Tbx2 (T-box 2) - Rat Genome Database

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Gene: Tbx2 (T-box 2) Mus musculus
Analyze
Symbol: Tbx2
Name: T-box 2
RGD ID: 1322244
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in several processes, including circulatory system development; embryonic morphogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of with a negative effect on pigment metabolic process involved in pigmentation. Acts upstream of or within several processes, including heart development; mammary placode formation; and ureteric peristalsis. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in atrial heart septal defect; heart septal defect; and vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: T-box protein 2; T-box transcription factor TBX2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,723,441 - 85,732,774 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,723,377 - 85,732,774 (+)EnsemblGRCm39 Ensembl
GRCm381185,832,615 - 85,841,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1185,832,551 - 85,841,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371185,646,117 - 85,655,450 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,649,273 - 85,657,325 (+)NCBIMGSCv36mm8
Celera1195,458,950 - 95,468,278 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
caffeine  (ISO)
CHIR 99021  (ISO)
chlordecone  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
clothianidin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (EXP)
diquat  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
flutamide  (EXP)
folic acid  (EXP)
folpet  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead nitrate  (EXP)
malonaldehyde  (ISO)
menadione  (ISO)
methimazole  (ISO)
nitrofen  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
phosgene  (EXP)
propiconazole  (ISO)
raloxifene  (ISO)
retinyl acetate  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aorta morphogenesis  (IMP)
apoptotic process  (IMP)
atrioventricular canal development  (IGI,IMP)
atrioventricular canal morphogenesis  (IGI)
cardiac jelly development  (ISO)
cardiac muscle cell myoblast differentiation  (IDA)
cardiac muscle tissue development  (IMP)
cell fate specification  (IBA)
cellular response to dexamethasone stimulus  (ISO)
cellular senescence  (IDA,ISO)
cochlea morphogenesis  (IMP)
developmental growth involved in morphogenesis  (IMP)
embryonic camera-type eye morphogenesis  (IMP)
embryonic digit morphogenesis  (IMP)
endocardial cushion formation  (ISO)
endocardial cushion morphogenesis  (IMP)
epithelial tube branching involved in lung morphogenesis  (IGI)
fibroblast growth factor receptor signaling pathway  (IMP)
heart morphogenesis  (IMP)
mammary placode formation  (IGI)
melanocyte proliferation  (IMP)
mesenchymal cell proliferation involved in lung development  (IMP)
muscle cell fate determination  (IMP)
negative regulation of cardiac chamber formation  (IMP)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA-templated transcription  (IDA,ISO)
negative regulation of heart looping  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,IMP,ISO)
neurogenesis  (IMP)
Notch signaling pathway  (IDA)
outflow tract morphogenesis  (IMP)
outflow tract septum morphogenesis  (IMP)
pharyngeal system development  (IMP)
pigment metabolic process involved in pigmentation  (IMP)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of cell cycle G1/S phase transition  (IMP)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of transcription by RNA polymerase II  (IDA,IMP)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IBA,IDA)
response to retinoic acid  (IDA)
roof of mouth development  (IGI,IMP)
smooth muscle cell differentiation  (IGI)
ureteric peristalsis  (IGI)

