PTPN7 (protein tyrosine phosphatase non-receptor type 7) - Rat Genome Database

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Gene: PTPN7 (protein tyrosine phosphatase non-receptor type 7) Sus scrofa
Analyze
Symbol: PTPN7
Name: protein tyrosine phosphatase non-receptor type 7
RGD ID: 14077260
Description: ENCODES a protein that exhibits protein kinase binding (inferred); protein tyrosine phosphatase activity (inferred); INVOLVED IN signal transduction (inferred); ASSOCIATED WITH familial adult myoclonic epilepsy 5 (ortholog); gastrointestinal stromal tumor (ortholog); Hypokalemic Periodic Paralysis, Type 1 (ortholog); FOUND IN cell junction (inferred); cytoplasm (inferred); cytoplasmic side of plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: splicing factor, proline- and glutamine-rich; tyrosine-protein phosphatase non-receptor type 7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,325,293 - 24,336,419 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,325,289 - 24,336,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,744,132 - 28,748,147 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPN7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1024,325,293 - 24,336,419 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11024,325,289 - 24,336,426 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21028,744,132 - 28,748,147 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381202,147,013 - 202,161,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1202,147,013 - 202,161,588 (-)EnsemblGRCh38hg38GRCh38
GRCh371202,116,141 - 202,130,716 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,382,766 - 200,396,374 (-)NCBINCBI36Build 36hg18NCBI36
Celera1175,240,001 - 175,253,609 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1173,281,692 - 173,296,269 (-)NCBIHuRef
CHM1_11203,538,425 - 203,553,000 (-)NCBICHM1_1
T2T-CHM13v2.01201,404,580 - 201,419,169 (-)NCBIT2T-CHM13v2.0
Ptpn7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,059,577 - 135,073,064 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,060,438 - 135,073,055 (+)EnsemblGRCm39 Ensembl
GRCm381135,131,838 - 135,145,328 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,132,700 - 135,145,317 (+)EnsemblGRCm38mm10GRCm38
MGSCv371137,029,302 - 137,041,897 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361136,949,136 - 136,961,731 (+)NCBIMGSCv36mm8
Celera1137,759,680 - 137,772,179 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map158.24NCBI
Ptpn7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81349,122,679 - 49,136,096 (+)NCBIGRCr8
mRatBN7.21346,570,904 - 46,584,048 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1346,571,712 - 46,583,308 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1349,178,503 - 49,190,055 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01350,466,576 - 50,478,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01347,732,661 - 47,744,208 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01351,958,023 - 51,971,431 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1351,958,834 - 51,972,777 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01357,009,427 - 57,023,148 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41348,094,119 - 48,105,707 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11348,108,161 - 48,119,750 (+)NCBI
Celera1346,897,613 - 46,908,578 (+)NCBICelera
Cytogenetic Map13q13NCBI
Ptpn7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540638,232,589 - 38,250,195 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540638,233,409 - 38,249,940 (-)NCBIChiLan1.0ChiLan1.0
PTPN7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2147,220,186 - 47,234,828 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1147,184,863 - 47,199,505 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01177,744,963 - 177,759,611 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11182,047,418 - 182,061,889 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1182,049,084 - 182,061,151 (-)Ensemblpanpan1.1panPan2
PTPN7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.17859,124 - 869,168 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl7859,214 - 869,183 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha7911,497 - 921,564 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.07867,172 - 877,245 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl7867,266 - 877,241 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.17855,561 - 865,624 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.07963,852 - 973,174 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.07987,836 - 997,900 (+)NCBIUU_Cfam_GSD_1.0
Ptpn7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934473,146,132 - 73,158,479 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365672,382,931 - 2,391,542 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365672,381,519 - 2,392,562 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12527,243,907 - 27,258,088 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605528,023,104 - 28,038,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248078,575,371 - 8,593,552 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248078,575,414 - 8,593,063 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTPN7
256 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 9 2 5 3 1 3
Below cutoff 1 2 3 2 14 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000040718   ⟹   ENSSSCP00000054017
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1024,325,292 - 24,335,193 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000045897   ⟹   ENSSSCP00000058871
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1024,325,293 - 24,336,419 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000082552   ⟹   ENSSSCP00000066944
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1024,324,436 - 24,335,776 (-)Ensembl
RefSeq Acc Id: XM_021064534   ⟹   XP_020920193
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11024,325,289 - 24,336,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064535   ⟹   XP_020920194
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11024,325,289 - 24,336,030 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021064536   ⟹   XP_020920195
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11024,325,289 - 24,336,032 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020920193   ⟸   XM_021064534
- Peptide Label: isoform X1
- UniProtKB: A0A8D1Z4D6 (UniProtKB/TrEMBL),   A0A287BQT1 (UniProtKB/TrEMBL),   A0A8D0PQN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920195   ⟸   XM_021064536
- Peptide Label: isoform X2
- UniProtKB: A0A8D0PQN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020920194   ⟸   XM_021064535
- Peptide Label: isoform X1
- UniProtKB: A0A8D1Z4D6 (UniProtKB/TrEMBL),   A0A287BQT1 (UniProtKB/TrEMBL),   A0A8D0PQN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000054017   ⟸   ENSSSCT00000040718
RefSeq Acc Id: ENSSSCP00000058871   ⟸   ENSSSCT00000045897
RefSeq Acc Id: ENSSSCP00000066944   ⟸   ENSSSCT00000082552
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037669 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015069034 UniProtKB/TrEMBL
  ENSSSCG00040044330 UniProtKB/TrEMBL
  ENSSSCG00045017427 UniProtKB/TrEMBL
  ENSSSCG00055016216 UniProtKB/TrEMBL
  ENSSSCG00065052821 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000045897 ENTREZGENE
  ENSSSCT00000045897.2 UniProtKB/TrEMBL
  ENSSSCT00015092691.1 UniProtKB/TrEMBL
  ENSSSCT00040059441.1 UniProtKB/TrEMBL
  ENSSSCT00045029661.1 UniProtKB/TrEMBL
  ENSSSCT00045029727.1 UniProtKB/TrEMBL
  ENSSSCT00055031929.1 UniProtKB/TrEMBL
  ENSSSCT00055031984.1 UniProtKB/TrEMBL
  ENSSSCT00065072326.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_KIM-con UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene PTPN7 ENTREZGENE
PANTHER PROTEIN-TYROSINE-PHOSPHATASE UniProtKB/TrEMBL
  PTHR46198 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PRINTS KIMPTPASE UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A287BQT1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0PQN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1QVF4_PIG UniProtKB/TrEMBL
  A0A8D1Z4D6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:108279 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN7  protein tyrosine phosphatase non-receptor type 7    protein tyrosine phosphatase, non-receptor type 7  Symbol and/or name change 5135510 APPROVED