MIR96 (microRNA 96) - Rat Genome Database

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Gene: MIR96 (microRNA 96) Homo sapiens
Analyze
Symbol: MIR96
Name: microRNA 96
RGD ID: 1349367
HGNC Page HGNC:31648
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including cellular response to cholesterol; miRNA-mediated post-transcriptional gene silencing; and negative regulation of high-density lipoprotein particle clearance. Predicted to be part of RISC complex. Implicated in attention deficit hyperactivity disorder and autosomal dominant nonsyndromic deafness 50. Biomarker of hepatocellular carcinoma and multiple system atrophy.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: REVIEWED
Previously known as: deafness, autosomal dominant 50; DFNA50; hsa-mir-96; miR-96; MIRN96; miRNA96
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387129,774,692 - 129,774,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7129,774,692 - 129,774,769 (-)EnsemblGRCh38hg38GRCh38
GRCh377129,414,532 - 129,414,609 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,201,767 - 129,201,844 (-)NCBINCBI36Build 36hg18NCBI36
Celera7124,210,277 - 124,210,354 (-)NCBICelera
Cytogenetic Map7q32.2NCBI
HuRef7123,775,817 - 123,775,894 (-)NCBIHuRef
CHM1_17129,347,923 - 129,348,000 (-)NCBICHM1_1
T2T-CHM13v2.07131,087,826 - 131,087,903 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27128,798,808 - 128,798,885 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Aldrich BT, etal., Neuroscience. 2009 Dec 1;164(2):711-23. doi: 10.1016/j.neuroscience.2009.08.033. Epub 2009 Aug 20.
2. Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury. Chen HP, etal., Neurochem Res. 2014 Jan;39(1):76-83.
3. Wnt/β-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Leung WK, etal., Cancer Lett. 2015 Jun 28;362(1):97-105. doi: 10.1016/j.canlet.2015.03.023. Epub 2015 Mar 23.
4. miR-96 targets SOX6 and promotes proliferation, migration, and invasion of hepatocellular carcinoma. Li Z and Wang Y, Biochem Cell Biol. 2018 Jun;96(3):365-371. doi: 10.1139/bcb-2017-0183. Epub 2017 Sep 11.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
9. Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs). Sanchez-Mora C, etal., Eur Neuropsychopharmacol. 2013 Nov;23(11):1463-73. doi: 10.1016/j.euroneuro.2013.07.002. Epub 2013 Jul 29.
10. Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Ubhi K, etal., Eur J Neurosci. 2014 Mar;39(6):1026-41. doi: 10.1111/ejn.12444. Epub 2013 Dec 5.
11. miR-96 and miR-330 overexpressed and targeted AQP5 in lipopolysaccharide-induced rat lung damage of disseminated intravascular coagulation. Zhang Y, etal., Blood Coagul Fibrinolysis. 2014 Oct;25(7):731-7. doi: 10.1097/MBC.0000000000000133.
Additional References at PubMed
PMID:11914277   PMID:14757864   PMID:16381832   PMID:17597072   PMID:17604727   PMID:17616659   PMID:19363479   PMID:19574223   PMID:19943878   PMID:20301607   PMID:20610624   PMID:21037258  
PMID:21203424   PMID:21829531   PMID:21993544   PMID:22038834   PMID:22045813   PMID:22414602   PMID:22441842   PMID:22761336   PMID:22864280   PMID:23151657   PMID:23262295   PMID:23459944  
PMID:23583389   PMID:23637338   PMID:23752186   PMID:23823476   PMID:23951320   PMID:24260486   PMID:24277930   PMID:24366472   PMID:24375867   PMID:24469470   PMID:24633705   PMID:24678958  
PMID:24736782   PMID:24804999   PMID:24960647   PMID:25071021   PMID:25172912   PMID:25242509   PMID:25256312   PMID:25286764   PMID:25333253   PMID:25369914   PMID:25394902   PMID:25465153  
PMID:25502560   PMID:25511320   PMID:25531317   PMID:25663355   PMID:25695717   PMID:25739014   PMID:25798833   PMID:25871906   PMID:25873390   PMID:26138586   PMID:26419932   PMID:26564979  
PMID:26617698   PMID:26806656   PMID:26846266   PMID:27012708   PMID:27044381   PMID:27071841   PMID:27081087   PMID:27164937   PMID:27431799   PMID:27746161   PMID:27857177   PMID:27903254  
