EIF3D (eukaryotic translation initiation factor 3 subunit D) - Rat Genome Database

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Gene: EIF3D (eukaryotic translation initiation factor 3 subunit D) Homo sapiens
Analyze
Symbol: EIF3D
Name: eukaryotic translation initiation factor 3 subunit D
RGD ID: 1352969
HGNC Page HGNC:3278
Description: Enables mRNA cap binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; cap-dependent translational initiation; and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: eIF-3-zeta; eIF3 p66; eIF3-p66; eIF3-zeta; EIF3S7; eukaryotic translation initiation factor 3 subunit 7; eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa; eukaryotic translation initiation factor 3, subunit D; MGC126526; MGC17258; translation initiation factor eIF3 p66 subunit
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,510,855 - 36,529,166 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,510,855 - 36,529,184 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,906,902 - 36,925,213 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,236,843 - 35,255,223 (-)NCBINCBI36Build 36hg18NCBI36
Build 342235,231,397 - 35,249,983NCBI
Celera2220,709,038 - 20,727,412 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2219,874,728 - 19,893,087 (-)NCBIHuRef
CHM1_12236,865,836 - 36,884,218 (-)NCBICHM1_1
T2T-CHM13v2.02236,971,029 - 36,989,335 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG Annu Rev Biochem. 2014;83:779-812. doi: 10.1146/annurev-biochem-060713-035802. Epub 2014 Jan 29.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8995409   PMID:8995410   PMID:9341143   PMID:9573242   PMID:9822659   PMID:10591208   PMID:11331597   PMID:11369516   PMID:11590142   PMID:12477932   PMID:12588972   PMID:14519125  
PMID:15047060   PMID:15461802   PMID:15489334   PMID:15592455   PMID:16920360   PMID:17322308   PMID:17353931   PMID:17403899   PMID:17474147   PMID:17581632   PMID:18571626   PMID:18599441  
PMID:18628297   PMID:19615732   PMID:19738201   PMID:19946888   PMID:20171186   PMID:20360068   PMID:20890303   PMID:21145461   PMID:21347434   PMID:21873635   PMID:21900206   PMID:22145905  
PMID:22190034   PMID:22586326   PMID:22658674   PMID:22681889   PMID:22863883   PMID:22939629   PMID:22944692   PMID:23125841   PMID:23623729   PMID:24092755   PMID:24248602   PMID:24457600  
PMID:24711643   PMID:24981860   PMID:25315684   PMID:25322666   PMID:25370813   PMID:25416956   PMID:25437307   PMID:25476789   PMID:25515538   PMID:25659154   PMID:25682860   PMID:25849773  
PMID:25921289   PMID:25963833   PMID:26186194   PMID:26344197   PMID:26460568   PMID:26496610   PMID:26617750   PMID:26673895   PMID:26687479   PMID:26777405   PMID:26949251   PMID:27035563  
PMID:27173435   PMID:27462815   PMID:27477275   PMID:27591049   PMID:27684187   PMID:28031328   PMID:28077445   PMID:28302793   PMID:28514442   PMID:28515276   PMID:28581483   PMID:28594409  
PMID:28680062   PMID:28685749   PMID:28801778   PMID:28977666   PMID:29117863   PMID:29128334   PMID:29228324   PMID:29229926   PMID:29298432   PMID:29467282   PMID:29507755   PMID:29509190  
PMID:29676528   PMID:29844126   PMID:29845934   PMID:29955894   PMID:30021884   PMID:30033366   PMID:30196744   PMID:30279242   PMID:30462309   PMID:30463901   PMID:30833792   PMID:30948266  
PMID:31048545   PMID:31059266   PMID:31091453   PMID:31118081   PMID:31239290   PMID:31280863   PMID:31478661   PMID:31527615   PMID:31527668   PMID:31586073   PMID:31669222   PMID:31722399  
PMID:31885740   PMID:32129710   PMID:32203420   PMID:32269044   PMID:32296183   PMID:32382008   PMID:32529326   PMID:32665550   PMID:32680882   PMID:32687490   PMID:32707033   PMID:32780723  
PMID:32807901   PMID:32963011   PMID:32994395   PMID:33022573   PMID:33060197   PMID:33239621   PMID:33273988   PMID:33306668   PMID:33644029   PMID:33658012   PMID:33742100   PMID:33863777  
PMID:33916271   PMID:33961781   PMID:33989516   PMID:34079125   PMID:34226595   PMID:34316702   PMID:34373451   PMID:34520790   PMID:34597346   PMID:34728620   PMID:34848685   PMID:35032548  
