PPBP (pro-platelet basic protein) - Rat Genome Database

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Gene: PPBP (pro-platelet basic protein) Sus scrofa
Analyze
Symbol: PPBP
Name: pro-platelet basic protein
RGD ID: 14048703
Description: ENCODES a protein that exhibits chemokine activity (inferred); cytokine activity (inferred); growth factor activity (inferred); INVOLVED IN leukocyte migration involved in inflammatory response (ortholog); positive regulation of granulocyte chemotaxis (ortholog); ASSOCIATED WITH acute myocardial infarction (ortholog); adult respiratory distress syndrome (ortholog); allergic disease (ortholog); FOUND IN platelet alpha granule (ortholog); INTERACTS WITH deoxynivalenol; resveratrol
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-X-C motif chemokine 7; CTAPIII/NAP-2; PBP; platelet basic protein; small-inducible cytokine B7
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,021,439 - 70,023,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,021,468 - 70,022,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,173,312 - 74,174,334 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:7513641   PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PPBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,021,439 - 70,023,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,021,468 - 70,022,490 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,173,312 - 74,174,334 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,986,439 - 73,988,190 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl473,986,439 - 73,988,190 (-)EnsemblGRCh38hg38GRCh38
GRCh37474,852,156 - 74,853,907 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,071,619 - 75,072,764 (-)NCBINCBI36Build 36hg18NCBI36
Build 34475,217,792 - 75,218,935NCBI
Celera472,212,305 - 72,214,056 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef470,663,087 - 70,664,838 (-)NCBIHuRef
CHM1_1474,888,045 - 74,889,796 (-)NCBICHM1_1
T2T-CHM13v2.0477,330,080 - 77,331,831 (-)NCBIT2T-CHM13v2.0
Ppbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,916,377 - 90,917,922 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl590,916,377 - 90,917,922 (+)EnsemblGRCm39 Ensembl
GRCm38590,768,518 - 90,770,063 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,768,518 - 90,770,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,197,544 - 91,199,086 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36591,843,718 - 91,845,260 (+)NCBIMGSCv36mm8
Celera588,920,145 - 88,921,687 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Ppbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81417,586,495 - 17,587,299 (-)NCBIGRCr8
mRatBN7.21417,302,326 - 17,303,130 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1417,302,326 - 17,303,130 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1417,302,459 - 17,303,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,621,380 - 18,622,184 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01417,313,684 - 17,314,488 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,852,433 - 18,853,237 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,851,954 - 18,853,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,762,075 - 18,762,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,816,434 - 18,817,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,816,433 - 18,817,238 (-)NCBI
Celera1416,678,302 - 16,679,106 (-)NCBICelera
Cytogenetic Map14p22NCBI
PPBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2356,071,080 - 56,073,080 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1456,260,189 - 56,262,313 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0450,203,168 - 50,204,303 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1456,035,433 - 56,036,580 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,035,060 - 56,037,702 (+)Ensemblpanpan1.1panPan2
PPBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,526,571 - 62,528,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,526,571 - 62,528,527 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,195,002 - 62,196,958 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01363,324,944 - 63,340,541 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1363,337,296 - 63,339,253 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11362,947,100 - 62,949,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01362,436,835 - 62,438,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01363,577,683 - 63,579,641 (+)NCBIUU_Cfam_GSD_1.0
Ppbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,267,431 - 13,268,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365981,719,480 - 1,720,911 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365981,719,501 - 1,720,890 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,470,670 - 22,471,841 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl722,470,573 - 22,471,809 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666084305,796 - 308,564 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in PPBP
17 total Variants

Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000009809   ⟹   ENSSSCP00000009556
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl870,027,741 - 70,028,949 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000041161   ⟹   ENSSSCP00000045908
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl870,021,439 - 70,023,964 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000045421   ⟹   ENSSSCP00000040152
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl870,021,433 - 70,029,998 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076203   ⟹   ENSSSCP00000071947
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl870,021,433 - 70,026,986 (+)Ensembl
RefSeq Acc Id: NM_213862   ⟹   NP_999027
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1870,021,468 - 70,022,490 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_999027   ⟸   NM_213862
- Peptide Label: precursor
- UniProtKB: P43030 (UniProtKB/Swiss-Prot),   A0A8D1JR32 (UniProtKB/TrEMBL),   A0A8D1XN14 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000009556   ⟸   ENSSSCT00000009809
RefSeq Acc Id: ENSSSCP00000045908   ⟸   ENSSSCT00000041161
RefSeq Acc Id: ENSSSCP00000040152   ⟸   ENSSSCT00000045421
RefSeq Acc Id: ENSSSCP00000071947   ⟸   ENSSSCT00000076203
Protein Domains
Chemokine interleukin-8-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00005040808 UniProtKB/Swiss-Prot
  ENSSSCG00015028911 UniProtKB/Swiss-Prot
  ENSSSCG00030036728 UniProtKB/Swiss-Prot
  ENSSSCG00045010101 UniProtKB/TrEMBL
  ENSSSCG00050007627 UniProtKB/TrEMBL
  ENSSSCG00055030644 UniProtKB/Swiss-Prot
  ENSSSCG00060040430 UniProtKB/Swiss-Prot
  ENSSSCG00065014898 UniProtKB/TrEMBL
  ENSSSCG00070006337 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000041161 ENTREZGENE
  ENSSSCT00000041161.2 UniProtKB/Swiss-Prot
  ENSSSCT00005065283.1 UniProtKB/Swiss-Prot
  ENSSSCT00015038321.1 UniProtKB/Swiss-Prot
  ENSSSCT00030051075.1 UniProtKB/Swiss-Prot
  ENSSSCT00045017107.1 UniProtKB/TrEMBL
  ENSSSCT00050010391.1 UniProtKB/TrEMBL
  ENSSSCT00055061081.1 UniProtKB/Swiss-Prot
  ENSSSCT00060054732.1 UniProtKB/Swiss-Prot
  ENSSSCT00065019813.1 UniProtKB/TrEMBL
  ENSSSCT00070012108.1 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:396870 UniProtKB/Swiss-Prot
NCBI Gene PPBP ENTREZGENE
PANTHER PLATELET BASIC PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALL INDUCIBLE CYTOKINE A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTERLEUKIN8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMALLCYTKCXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Interleukin 8-like chemokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A0A8D1JR32 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XN14 ENTREZGENE, UniProtKB/TrEMBL
  CXCL7_PIG UniProtKB/Swiss-Prot, ENTREZGENE