PMID:28026121   PMID:28224282   PMID:28412207   PMID:28539816   PMID:28656287   PMID:28944851   PMID:29032398   PMID:29051972   PMID:29131261   PMID:29257267   PMID:29288578   PMID:29599320  
PMID:29656060   PMID:29658604   PMID:29923283   PMID:30066909   PMID:30106139   PMID:30120411   PMID:30201436   PMID:30380528   PMID:30460077   PMID:30509302   PMID:30536654   PMID:30883918  
PMID:30917455   PMID:30925916   PMID:31081096   PMID:31111563   PMID:31160270   PMID:31212131   PMID:31226636   PMID:31228941   PMID:31325400   PMID:31498486   PMID:31518872   PMID:31545491  
PMID:31598681   PMID:31738404   PMID:31822509   PMID:31860169   PMID:31885423   PMID:31913290   PMID:31957819   PMID:32045906   PMID:32057517   PMID:32100957   PMID:32196830   PMID:32377722  
PMID:32396572   PMID:32527205   PMID:32578051   PMID:32618342   PMID:32635855   PMID:32752071   PMID:32893872   PMID:33078195   PMID:33183350   PMID:33308119   PMID:33322515   PMID:33331954  
PMID:33443164   PMID:33538115   PMID:33674746   PMID:33715625   PMID:33751900   PMID:33766457   PMID:33812412   PMID:34032694   PMID:34085193   PMID:34338998   PMID:34343834   PMID:34456284  
PMID:34655124   PMID:35109756   PMID:35241735   PMID:35690607   PMID:35912726   PMID:36017148   PMID:36354205   PMID:36473369   PMID:36586536   PMID:36840403   PMID:36943602   PMID:37011707  
PMID:37515685   PMID:37717559   PMID:38070324   PMID:38430012   PMID:38511985  


Genomics

Comparative Map Data
MIR96
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387129,774,692 - 129,774,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7129,774,692 - 129,774,769 (-)EnsemblGRCh38hg38GRCh38
GRCh377129,414,532 - 129,414,609 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,201,767 - 129,201,844 (-)NCBINCBI36Build 36hg18NCBI36
Celera7124,210,277 - 124,210,354 (-)NCBICelera
Cytogenetic Map7q32.2NCBI
HuRef7123,775,817 - 123,775,894 (-)NCBIHuRef
CHM1_17129,347,923 - 129,348,000 (-)NCBICHM1_1
T2T-CHM13v2.07131,087,826 - 131,087,903 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27128,798,808 - 128,798,885 (-)NCBI
Mir96
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39630,169,445 - 30,169,550 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl630,169,445 - 30,169,550 (-)EnsemblGRCm39 Ensembl
GRCm38630,169,446 - 30,169,551 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl630,169,446 - 30,169,551 (-)EnsemblGRCm38mm10GRCm38
MGSCv37630,119,446 - 30,119,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera630,176,274 - 30,176,379 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.52NCBI
Mir96
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,755,841 - 59,755,946 (-)NCBIGRCr8
mRatBN7.2458,788,411 - 58,788,516 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,788,411 - 58,788,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx463,765,533 - 63,765,638 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,681,700 - 59,681,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,083,605 - 58,083,710 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0457,463,366 - 57,463,471 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,463,366 - 57,463,471 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0457,225,167 - 57,225,272 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera453,887,982 - 53,888,087 (-)NCBICelera
Cytogenetic Map4q22NCBI
MIR96
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,068,754 - 7,068,842 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,068,754 - 7,068,842 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha146,754,051 - 6,754,139 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0146,831,753 - 6,831,841 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl146,831,753 - 6,831,841 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,037,336 - 7,037,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0146,779,495 - 6,779,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,923,777 - 6,923,865 (+)NCBIUU_Cfam_GSD_1.0