PMID:35104170   PMID:35140242   PMID:35232816   PMID:35235311   PMID:35256949   PMID:35271311   PMID:35446349   PMID:35509820   PMID:35563538   PMID:35652658   PMID:35831314   PMID:35914814  
PMID:35944360   PMID:35987950   PMID:36057605   PMID:36168627   PMID:36168628   PMID:36215168   PMID:36232890   PMID:36264610   PMID:36266428   PMID:36376293   PMID:36424410   PMID:36517590  
PMID:36526897   PMID:36634849   PMID:36736316   PMID:36997088   PMID:37144468   PMID:37314929   PMID:37683648   PMID:37689310   PMID:37827155   PMID:38113892  


Genomics

Comparative Map Data
EIF3D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382236,510,855 - 36,529,166 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2236,510,855 - 36,529,184 (-)EnsemblGRCh38hg38GRCh38
GRCh372236,906,902 - 36,925,213 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362235,236,843 - 35,255,223 (-)NCBINCBI36Build 36hg18NCBI36
Build 342235,231,397 - 35,249,983NCBI
Celera2220,709,038 - 20,727,412 (-)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2219,874,728 - 19,893,087 (-)NCBIHuRef
CHM1_12236,865,836 - 36,884,218 (-)NCBICHM1_1
T2T-CHM13v2.02236,971,029 - 36,989,335 (-)NCBIT2T-CHM13v2.0
Eif3d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391577,843,201 - 77,855,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1577,843,198 - 77,855,013 (-)EnsemblGRCm39 Ensembl
GRCm381577,958,998 - 77,970,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1577,958,998 - 77,970,813 (-)EnsemblGRCm38mm10GRCm38
MGSCv371577,789,428 - 77,801,254 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361577,786,256 - 77,798,015 (-)NCBIMGSCv36mm8
Celera1579,418,242 - 79,430,068 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1536.92NCBI
Eif3d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87111,420,351 - 111,432,761 (-)NCBIGRCr8
mRatBN7.27109,539,795 - 109,552,184 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7109,539,356 - 109,552,206 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7111,289,645 - 111,302,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07113,513,203 - 113,525,595 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07113,481,200 - 113,493,575 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07119,188,189 - 119,200,578 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7119,188,185 - 119,200,623 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07119,182,951 - 119,195,340 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47115,877,161 - 115,889,550 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17115,911,390 - 115,923,780 (-)NCBI
Celera7105,880,627 - 105,893,016 (-)NCBICelera
Cytogenetic Map7q34NCBI
Eif3d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541323,092,749 - 23,110,312 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541323,096,440 - 23,110,312 (-)NCBIChiLan1.0ChiLan1.0
EIF3D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22346,365,301 - 46,383,977 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12249,056,546 - 49,075,197 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02217,425,745 - 17,444,130 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12235,262,541 - 35,282,360 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2235,262,541 - 35,282,360 (-)Ensemblpanpan1.1panPan2
EIF3D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11027,890,913 - 27,904,887 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1027,890,938 - 27,904,886 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1027,844,591 - 27,858,525 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01028,676,131 - 28,690,129 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1028,676,132 - 28,690,138 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11028,404,604 - 28,418,627 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01028,712,367 - 28,726,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01028,891,157 - 28,905,180 (+)NCBIUU_Cfam_GSD_1.0
