NUPR1 (nuclear protein 1, transcriptional regulator) - Rat Genome Database

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Gene: NUPR1 (nuclear protein 1, transcriptional regulator) Sus scrofa
Analyze
Symbol: NUPR1
Name: nuclear protein 1, transcriptional regulator
RGD ID: 13938780
Description: ENCODES a protein that exhibits acetyltransferase activator activity (inferred); chromatin binding (inferred); DNA binding (inferred); INVOLVED IN acute inflammatory response (ortholog); fibroblast apoptotic process (ortholog); fibroblast proliferation (ortholog); ASSOCIATED WITH diastolic heart failure (ortholog); Experimental Liver Cirrhosis (ortholog); lipid storage disease (ortholog); FOUND IN cytoplasm (inferred); intercellular bridge (inferred); nucleoplasm (inferred); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,402,935 - 18,511,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,402,781 - 18,404,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute inflammatory response  (IEA,ISO)
fibroblast apoptotic process  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IEA,ISO)
male gonad development  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of autophagosome assembly  (IEA)
negative regulation of autophagy  (IEA)
negative regulation of cardiac muscle cell apoptotic process  (IEA)
negative regulation of cell cycle  (IBA,IEA,ISO)
negative regulation of cell population proliferation  (IBA,IEA)
negative regulation of epithelial cell apoptotic process  (IEA)
negative regulation of epithelial cell proliferation  (IEA)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of glycolytic process  (IEA)
negative regulation of programmed necrotic cell death  (IEA)
negative regulation of type B pancreatic cell proliferation  (IEA)
positive regulation of cell cycle  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of fibroblast apoptotic process  (IEA,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IEA)
positive regulation of neuroinflammatory response  (IEA)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of oxidative phosphorylation  (IEA)
positive regulation of proteasomal protein catabolic process  (IEA)
positive regulation of protein modification process  (IEA,ISO)
protein-containing complex assembly  (IEA,ISO)
regulation of autophagy  (ISO)
regulation of female gonad development  (IEA,ISO)
regulation of response to endoplasmic reticulum stress  (IEA)
response to toxic substance  (IEA,ISO)
skeletal muscle cell differentiation  (IEA,ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NUPR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl318,402,935 - 18,511,087 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1318,402,781 - 18,404,411 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NUPR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381628,532,708 - 28,538,974 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1628,532,708 - 28,539,008 (-)EnsemblGRCh38hg38GRCh38
GRCh371628,544,029 - 28,550,295 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361628,456,163 - 28,457,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 341628,456,162 - 28,457,831NCBI
Celera1627,653,286 - 27,655,119 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1626,574,331 - 26,576,164 (-)NCBIHuRef
CHM1_11629,560,413 - 29,562,246 (-)NCBICHM1_1
T2T-CHM13v2.01628,856,812 - 28,863,107 (+)NCBIT2T-CHM13v2.0
Nupr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397126,222,418 - 126,224,642 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7126,222,421 - 126,230,033 (-)EnsemblGRCm39 Ensembl
GRCm387126,623,246 - 126,625,470 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7126,623,249 - 126,630,861 (-)EnsemblGRCm38mm10GRCm38
MGSCv377133,766,760 - 133,768,984 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367126,414,394 - 126,416,618 (-)NCBIMGSCv36mm8
Celera7126,472,385 - 126,474,623 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.21NCBI
Nupr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81190,643,866 - 190,645,901 (-)NCBIGRCr8
mRatBN7.21181,213,292 - 181,215,327 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,213,368 - 181,215,281 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,564,465 - 189,566,500 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01196,750,541 - 196,752,576 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01189,417,969 - 189,420,004 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01194,767,484 - 194,769,519 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1194,767,474 - 194,769,524 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01205,021,877 - 205,023,912 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,770,310 - 185,772,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1178,871,291 - 178,873,326 (-)NCBICelera