MIR96
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,982,506 - 18,982,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,982,506 - 18,982,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,030,888 - 20,030,972 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in MIR96
10 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NR_029512.1(MIR96):n.13G>A single nucleotide variant Autosomal dominant nonsyndromic hearing loss 50 [RCV000000913] Chr7:129774757 [GRCh38]
Chr7:129414597 [GRCh37]
Chr7:7q32.2		 pathogenic
NR_029512.1(MIR96):n.14C>A single nucleotide variant Autosomal dominant nonsyndromic hearing loss 50 [RCV000000914] Chr7:129774756 [GRCh38]
Chr7:129414596 [GRCh37]
Chr7:7q32.2		 pathogenic
GRCh38/hg38 7q32.1-36.3(chr7:129310166-159282390)x3 copy number gain See cases [RCV000050876] Chr7:129310166..159282390 [GRCh38]
Chr7:128950007..159075079 [GRCh37]
Chr7:128737243..158767840 [NCBI36]
Chr7:7q32.1-36.3		 pathogenic
GRCh38/hg38 7q32.1-33(chr7:128747478-134018250)x3 copy number gain See cases [RCV000051072] Chr7:128747478..134018250 [GRCh38]
Chr7:128387532..133703003 [GRCh37]
Chr7:128174768..133353543 [NCBI36]
Chr7:7q32.1-33		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q31.33-32.3(chr7:126859732-132750936)x1 copy number loss See cases [RCV000054171] Chr7:126859732..132750936 [GRCh38]
Chr7:126499786..132435696 [GRCh37]
Chr7:126287022..132086236 [NCBI36]
Chr7:7q31.33-32.3		 pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3		 pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3		 pathogenic
GRCh38/hg38 7q31.2-33(chr7:117326805-134790689)x1 copy number loss See cases [RCV000138226] Chr7:117326805..134790689 [GRCh38]
Chr7:116966859..134475440 [GRCh37]
Chr7:116754095..134125980 [NCBI36]
Chr7:7q31.2-33		 pathogenic
GRCh38/hg38 7q31.32-36.3(chr7:121863759-159335865)x3 copy number gain See cases [RCV000138847] Chr7:121863759..159335865 [GRCh38]
Chr7:121503813..159128555 [GRCh37]
Chr7:121291049..158821316 [NCBI36]
Chr7:7q31.32-36.3		 pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3		 pathogenic
GRCh38/hg38 7q31.33-33(chr7:124170657-134163594)x1 copy number loss See cases [RCV000142552] Chr7:124170657..134163594 [GRCh38]
Chr7:123810711..133848346 [GRCh37]
Chr7:123597947..133498886 [NCBI36]
Chr7:7q31.33-33		 pathogenic
NR_029512.1(MIR96):n.42C>T single nucleotide variant not provided [RCV000992333]|not specified [RCV000151022] Chr7:129774728 [GRCh38]
Chr7:129414568 [GRCh37]
Chr7:7q32.2		 benign|likely benign
NR_029512.1(MIR96):n.36T>C single nucleotide variant not provided [RCV000992332]|not specified [RCV000151023] Chr7:129774734 [GRCh38]
Chr7:129414574 [GRCh37]
Chr7:7q32.2		 benign|likely benign|conflicting interpretations of pathogenicity
GRCh37/hg19 7q32.1-36.3(chr7:128312450-159119220) copy number gain not provided [RCV000767558] Chr7:128312450..159119220 [GRCh37]
Chr7:7q32.1-36.3		 pathogenic
TMEM106B-BRAF fusion deletion Pleomorphic xanthoastrocytoma [RCV000454357] Chr7:12258147..140494267 [GRCh37]
Chr7:7p21.3-q34		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43360-159119707)x1 copy number loss See cases [RCV000446044] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98969247-159119707)x3 copy number gain See cases [RCV000447709] Chr7:98969247..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358)x1 copy number loss See cases [RCV000447722] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34		 pathogenic
GRCh37/hg19 7q32.1-36.3(chr7:128276078-159119707)x3 copy number gain See cases [RCV000447956] Chr7:128276078..159119707 [GRCh37]
