OSBPL7 (oxysterol binding protein like 7) - Rat Genome Database

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Gene: OSBPL7 (oxysterol binding protein like 7) Homo sapiens
Analyze
Symbol: OSBPL7
Name: oxysterol binding protein like 7
RGD ID: 1319316
HGNC Page HGNC:16387
Description: Enables cholesterol binding activity. Involved in cellular response to cholesterol and positive regulation of proteasomal protein catabolic process. Located in several cellular components, including autophagosome; nucleoplasm; and perinuclear endoplasmic reticulum. Biomarker of cholangiocarcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC71150; ORP-7; ORP7; OSBP-related protein 7; oxysterol binding protein-like 7; oxysterol-binding protein-related protein 7
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,807,372 - 47,821,794 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,807,372 - 47,821,803 (-)EnsemblGRCh38hg38GRCh38
GRCh371745,884,738 - 45,899,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,239,732 - 43,254,146 (-)NCBINCBI36Build 36hg18NCBI36
Build 341743,239,731 - 43,254,146NCBI
Celera1742,337,538 - 42,351,952 (-)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,253,652 - 41,268,065 (-)NCBIHuRef
CHM1_11745,949,693 - 45,964,103 (-)NCBICHM1_1
T2T-CHM13v2.01748,669,144 - 48,683,591 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis. Loilome W, etal., Parasitol Int. 2012 Mar;61(1):136-9. doi: 10.1016/j.parint.2011.07.003. Epub 2011 Jul 8.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:11483621   PMID:11735225   PMID:12477932   PMID:14593528   PMID:15489334   PMID:17428193   PMID:18976975   PMID:19913121   PMID:20379614   PMID:20628086   PMID:20686565  
PMID:21669198   PMID:21873635   PMID:23535033   PMID:24097068   PMID:25544563   PMID:28986522   PMID:32393512   PMID:33961781  


Genomics

Comparative Map Data
OSBPL7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,807,372 - 47,821,794 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1747,807,372 - 47,821,803 (-)EnsemblGRCh38hg38GRCh38
GRCh371745,884,738 - 45,899,160 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,239,732 - 43,254,146 (-)NCBINCBI36Build 36hg18NCBI36
Build 341743,239,731 - 43,254,146NCBI
Celera1742,337,538 - 42,351,952 (-)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1741,253,652 - 41,268,065 (-)NCBIHuRef
CHM1_11745,949,693 - 45,964,103 (-)NCBICHM1_1
T2T-CHM13v2.01748,669,144 - 48,683,591 (-)NCBIT2T-CHM13v2.0
Osbpl7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391196,941,459 - 96,959,730 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1196,941,454 - 96,959,730 (+)EnsemblGRCm39 Ensembl
GRCm381197,050,633 - 97,068,904 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1197,050,628 - 97,068,904 (+)EnsemblGRCm38mm10GRCm38
MGSCv371196,912,134 - 96,930,218 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361196,866,716 - 96,884,994 (+)NCBIMGSCv36mm8
Celera11106,702,278 - 106,720,368 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1160.75NCBI
Osbpl7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81082,532,335 - 82,549,999 (+)NCBIGRCr8
mRatBN7.21082,035,995 - 82,053,566 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,036,042 - 82,053,557 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1086,983,948 - 87,001,614 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01086,481,998 - 86,499,664 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01081,874,581 - 81,892,251 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01084,986,330 - 85,003,947 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1084,986,328 - 85,004,562 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01084,776,868 - 84,794,432 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41085,771,941 - 85,789,490 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11085,787,018 - 85,803,123 (+)NCBI
Celera1080,797,350 - 80,814,860 (+)NCBICelera
Cytogenetic Map10q31NCBI
Osbpl7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545113,291,577 - 13,300,322 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545113,289,938 - 13,301,243 (+)NCBIChiLan1.0ChiLan1.0
