Smpdl3a (sphingomyelin phosphodiesterase, acid-like 3A)

Gene: Smpdl3a (sphingomyelin phosphodiesterase, acid-like 3A) Rattus norvegicus

Analyze

Symbol:

Smpdl3a

Name:

sphingomyelin phosphodiesterase, acid-like 3A

RGD ID:

1359277

Description:

Predicted to enable phosphoric diester hydrolase activity and zinc ion binding activity. Predicted to be involved in nucleoside triphosphate catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SMPDL3A (sphingomyelin phosphodiesterase acid like 3A); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

2',3'-cGAMP phosphodiesterase SMPDL3A; acid sphingomyelinase-like phosphodiesterase 3A; ASM-like phosphodiesterase 3a; cyclic GMP-AMP phosphodiesterase SMPDL3A; MGC95161

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	37,679,004 - 37,701,979 (+)	NCBI		GRCr8
mRatBN7.2	20	37,132,592 - 37,155,567 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	37,132,592 - 37,155,567 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	38,164,650 - 38,187,612 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	37,555,362 - 37,578,323 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	38,282,400 - 38,305,383 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	40,779,022 - 40,800,842 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	40,778,927 - 40,800,868 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	42,510,561 - 42,532,381 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	36,821,916 - 36,844,891 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	36,835,715 - 36,858,691 (+)	NCBI
Celera	20	38,445,334 - 38,468,295 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

endometriosis (ISO)

epilepsy (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzoates (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

cobalt atom (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

cytarabine (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diuron (EXP)

dorsomorphin (ISO)

etoposide (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

genistein (EXP)

glafenine (EXP)

L-methionine (ISO)

lead diacetate (ISO)

leflunomide (EXP)

menadione (ISO)

mercury dibromide (ISO)

methidathion (ISO)

mitomycin C (ISO)

nickel sulfate (ISO)

nitrofen (EXP)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

progesterone (ISO)

protein kinase inhibitor (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

SB 431542 (ISO)

sodium dichromate (EXP,ISO)

sunitinib (ISO)

tamoxifen (ISO)

testosterone (EXP,ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

Tributyltin oxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

tris(2-butoxyethyl) phosphate (ISO)

Tungsten carbide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nucleoside triphosphate catabolic process (ISO,ISS)

sphingomyelin catabolic process (ISO,ISS)

Cellular Component

extracellular region (ISO,ISS)

extracellular space (IBA,ISO,ISS)

Molecular Function

ATP hydrolysis activity (IEA)

phosphoric diester hydrolase activity (IBA,ISO,ISS)

protein binding (ISO)

sphingomyelin phosphodiesterase activity (ISO,ISS)

zinc ion binding (ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7.	Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors.	Wright KO, etal., J Urol 2002 Dec;168(6):2645-9.

Additional References at PubMed

PMID:15489334	PMID:19926744	PMID:23533145	PMID:24006456	PMID:25288789	PMID:26095358	PMID:26783088

Genomics

Comparative Map Data

Smpdl3a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	37,679,004 - 37,701,979 (+)	NCBI		GRCr8
mRatBN7.2	20	37,132,592 - 37,155,567 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	37,132,592 - 37,155,567 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	38,164,650 - 38,187,612 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	37,555,362 - 37,578,323 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	38,282,400 - 38,305,383 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	40,779,022 - 40,800,842 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	40,778,927 - 40,800,868 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	42,510,561 - 42,532,381 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	36,821,916 - 36,844,891 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	36,835,715 - 36,858,691 (+)	NCBI
Celera	20	38,445,334 - 38,468,295 (+)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

SMPDL3A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	122,789,258 - 122,809,720 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	122,789,049 - 122,809,720 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	123,110,403 - 123,130,865 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	123,152,123 - 123,172,564 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	123,152,122 - 123,172,561	NCBI
Celera	6	123,854,285 - 123,875,174 (+)	NCBI		Celera
Cytogenetic Map	6	q22.31	NCBI
HuRef	6	120,686,989 - 120,707,854 (+)	NCBI		HuRef
CHM1_1	6	123,373,788 - 123,394,652 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	123,977,551 - 123,998,013 (+)	NCBI		T2T-CHM13v2.0

Smpdl3a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	57,670,640 - 57,687,926 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	57,670,431 - 57,687,926 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	57,794,544 - 57,811,830 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	57,794,335 - 57,811,830 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	57,514,350 - 57,531,636 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	57,483,015 - 57,500,236 (+)	NCBI		MGSCv36	mm8
Celera	10	58,611,953 - 58,629,235 (+)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	29.25	NCBI

Smpdl3a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955436	4,655,732 - 4,663,638 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955436	4,655,730 - 4,663,993 (+)	NCBI	ChiLan1.0	ChiLan1.0

SMPDL3A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	142,783,477 - 142,805,986 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	140,682,622 - 140,708,208 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	120,577,885 - 120,600,371 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	124,701,094 - 124,723,469 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	124,701,089 - 124,726,484 (+)	Ensembl	panpan1.1		panPan2

