Mccc2 (methylcrotonoyl-Coenzyme A carboxylase 2 (beta))

Gene: Mccc2 (methylcrotonoyl-Coenzyme A carboxylase 2 (beta)) Mus musculus

Analyze

Symbol:

Mccc2

Name:

methylcrotonoyl-Coenzyme A carboxylase 2 (beta)

RGD ID:

1321087

MGI Page

MGI

Description:

Predicted to enable ATP binding activity and ligase activity. Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be involved in coenzyme A metabolic process and leucine catabolic process. Located in mitochondrion. Is expressed in metanephros and spinal cord. Human ortholog(s) of this gene implicated in 3-Methylcrotonyl-CoA carboxylase 2 deficiency and mitochondrial metabolism disease. Orthologous to human MCCC2 (methylcrotonyl-CoA carboxylase subunit 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

3-methylcrotonyl-CoA carboxylase 2; 3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta; 4930552N12Rik; MCCase subunit beta; MCCB; methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Mccc2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mccc2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mccc2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mccc2 (methylcrotonyl-CoA carboxylase subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Mccc2 (methylcrotonyl-CoA carboxylase subunit 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	MCCC2 (methylcrotonyl-CoA carboxylase subunit 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mccc2 (methylcrotonoyl-CoA carboxylase 2 (beta))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	Mccc2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F02A9.10	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	mccc2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	100,085,040 - 100,152,147 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	100,085,038 - 100,152,147 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	99,948,532 - 100,015,639 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	99,948,530 - 100,015,639 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	100,718,487 - 100,785,594 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	101,048,783 - 101,115,886 (-)	NCBI		MGSCv36	mm8
Celera	13	103,601,615 - 103,669,283 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	52.9	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Methylcrotonyl-CoA carboxylase 2 deficiency (ISO)

3-methylcrotonyl-CoA carboxylase deficiency (ISO)

autism spectrum disorder (ISO)

genetic disease (ISO)

mitochondrial metabolism disease (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-dexrazoxane (EXP)

(+)-schisandrin B (ISO)

(-)-demecolcine (ISO)

1,1-dichloroethene (EXP)

1,2-dimethylhydrazine (EXP)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrabromodibenzodioxine (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (ISO)

2,6-dinitrotoluene (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

acetamide (ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (EXP)

carbon nanotube (EXP)

chlorpyrifos (EXP)

choline (EXP)

chromium(6+) (EXP)

clopidogrel (EXP)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (EXP,ISO)

dibutyl phthalate (EXP,ISO)

dicrotophos (ISO)

diuron (ISO)

doxorubicin (EXP,ISO)

endosulfan (ISO)

enzyme inhibitor (ISO)

folic acid (EXP)

formaldehyde (ISO)

genistein (ISO)

glafenine (ISO)

irinotecan (ISO)

isoprenaline (EXP)

isotretinoin (ISO)

ivermectin (ISO)

L-methionine (EXP)

lead(0) (ISO)

lipopolysaccharide (EXP)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylparaben (ISO)

methylseleninic acid (ISO)

N-nitrosomorpholine (ISO)

nimesulide (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

phlorizin (EXP)

pirinixic acid (EXP,ISO)

propiconazole (EXP)

resveratrol (ISO)

rotenone (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

sunitinib (ISO)

testosterone (EXP,ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (ISO)

trichloroethene (ISO)

troglitazone (EXP)

tungsten (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vancomycin (EXP)

vinclozolin (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

coenzyme A metabolic process (ISO)

L-leucine catabolic process (IBA)

Cellular Component

3-methylcrotonyl-CoA carboxylase complex, mitochondrial (ISO)

methylcrotonoyl-CoA carboxylase complex (IBA,ISO)

mitochondrial matrix (ISO)

mitochondrion (HDA,IBA,ISO)

Molecular Function

ATP binding (IEA)

ligase activity (IEA)

methylcrotonoyl-CoA carboxylase activity (IBA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway (ISO)

3-hydroxyisobutyric aciduria pathway (ISO)

3-methylcrotonyl CoA carboxylase 1 deficiency pathway (ISO)

3-methylglutaconic aciduria type 1 pathway (ISO)

