEMBL
  ENSSSCT00000055704.3 UniProtKB/TrEMBL
  ENSSSCT00000104921 ENTREZGENE
  ENSSSCT00000104921.1 UniProtKB/TrEMBL
  ENSSSCT00005031756.1 UniProtKB/TrEMBL
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:414905 UniProtKB/TrEMBL
NCBI Gene TNNC2 ENTREZGENE
PANTHER MYOSIN LIGHT CHAIN 1, 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TROPONIN C2, FAST SKELETAL TYPE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287A4C5_PIG UniProtKB/TrEMBL
  A0A287B1R0_PIG UniProtKB/TrEMBL
  A1XQV5_PIG UniProtKB/TrEMBL
  P02587 ENTREZGENE
  Q6PVW3 ENTREZGENE, UniProtKB/TrEMBL
  TNNC2_PIG UniProtKB/Swiss-Prot
UniProt Secondary A0A8D1V2N6 UniProtKB/TrEMBL
  A7L644 UniProtKB/TrEMBL
VGNC ID VGNC:95547 ENTREZGENE