Chr7:7q32.1-36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707) copy number gain See cases [RCV000510686] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:43361-159119707)x3 copy number gain See cases [RCV000511549] Chr7:43361..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7q22.1-36.3(chr7:98693388-159119707)x3 copy number gain not provided [RCV000682911] Chr7:98693388..159119707 [GRCh37]
Chr7:7q22.1-36.3		 pathogenic
Single allele complex Renal transitional cell carcinoma [RCV000754611] Chr7:129367205..140482957 [GRCh37]
Chr7:7q32.2-34		 likely pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:44935-159126310)x3 copy number gain not provided [RCV000746280] Chr7:44935..159126310 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10704-159122532)x3 copy number gain not provided [RCV000746278] Chr7:10704..159122532 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
GRCh37/hg19 7p22.3-q36.3(chr7:10365-159119707)x3 copy number gain not provided [RCV000848126] Chr7:10365..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NC_000007.14:g.129774774G>A single nucleotide variant not specified [RCV000825956] Chr7:129774774 [GRCh38]
Chr7:129414614 [GRCh37]
Chr7:7q32.2		 uncertain significance
Single allele deletion not specified [RCV000825957] Chr7:129414532..129414609 [GRCh37]
Chr7:7q32.2		 uncertain significance
GRCh37/hg19 7q31.1-36.3(chr7:109251060-159119707)x3 copy number gain not provided [RCV001005994] Chr7:109251060..159119707 [GRCh37]
Chr7:7q31.1-36.3		 pathogenic
NC_000007.14:g.129774400G>A single nucleotide variant not provided [RCV001693172] Chr7:129774400 [GRCh38]
Chr7:129414240 [GRCh37]
Chr7:7q32.2		 benign
Single allele complex Ring chromosome 7 [RCV002280646] Chr7:43360..159119707 [GRCh37]
Chr7:7p22.3-q36.3		 pathogenic
NR_029512.1(MIR96):n.68A>G single nucleotide variant Hearing impairment [RCV001375468] Chr7:129774702 [GRCh38]
Chr7:129414542 [GRCh37]
Chr7:7q32.2		 uncertain significance
NR_029615.1(MIR183):n.51G>T single nucleotide variant not provided [RCV001753532]|not specified [RCV000151019] Chr7:129774964 [GRCh38]
Chr7:129414804 [GRCh37]
Chr7:7q32.2		 likely benign
NC_000007.14:g.129775020C>A single nucleotide variant not provided [RCV001774136] Chr7:129775020 [GRCh38]
Chr7:129414860 [GRCh37]
Chr7:7q32.2		 likely benign
NC_000007.14:g.129774674G>A single nucleotide variant not provided [RCV001758027] Chr7:129774674 [GRCh38]
Chr7:129414514 [GRCh37]
Chr7:7q32.2		 likely benign
NC_000007.14:g.129774566C>T single nucleotide variant not provided [RCV001772470] Chr7:129774566 [GRCh38]
Chr7:129414406 [GRCh37]
Chr7:7q32.2		 likely benign
GRCh37/hg19 7q31.33-33(chr7:123967475-132729981) copy number loss not specified [RCV002053723] Chr7:123967475..132729981 [GRCh37]
Chr7:7q31.33-33		 pathogenic
GRCh37/hg19 7q32.1-34(chr7:127295698-139524358) copy number loss not specified [RCV002053727] Chr7:127295698..139524358 [GRCh37]
Chr7:7q32.1-34		 pathogenic
GRCh37/hg19 7q31.33-33(chr7:124103982-134693590) copy number loss not specified [RCV002053726] Chr7:124103982..134693590 [GRCh37]
Chr7:7q31.33-33		 pathogenic
NR_029512.1(MIR96):n.4C>T single nucleotide variant not provided [RCV001990492] Chr7:129774766 [GRCh38]
Chr7:129414606 [GRCh37]
Chr7:7q32.2		 uncertain significance
NR_029512.1(MIR96):n.14C>T single nucleotide variant not provided [RCV001934737] Chr7:129774756 [GRCh38]
Chr7:129414596 [GRCh37]
Chr7:7q32.2		 uncertain significance
NR_029512.1(MIR96):n.39C>T single nucleotide variant not provided [RCV002028781] Chr7:129774731 [GRCh38]
Chr7:129414571 [GRCh37]
Chr7:7q32.2		 uncertain significance
GRCh37/hg19 7p22.3-q36.3(chr7:56604613-96692931)x1 copy number loss See cases [RCV002287832] Chr7:56604613..96692931 [GRCh37]
Chr7:7p22.3-q36.3		 uncertain significance
GRCh37/hg19 7q32.1-33(chr7:129147455-132777678)x1 copy number loss not provided [RCV002473525] Chr7:129147455..132777678 [GRCh37]