Eif3d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494511,245,864 - 11,260,055 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364924,255,977 - 4,271,081 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364924,256,210 - 4,270,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF3D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl511,213,312 - 11,229,158 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1511,213,312 - 11,229,158 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.258,895,436 - 8,911,620 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF3D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11919,220,542 - 19,238,534 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1919,221,199 - 19,238,468 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045106,632,591 - 106,651,239 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif3d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475211,197,189 - 11,212,440 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EIF3D
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q12.3-13.1(chr22:35333993-38900177)x1 copy number loss See cases [RCV000051364] Chr22:35333993..38900177 [GRCh38]
Chr22:35729986..39296182 [GRCh37]
Chr22:34059986..37626128 [NCBI36]
Chr22:22q12.3-13.1		 pathogenic
GRCh38/hg38 22q12.3-13.1(chr22:36068124-38002382)x3 copy number gain See cases [RCV000051683] Chr22:36068124..38002382 [GRCh38]
Chr22:36464172..38398389 [GRCh37]
Chr22:34794118..36728335 [NCBI36]
Chr22:22q12.3-13.1		 pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:33768441-50739977)x3 copy number gain See cases [RCV000051682] Chr22:33768441..50739977 [GRCh38]
Chr22:34164428..51178405 [GRCh37]
Chr22:32494428..49525271 [NCBI36]
Chr22:22q12.3-13.33		 pathogenic
GRCh38/hg38 22q12.3(chr22:35753347-36593973)x3 copy number gain See cases [RCV000052854] Chr22:35753347..36593973 [GRCh38]
Chr22:36149394..36990020 [GRCh37]
Chr22:34479340..35319966 [NCBI36]
Chr22:22q12.3		 uncertain significance
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33		 pathogenic
GRCh38/hg38 22q12.3(chr22:36313122-36561017)x3 copy number gain See cases [RCV000138088] Chr22:36313122..36561017 [GRCh38]
Chr22:36709167..36957064 [GRCh37]
Chr22:35039113..35287010 [NCBI36]
Chr22:22q12.3		 uncertain significance
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3		 pathogenic
GRCh37/hg19 22q12.3-13.1(chr22:35680095-38098981)x1 copy number loss See cases [RCV000207444] Chr22:35680095..38098981 [GRCh37]
Chr22:22q12.3-13.1		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q12.3-13.33(chr22:35728929-51220961)x3 copy number gain See cases [RCV000240469] Chr22:35728929..51220961 [GRCh37]
Chr22:22q12.3-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q12.3-13.1(chr22:36877226-38548989)x1 copy number loss See cases [RCV000512008] Chr22:36877226..38548989 [GRCh37]
Chr22:22q12.3-13.1		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q12.3-13.1(chr22:35674826-39466442)x3 copy number gain See cases [RCV000512385] Chr22:35674826..39466442 [GRCh37]
Chr22:22q12.3-13.1		 likely pathogenic
Single allele duplication not provided [RCV000677973] Chr22:36785240..36995848 [GRCh37]
Chr22:22q12.3		 uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q12.3(chr22:36844619-36988654)x3 copy number gain not provided [RCV000741942] Chr22:36844619..36988654 [GRCh37]
Chr22:22q12.3		 benign
GRCh37/hg19 22q12.3(chr22:36870845-37007470)x3 copy number gain not provided [RCV000741943] Chr22:36870845..37007470 [GRCh37]
Chr22:22q12.3		 benign
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
NM_003753.4(EIF3D):c.699T>C (p.Pro233=) single nucleotide variant not provided [RCV000915565] Chr22:36519417 [GRCh38]
Chr22:36915464 [GRCh37]
Chr22:22q12.3		 benign
GRCh37/hg19 22q12.3(chr22:36831022-37009180)x4 copy number gain not provided [RCV000848098] Chr22:36831022..37009180 [GRCh37]
Chr22:22q12.3		 uncertain significance
GRCh37/hg19 22q12.3(chr22:36831984-37009111)x3 copy number gain not provided [RCV000849512] Chr22:36831984..37009111 [GRCh37]
Chr22:22q12.3		 uncertain significance
GRCh37/hg19 22q12.3(chr22:36704833-36911784)x3 copy number gain not provided [RCV000849820] Chr22:36704833..36911784 [GRCh37]
Chr22:22q12.3		 uncertain significance