OSBPL7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21917,281,312 - 17,295,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11719,246,921 - 19,261,400 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0179,715,464 - 9,729,950 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,897,612 - 9,912,065 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,897,768 - 9,912,065 (+)Ensemblpanpan1.1panPan2
OSBPL7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1924,139,641 - 24,156,692 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl924,139,630 - 24,154,924 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha923,607,684 - 23,624,709 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0924,934,673 - 24,951,704 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl924,934,695 - 24,949,974 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1923,704,814 - 23,721,844 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,965,653 - 23,982,678 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0924,092,310 - 24,109,348 (-)NCBIUU_Cfam_GSD_1.0
Osbpl7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560223,564,229 - 23,583,463 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649013,491,544 - 13,506,768 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649013,491,704 - 13,506,742 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSBPL7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1224,059,124 - 24,076,109 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11224,059,128 - 24,075,102 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,930,641 - 23,952,287 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OSBPL7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11668,208,121 - 68,222,684 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607739,258,654 - 39,273,203 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Osbpl7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247954,469,551 - 4,479,798 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247954,468,767 - 4,479,654 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OSBPL7
32 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2		 pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3		 pathogenic
GRCh38/hg38 17q21.31-21.33(chr17:44955325-49381173)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052480]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052480]|See cases [RCV000052480] Chr17:44955325..49381173 [GRCh38]
Chr17:43032693..47458535 [GRCh37]
Chr17:40388219..44813534 [NCBI36]
Chr17:17q21.31-21.33		 pathogenic
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1		 pathogenic
GRCh38/hg38 17q21.32(chr17:47686487-47986961)x1 copy number loss See cases [RCV000134967] Chr17:47686487..47986961 [GRCh38]
Chr17:45763853..46064327 [GRCh37]
Chr17:43118852..43419326 [NCBI36]
Chr17:17q21.32		 likely pathogenic|uncertain significance
chr17:45008570..45994044 complex variant complex Breast ductal adenocarcinoma [RCV000207217] Chr17:45008570..45994044 [GRCh37]
Chr17:17q21.32		 uncertain significance
GRCh37/hg19 17q21.31-25.3(chr17:42580684-81085615)x3 copy number gain See cases [RCV000447823] Chr17:42580684..81085615 [GRCh37]
Chr17:17q21.31-25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938) copy number gain See cases [RCV000511439] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:526-81041938)x3 copy number gain See cases [RCV000512441] Chr17:526..81041938 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17q21.32(chr17:45884442-46124946)x3 copy number gain not provided [RCV000683940] Chr17:45884442..46124946 [GRCh37]
Chr17:17q21.32		 uncertain significance
GRCh37/hg19 17p13.3-q25.3(chr17:12344-81057996)x3 copy number gain not provided [RCV000739325] Chr17:12344..81057996 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:8547-81060040)x3 copy number gain not provided [RCV000739324] Chr17:8547..81060040 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
GRCh37/hg19 17p13.3-q25.3(chr17:7214-81058310)x3 copy number gain not provided [RCV000739320] Chr17:7214..81058310 [GRCh37]
Chr17:17p13.3-q25.3		 pathogenic
NM_145798.3(OSBPL7):c.1712G>T (p.Arg571Leu) single nucleotide variant Inborn genetic diseases [RCV003242778] Chr17:47813291 [GRCh38]
Chr17:45890657 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1078G>A (p.Asp360Asn) single nucleotide variant Encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 [RCV000770960] Chr17:47816148 [GRCh38]
Chr17:45893514 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1339C>T (p.Arg447Cys) single nucleotide variant Inborn genetic diseases [RCV003241437] Chr17:47814533 [GRCh38]