SMPDL3A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	62,091,947 - 62,110,081 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	62,092,121 - 62,109,773 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	62,901,586 - 62,919,687 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	62,296,228 - 62,314,394 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	62,171,111 - 62,314,381 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	62,230,501 - 62,248,649 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	62,018,563 - 62,036,619 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	62,666,962 - 62,685,313 (+)	NCBI		UU_Cfam_GSD_1.0

Smpdl3a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	112,987,002 - 113,004,982 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936802	1,070,683 - 1,088,614 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936802	1,070,919 - 1,089,222 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMPDL3A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	39,848,648 - 39,868,731 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	39,848,641 - 39,869,184 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	44,076,443 - 44,094,659 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SMPDL3A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	50,996,472 - 51,017,056 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	50,996,674 - 51,016,108 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	23,291,116 - 23,312,930 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smpdl3a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624798	8,409,960 - 8,418,575 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624798	8,410,048 - 8,422,900 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Smpdl3a
124 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	39
Count of miRNA genes:	36
Interacting mature miRNAs:	37
Transcripts:	ENSRNOT00000001081
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	29244388	54435887	Rat
70158	Bp60	Blood pressure QTL 60	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	31614284	44396023	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	27	53	37	19	37	8	11	21	25	22	11	8
Low		16	4	4		4			53	10	19
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC082029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ230988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000001081 ⟹ ENSRNOP00000001081

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	37,132,592 - 37,155,567 (+)	Ensembl
Rnor_6.0 Ensembl	20	40,778,927 - 40,800,868 (+)	Ensembl

RefSeq Acc Id:

NM_001005539 ⟹ NP_001005539

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	37,679,004 - 37,701,979 (+)	NCBI
mRatBN7.2	20	37,132,592 - 37,155,567 (+)	NCBI
Rnor_6.0	20	40,779,022 - 40,800,842 (+)	NCBI
Rnor_5.0	20	42,510,561 - 42,532,381 (+)	NCBI
RGSC_v3.4	20	36,821,916 - 36,844,891 (+)	RGD
Celera	20	38,445,334 - 38,468,295 (+)	RGD

Sequence:

show sequence

GGGCAGTGTCCTCCATGGCGTTGCCGGGCAACTTCCTCTGCTGCCTGCTGGTTGCCTGGCTCTG
CGATCCGGGGCTCGGGGTGCCCTTGGCGCCCGCGTATGGCGCCCCAGCTGTGGGGCAATTTTGG
CACGTGACTGACTTACATCTAGACCCTACTTACCACATTACAGATGACCATACCAAAGTCTGTG
CTTCATCTAAAGGTGCAAATGTCTCCAATCCCGGCCCTTTTGGAGATGTCCTGTGTGACTCTCC
ATATCAACTTATTTTATCAGCCTTTGATTTTATTAAGAATTCAGGACAAGAAGCATCTTTCATG
ATATGGACAGGGGACAGCCCACCTCATGTCCCAGTACGTGAACTGTCCACAGGCTCTGTTATAG
AGGTGATCACTAACATGACAGTGACTGTCCAGAACCTGTTTCCAAACCTCCAGGTTTTCCCTGC
ACTGGGCAATCATGACTACTGGCCACAGGACCAGCTGCCAATAGCCACCAGTAAGGTCTACAGT
GCTGTCAGTGACCTCTGGAAACCCTGGCTTGATGAAGAAGCTATTAGCACTTTAAGGAAAGGTG
GTTTTTACTCACAGAAAGTTGCAAGTAATCCAGACTTGAGGATCATTAGCCTAAACACAAACTT
GTACTATGGCCCAAATATCATGACCCTGAACAAGACAGACCCAGCAAATCAGTTTGAATGGCTG
GAAAATACACTCAACAGCTCTCTGCGAAATAAGGAGAAGGTATACGTCATAGCACATGTGCCAG
TGGGCTATCTCCCTTATGCAACCAAGACCCCAGCAATGAGGCAGTACTATAATGAGAAACTGGT
TGATATTTTCAGAAGATACAGCTCCGTTATTGCCGGACAGTTCTATGGCCACACCCATAGAGAC
AGCCTTATGGTCCTTTCAGATAAAAACGGTAATCCAATAAATTCTGTGTTTGTGGCACCTGCTG
TTACACCAGTGAAAGGAGTTTTAGAAAAAGAGACCAACAATCCTGGCGTCCGTCTGTTTCAGTA
CAAGCCTGGTGATTACACACTGCTGGACATGTTGCAGTATTACTTGAACTTGACAGAAGCCAAT
CTAAAAGGAGAATCCAATTGGACCCTGGAGTACACCTTGACTCAGGCCTATGGTGTCGCAGACC
TGCAGCCAAAGAGCTTACATGGATTAGCTCAGCAGCTTGCTACCATAGACAGCAAGCAGTTCCT
GAAATACTACCATTATTTTTTTGTGAGTTATGACAGCAGCGCACCTTGTGATCAACGATGTAAG
ACCTTACAGATATGTGCAATTATGAATCTTGACCTTGTTTCCTATGAGGATTGCCTTAAACGAC
ATTTATAAAGCATAGTCACTGGTATTCCAGTTGTGTTTGTAGGAAAAGCAGTCACATCATTGGT
GCTCCTGTGATCAGCTTGTGGAATACTGAGGGCATTGGAAAAGTTACTTTCTGTGCTGTGTTAC
TTGTGACGTTCAGAGGCAGACACCAGTAACATTCAAAATTAATTTCACACGCTGTGTACCTTTA
AACCGTTCATTAATGGAGTGGCATTTGGACATAAATATCTTGTCTTCCGACTTTATGTAATTAT
ACCTAAAGTATATGCTTGTAAAACTTGCCATCTTTGCAATAAAGCAGGTGACTTCTCTGTGAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001005539	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH82029	(Get FASTA)	NCBI Sequence Viewer
	EDL92885	(Get FASTA)	NCBI Sequence Viewer
	EDL92886	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001081
	ENSRNOP00000001081.3
	ENSRNOP00055020260
	ENSRNOP00060009778
	ENSRNOP00065003275
GenBank Protein	Q641Z7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001005539 ⟸ NM_001005539
- Peptide Label:	precursor
- UniProtKB:	Q641Z7 (UniProtKB/Swiss-Prot), A6K4D6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALPGNFLCCLLVAWLCDPGLGVPLAPAYGAPAVGQFWHVTDLHLDPTYHITDDHTKVCASSKG ANVSNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVRELSTGSVIEVITN MTVTVQNLFPNLQVFPALGNHDYWPQDQLPIATSKVYSAVSDLWKPWLDEEAISTLRKGGFYSQ KVASNPDLRIISLNTNLYYGPNIMTLNKTDPANQFEWLENTLNSSLRNKEKVYVIAHVPVGYLP YATKTPAMRQYYNEKLVDIFRRYSSVIAGQFYGHTHRDSLMVLSDKNGNPINSVFVAPAVTPVK GVLEKETNNPGVRLFQYKPGDYTLLDMLQYYLNLTEANLKGESNWTLEYTLTQAYGVADLQPKS LHGLAQQLATIDSKQFLKYYHYFFVSYDSSAPCDQRCKTLQICAIMNLDLVSYEDCLKRHL hide sequence

