SEPHS2 (selenophosphate synthetase 2)

Gene: SEPHS2 (selenophosphate synthetase 2) Sus scrofa

Analyze

Symbol:

SEPHS2

Name:

selenophosphate synthetase 2

RGD ID:

14014297

Description:

ENCODES a protein that exhibits ATP binding (inferred); kinase activity (inferred); metal ion binding (inferred); INVOLVED IN selenium compound metabolic process (ortholog); selenocysteine biosynthetic process (ortholog); PARTICIPATES IN selenoamino acid metabolic pathway; ASSOCIATED WITH colorectal adenoma (ortholog); colorectal carcinoma (ortholog); FOUND IN cytoplasm (inferred)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

selenide, water dikinase 2; selenium donor protein 2; selenophosphate synthase 2; SPS2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	17,886,965 - 17,889,128 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	18,323,331 - 18,325,492 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

colorectal adenoma (ISO)

colorectal carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

selenium compound metabolic process (ISO)

selenocysteine biosynthetic process (IBA,IEA,ISO)

Cellular Component

cytoplasm (IBA,IEA)

Molecular Function

ATP binding (IEA)

kinase activity (IEA)

metal ion binding (IEA)

selenide, water dikinase activity (IBA,IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

selenoamino acid metabolic pathway (ISO)

References

Additional References at PubMed

PMID:14681463	PMID:22301074	PMID:30032202	PMID:32869810

Genomics

Comparative Map Data

SEPHS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	17,886,965 - 17,889,128 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	18,323,331 - 18,325,492 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SEPHS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	30,443,631 - 30,445,874 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	30,443,631 - 30,445,874 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	30,454,952 - 30,457,195 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	30,362,453 - 30,364,725 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	30,362,453 - 30,364,725	NCBI
Celera	16	29,841,772 - 29,844,044 (+)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	28,017,181 - 28,019,453 (-)	NCBI		HuRef
CHM1_1	16	31,771,415 - 31,773,687 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	30,829,870 - 30,832,113 (-)	NCBI		T2T-CHM13v2.0

Sephs2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	126,871,051 - 126,873,231 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	126,871,051 - 126,873,227 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,271,879 - 127,274,059 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,271,879 - 127,274,055 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	134,415,393 - 134,417,573 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	127,063,027 - 127,065,207 (-)	NCBI		MGSCv36	mm8
Celera	7	127,120,930 - 127,123,110 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.43	NCBI

Sephs2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	191,323,637 - 191,325,955 (-)	NCBI		GRCr8
mRatBN7.2	1	181,893,146 - 181,895,464 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	181,892,599 - 181,895,497 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,243,816 - 190,246,134 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	197,429,904 - 197,432,222 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	190,098,269 - 190,100,587 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	198,719,158 - 198,721,476 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	198,719,162 - 198,721,476 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	205,712,718 - 205,715,036 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	186,535,717 - 186,538,035 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	186,685,595 - 186,687,642 (-)	NCBI
Celera	1	179,544,591 - 179,546,909 (-)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

Sephs2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955493	7,371,617 - 7,372,945 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955493	7,370,869 - 7,373,121 (-)	NCBI	ChiLan1.0	ChiLan1.0

SEPHS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	33,649,882 - 33,652,066 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	38,450,922 - 38,453,223 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	24,523,111 - 24,525,390 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	30,815,074 - 30,817,414 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SEPHS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	17,667,766 - 17,670,007 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	19,241,719 - 19,243,960 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	17,798,734 - 17,800,975 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	17,799,228 - 17,800,328 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	17,598,938 - 17,601,179 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	17,514,421 - 17,516,662 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	17,829,399 - 17,831,640 (+)	NCBI		UU_Cfam_GSD_1.0

Sephs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	124,793,070 - 124,795,334 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936501	12,891,303 - 12,893,201 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SEPHS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	27,130,108 - 27,132,376 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666068	2,385,417 - 2,387,961 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sephs2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624782	13,610,166 - 13,612,553 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in SEPHS2
32 total Variants

