DPYD (dihydropyrimidine dehydrogenase) - Rat Genome Database

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Gene: DPYD (dihydropyrimidine dehydrogenase) Sus scrofa
Analyze
Symbol: DPYD
Name: dihydropyrimidine dehydrogenase
RGD ID: 14070176
Description: ENCODES a protein that exhibits dihydropyrimidine dehydrogenase (NADP+) activity; flavin adenine dinucleotide binding; FMN binding; INVOLVED IN circadian rhythm (ortholog); pyrimidine nucleobase catabolic process (ortholog); response to glucocorticoid (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DHPDHase; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase; DPD
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,414 - 120,712,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISS)
cytosol  (IBA,IEA)

References
Additional References at PubMed
PMID:1544906   PMID:1901022   PMID:2319593   PMID:8083224   PMID:8373446   PMID:9860876   PMID:11988088   PMID:20831907   PMID:22301074   PMID:30032202   PMID:32516529  


Genomics

Comparative Map Data
DPYD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,414 - 120,712,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,077,743 - 97,921,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,077,743 - 97,995,000 (-)EnsemblGRCh38hg38GRCh38
GRCh37197,543,299 - 98,386,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,315,887 - 98,159,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 34197,255,322 - 98,098,600NCBI
Celera195,797,301 - 96,640,303 (-)NCBICelera
Cytogenetic Map1p21.3NCBI
HuRef195,664,181 - 96,508,076 (-)NCBIHuRef
CHM1_1197,659,318 - 98,502,216 (-)NCBICHM1_1
T2T-CHM13v2.0196,925,834 - 97,768,903 (-)NCBIT2T-CHM13v2.0
Dpyd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393118,355,758 - 119,226,573 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3118,355,778 - 119,226,573 (+)EnsemblGRCm39 Ensembl
GRCm383118,562,109 - 119,432,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv373118,265,096 - 119,135,836 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363118,554,182 - 119,424,922 (+)NCBIMGSCv36mm8
Celera3124,970,410 - 125,843,833 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map351.96NCBI
Dpyd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82209,293,902 - 210,159,777 (+)NCBIGRCr8
mRatBN7.22206,609,043 - 207,474,982 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2206,609,122 - 207,474,982 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2214,264,321 - 215,128,440 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02212,171,713 - 213,035,662 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02206,997,314 - 207,861,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q42NCBI
Dpyd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554352,007,185 - 2,766,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554352,007,185 - 2,800,907 (-)NCBIChiLan1.0ChiLan1.0
DPYD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21129,109,066 - 129,949,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11128,263,454 - 129,104,473 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,736,145 - 100,576,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,457,934 - 99,300,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensemblpanpan1.1panPan2
DPYD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1651,789,786 - 52,564,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl651,814,573 - 52,580,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha654,459,524 - 55,250,294 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0652,128,811 - 52,919,237 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl652,128,798 - 52,936,245 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1651,820,117 - 52,610,968 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0651,800,205 - 52,590,810 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0652,232,854 - 53,023,930 (+)NCBIUU_Cfam_GSD_1.0
Dpyd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058106,508,890 - 107,287,521 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365371,660,477 - 2,439,273 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365371,660,461 - 2,439,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12035,376,738 - 36,215,388 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2035,377,266 - 36,215,679 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603555,476 - 898,213 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in DPYD
30903 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 3 2 1 3
Low 2 20 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007532   ⟹   ENSSSCP00000007333
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4119,931,414 - 120,712,459 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000054080   ⟹   ENSSSCP00000035249
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl4119,931,458 - 120,712,462 (+)Ensembl
RefSeq Acc Id: NM_214044   ⟹   NP_999209
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021088696   ⟹   XP_020944355
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.14120,152,723 - 120,712,458 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_999209   ⟸   NM_214044
- Peptide Label: precursor
- UniProtKB: Q28943 (UniProtKB/Swiss-Prot),   A0A8D1ZEM2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020944355   ⟸   XM_021088696
- Peptide Label: isoform X1
- UniProtKB: A0A8D0X794 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000035249   ⟸   ENSSSCT00000054080
RefSeq Acc Id: ENSSSCP00000007333   ⟸   ENSSSCT00000007532
Protein Domains
4Fe-4S ferredoxin-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006878 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030050630 UniProtKB/TrEMBL
  ENSSSCG00065052341 UniProtKB/TrEMBL
  ENSSSCG00070012273 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007532 ENTREZGENE
  ENSSSCT00000007532.5 UniProtKB/TrEMBL
  ENSSSCT00030070707.1 UniProtKB/TrEMBL
  ENSSSCT00065071856.1 UniProtKB/TrEMBL
  ENSSSCT00070024045.1 UniProtKB/TrEMBL
  ENSSSCT00070024056.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1060.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4Fe4S_Fe-S-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4Fe4S_Fe_S_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DPD_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helical_ferredxn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397109 UniProtKB/Swiss-Prot
NCBI Gene DPYD ENTREZGENE
PANTHER DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)] UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHO_dh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer4_20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Fer4_21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ADXRDTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 4FE4S_FER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4FE4S_FER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP 4Fe-4S ferredoxins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  alpha-helical ferredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FMN-linked oxidoreductases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1TWU6_PIG UniProtKB/TrEMBL
  A0A4X1TWV6_PIG UniProtKB/TrEMBL
  A0A8D0X794 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1ZEM2 ENTREZGENE, UniProtKB/TrEMBL
  DPYD_PIG UniProtKB/Swiss-Prot
  F1S550_PIG UniProtKB/TrEMBL
  Q28943 ENTREZGENE
VGNC ID VGNC:98787 ENTREZGENE