Chr17:45891899 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1340G>A (p.Arg447His) single nucleotide variant Inborn genetic diseases [RCV003239806] Chr17:47814532 [GRCh38]
Chr17:45891898 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.566G>A (p.Arg189Lys) single nucleotide variant Inborn genetic diseases [RCV003294803] Chr17:47818301 [GRCh38]
Chr17:45895667 [GRCh37]
Chr17:17q21.32		 uncertain significance
GRCh37/hg19 17q21.32(chr17:44949883-46507482) copy number gain PNPO-related disorders [RCV003236737] Chr17:44949883..46507482 [GRCh37]
Chr17:17q21.32		 likely pathogenic
NM_145798.3(OSBPL7):c.461C>T (p.Pro154Leu) single nucleotide variant Inborn genetic diseases [RCV002945685] Chr17:47818525 [GRCh38]
Chr17:45895891 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1150C>T (p.Leu384Phe) single nucleotide variant Inborn genetic diseases [RCV002836675] Chr17:47815322 [GRCh38]
Chr17:45892688 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.2087G>A (p.Arg696His) single nucleotide variant Inborn genetic diseases [RCV002707243] Chr17:47809159 [GRCh38]
Chr17:45886525 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1051C>T (p.Arg351Cys) single nucleotide variant Inborn genetic diseases [RCV002884910] Chr17:47816175 [GRCh38]
Chr17:45893541 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.682C>T (p.Pro228Ser) single nucleotide variant Inborn genetic diseases [RCV002910290] Chr17:47817276 [GRCh38]
Chr17:45894642 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1966G>A (p.Glu656Lys) single nucleotide variant Inborn genetic diseases [RCV002844653] Chr17:47809393 [GRCh38]
Chr17:45886759 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.707C>T (p.Ser236Leu) single nucleotide variant Inborn genetic diseases [RCV002830713] Chr17:47816868 [GRCh38]
Chr17:45894234 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.2132G>A (p.Arg711Gln) single nucleotide variant Inborn genetic diseases [RCV002803643] Chr17:47809114 [GRCh38]
Chr17:45886480 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1987C>G (p.Gln663Glu) single nucleotide variant Inborn genetic diseases [RCV002930079] Chr17:47809372 [GRCh38]
Chr17:45886738 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1387C>T (p.Arg463Cys) single nucleotide variant Inborn genetic diseases [RCV003004716] Chr17:47813799 [GRCh38]
Chr17:45891165 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1406C>T (p.Ala469Val) single nucleotide variant Inborn genetic diseases [RCV002719979] Chr17:47813780 [GRCh38]
Chr17:45891146 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.293G>A (p.Arg98Gln) single nucleotide variant Inborn genetic diseases [RCV002669992] Chr17:47819062 [GRCh38]
Chr17:45896428 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.2119G>C (p.Glu707Gln) single nucleotide variant Inborn genetic diseases [RCV002648341] Chr17:47809127 [GRCh38]
Chr17:45886493 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1912A>G (p.Thr638Ala) single nucleotide variant Inborn genetic diseases [RCV002959944] Chr17:47809447 [GRCh38]
Chr17:45886813 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.247C>T (p.Arg83Trp) single nucleotide variant Inborn genetic diseases [RCV002939759] Chr17:47819737 [GRCh38]
Chr17:45897103 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1625C>T (p.Ser542Leu) single nucleotide variant Inborn genetic diseases [RCV003254776] Chr17:47813378 [GRCh38]
Chr17:45890744 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.371T>A (p.Ile124Asn) single nucleotide variant Inborn genetic diseases [RCV003256576] Chr17:47818615 [GRCh38]
Chr17:45895981 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.848G>A (p.Arg283Gln) single nucleotide variant Inborn genetic diseases [RCV003192672] Chr17:47816643 [GRCh38]
Chr17:45894009 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.412C>T (p.Arg138Cys) single nucleotide variant Inborn genetic diseases [RCV003259565] Chr17:47818574 [GRCh38]
Chr17:45895940 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.863C>T (p.Thr288Ile) single nucleotide variant Inborn genetic diseases [RCV003357551] Chr17:47816628 [GRCh38]
Chr17:45893994 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1722C>T (p.Arg574=) single nucleotide variant not provided [RCV003419767] Chr17:47813281 [GRCh38]