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001093735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK231490	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK234173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK395303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK399641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY609782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CU928725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF033624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

NM_001093735 ⟹ NP_001087204

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	3	17,886,965 - 17,889,128 (+)	NCBI

Sequence:

show sequence

CCGGGTCGACCCCGCGTCCGCTCCGTATTAACTGGAGTCGAAAGTAAACGGGACCTCTCCTCCT
CTCTCTTTTCCCCTCCCTGCCGGGCAGGCGTGATGGCGGAAGCCGCGGCGACGGGCGCCGGCGG
AGAGATGATGGCGGCGGTGGCGGCGGGTGAAGGCTGCTCGGGCCCGGCGGGCTTGTCTCTAGGT
CGGGGCTTCTCGGGCTACCGGCCCTTCGAGCCCCAGGCGTTGGGCCTGAGCCCGAGCTGGCGGC
TGACTGGCTTCTCTGGCATGAAGGGCTGAGGCTGCAAAGTCCCCCAGGAGACGCTGCTCAAACT
CCTGGCGGGACTGACGCGGCCGGAGGTGCGGCCCCCTGTGGGCCGGGGCCTGGTCGGAGGCCTT
GAAGAGGCGGCCCAGGAAGCCGGCCTGCCGGTGAGGGCGGAACCCAGCCCAACCTTCCCAACCC
TCGGCATTGGCCTGGACTCCTGCGTCATCCCCCTGAGGCACGGGGGCCTGTCCCTTGTGCAGAC
CACGGACTTTTTCTACCCCTTGGTGGAAGATCCCTACATGATGGGGCGCATAGCTTGTGCCAAC
GTGCTGAGTGACCTCTACGCCATGGGCATTACTGAGTGTGACAACATGTTGATGCTCCTCAGCG
TCAGCCAGAATATGATTGAGGAGGAACGAGAGAAAATAACCCCCCTCATGATCAAAGGCTTTCG
GGATGCCGCGGAGGAAGGAGGGACTGCAGTGACTGGCGGGCAGACGGTGATAAACCCTTGGATT
ATCATCGGCGGAGTGGCCACTGTGGTCTGTCAGCCAAATGAATTCATTATGCCCGACAGTGCCG
TTGTTGGGGATGTGCTGGTGTTAACCAAACCCCTAGGAACCCAAGTCGCCGTCAATGCCCACCA
ATGGCTGGATAATCCTGAAAGATGGAATAAGATAAAGATGGTCGTCTCAAGAGAAGAGGTAGAG
CTGGCCTATCAGGAAGCCATGTTCAACATGGCTACTCTAAATAGAACCGCTGCTGGCTTGATGC
ACACGTTTAACGCCCACGCCGCCACAGATATCACGGGCTTTGGCATTCTGGGACACTCGCAGAA
CCTTGCAAAACAACAGAGAAATGAGGTGTCCTTTGTCATTCATAATCTGCCGATCATCGCCAAG
ATGGCTGCCATCAGCAAGGCCAGCGGCCGCTTTGGGCTCCTTCAGGGAACCTCCGCAGAAACTT
CTGGGGGGTTACTGATTTGTCTGCCAAGGGAGCAAGCAGCTCGCTTTTGTTCGGAAATCAAATC
TTCAAAGTACGGAGAGGGTCACCAAGCCTGGATCGTGGGCATAGTGGAAAAGGGAAACCGGACA
GCCCGGATCATTGACAAGCCTCGAGTTATTGAGGTCCTACCTCGTGGGACCGCTGCTACTGCTC
TTGCTCCTGAGAATTCCAGTGCCTCCTCTGAGCCTAGCTTGTGAAATGGAATAGCAGAGGTTGT
TTGGACTGTAGAGCCTTTGAACAAAATCATGGACAATTCTCAGGAGTTACTTTTAGGAAGAAAT
TTCCAAAGAAGGCTGCCTGCATAGTAGTTCCAGCTGTCTTTTCTAGGTGATTTGAATCGGCCCA
TCAAAAGCTGCACATTCCAAGGTCAGAAGTAACATTTTGGACTTCCATTGGGTAGGTCTGTTAA
TCTCTTGAGTGGAAGAAGAACAGAAAAACCTCTCTTTCCTCTTTCCAAGAGCAAGATGAGGCTT
CTCGGGTCTGAGAGATTTTTCTTGGCACAGGGTTGACTGATTTCTGCACAGGGGATGAGATTAT
TAAAATTACATAGACACCAAAAATAAATTGCAAAATGGAAAACATTTAGATCAGAAGCAAATAA
GTTTGGACCAATACTGTTGACAAACCTAAATTGTTCAGGGAGAGATTAAAATGCAATGTCAAAT
TCCTTGTTAGATTTCTTTGAAATACTGGCTCTTTCCTGCTCTGGACAAGAATTGAGCAGCTTGT
CCAATGACTGGGAAAGGAGGACTTCCAGCCACCTTACTTGGTCTCTGTTAATGATGTTTCTCCC
TCTAAACCCCTTCAAGGACTGGGAGAGGCAGAGCAAACTCCAGAGTCCAGGCCTTGGTGGACAT
TAAATCTTGTGCTGAAAATTCCTGGTGATTTAATCCATAAAGTGATTTCTAGTGAAATAAATAA
AGATTTTGTCGAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001087204	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A1YIZ1	(Get FASTA)	NCBI Sequence Viewer
	ABM46855	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00030043937.1
	ENSSSCP00035035935.1
	ENSSSCP00040018556.1
	ENSSSCP00055043833.1
	ENSSSCP00060046661.1