GRCh37/hg19 22q12.3(chr22:36746223-36971882)x3 copy number gain not provided [RCV000846041] Chr22:36746223..36971882 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.711+7G>A single nucleotide variant not provided [RCV000961753] Chr22:36519398 [GRCh38]
Chr22:36915445 [GRCh37]
Chr22:22q12.3		 benign
GRCh37/hg19 22q12.3(chr22:36704833-36968932)x3 copy number gain not provided [RCV000847397] Chr22:36704833..36968932 [GRCh37]
Chr22:22q12.3		 uncertain significance
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3 copy number gain not provided [RCV001007181] Chr22:30654764..51197838 [GRCh37]
Chr22:22q12.2-13.33		 pathogenic
NM_003753.4(EIF3D):c.124-5C>T single nucleotide variant not provided [RCV000887213] Chr22:36525714 [GRCh38]
Chr22:36921761 [GRCh37]
Chr22:22q12.3		 benign
NM_003753.4(EIF3D):c.712-10C>T single nucleotide variant not provided [RCV000961752] Chr22:36518920 [GRCh38]
Chr22:36914967 [GRCh37]
Chr22:22q12.3		 benign
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33		 pathogenic
GRCh37/hg19 22q12.3(chr22:36831028-37009180)x3 copy number gain not provided [RCV001825267] Chr22:36831028..37009180 [GRCh37]
Chr22:22q12.3		 not provided
NC_000022.10:g.(?_35776672)_(42486826_?)dup duplication Adenylosuccinate lyase deficiency [RCV003119093] Chr22:35776672..42486826 [GRCh37]
Chr22:22q12.3-13.2		 uncertain significance
GRCh37/hg19 22q12.3(chr22:36693899-36963432)x3 copy number gain not provided [RCV002472427] Chr22:36693899..36963432 [GRCh37]
Chr22:22q12.3		 uncertain significance
GRCh37/hg19 22q12.3(chr22:36751242-36971521)x3 copy number gain not provided [RCV002473502] Chr22:36751242..36971521 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.1019C>G (p.Pro340Arg) single nucleotide variant not specified [RCV004237549] Chr22:36516762 [GRCh38]
Chr22:36912809 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.446A>G (p.Lys149Arg) single nucleotide variant not specified [RCV004241372] Chr22:36523228 [GRCh38]
Chr22:36919275 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.1484T>C (p.Ile495Thr) single nucleotide variant not specified [RCV004349825] Chr22:36511652 [GRCh38]
Chr22:36907699 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.77G>A (p.Arg26Gln) single nucleotide variant not specified [RCV004359247] Chr22:36526045 [GRCh38]
Chr22:36922092 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.1077-1G>C single nucleotide variant not provided [RCV003740594] Chr22:36516608 [GRCh38]
Chr22:36912655 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.1474C>T (p.Arg492Cys) single nucleotide variant not specified [RCV004377784] Chr22:36511662 [GRCh38]
Chr22:36907709 [GRCh37]
Chr22:22q12.3		 uncertain significance
NM_003753.4(EIF3D):c.262A>C (p.Thr88Pro) single nucleotide variant not specified [RCV004377785] Chr22:36524640 [GRCh38]
Chr22:36920687 [GRCh37]
Chr22:22q12.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1789
Count of miRNA genes:830
Interacting mature miRNAs:966
Transcripts:ENST00000216190, ENST00000402116, ENST00000405442, ENST00000426531, ENST00000432675, ENST00000455547, ENST00000457241, ENST00000458572, ENST00000462641, ENST00000462794, ENST00000478547, ENST00000496875, ENST00000541106
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
SHGC-24001  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372236,906,929 - 36,907,036UniSTSGRCh37
Build 362235,236,875 - 35,236,982RGDNCBI36
Celera2220,709,070 - 20,709,177RGD
Cytogenetic Map22q13.1UniSTS
HuRef2219,874,760 - 19,874,867UniSTS
TNG Radiation Hybrid Map2213051.0UniSTS
Stanford-G3 RH Map22981.0UniSTS
NCBI RH Map22149.5UniSTS
GeneMap99-G3 RH Map22981.0UniSTS
RH121185  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372236,906,589 - 36,906,807UniSTSGRCh37
Build 362235,236,535 - 35,236,753RGDNCBI36
Celera2220,708,730 - 20,708,948RGD
Cytogenetic Map22q13.1UniSTS
HuRef2219,874,420 - 19,874,638UniSTS
TNG Radiation Hybrid Map228381.0UniSTS
SHGC-32716  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372236,907,616 - 36,907,740UniSTSGRCh37
Build 362235,237,562 - 35,237,686RGDNCBI36