Chr17:45890647 [GRCh37]
Chr17:17q21.32		 likely benign
NM_145798.3(OSBPL7):c.449G>A (p.Arg150His) single nucleotide variant Inborn genetic diseases [RCV003366419] Chr17:47818537 [GRCh38]
Chr17:45895903 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.1654G>A (p.Gly552Ser) single nucleotide variant Inborn genetic diseases [RCV003353525] Chr17:47813349 [GRCh38]
Chr17:45890715 [GRCh37]
Chr17:17q21.32		 uncertain significance
NM_145798.3(OSBPL7):c.795+8C>T single nucleotide variant not provided [RCV003428321] Chr17:47816772 [GRCh38]
Chr17:45894138 [GRCh37]
Chr17:17q21.32		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4921
Count of miRNA genes:1054
Interacting mature miRNAs:1343
Transcripts:ENST00000007414, ENST00000392507, ENST00000578461, ENST00000579728, ENST00000580140, ENST00000580226, ENST00000580808, ENST00000583167, ENST00000584698, ENST00000585051
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH64830  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371745,900,932 - 45,901,090UniSTSGRCh37
Build 361743,255,931 - 43,256,089RGDNCBI36
Celera1742,353,737 - 42,353,895RGD
Cytogenetic Map17q21UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef1741,269,844 - 41,270,002UniSTS
G59312  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371745,900,961 - 45,901,115UniSTSGRCh37
Build 361743,255,960 - 43,256,114RGDNCBI36
Celera1742,353,766 - 42,353,920RGD
Cytogenetic Map17q21UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef1741,269,873 - 41,270,027UniSTS
STS-AA039646  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371745,900,866 - 45,901,107UniSTSGRCh37
Build 361743,255,865 - 43,256,106RGDNCBI36
Celera1742,353,671 - 42,353,912RGD
Cytogenetic Map17q21UniSTS
Cytogenetic Map17q21.32UniSTS
HuRef1741,269,778 - 41,270,019UniSTS
GeneMap99-GB4 RH Map17337.7UniSTS
NCBI RH Map17604.8UniSTS
MARC_23479-23480:1041546652:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371745,896,408 - 45,897,382UniSTSGRCh37
Build 361743,251,407 - 43,252,381RGDNCBI36
Celera1742,349,213 - 42,350,187RGD
HuRef1741,265,326 - 41,266,300UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1362 1158 974 146 940 19 1367 456 2276 105 839 1347 135 407 1129
Low 1075 1830 726 452 1005 420 2988 1739 1458 313 612 261 40 1 797 1659 3 2
Below cutoff 2 2 26 26 4 26 1 2 1 7 4 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017024125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047435293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054314946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001752423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008484778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_934362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB208886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC003665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF323729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF392446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI955239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC028010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM674891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000007414   ⟹   ENSP00000007414
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,807,372 - 47,821,794 (-)Ensembl
RefSeq Acc Id: ENST00000392507   ⟹   ENSP00000376295
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,807,373 - 47,821,834 (-)Ensembl
RefSeq Acc Id: ENST00000578461   ⟹   ENSP00000464624
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,808,216 - 47,809,115 (-)Ensembl
RefSeq Acc Id: ENST00000579728   ⟹   ENSP00000463599
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,807,374 - 47,820,858 (-)Ensembl
RefSeq Acc Id: ENST00000580140
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,815,288 - 47,821,803 (-)Ensembl
RefSeq Acc Id: ENST00000580226
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,819,333 - 47,821,781 (-)Ensembl
RefSeq Acc Id: ENST00000580808
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,816,266 - 47,816,924 (-)Ensembl
RefSeq Acc Id: ENST00000583167
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,807,373 - 47,817,001 (-)Ensembl
RefSeq Acc Id: ENST00000584698
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,816,587 - 47,819,138 (-)Ensembl
RefSeq Acc Id: ENST00000585051