RefSeq Acc Id:

NP_001087204 ⟸ NM_001093735

- UniProtKB:

A1YIZ1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAEAAATGAGGEMMAAVAAGEGCSGPAGLSLGRGFSGYRPFEPQALGLSPSWRLTGFSGMKGUG
CKVPQETLLKLLAGLTRPEVRPPVGRGLVGGLEEAAQEAGLPVRAEPSPTFPTLGIGLDSCVIP
LRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQNMIEEERE
KITPLMIKGFRDAAEEGGTAVTGGQTVINPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKP
LGTQVAVNAHQWLDNPERWNKIKMVVSREEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDI
TGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAISKASGRFGLLQGTSAETSGGLLICLPRE
QAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGTAATALAPENSSASSE
PSL

hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00030068190	UniProtKB/Swiss-Prot
	ENSSSCG00035064131	UniProtKB/Swiss-Prot
	ENSSSCG00040032793	UniProtKB/Swiss-Prot
	ENSSSCG00055027768	UniProtKB/Swiss-Prot
	ENSSSCG00060077040	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSSSCT00030095354.1	UniProtKB/Swiss-Prot
	ENSSSCT00035086280.1	UniProtKB/Swiss-Prot
	ENSSSCT00040044154.1	UniProtKB/Swiss-Prot
	ENSSSCT00055054932.1	UniProtKB/Swiss-Prot
	ENSSSCT00060105907.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.1330.10	UniProtKB/Swiss-Prot
	3.90.650.10	UniProtKB/Swiss-Prot
InterPro	PurM-like_C_dom	UniProtKB/Swiss-Prot
	PurM-like_C_sf	UniProtKB/Swiss-Prot
	PurM-like_N	UniProtKB/Swiss-Prot
	PurM-like_N_sf	UniProtKB/Swiss-Prot
	SPS/SelD	UniProtKB/Swiss-Prot
KEGG Report	ssc:100037302	UniProtKB/Swiss-Prot
NCBI Gene	SEPHS2	ENTREZGENE
PANTHER	PTHR10256	UniProtKB/Swiss-Prot
	SELENIDE, WATER DIKINASE 2	UniProtKB/Swiss-Prot
Pfam	AIRS	UniProtKB/Swiss-Prot
	AIRS_C	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF55326	UniProtKB/Swiss-Prot
	SSF56042	UniProtKB/Swiss-Prot
UniProt	A1YIZ1	ENTREZGENE, UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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