3-methylglutaconic aciduria type 3 pathway (ISO)

isobutyryl-CoA dehydrogenase deficiency pathway (ISO)

isovaleric acidemia pathway (ISO)

maple syrup urine disease pathway (ISO)

methylmalonate semialdehyde dehydrogenase deficiency pathway (ISO)

methylmalonic acidemia pathway (ISO)

propionic acidemia pathway (ISO)

valine, leucine and isoleucine degradation pathway (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased bone mineral density (IEA)

decreased mean corpuscular hemoglobin (IEA)

decreased mean corpuscular volume (IEA)

increased erythrocyte cell number (IEA)

increased prepulse inhibition (IEA)

preweaning lethality, complete penetrance (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	The molecular basis of 3-methylcrotonylglycinuria, a disorder of leucine catabolism.	Gallardo ME, etal., Am J Hum Genet. 2001 Feb;68(2):334-46. Epub 2001 Jan 17.
2.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.	Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
5.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Database resources of the National Center for Biotechnology Information.	Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:11042159	PMID:11076861	PMID:12466305	PMID:12477932	PMID:12520002	PMID:14681479	PMID:16141072	PMID:16141073	PMID:18614015	PMID:20019802
PMID:21267068	PMID:21677750	PMID:21873635	PMID:22496890	PMID:26465331	PMID:28378742	PMID:29111324	PMID:30550785	PMID:32325033	PMID:36114006	PMID:36417873

Genomics

Comparative Map Data

Mccc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	100,085,040 - 100,152,147 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	13	100,085,038 - 100,152,147 (-)	Ensembl		GRCm39 Ensembl
GRCm38	13	99,948,532 - 100,015,639 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	99,948,530 - 100,015,639 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	100,718,487 - 100,785,594 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	13	101,048,783 - 101,115,886 (-)	NCBI		MGSCv36	mm8
Celera	13	103,601,615 - 103,669,283 (-)	NCBI		Celera
Cytogenetic Map	13	D1	NCBI
cM Map	13	52.9	NCBI

MCCC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	71,587,340 - 71,658,706 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	71,579,531 - 71,658,706 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	70,883,167 - 70,954,533 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	70,918,910 - 70,988,981 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	70,918,909 - 70,988,981	NCBI
Celera	5	66,778,848 - 66,850,229 (+)	NCBI		Celera
Cytogenetic Map	5	q13.2	NCBI
HuRef	5	66,088,903 - 66,160,527 (+)	NCBI		HuRef
CHM1_1	5	70,315,816 - 70,387,189 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	72,068,680 - 72,140,018 (+)	NCBI		T2T-CHM13v2.0

Mccc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	33,039,044 - 33,110,092 (-)	NCBI		GRCr8
mRatBN7.2	2	31,304,927 - 31,375,978 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	31,304,932 - 31,375,972 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	38,383,154 - 38,454,061 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	36,477,507 - 36,548,413 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	31,270,308 - 31,341,430 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	30,175,017 - 30,246,028 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	30,175,018 - 30,246,010 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	49,333,901 - 49,404,647 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	30,961,607 - 31,032,883 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	30,881,976 - 30,953,252 (-)	NCBI
Celera	2	27,327,945 - 27,397,754 (-)	NCBI		Celera
Cytogenetic Map	2	q12	NCBI

Mccc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955575	445,619 - 505,040 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955575	445,627 - 503,891 (+)	NCBI	ChiLan1.0	ChiLan1.0

MCCC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	43,651,293 - 43,726,414 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	41,804,951 - 41,880,028 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	43,650,993 - 43,724,877 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	44,298,650 - 44,369,106 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	44,298,650 - 44,369,106 (-)	Ensembl	panpan1.1		panPan2

MCCC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	54,751,703 - 54,825,133 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	54,751,698 - 54,823,273 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	51,718,218 - 51,791,623 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	55,265,241 - 55,340,500 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	55,265,213 - 55,340,215 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	52,327,887 - 52,401,292 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	53,094,755 - 53,168,219 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	53,986,123 - 54,059,570 (+)	NCBI		UU_Cfam_GSD_1.0