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,819,721 - 47,821,741 (-)Ensembl
RefSeq Acc Id: ENST00000613735   ⟹   ENSP00000479827
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1747,807,375 - 47,821,780 (-)Ensembl
RefSeq Acc Id: NM_145798   ⟹   NP_665741
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,807,372 - 47,821,794 (-)NCBI
GRCh371745,884,733 - 45,899,169 (-)NCBI
Build 361743,239,732 - 43,254,146 (-)NCBI Archive
Celera1742,337,538 - 42,351,952 (-)RGD
HuRef1741,253,652 - 41,268,065 (-)RGD
CHM1_11745,949,693 - 45,964,103 (-)NCBI
T2T-CHM13v2.01748,669,144 - 48,683,562 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047435292   ⟹   XP_047291248
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,807,372 - 47,821,794 (-)NCBI
RefSeq Acc Id: XM_047435293   ⟹   XP_047291249
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,807,372 - 47,821,794 (-)NCBI
RefSeq Acc Id: XM_054314946   ⟹   XP_054170921
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01748,669,144 - 48,683,591 (-)NCBI
RefSeq Acc Id: XR_008484778
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01748,670,340 - 48,683,562 (-)NCBI
RefSeq Acc Id: XR_934362
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,808,568 - 47,821,794 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_665741   ⟸   NM_145798
- UniProtKB: D3DTT6 (UniProtKB/Swiss-Prot),   Q6PIV6 (UniProtKB/Swiss-Prot),   Q9BZF2 (UniProtKB/Swiss-Prot),   Q8WXP9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000007414   ⟸   ENST00000007414
RefSeq Acc Id: ENSP00000479827   ⟸   ENST00000613735
RefSeq Acc Id: ENSP00000376295   ⟸   ENST00000392507
RefSeq Acc Id: ENSP00000464624   ⟸   ENST00000578461
RefSeq Acc Id: ENSP00000463599   ⟸   ENST00000579728
RefSeq Acc Id: XP_047291249   ⟸   XM_047435293
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047291248   ⟸   XM_047435292
- Peptide Label: isoform X1
- UniProtKB: Q9BZF2 (UniProtKB/Swiss-Prot),   D3DTT6 (UniProtKB/Swiss-Prot),   Q6PIV6 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054170921   ⟸   XM_054314946
- Peptide Label: isoform X1
- UniProtKB: Q9BZF2 (UniProtKB/Swiss-Prot),   D3DTT6 (UniProtKB/Swiss-Prot),   Q6PIV6 (UniProtKB/Swiss-Prot)
Protein Domains
PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BZF2-F1-model_v2 AlphaFold Q9BZF2 1-842 view protein structure

Promoters
RGD ID:6794399
Promoter ID:HG_KWN:26459
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_145798
Position:
Human AssemblyChrPosition (strand)Source
Build 361743,253,881 - 43,254,381 (-)MPROMDB
RGD ID:7235425
Promoter ID:EPDNEW_H23458
Type:initiation region
Name:OSBPL7_1
Description:oxysterol binding protein like 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381747,821,779 - 47,821,839EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:16387 AgrOrtholog
COSMIC OSBPL7 COSMIC
Ensembl Genes ENSG00000006025 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000007414 ENTREZGENE
  ENST00000007414.8 UniProtKB/Swiss-Prot
  ENST00000578461.1 UniProtKB/TrEMBL
  ENST00000579728.5 UniProtKB/TrEMBL
  ENST00000613735.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.160.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.3490 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000006025 GTEx
HGNC ID HGNC:16387 ENTREZGENE
Human Proteome Map OSBPL7 Human Proteome Map
InterPro OSBP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxysterol-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Oxysterol-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:114881 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 114881 ENTREZGENE
OMIM 606735 OMIM
PANTHER OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10972 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Oxysterol_BP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA32831 PharmGKB
PROSITE OSBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF144000 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3DTT6 ENTREZGENE
  J3QLK7_HUMAN UniProtKB/TrEMBL
  J3QSC2_HUMAN UniProtKB/TrEMBL
  OSBL7_HUMAN UniProtKB/Swiss-Prot
  Q6PIV6 ENTREZGENE
  Q8WXP9 ENTREZGENE, UniProtKB/TrEMBL
  Q9BZF2 ENTREZGENE
UniProt Secondary D3DTT6 UniProtKB/Swiss-Prot
  Q6PIV6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 OSBPL7  oxysterol binding protein like 7  OSBPL7  oxysterol binding protein-like 7  Symbol and/or name change 5135510 APPROVED