Cellular Component
chromatin  (IBA)
cytoplasm  (IDA)
nucleus  (IBA,IDA,ISO)
transcription regulator complex  (IDA,IPI)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells. Shier P, etal., Immunogenetics 2000 Aug;51(10):771-8.
6. Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. Vance KW, etal., Cancer Res. 2005 Mar 15;65(6):2260-8.
7. Susceptibility to congenital heart defects associated with a polymorphism in TBX2 3' untranslated region in the Han Chinese population. Wang J, etal., Pediatr Res. 2019 Feb;85(3):378-383. doi: 10.1038/s41390-018-0181-y. Epub 2018 Sep 18.
8. A regulatory variant in TBX2 promoter is related to the decreased susceptibility of congenital heart disease in the Han Chinese population. Zhang RR, etal., Mol Genet Genomic Med. 2019 Feb;7(2):e00530. doi: 10.1002/mgg3.530. Epub 2018 Dec 7.
Additional References at PubMed
PMID:1375456   PMID:7774921   PMID:7920656   PMID:8530034   PMID:8597636   PMID:8798150   PMID:8853987   PMID:8878690   PMID:8954725   PMID:8988164   PMID:9196325   PMID:9503012  
PMID:9710594   PMID:10079226   PMID:10349636   PMID:10770922   PMID:11042159   PMID:11076861   PMID:11087629   PMID:11124112   PMID:11217851   PMID:11437453   PMID:11572777   PMID:11726608  
PMID:11748239   PMID:11854453   PMID:11867218   PMID:11978781   PMID:12023302   PMID:12200366   PMID:12413903   PMID:12466851   PMID:12508227   PMID:12654290   PMID:12668638   PMID:12736212  
PMID:14723846   PMID:14996726   PMID:15042700   PMID:15093729   PMID:15136151   PMID:15226823   PMID:15385444   PMID:15459098   PMID:15581864   PMID:15591049   PMID:15618518   PMID:15778864  
PMID:15781699   PMID:15843407   PMID:15843414   PMID:15901664   PMID:16141072   PMID:16141073   PMID:16207751   PMID:16222716   PMID:16314491   PMID:16554359   PMID:16556915   PMID:16556916  
PMID:16602821   PMID:16730707   PMID:16870172   PMID:16912158   PMID:16958122   PMID:17119020   PMID:17173667   PMID:17259303   PMID:17519333   PMID:17585069   PMID:17588959   PMID:17668378  
PMID:18025091   PMID:18039967   PMID:18285513   PMID:18287559   PMID:18356246   PMID:18377888   PMID:18410737   PMID:18467625   PMID:18534921   PMID:18617694   PMID:18667074   PMID:18723448  
PMID:18936168   PMID:19248778   PMID:19334288   PMID:19423846   PMID:19563797   PMID:19576202   PMID:19661464   PMID:19703439   PMID:19769959   PMID:19846762   PMID:19960541   PMID:20025935  
PMID:20059953   PMID:20095052   PMID:20139090   PMID:20386744   PMID:20436479   PMID:20651287   PMID:20732316   PMID:20824138   PMID:20929948   PMID:20941780   PMID:21068058   PMID:21266775  
PMID:21267068   PMID:21330551   PMID:21509901   PMID:21677750   PMID:21708977   PMID:21731673   PMID:21867776   PMID:21873635   PMID:21890625   PMID:21983003   PMID:22002537   PMID:22116936  
PMID:22130515   PMID:22186728   PMID:22203979   PMID:22223620   PMID:22312437   PMID:22421044   PMID:22438573   PMID:22573616   PMID:22615585   PMID:22841643   PMID:22844464   PMID:22921202  
PMID:22932696   PMID:22966238   PMID:23020925   PMID:23117660   PMID:23341776   PMID:23506836   PMID:23536097   PMID:23624936   PMID:23633963   PMID:23661717   PMID:23674600   PMID:23720046  
PMID:23936153   PMID:24089201   PMID:24146773   PMID:24356861   PMID:24441423   PMID:24680892   PMID:24700869   PMID:24705356   PMID:24952961   PMID:25296024   PMID:25336743   PMID:25453830  
PMID:25487574   PMID:25599332   PMID:26238476   PMID:26486273   PMID:26493106   PMID:26764381   PMID:26971330   PMID:27046536   PMID:27253890   PMID:27606604   PMID:27720610   PMID:27856909  
PMID:28069742   PMID:28807898   PMID:28910203   PMID:29031500   PMID:29374072   PMID:29409032   PMID:29540665   PMID:29853617   PMID:29891551   PMID:30201295   PMID:30292786   PMID:30305733  
PMID:30478225   PMID:31870435   PMID:31896583   PMID:32325033   PMID:32404924   PMID:33302058   PMID:33321106   PMID:33410138   PMID:33731112   PMID:33795231   PMID:33846290   PMID:34584102  
PMID:34822715   PMID:35320729   PMID:35506352   PMID:35508658   PMID:35905011   PMID:36293499   PMID:36494345   PMID:36521641   PMID:36687561   PMID:36941249   PMID:36941669   PMID:37198424  
PMID:37442233  