Mccc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	186,028,772 - 186,100,599 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936549	4,755,546 - 4,830,242 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936549	4,760,073 - 4,830,190 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MCCC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	47,917,291 - 47,996,534 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	47,917,308 - 47,996,540 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	51,863,689 - 51,939,708 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MCCC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	65,944,742 - 66,013,663 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	65,944,840 - 66,013,663 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666049	14,689,886 - 14,759,320 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mccc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624905	645,715 - 712,364 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624905	645,782 - 709,611 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mccc2
13 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	90
Count of miRNA genes:	76
Interacting mature miRNAs:	86
Transcripts:	ENSMUST00000022148
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4142147	Mvwf4_m	modifier of von Willebrand factor 4 (mouse)			Not determined			20477612	112898424	Mouse
4142314	Tailaq3_m	tail length adjusted QTL 3 (mouse)			Not determined			55720354	112431103	Mouse
4140959	W10q17_m	weight 10 weeks QTL 17 (mouse)			Not determined			55720354	112431103	Mouse
4141992	W6q16_m	weight 6 weeks QTL 16 (mouse)			Not determined			55720354	112431103	Mouse
4142241	Tailq3_m	tail length QTL 3 (mouse)			Not determined			55720354	112431103	Mouse
10402414	Sgp5_m	serum gp70 production 5 (mouse)			Not determined		13	56470456	105422186	Mouse
1301445	Listr2_m	listeriosis resistance 2 (mouse)			Not determined		13	66744601	100744746	Mouse
1301593	Heal8_m	wound healing/regeneration 8 (mouse)			Not determined		13	68053999	102054119	Mouse
14696726	Kidrq3_m	kidney weight, right QTL 3 (mouse)					13	68217066	102217066	Mouse
14747007	Mancz11_m	mandible centroid size 11 (mouse)					13	70111284	104111284	Mouse
4141266	Mol3_m	modifier of LPS-response 3 (mouse)			Not determined			76132600	112431103	Mouse
12880414	V125Dq10_m	vitamin D active form serum level QTL 10 (mouse)					13	78036508	112036508	Mouse
10043997	Bw40_m	body weight QTL 40 (mouse)			Not determined		14	79239045	113239162	Mouse
10045623	Heal18_m	wound healing regeneration 18 (mouse)			Not determined		13	79239045	113239162	Mouse
1558741	Ses10_m	salmonella enteritidis susceptibility 10 (mouse)			Not determined		13	82739968	116740106	Mouse
4142465	Pbwg17_m	postnatal body weight growth 17 (mouse)			Not determined		13	83876060	117876256	Mouse
14700691	Cisaq1_m	coxsackieviral infection serum ALT QTL 1 (mouse)					13	86148119	120461536	Mouse
4140995	Fbtq6_m	femoral bone trait QTL 6 (mouse)			Not determined		13	86341617	120341758	Mouse
4141728	Egaq4_m	early growth adjusted QTL 4 (mouse)			Not determined			87901985	112431103	Mouse
1300939	Hrtfm6_m	heart failure modifier 6 (mouse)			Not determined		13	91383692	120883175	Mouse
1300876	Tanidd2_m	tally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)			Not determined		13	91965303	120883175	Mouse
1301142	Heal2_m	wound healing/regeneration 2 (mouse)			Not determined		13	93875267	120883175	Mouse
4142338	Skmw18_m	skeletal muscle weight 18 (mouse)			Not determined		13	94528399	120883175	Mouse
1558763	Gct9_m	granulosa cell tumorigenesis 9 (mouse)			Not determined		13	95036824	120883175	Mouse
1357468	Rplag_m	reduced platelet aggregation (mouse)			Not determined		13	95502130	120883175	Mouse
14746974	Manh75_m	mandible shape 75 (mouse)					13	99386647	120883175	Mouse
4141102	Sod1m_m	superoxide dismutase 1, soluble, modifier (mouse)			Not determined			99739968	110699911	Mouse

Markers in Region

D13Die38

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	99,960,709 - 99,960,979	UniSTS	GRCm38
MGSCv37	13	100,730,664 - 100,730,934	UniSTS	GRCm37
Celera	13	103,613,790 - 103,614,060	UniSTS
Cytogenetic Map	13	D1	UniSTS
cM Map	13	52.5	UniSTS

D13Die39

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	99,991,490 - 99,991,682	UniSTS	GRCm38
MGSCv37	13	100,761,445 - 100,761,637	UniSTS	GRCm37
Celera	13	103,645,137 - 103,645,329	UniSTS
Cytogenetic Map	13	D1	UniSTS
cM Map	13	52.6	UniSTS

