GNB2 (G protein subunit beta 2) - Rat Genome Database

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Gene: GNB2 (G protein subunit beta 2) Sus scrofa
Analyze
Symbol: GNB2
Name: G protein subunit beta 2
RGD ID: 13969808
Description: ENCODES a protein that exhibits calcium channel regulator activity (ortholog); INVOLVED IN G protein-coupled receptor signaling pathway (inferred); regulation of potassium ion transmembrane transport (inferred); signal transduction (inferred); ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); NEURODEVELOPMENTAL DISORDER WITH HYPOTONIA AND DYSMORPHIC FACIES (ortholog); FOUND IN cell body (ortholog); parallel fiber to Purkinje cell synapse (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,579,122 - 8,584,266 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,579,037 - 8,585,268 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,974,039 - 7,979,398 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GNB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,579,122 - 8,584,266 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,579,037 - 8,585,268 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,974,039 - 7,979,398 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GNB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,673,740 - 100,679,169 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,673,567 - 100,679,174 (+)EnsemblGRCh38hg38GRCh38
GRCh377100,271,363 - 100,276,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,109,311 - 100,114,728 (+)NCBINCBI36Build 36hg18NCBI36
Build 34799,916,025 - 99,921,442NCBI
Celera795,001,927 - 95,007,353 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,902,070 - 94,907,496 (+)NCBIHuRef
CHM1_17100,201,871 - 100,207,297 (+)NCBICHM1_1
T2T-CHM13v2.07101,913,819 - 101,919,248 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,630,968 - 99,636,397 (+)NCBI
Gnb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,526,389 - 137,533,085 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,526,389 - 137,531,772 (-)EnsemblGRCm39 Ensembl
GRCm385137,528,127 - 137,533,449 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,528,127 - 137,533,510 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,969,357 - 137,974,457 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,757,917 - 137,763,017 (-)NCBIMGSCv36mm8
Celera5134,511,768 - 134,516,867 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.54NCBI
Gnb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,795,505 - 24,800,796 (+)NCBIGRCr8
mRatBN7.21219,159,002 - 19,164,021 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,158,973 - 19,164,019 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,315,269 - 20,320,289 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,928,193 - 20,933,213 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,992,543 - 19,997,563 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,229,079 - 22,234,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,229,079 - 22,234,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,245,847 - 24,250,864 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,597,312 - 19,602,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,586,873 - 19,591,891 (-)NCBI
Celera1220,964,068 - 20,969,085 (+)NCBICelera
Cytogenetic Map12q12NCBI
Gnb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573241,854 - 247,849 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573242,815 - 247,740 (-)NCBIChiLan1.0ChiLan1.0
GNB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,585,659 - 118,591,092 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,850,298 - 166,855,723 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,700,807 - 92,706,211 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,104,339 - 106,107,270 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,104,339 - 106,107,270 (+)Ensemblpanpan1.1panPan2
GNB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,032,536 - 9,037,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,032,811 - 9,037,668 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,736,967 - 10,742,162 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,966,708 - 8,971,903 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,966,710 - 8,971,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,819,250 - 8,824,439 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,796,973 - 8,802,181 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.068,979,149 - 8,984,345 (-)NCBIUU_Cfam_GSD_1.0
Gnb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,326,473 - 133,329,113 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543706,505 - 714,462 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543706,505 - 710,057 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,533,667 - 12,539,060 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,533,659 - 12,536,570 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,766,511 - 3,772,471 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gnb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,419,165 - 16,424,935 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,421,372 - 16,426,408 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GNB2
55 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9 2 3 5 1 22 2 3 3
Low 1 2 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000008409   ⟹   ENSSSCP00000008190
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl38,579,122 - 8,584,266 (+)Ensembl
RefSeq Acc Id: XM_003480989   ⟹   XP_003481037
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.138,579,037 - 8,585,268 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021086249   ⟹   XP_020941908
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.138,581,489 - 8,584,260 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_003481037   ⟸   XM_003480989
- UniProtKB: F2Z4Z8 (UniProtKB/TrEMBL),   A0A4X1UES8 (UniProtKB/TrEMBL),   A0A481D4T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020941908   ⟸   XM_021086249
- UniProtKB: A0A4X1UES8 (UniProtKB/TrEMBL),   F2Z4Z8 (UniProtKB/TrEMBL),   A0A481D4T2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000008190   ⟸   ENSSSCT00000008409


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007669 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015049764 UniProtKB/TrEMBL
  ENSSSCG00045017960 UniProtKB/TrEMBL
  ENSSSCG00060040022 UniProtKB/TrEMBL
  ENSSSCG00065016523 UniProtKB/TrEMBL
  ENSSSCG00070016246 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008409 ENTREZGENE
  ENSSSCT00000008409.5 UniProtKB/TrEMBL
  ENSSSCT00015067439.1 UniProtKB/TrEMBL
  ENSSSCT00045030700.1 UniProtKB/TrEMBL
  ENSSSCT00045030762.1 UniProtKB/TrEMBL
  ENSSSCT00060054230.1 UniProtKB/TrEMBL
  ENSSSCT00065021958.1 UniProtKB/TrEMBL
  ENSSSCT00070031921.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  Gprotein_B UniProtKB/TrEMBL
  Guanine_nucleotide-bd_bsu UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100516546 UniProtKB/TrEMBL
NCBI Gene GNB2 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(T) SUBUNIT BETA-2 UniProtKB/TrEMBL
  PTHR19850 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PIRSF GN-bd_beta UniProtKB/TrEMBL
PRINTS GPROTEINB UniProtKB/TrEMBL
  GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A481D4T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UES8 ENTREZGENE, UniProtKB/TrEMBL
  F2Z4Z8 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88531 ENTREZGENE