RefSeq Acc Id:

ENSRNOP00000001081 ⟸ ENSRNOT00000001081

Protein Domains

Calcineurin-like phosphoesterase Sphingomyelin phosphodiesterase C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q641Z7-F1-model_v2	AlphaFold	Q641Z7	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701638

Promoter ID:

EPDNEW_R12162

Type:

initiation region

Name:

Smpdl3a_1

Description:

sphingomyelin phosphodiesterase, acid-like 3A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	40,779,026 - 40,779,086	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359277	AgrOrtholog
BioCyc Gene	G2FUF-3580	BioCyc
Ensembl Genes	ENSRNOG00000000815	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055014438	UniProtKB/Swiss-Prot
	ENSRNOG00060007824	UniProtKB/Swiss-Prot
	ENSRNOG00065003230	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001081	ENTREZGENE
	ENSRNOT00000001081.6	UniProtKB/Swiss-Prot
	ENSRNOT00055024783	UniProtKB/Swiss-Prot
	ENSRNOT00060012902	UniProtKB/Swiss-Prot
	ENSRNOT00065004574	UniProtKB/Swiss-Prot
Gene3D-CATH	3.60.21.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7130096	IMAGE-MGC_LOAD
InterPro	ASM-like_Pdiesterase_prd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ASM_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ASMase/PPN1_MPP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Calcineurin-like_PHP_ApaH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Metallo-depent_PP-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:294422	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:95161	IMAGE-MGC_LOAD
NCBI Gene	294422	ENTREZGENE
PANTHER	ACID SPHINGOMYELINASE-LIKE PHOSPHODIESTERASE 3A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SPHINGOMYELIN PHOSPHODIESTERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	ASMase_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Metallophos	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Smpdl3a	PhenoGen
PIRSF	ASM-like_PDE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000815	RatGTEx
	ENSRNOG00055014438	RatGTEx
	ENSRNOG00060007824	RatGTEx
	ENSRNOG00065003230	RatGTEx
Superfamily-SCOP	Metallo-dependent phosphatases	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6K4D6	ENTREZGENE, UniProtKB/TrEMBL
	A6K4D7_RAT	UniProtKB/TrEMBL
	ASM3A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Smpdl3a	sphingomyelin phosphodiesterase, acid-like 3A		acid sphingomyelinase-like phosphodiesterase 3A	Name updated	1299863	APPROVED
2005-07-29	Smpdl3a	acid sphingomyelinase-like phosphodiesterase 3A			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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