D13Die40

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	100,003,624 - 100,003,942	UniSTS	GRCm38
MGSCv37	13	100,773,579 - 100,773,897	UniSTS	GRCm37
Celera	13	103,657,271 - 103,657,589	UniSTS
Cytogenetic Map	13	D1	UniSTS
cM Map	13	52.7	UniSTS

11.MMHAP69FLD2.seq

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	99,962,175 - 99,962,353	UniSTS	GRCm38
MGSCv37	13	100,732,130 - 100,732,308	UniSTS	GRCm37
Celera	13	103,615,268 - 103,615,446	UniSTS
Cytogenetic Map	13	D1	UniSTS
Whitehead/MRC_RH	13	859.39	UniSTS
Whitehead_YAC	13		UniSTS

D13Die20

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	100,003,659 - 100,003,803	UniSTS	GRCm38
MGSCv37	13	100,773,614 - 100,773,758	UniSTS	GRCm37
Celera	13	103,657,306 - 103,657,450	UniSTS
Cytogenetic Map	13	D1	UniSTS
cM Map	13	54.0	UniSTS

D13Die5

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	100,013,611 - 100,013,736	UniSTS	GRCm38
MGSCv37	13	100,783,566 - 100,783,691	UniSTS	GRCm37
Celera	13	103,667,257 - 103,667,380	UniSTS
Cytogenetic Map	13	D1	UniSTS
cM Map	13	54.0	UniSTS

D13Die8

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	13	99,961,574 - 99,961,741	UniSTS	GRCm38
MGSCv37	13	100,731,529 - 100,731,696	UniSTS	GRCm37
Celera	13	103,614,667 - 103,614,834	UniSTS
Cytogenetic Map	13	D1	UniSTS
cM Map	13	54.0	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_030026	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK019760	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK132265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK143233	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK145564	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK146844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK146865	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC027640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC033050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC040098	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC051500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC058987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC141193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC141194	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ551658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY138007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY237319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY276243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BY713615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CAAA01112283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK620826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT025569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000022148 ⟹ ENSMUSP00000022148

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	100,085,041 - 100,152,147 (-)	Ensembl
GRCm38.p6 Ensembl	13	99,948,533 - 100,015,639 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000221034

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	100,085,038 - 100,097,558 (-)	Ensembl
GRCm38.p6 Ensembl	13	99,948,530 - 99,961,050 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000221344 ⟹ ENSMUSP00000152799

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	100,126,830 - 100,152,102 (-)	Ensembl
GRCm38.p6 Ensembl	13	99,990,322 - 100,015,594 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000221846

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	100,138,800 - 100,152,126 (-)	Ensembl
GRCm38.p6 Ensembl	13	100,002,292 - 100,015,618 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000222083 ⟹ ENSMUSP00000152781

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	100,085,038 - 100,108,324 (-)	Ensembl
GRCm38.p6 Ensembl	13	99,948,530 - 99,971,816 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000223013

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	13	100,094,999 - 100,111,824 (-)	Ensembl
GRCm38.p6 Ensembl	13	99,958,491 - 99,975,316 (-)	Ensembl

RefSeq Acc Id:

NM_030026 ⟹ NP_084302

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	13	100,085,040 - 100,152,147 (-)	NCBI
GRCm38	13	99,948,532 - 100,015,639 (-)	NCBI
MGSCv37	13	100,718,487 - 100,785,594 (-)	RGD
Celera	13	103,601,615 - 103,669,283 (-)	RGD
cM Map	13		ENTREZGENE

Sequence:

show sequence

GGGGCTGGCCTGGGAGCTGATGGACCAGGGCTGGTGCTGCAAGGACTCTGGAGGAGCAGCCCCC
AGGAGCTGCAGAACCGAGCTGCAGGGCCGCTCTCTTTCTCTTTTGGGTGTTTGCCATCGCCATG
TGGGGCGCGCTGAGGTCAGCTCTGCGACCGTGCTGTCGGGCTGCTGTACCCCCGCAGCGTGCCT
ATCACGGGGACTCAGTGGCCCGACTGGGCACCCAGCCTGACTCGGCCTCCTCCACCTACCAGGA
GAACTATGAGCAGATGAAAGCTTTAGTGAGTCAACTTCATGAGCGAGCCCAGTATGTGAGACTA
GGAGGGAGTGAGAAGGCCCGGGCGCGGCACACATCCAGAGGAAAACTGCTCCCCAGAGACAGAA
TCGACAATCTCATAGACCCAGGGTCTCCCTTTCTGGAATTCTCCCAGTTTGCAGGTTACCAGTT
ATATGGCGACGAGGAAGTCCCCGCCGGTGGCATCATCACGGGCATTGGGCGAGTGTCGGGGGTA
GAATGCATGATTGTGGCTAACGATGCCACCGTCAAAGGAGGCACCTACTACCCAGTGACTGTGA
AAAAGCACGTGCGGGCACAAGAGATTGCGCTGCAGAACCGACTCCCATGCATCTATCTGGTTGA
CTCAGGAGGGGCCAACTTACCTCGGCAAGCAGACACCTTTCCAGACCGGGACCACTTTGGCCGC
ATATTCTATAATCAGGCAATTATGTCTTCTAAAAACATCACACAGATAGCTGTGGTCATGGGCT
CCTGTACGGCAGGAGGTGCGTATGTGCCTGCAATGGCTGATGAAAACATCATTGTACAGAAGCA
GGGTACCATCTTCTTGGCTGGACCACCCTTGGTGAAGGCAGCTACAGGTGAAGAGGTGTCCGCT
GAGGATCTCGGAGGTGCCGACCTGCATTGCAGAAAGTCTGGGGTCACTGACCACTATGCTTTGG
ACGACCACCACGCCCTCCACTTAACAAGGAAGGTTGTGAGGAGTCTCAATTATCAGAAGAAAAT
GGATGTTACCATTGAGCCTTCTGAGGAGCCCTTGTTCCCTGCAGATGAGCTCTATGGAATAGTT
GGTGCAAACCTGAAGAGGAGCTTTGATGTCCGAGAGGTCATTGCTAGAATCGTGGATGGAAGCA
GATTCAATGAGTTCAAGGCCTTATATGGAGACACCCTAGTTACAGGATTTGCTCGAATATTTGG
GTACCCCGTTGGCATCATTGGAAACAATGGAGTTTTGTTTTCTGAATCTGCTAAGAAGGGTGCT
CACTTCGTCCAGCTGTGCTGCCAGAGAAATATCCCTCTGCTGTTTCTTCAGAATATCACCGGAT
TCATGGTTGGCAGAGACTATGAAGCTGAAGGGATTGCCAAGGATGGTGCCAAAATGGTAGCTGC
AGTAGCCTGTGCCAAAGTGCCTAAGATAACTGTCATAATTGGGGGATCGTACGGGGCTGGAAAC
TACGGAATGTGTGGCAGAGCATACAGTCCAAGGTTTCTCTACATGTGGCCAAATGCCCGCATCT
CTGTGATGGGAGGAGAGCAGGCAGCCACGGTGTTAGCCACAGTGGCTAGAGACCAGAAAGCACG
CGAGGGGAAGCAGTTCTCCAGTGCAGAGGAGGCAGCTTTGAAAGAACCCATCATTAAGAGGTTC
GAAGAGGAAGGGAACCCTTACTACTCTAGTGCAAGGCTGTGGGACGATGGGATTATTGACCCGG
TGGACACCAGGCTGGTCCTGGGGCTCAGCCTCAGTGCAGCCCTCAATGCGCCCATCCAGAGGAC
TGACTTTGGCATCTTCAGGATGTAACCCAGATATGGAACATGCTGCCACACCCGTAACAAGAAT
TAGCGCGTGTAACTAGCCTTGAAACTTGAGATTTACTGGACATGTAGCTGTCACAGGAATTCTT
TTCTTAACAGTATGATTTGTTAAAACTGTGAAAATCAGTGACTAGTCTGCCTGATGAGCTTTGA
CTTTTTTTTTAAAAAAAAATTTTTTTCTTACAGACATTTTTCACGGCTCATTTTTACCACCCAT
AAAATGAAGAGAGCGATTTTGCAATTATCCTTTGAGTACCACAAACAGTATGAAAAATAAATCT
CTTTAATCTGTAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_084302	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH27640	(Get FASTA)	NCBI Sequence Viewer
	AAH58987	(Get FASTA)	NCBI Sequence Viewer
	AAI41194	(Get FASTA)	NCBI Sequence Viewer
	AAI41195	(Get FASTA)	NCBI Sequence Viewer
	BAB31847	(Get FASTA)	NCBI Sequence Viewer
	BAE21068	(Get FASTA)	NCBI Sequence Viewer
	BAE25319	(Get FASTA)	NCBI Sequence Viewer
	BAE26513	(Get FASTA)	NCBI Sequence Viewer
	BAE27475	(Get FASTA)	NCBI Sequence Viewer
	BAE27489	(Get FASTA)	NCBI Sequence Viewer
	EDL00826	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000022148
	ENSMUSP00000022148.7
	ENSMUSP00000152781.2
	ENSMUSP00000152799.2
GenBank Protein	Q3ULD5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_084302 ⟸ NM_030026