Chr7:7q32.1-33		 uncertain significance
NR_029512.1(MIR96):n.5C>T single nucleotide variant not provided [RCV002786376] Chr7:129774765 [GRCh38]
Chr7:129414605 [GRCh37]
Chr7:7q32.2		 likely benign
NR_029512.1(MIR96):n.69A>G single nucleotide variant not provided [RCV003823214] Chr7:129774701 [GRCh38]
Chr7:129414541 [GRCh37]
Chr7:7q32.2		 uncertain significance
GRCh37/hg19 7q31.31-33(chr7:120582003-137699953)x1 copy number loss not specified [RCV003986721] Chr7:120582003..137699953 [GRCh37]
Chr7:7q31.31-33		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
FOXO1hsa-miR-96-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19574223
FOXO1hsa-miR-96-5pMirtarbaseexternal_infoImmunohistochemistry//Northern blot//qRT-PCR//WestFunctional MTI20028871
ADCY6hsa-miR-96-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
HTR1Bhsa-miR-96-5pMirtarbaseexternal_infoReporter assayFunctional MTI18283276
MITFhsa-miR-96-5pMirtarbaseexternal_infoimmunohistochemistry//Microarray//qRT-PCR//WesternFunctional MTI19167416
CDKN1Ahsa-miR-96-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI19422085
PRMT5hsa-miR-96-5pMirtarbaseexternal_infoWestern blotFunctional MTI18694959
FOXO3hsa-miR-96-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21203424
KRAShsa-miR-96-5pMirtarbaseexternal_infoImmunoblot//Immunohistochemistry//Northern blot//QFunctional MTI20610624
SCARB1hsa-miR-96-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23459944
OTULINhsa-miR-96-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
KRAShsa-miR-96-5pTarbaseexternal_infoReporter GenePOSITIVE
KRAShsa-miR-96-5pTarbaseexternal_infoqPCRNEGATIVE
KRAShsa-miR-96-5pTarbaseexternal_infoWesternblitPOSITIVE
APPL1hsa-miR-96-5pTarbaseexternal_infoSequencingPOSITIVE
FOXO3hsa-miR-96-5pOncomiRDBexternal_infoNANA23262295
RAD51hsa-miR-96-5pOncomiRDBexternal_infoNANA22761336
ALKhsa-miR-96-5pOncomiRDBexternal_infoNANA22414602
FOXO3hsa-miR-96-5pOncomiRDBexternal_infoNANA21203424
KRAShsa-miR-96-5pOncomiRDBexternal_infoNANA20610624
FOXO1hsa-miR-96-5pOncomiRDBexternal_infoNANA19574223
HTR1Bhsa-miR-96-3pMirecordsexternal_infoNANA18283276
ADCY6hsa-miR-96-3pMirecordsexternal_infoNANA17597072
FOXO1hsa-miR-96-3pMirecordsexternal_infoNANA20028871
IRS1hsa-miR-96-3pMirecordsexternal_infoNANA19502786
AQP5hsa-miR-96-3pMirecordsexternal_infoNANA19363479

Predicted Targets
Summary Value
Count of predictions:27284
Count of gene targets:10985
Count of transcripts:21384
Interacting mature miRNAs:hsa-miR-96-3p, hsa-miR-96-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 11 5 4 12 8 4 24 3 8 16 1 2
Below cutoff 7 13 2 1 4 1 13 19 2 1 7 8 4 8 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000362288
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl7129,774,692 - 129,774,769 (-)Ensembl
RefSeq Acc Id: NR_029512
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387129,774,692 - 129,774,769 (-)NCBI
GRCh377129,414,532 - 129,414,609 (-)RGD
Celera7124,210,277 - 124,210,354 (-)RGD
HuRef7123,775,817 - 123,775,894 (-)ENTREZGENE
CHM1_17129,347,923 - 129,348,000 (-)NCBI
T2T-CHM13v2.07131,087,826 - 131,087,903 (-)NCBI
CRA_TCAGchr7v27128,798,808 - 128,798,885 (-)ENTREZGENE
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31648 AgrOrtholog
COSMIC MIR96 COSMIC
Ensembl Genes ENSG00000199158 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000362288 ENTREZGENE
GTEx ENSG00000199158 GTEx
HGNC ID HGNC:31648 ENTREZGENE
Human Proteome Map MIR96 Human Proteome Map
miRBase MI0000098 ENTREZGENE
NCBI Gene 407053 ENTREZGENE
OMIM 611606 OMIM
PharmGKB PA164723022 PharmGKB
RNAcentral URS000016FF9C RNACentral
  URS00004E4AD0 RNACentral
  URS00005176F0 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-16 MIR96  microRNA 96  DFNA50  deafness, autosomal dominant 50  Data merged from RGD:1349658 737654 PROVISIONAL