Cytogenetic Map1q36NCBI
Nupr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554936,746,380 - 6,747,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554936,746,380 - 6,747,763 (-)NCBIChiLan1.0ChiLan1.0
NUPR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21831,142,620 - 31,144,387 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11634,949,566 - 34,951,364 (+)NCBINHGRI_mPanPan1
PanPan1.11629,015,155 - 29,016,987 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1629,015,155 - 29,016,987 (-)Ensemblpanpan1.1panPan2
NUPR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1618,222,367 - 18,224,015 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl618,222,515 - 18,224,014 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha619,801,224 - 19,802,818 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0618,358,557 - 18,360,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl618,358,631 - 18,360,130 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1618,157,477 - 18,159,070 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0618,072,694 - 18,074,288 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0618,388,742 - 18,390,336 (+)NCBIUU_Cfam_GSD_1.0
Nupr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344123,900,204 - 123,901,559 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650111,997,834 - 11,999,709 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650111,998,064 - 11,999,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUPR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1526,382,125 - 26,385,605 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl526,382,132 - 26,385,348 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660683,184,304 - 3,186,193 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nupr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478213,042,939 - 13,044,267 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478213,042,938 - 13,044,298 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NUPR1
16 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 2 3 5 2 4 2 3 3
Low 2 17
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000062041   ⟹   ENSSSCP00000036030
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl318,402,935 - 18,511,087 (+)Ensembl
RefSeq Acc Id: XM_021088038   ⟹   XP_020943697
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1318,402,781 - 18,404,411 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020943697   ⟸   XM_021088038
- UniProtKB: A0A286ZX41 (UniProtKB/TrEMBL),   A0A4X1U5T6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000036030   ⟸   ENSSSCT00000062041


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040162 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015064153 UniProtKB/TrEMBL
  ENSSSCG00025067664 UniProtKB/TrEMBL
  ENSSSCG00030074274 UniProtKB/TrEMBL
  ENSSSCG00035067834 UniProtKB/TrEMBL
  ENSSSCG00040053203 UniProtKB/TrEMBL
  ENSSSCG00045014612 UniProtKB/TrEMBL
  ENSSSCG00055030648 UniProtKB/TrEMBL
  ENSSSCG00060014500 UniProtKB/TrEMBL
  ENSSSCG00065037277 UniProtKB/TrEMBL
  ENSSSCG00070014800 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000062041 ENTREZGENE
  ENSSSCT00000062041.2 UniProtKB/TrEMBL
  ENSSSCT00015085805.1 UniProtKB/TrEMBL
  ENSSSCT00025092922.1 UniProtKB/TrEMBL
  ENSSSCT00030104168.1 UniProtKB/TrEMBL
  ENSSSCT00030104174.1 UniProtKB/TrEMBL
  ENSSSCT00035091524.1 UniProtKB/TrEMBL
  ENSSSCT00040071905.1 UniProtKB/TrEMBL
  ENSSSCT00040071943.1 UniProtKB/TrEMBL
  ENSSSCT00045024897.1 UniProtKB/TrEMBL
  ENSSSCT00055061083.1 UniProtKB/TrEMBL
  ENSSSCT00055061087.1 UniProtKB/TrEMBL
  ENSSSCT00060019203.1 UniProtKB/TrEMBL
  ENSSSCT00065050852.1 UniProtKB/TrEMBL
  ENSSSCT00065050854.1 UniProtKB/TrEMBL
  ENSSSCT00070029028.1 UniProtKB/TrEMBL
  ENSSSCT00070029034.1 UniProtKB/TrEMBL
InterPro NUPR1-like UniProtKB/TrEMBL
NCBI Gene NUPR1 ENTREZGENE
PANTHER NUCLEAR PROTEIN 1 UniProtKB/TrEMBL
  PTHR17149 UniProtKB/TrEMBL
Pfam Phospho_p8 UniProtKB/TrEMBL
UniProt A0A286ZX41 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1U5T6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1KF15_PIG UniProtKB/TrEMBL
  A0A8D1T4F7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90989 ENTREZGENE