Genomics

Comparative Map Data
Tbx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,723,441 - 85,732,774 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,723,377 - 85,732,774 (+)EnsemblGRCm39 Ensembl
GRCm381185,832,615 - 85,841,948 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1185,832,551 - 85,841,948 (+)EnsemblGRCm38mm10GRCm38
MGSCv371185,646,117 - 85,655,450 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361185,649,273 - 85,657,325 (+)NCBIMGSCv36mm8
Celera1195,458,950 - 95,468,278 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.34NCBI
TBX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381761,399,843 - 61,409,466 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1761,399,843 - 61,409,466 (+)EnsemblGRCh38hg38GRCh38
GRCh371759,477,204 - 59,486,827 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361756,832,039 - 56,841,609 (+)NCBINCBI36Build 36hg18NCBI36
Build 341756,832,038 - 56,841,607NCBI
Celera1758,578,306 - 58,587,856 (+)NCBICelera
Cytogenetic Map17q23.2NCBI
HuRef1754,844,115 - 54,856,411 (+)NCBIHuRef
CHM1_11759,541,779 - 59,551,327 (+)NCBICHM1_1
T2T-CHM13v2.01762,268,710 - 62,278,311 (+)NCBIT2T-CHM13v2.0
Tbx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,177,082 - 71,186,275 (+)NCBIGRCr8
mRatBN7.21070,679,670 - 70,688,868 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1070,679,518 - 70,688,529 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1075,299,645 - 75,308,837 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01074,804,435 - 74,813,625 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01070,269,072 - 70,278,263 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01073,278,932 - 73,290,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,279,119 - 73,289,921 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01073,184,210 - 73,193,085 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41074,085,203 - 74,092,988 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11074,096,142 - 74,107,239 (+)NCBI
Celera1069,604,924 - 69,612,748 (+)NCBICelera
Cytogenetic Map10q26NCBI
Tbx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554512,457,568 - 2,466,639 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554512,458,612 - 2,466,264 (+)NCBIChiLan1.0ChiLan1.0
TBX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21977,598,977 - 77,608,279 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11782,410,276 - 82,419,751 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01755,501,932 - 55,511,537 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11760,617,169 - 60,631,148 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1760,622,098 - 60,630,189 (+)Ensemblpanpan1.1panPan2
TBX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1935,237,323 - 35,245,066 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl935,235,649 - 35,245,736 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha934,466,401 - 34,475,666 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0936,048,354 - 36,057,619 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl936,049,321 - 36,057,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1934,829,267 - 34,838,524 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0935,114,884 - 35,124,167 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0935,202,696 - 35,211,975 (-)NCBIUU_Cfam_GSD_1.0
Tbx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560234,296,708 - 34,306,109 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364902,769,231 - 2,805,238 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364902,769,264 - 2,778,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,878,675 - 36,887,513 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,878,662 - 36,887,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21238,329,004 - 38,337,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TBX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11632,627,296 - 32,636,797 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1632,627,819 - 32,636,880 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660773,378,641 - 3,388,263 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248712,429,407 - 2,437,447 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248712,428,757 - 2,437,447 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbx2
195 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:378
Count of miRNA genes:273
Interacting mature miRNAs:320
Transcripts:ENSMUST00000000095
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
15092049Wsigrme3_mweek six growth rate, maternal effect 3 (mouse)118487732496629512Mouse
15092057Lgrme3_mlate growth rate, maternal effect 3 (mouse)118487732496629512Mouse

Markers in Region
Tbx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381185,834,815 - 85,835,893UniSTSGRCm38
MGSCv371185,648,317 - 85,649,395UniSTSGRCm37
Celera1195,461,150 - 95,462,223UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
cM Map1149.0UniSTS
TBX2_2169  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381185,840,943 - 85,841,759UniSTSGRCm38
MGSCv371185,654,445 - 85,655,261UniSTSGRCm37
Celera1195,467,273 - 95,468,089UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS
Tbx2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381185,835,908 - 85,837,286UniSTSGRCm38
MGSCv371185,649,410 - 85,650,788UniSTSGRCm37
Celera1195,462,238 - 95,463,616UniSTS
Cytogenetic Map11CUniSTS
cM Map1149.0UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000000095   ⟹   ENSMUSP00000000095
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1185,723,377 - 85,732,774 (+)Ensembl
GRCm38.p6 Ensembl1185,832,551 - 85,841,948 (+)Ensembl
RefSeq Acc Id: NM_009324   ⟹   NP_033350
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391185,723,441 - 85,732,774 (+)NCBI
GRCm381185,832,615 - 85,841,948 (+)ENTREZGENE
MGSCv371185,646,117 - 85,655,450 (+)RGD
Celera1195,458,950 - 95,468,278 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_033350 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52697 (Get FASTA)   NCBI Sequence Viewer  
  AAF90050 (Get FASTA)   NCBI Sequence Viewer  
  BAE28824 (Get FASTA)   NCBI Sequence Viewer  
  EDL15775 (Get FASTA)   NCBI Sequence Viewer  
  EDL15776 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000000095
  ENSMUSP00000000095.7
GenBank Protein Q60707 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_033350   ⟸   NM_009324
- UniProtKB: Q5SSP7 (UniProtKB/Swiss-Prot),   Q60707 (UniProtKB/Swiss-Prot),   Q3UET7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000000095   ⟸   ENSMUST00000000095
Protein Domains
T-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q60707-F1-model_v2 AlphaFold Q60707 1-711 view protein structure

Promoters
RGD ID:6822343
Promoter ID:MM_KWN:8995
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000002057,   OTTMUST00000002070,   OTTMUST00000002071,   UC007KRX.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361185,645,006 - 85,646,207 (+)MPROMDB
RGD ID:6846919
Promoter ID:MM_ACW:8399
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:TBX2.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361185,653,856 - 85,654,356 (+)MPROMDB
RGD ID:8675998
Promoter ID:EPDNEW_M16030
Type:initiation region
Name:Tbx2_1
Description:Mus musculus T-box 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381185,832,812 - 85,832,872EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98494 AgrOrtholog
Ensembl Genes ENSMUSG00000000093 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000000095 ENTREZGENE
  ENSMUST00000000095.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBX2_3_RD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_Brachyury UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98494 ENTREZGENE
NCBI Gene 21385 ENTREZGENE
PANTHER PTHR11267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-BOX TRANSCRIPTION FACTOR TBX2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBX2-3_RD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tbx2 PhenoGen
PRINTS BRACHYURY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Q3UET7 ENTREZGENE, UniProtKB/TrEMBL
  Q5SSP7 ENTREZGENE
  Q60707 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5SSP7 UniProtKB/Swiss-Prot