Celera2220,709,757 - 20,709,881RGD
Cytogenetic Map22q13.1UniSTS
HuRef2219,875,447 - 19,875,571UniSTS
TNG Radiation Hybrid Map2213051.0UniSTS
SGC31879  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map22q13.1UniSTS
GeneMap99-GB4 RH Map22113.14UniSTS
Whitehead-RH Map22120.5UniSTS
A002O22  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map22q13.1UniSTS
GeneMap99-GB4 RH Map22122.77UniSTS
NCBI RH Map22154.0UniSTS
MARC_13472-13473:1002304233:5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372236,907,681 - 36,908,575UniSTSGRCh37
Celera2220,709,822 - 20,710,716UniSTS
HuRef2219,875,512 - 19,876,408UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 4
Medium 2432 2951 1716 615 1944 457 4355 2165 3659 417 1444 1608 171 1204 2788 4
Low 7 40 10 9 7 8 1 32 75 2 12 5 4 1 2 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_156418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047441560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054326077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK300199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL022313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW575097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC080515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC101477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG718662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U54558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000216190   ⟹   ENSP00000216190
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,510,855 - 36,529,166 (-)Ensembl
RefSeq Acc Id: ENST00000402116   ⟹   ENSP00000385212
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,523,916 - 36,528,942 (-)Ensembl
RefSeq Acc Id: ENST00000405442   ⟹   ENSP00000385812
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,510,899 - 36,528,897 (-)Ensembl
RefSeq Acc Id: ENST00000426531
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,511,577 - 36,516,931 (-)Ensembl
RefSeq Acc Id: ENST00000432675
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,523,115 - 36,529,184 (-)Ensembl
RefSeq Acc Id: ENST00000455547   ⟹   ENSP00000390438
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,518,813 - 36,529,166 (-)Ensembl
RefSeq Acc Id: ENST00000457241   ⟹   ENSP00000403584
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,520,633 - 36,529,077 (-)Ensembl
RefSeq Acc Id: ENST00000458572   ⟹   ENSP00000391061
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,511,701 - 36,519,501 (-)Ensembl
RefSeq Acc Id: ENST00000462641
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,510,868 - 36,512,929 (-)Ensembl
RefSeq Acc Id: ENST00000462794
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,516,063 - 36,516,923 (-)Ensembl
RefSeq Acc Id: ENST00000478547   ⟹   ENSP00000487325
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,510,856 - 36,511,641 (-)Ensembl
RefSeq Acc Id: ENST00000496875
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2236,524,695 - 36,529,173 (-)Ensembl
RefSeq Acc Id: NM_003753   ⟹   NP_003744
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382236,510,855 - 36,529,166 (-)NCBI
GRCh372236,906,897 - 36,925,277 (-)RGD
Build 362235,236,843 - 35,255,223 (-)NCBI Archive
Celera2220,709,038 - 20,727,412 (-)RGD
HuRef2219,874,728 - 19,893,087 (-)RGD
CHM1_12236,865,836 - 36,884,218 (-)NCBI
T2T-CHM13v2.02236,971,029 - 36,989,335 (-)NCBI
Sequence:
RefSeq Acc Id: NR_156418
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382236,510,855 - 36,529,166 (-)NCBI
T2T-CHM13v2.02236,971,029 - 36,989,335 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047441560   ⟹   XP_047297516
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382236,517,300 - 36,529,166 (-)NCBI
RefSeq Acc Id: XM_054326077   ⟹   XP_054182052
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02236,977,470 - 36,989,335 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_003744   ⟸   NM_003753
- UniProtKB: Q3MJD9 (UniProtKB/Swiss-Prot),   B4DVY1 (UniProtKB/Swiss-Prot),   B4DTF8 (UniProtKB/Swiss-Prot),   B2R7D4 (UniProtKB/Swiss-Prot),   A8MWD3 (UniProtKB/Swiss-Prot),   Q5M9Q6 (UniProtKB/Swiss-Prot),   O15371 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000487325   ⟸   ENST00000478547
