Ctsr (cathepsin R) - Rat Genome Database

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Pathways
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Gene: Ctsr (cathepsin R) Mus musculus
Analyze
No known orthologs.
Symbol: Ctsr
Name: cathepsin R
RGD ID: 1332156
MGI Page MGI
Description: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within protein catabolic process. Predicted to be active in extracellular space and lysosome. Is expressed in brain; extraembryonic component; head; and placenta.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AI428350; lysosomal cysteine protease
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391361,307,029 - 61,312,002 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1361,307,018 - 61,312,070 (-)EnsemblGRCm39 Ensembl
GRCm381361,159,215 - 61,164,188 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1361,159,204 - 61,164,256 (-)EnsemblGRCm38mm10GRCm38
MGSCv371361,260,576 - 61,265,549 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361361,168,838 - 61,173,811 (-)NCBIMGSCv36mm8
Celera1362,200,758 - 62,205,582 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1332.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular space  (IBA)
lysosome  (IBA,ISA)

References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Characterization of mouse cathepsin R, a new member of a family of placentally expressed cysteine proteases. Sol-Church K, etal., Biochim Biophys Acta 2000 Jul 24;1492(2-3):488-92.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11829493   PMID:12477932   PMID:15514457   PMID:16097084   PMID:16141072   PMID:16141073   PMID:16862160   PMID:21873635   PMID:22967998  
PMID:24391757   PMID:24952961  


Genomics

Variants

.
Variants in Ctsr
170 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:75
Interacting mature miRNAs:79
Transcripts:ENSMUST00000021889
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
10401111Pgia40_mproteoglycan induced arthritis 40 (mouse)Not determined132791846961918560Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
10045621Heal21_mwound healing/regeneration 21 (mouse)Not determined132821737962217515Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300710Pcd4ts2_mp-glycoprotein positive CD4 T cell subset 2 (mouse)Not determined132821044262210544Mouse
1357802Vtbt15_mvertebral trabecular bone trait 15 (mouse)Not determined132821737962217515Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse

Markers in Region
AI428350  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381361,159,356 - 61,159,459UniSTSGRCm38
MGSCv371361,260,717 - 61,260,820UniSTSGRCm37
Celera1362,200,899 - 62,201,002UniSTS
Cytogenetic Map13B2UniSTS
cM Map1335.0UniSTS
Whitehead/MRC_RH13634.27UniSTS
mHAa31g11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381361,160,872 - 61,161,029UniSTSGRCm38
MGSCv371361,262,233 - 61,262,390UniSTSGRCm37
Celera1362,202,415 - 62,202,572UniSTS
Cytogenetic Map13B2UniSTS
cM Map1335.0UniSTS
Whitehead_YAC13 UniSTS
Ctsr  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381361,162,706 - 61,163,222UniSTSGRCm38
MGSCv371361,264,067 - 61,264,583UniSTSGRCm37
Celera1362,204,249 - 62,204,765UniSTS
Cytogenetic Map13B2UniSTS
cM Map1335.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021889   ⟹   ENSMUSP00000021889
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1361,307,018 - 61,312,070 (-)Ensembl
GRCm38.p6 Ensembl1361,159,204 - 61,164,256 (-)Ensembl
RefSeq Acc Id: NM_020284   ⟹   NP_064680
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391361,307,029 - 61,312,002 (-)NCBI
GRCm381361,159,215 - 61,164,188 (-)ENTREZGENE
MGSCv371361,260,576 - 61,265,549 (-)RGD
Celera1362,200,758 - 62,205,582 (-)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_064680   ⟸   NM_020284
- Peptide Label: precursor
- UniProtKB: Q9JIA9 (UniProtKB/Swiss-Prot),   Q497X4 (UniProtKB/TrEMBL),   Q58IU7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021889   ⟸   ENSMUST00000021889
Protein Domains
Cathepsin propeptide inhibitor   Peptidase C1A papain C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIA9-F1-model_v2 AlphaFold Q9JIA9 1-334 view protein structure

Promoters
RGD ID:8680590
Promoter ID:EPDNEW_M18326
Type:multiple initiation site
Name:Ctsr_1
Description:Mus musculus cathepsin R , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381361,164,203 - 61,164,263EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1861723 AgrOrtholog
Ensembl Genes ENSMUSG00000055679 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021889 ENTREZGENE
  ENSMUST00000021889.6 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56835 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1861723 ENTREZGENE
NCBI Gene 56835 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12411:SF141 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ctsr PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Inhibitor_I29 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_C1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CATR_MOUSE UniProtKB/Swiss-Prot
  Q497X4 ENTREZGENE, UniProtKB/TrEMBL
  Q58IU7 ENTREZGENE, UniProtKB/TrEMBL
  Q9JIA9 ENTREZGENE