- UniProtKB:

Q3UPS6 (UniProtKB/Swiss-Prot), Q3ULD5 (UniProtKB/Swiss-Prot), B2RUK5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWGALRSALRPCCRAAVPPQRAYHGDSVARLGTQPDSASSTYQENYEQMKALVSQLHERAQYVR
LGGSEKARARHTSRGKLLPRDRIDNLIDPGSPFLEFSQFAGYQLYGDEEVPAGGIITGIGRVSG
VECMIVANDATVKGGTYYPVTVKKHVRAQEIALQNRLPCIYLVDSGGANLPRQADTFPDRDHFG
RIFYNQAIMSSKNITQIAVVMGSCTAGGAYVPAMADENIIVQKQGTIFLAGPPLVKAATGEEVS
AEDLGGADLHCRKSGVTDHYALDDHHALHLTRKVVRSLNYQKKMDVTIEPSEEPLFPADELYGI
VGANLKRSFDVREVIARIVDGSRFNEFKALYGDTLVTGFARIFGYPVGIIGNNGVLFSESAKKG
AHFVQLCCQRNIPLLFLQNITGFMVGRDYEAEGIAKDGAKMVAAVACAKVPKITVIIGGSYGAG
NYGMCGRAYSPRFLYMWPNARISVMGGEQAATVLATVARDQKAREGKQFSSAEEAALKEPIIKR
FEEEGNPYYSSARLWDDGIIDPVDTRLVLGLSLSAALNAPIQRTDFGIFRM

hide sequence

RefSeq Acc Id:

ENSMUSP00000152781 ⟸ ENSMUST00000222083

RefSeq Acc Id:

ENSMUSP00000022148 ⟸ ENSMUST00000022148

RefSeq Acc Id:

ENSMUSP00000152799 ⟸ ENSMUST00000221344

Protein Domains

CoA carboxyltransferase C-terminal CoA carboxyltransferase N-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q3ULD5-F1-model_v2	AlphaFold	Q3ULD5	1-563	view protein structure

Promoters

RGD ID:

8681148

Promoter ID:

EPDNEW_M18605

Type:

initiation region

Name:

Mccc2_1

Description:

Mus musculus methylcrotonoyl-Coenzyme A carboxylase 2 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	13	100,015,618 - 100,015,678	EPDNEW

RGD ID:

6824137

Promoter ID:

MM_KWN:15058

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, 3T3L1_Day4, 3T3L1_Day6, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B4, MEF_B6, Spleen

Transcripts:

ENSMUST00000091326, NM_030026

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	13	100,785,379 - 100,785,879 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1925288	AgrOrtholog
Ensembl Genes	ENSMUSG00000021646	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000022148	ENTREZGENE
	ENSMUST00000022148.7	UniProtKB/Swiss-Prot
	ENSMUST00000221344.2	UniProtKB/TrEMBL
	ENSMUST00000222083.2	UniProtKB/TrEMBL
InterPro	AcCoA_carboxyl	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ClpP/crotonase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COA_CT_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COA_CT_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MCCB/AccD1-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:78038	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD	MGI:1925288	ENTREZGENE
NCBI Gene	78038	ENTREZGENE
PANTHER	METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR22855	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Carboxyl_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	MCCC2	RGD
PhenoGen	Mccc2	PhenoGen
PROSITE	COA_CT_CTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	COA_CT_NTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF52096	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A1Y7VK60_MOUSE	UniProtKB/TrEMBL
	B2RUK5	ENTREZGENE, UniProtKB/TrEMBL
	MCCB_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q3UPS6	ENTREZGENE
	Q6PD20_MOUSE	UniProtKB/TrEMBL
	Q8K1L7_MOUSE	UniProtKB/TrEMBL
	Q9D2F6_MOUSE	UniProtKB/TrEMBL
UniProt Secondary	Q3UPS6	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype