FTH1 (ferritin heavy chain 1) - Rat Genome Database

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Pathways
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Gene: FTH1 (ferritin heavy chain 1) Sus scrofa
Analyze
Symbol: FTH1
Name: ferritin heavy chain 1
RGD ID: 14092745
Description: ENCODES a protein that exhibits identical protein binding (ortholog); iron ion binding (ortholog); iron ion sequestering activity (ortholog); INVOLVED IN iron ion transport (ortholog); negative regulation of cellular process (ortholog); negative regulation of ferroptosis (ortholog); PARTICIPATES IN iron storage pathway; ASSOCIATED WITH autosomal dominant vitreoretinochoroidopathy (ortholog); bestrophinopathy (ortholog); Chronic Cerebral Hypoperfusion (ortholog); FOUND IN autolysosome (ortholog); cytosol (ortholog); membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ferritin H subunit; ferritin heavy chain
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.129,535,051 - 9,537,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,983,179 - 8,986,091 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
autolysosome  (ISO)
cytoplasm  (IBA,IEA)
cytosol  (ISO)
membrane  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:3688879   PMID:14681463   PMID:15679890   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FTH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.129,535,051 - 9,537,979 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,983,179 - 8,986,091 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FTH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,964,285 - 61,967,634 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,959,718 - 61,967,634 (-)EnsemblGRCh38hg38GRCh38
GRCh371161,731,757 - 61,735,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,488,333 - 61,491,708 (-)NCBINCBI36Build 36hg18NCBI36
Build 341161,488,334 - 61,491,708NCBI
Celera1159,067,058 - 59,070,433 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,059,745 - 58,063,103 (-)NCBIHuRef
CHM1_11161,614,953 - 61,618,328 (-)NCBICHM1_1
T2T-CHM13v2.01161,953,110 - 61,956,459 (-)NCBIT2T-CHM13v2.0
Fth1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39199,957,964 - 9,962,475 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl199,957,962 - 9,962,462 (+)EnsemblGRCm39 Ensembl
GRCm38199,980,600 - 9,985,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl199,980,598 - 9,985,098 (+)EnsemblGRCm38mm10GRCm38
MGSCv371910,057,193 - 10,059,582 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361910,049,748 - 10,052,137 (+)NCBIMGSCv36mm8
Celera1910,680,030 - 10,682,419 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.23NCBI
Fth1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,052,037 - 216,054,325 (+)NCBIGRCr8
mRatBN7.21206,627,142 - 206,629,430 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,627,103 - 206,725,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,005,534 - 215,007,822 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,060,660 - 222,062,948 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,755,668 - 214,757,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01226,030,940 - 226,033,228 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1226,030,938 - 226,033,228 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,979,122 - 232,981,410 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41212,430,453 - 212,432,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11212,588,882 - 212,591,171 (+)NCBI
Celera1204,122,676 - 204,124,964 (+)NCBICelera
RH 3.4 Map14258.8RGD
Cytogenetic Map1q43NCBI
Fth1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555115,771,777 - 5,773,112 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555115,772,374 - 5,773,224 (+)NCBIChiLan1.0ChiLan1.0
FTH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,197,979 - 63,203,292 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,241,728 - 64,244,902 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,329,163 - 57,332,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11160,687,517 - 60,690,080 (-)NCBIpanpan1.1PanPan1.1panPan2
FTH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,466,167 - 54,468,733 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,466,023 - 54,468,732 (+)EnsemblCanFam3.1canFam3CanFam3.1
UMICH_Zoey_3.12832,593,900 - 32,594,536 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02832,618,740 - 32,619,377 (-)NCBIUNSW_CanFamBas_1.0
Fth1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494711,005,083 - 11,006,769 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365811,118,905 - 1,120,592 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,837,533 - 11,840,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038109,211,114 - 109,214,623 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fth1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624926469,870 - 471,142 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FTH1
116 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High 3 1 2 1 1 2
Medium 7 4 3 4 2 21 1 2 1
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_213975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005660803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK232377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK235373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK344744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK352179 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK393048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK394517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY610310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D15071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FP312689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01038768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: NM_213975   ⟹   NP_999140
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.129,535,170 - 9,537,978 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005660803   ⟹   XP_005660860
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.129,535,051 - 9,537,979 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005660860   ⟸   XM_005660803
- Peptide Label: isoform X1
- UniProtKB: A0A287AL10 (UniProtKB/TrEMBL),   A0A4X1VGP9 (UniProtKB/TrEMBL),   A0A8D1KMQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_999140   ⟸   NM_213975
- UniProtKB: P19131 (UniProtKB/Swiss-Prot),   P19130 (UniProtKB/Swiss-Prot),   A0A8D1KMQ5 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Ferritin-like diiron


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000014540 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025064111 UniProtKB/TrEMBL
  ENSSSCG00030004566 UniProtKB/TrEMBL
  ENSSSCG00040074761 UniProtKB/TrEMBL
  ENSSSCG00045031531 UniProtKB/TrEMBL
  ENSSSCG00050036313 UniProtKB/TrEMBL
  ENSSSCG00055005678 UniProtKB/TrEMBL
  ENSSSCG00060002730 UniProtKB/TrEMBL
  ENSSSCG00065063918 UniProtKB/TrEMBL
  ENSSSCG00070025183 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000050390 ENTREZGENE
  ENSSSCT00000050390.3 UniProtKB/TrEMBL
  ENSSSCT00025087933.1 UniProtKB/TrEMBL
  ENSSSCT00030006119.1 UniProtKB/TrEMBL
  ENSSSCT00040103446.1 UniProtKB/TrEMBL
  ENSSSCT00040103469.1 UniProtKB/TrEMBL
  ENSSSCT00045053906.1 UniProtKB/TrEMBL
  ENSSSCT00050048857.1 UniProtKB/TrEMBL
  ENSSSCT00055011178.1 UniProtKB/TrEMBL
  ENSSSCT00055011201.1 UniProtKB/TrEMBL
  ENSSSCT00060003376.1 UniProtKB/TrEMBL
  ENSSSCT00060003381.1 UniProtKB/TrEMBL
  ENSSSCT00065087768.1 UniProtKB/TrEMBL
  ENSSSCT00065087778.1 UniProtKB/TrEMBL
  ENSSSCT00070050353.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1260.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ferritin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin-like_diiron UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin-like_SF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ferritin_DPS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397030 UniProtKB/Swiss-Prot
NCBI Gene FTH1 ENTREZGENE
PANTHER FERRITIN HEAVY CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11431 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ferritin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FERRITIN_1 UniProtKB/TrEMBL
  FERRITIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FERRITIN_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AL10 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VGP9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KMQ5 ENTREZGENE, UniProtKB/TrEMBL
  FRIH_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  P19131 ENTREZGENE
UniProt Secondary P19131 UniProtKB/Swiss-Prot