RefSeq Acc Id: ENSP00000216190   ⟸   ENST00000216190
RefSeq Acc Id: ENSP00000385212   ⟸   ENST00000402116
RefSeq Acc Id: ENSP00000390438   ⟸   ENST00000455547
RefSeq Acc Id: ENSP00000403584   ⟸   ENST00000457241
RefSeq Acc Id: ENSP00000391061   ⟸   ENST00000458572
RefSeq Acc Id: ENSP00000385812   ⟸   ENST00000405442
RefSeq Acc Id: XP_047297516   ⟸   XM_047441560
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054182052   ⟸   XM_054326077
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O15371-F1-model_v2 AlphaFold O15371 1-548 view protein structure

Promoters
RGD ID:6799839
Promoter ID:HG_KWN:42611
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000319036
Position:
Human AssemblyChrPosition (strand)Source
Build 362235,237,156 - 35,238,122 (-)MPROMDB
RGD ID:6799840
Promoter ID:HG_KWN:42612
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000319037
Position:
Human AssemblyChrPosition (strand)Source
Build 362235,238,446 - 35,238,946 (-)MPROMDB
RGD ID:6799837
Promoter ID:HG_KWN:42613
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000319033,   OTTHUMT00000319034
Position:
Human AssemblyChrPosition (strand)Source
Build 362235,242,546 - 35,243,557 (-)MPROMDB
RGD ID:6799838
Promoter ID:HG_KWN:42614
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Jurkat,   Lymphoblastoid
Transcripts:OTTHUMT00000319035
Position:
Human AssemblyChrPosition (strand)Source
Build 362235,245,041 - 35,245,597 (-)MPROMDB
RGD ID:6799844
Promoter ID:HG_KWN:42615
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000397177,   ENST00000402116,   OTTHUMT00000319026,   OTTHUMT00000319028,   OTTHUMT00000319029,   OTTHUMT00000319030,   OTTHUMT00000319031,   UC003APQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362235,255,066 - 35,255,572 (-)MPROMDB
RGD ID:6851576
Promoter ID:EP73590
Type:initiation region
Name:HS_EIF3S7
Description:Eukaryotic translation initiation factor 3, subunit 7 zeta,66/67kDa.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 362235,255,159 - 35,255,219EPD
RGD ID:13603904
Promoter ID:EPDNEW_H28136
Type:initiation region
Name:EIF3D_1
Description:eukaryotic translation initiation factor 3 subunit D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382236,529,166 - 36,529,226EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3278 AgrOrtholog
COSMIC EIF3D COSMIC
Ensembl Genes ENSG00000100353 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000216190 ENTREZGENE
  ENST00000216190.13 UniProtKB/Swiss-Prot
  ENST00000402116.2 UniProtKB/TrEMBL
  ENST00000405442.5 UniProtKB/Swiss-Prot
  ENST00000455547 ENTREZGENE
  ENST00000455547.5 UniProtKB/TrEMBL
  ENST00000457241.5 UniProtKB/TrEMBL
  ENST00000458572.1 UniProtKB/TrEMBL
  ENST00000478547.1 UniProtKB/TrEMBL
GTEx ENSG00000100353 GTEx
HGNC ID HGNC:3278 ENTREZGENE
Human Proteome Map EIF3D Human Proteome Map
InterPro eIF3d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8664 UniProtKB/Swiss-Prot
NCBI Gene 8664 ENTREZGENE
OMIM 603915 OMIM
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12399 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam eIF-3_zeta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA162384740 PharmGKB
PIRSF EIF-3_zeta UniProtKB/Swiss-Prot
UniProt A0A0D9SGB5_HUMAN UniProtKB/TrEMBL
  A8MWD3 ENTREZGENE
  B0QYA4_HUMAN UniProtKB/TrEMBL
  B0QYA5_HUMAN UniProtKB/TrEMBL
  B0QYA6_HUMAN UniProtKB/TrEMBL
  B0QYA8_HUMAN UniProtKB/TrEMBL
  B2R7D4 ENTREZGENE
  B4DTF8 ENTREZGENE
  B4DVY1 ENTREZGENE
  B4E1K8_HUMAN UniProtKB/TrEMBL
  EIF3D_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q3MJD9 ENTREZGENE
  Q5M9Q6 ENTREZGENE
UniProt Secondary A8MWD3 UniProtKB/Swiss-Prot
  B2R7D4 UniProtKB/Swiss-Prot
  B4DTF8 UniProtKB/Swiss-Prot
  B4DVY1 UniProtKB/Swiss-Prot
  Q3MJD9 UniProtKB/Swiss-Prot
  Q5M9Q6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-08 EIF3D  eukaryotic translation initiation factor 3 subunit D  EIF3D  eukaryotic translation initiation factor 3, subunit D  Symbol and/or name change 5135510 APPROVED