Chil6 (chitinase-like 6) - Rat Genome Database

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Gene: Chil6 (chitinase-like 6) Mus musculus
Analyze
No known orthologs.
Symbol: Chil6
Name: chitinase-like 6
RGD ID: 1319266
MGI Page MGI
Description: Predicted to enable chitin binding activity; chitinase activity; and kinase binding activity. Predicted to be involved in chitin catabolic process; positive regulation of chemokine production; and production of molecular mediator involved in inflammatory response. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in lung. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BYm; Chil8; hypothetical protein LOC229688; MGC58999; uncharacterized protein LOC229688
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,294,700 - 106,313,517 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3106,294,700 - 106,313,498 (-)EnsemblGRCm39 Ensembl
GRCm383106,387,384 - 106,406,201 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3106,387,384 - 106,406,182 (-)EnsemblGRCm38mm10GRCm38
MGSCv373106,190,302 - 106,209,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363106,515,440 - 106,534,238 (-)NCBIMGSCv36mm8
Celera3108,719,306 - 108,738,110 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:21677750   PMID:21873635   PMID:23558346   PMID:28431248  


Genomics

Variants

.
Variants in Chil6
576 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:107
Count of miRNA genes:104
Interacting mature miRNAs:107
Transcripts:ENSMUST00000029510
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
10043955Wt10q4_mbody weight, 10 weeks, QTL 4 (mouse)Not determined398624041132624197Mouse
11533920Mvb3_mmodifier of vibrator 3 (mouse)398635284132635383Mouse
12792984Modn1_mmodifier of Dstn neovascularization 1 (mouse)398635284132635383Mouse
1302114Tbs1_mtuberculosis severity 1 (mouse)Not determined398924105132924250Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100372912147045722Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100607316137205761Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101307316149805637Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103482659137482783Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029510   ⟹   ENSMUSP00000029510
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl3106,294,700 - 106,313,498 (-)Ensembl
GRCm38.p6 Ensembl3106,387,384 - 106,406,182 (-)Ensembl
RefSeq Acc Id: NM_178412   ⟹   NP_848499
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393106,294,700 - 106,313,498 (-)NCBI
GRCm383106,387,384 - 106,406,182 (-)NCBI
MGSCv373106,190,302 - 106,209,100 (-)RGD
Celera3108,719,306 - 108,738,110 (-)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017319554   ⟹   XP_017175043
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393106,294,719 - 106,313,517 (-)NCBI
GRCm383106,387,403 - 106,406,201 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003954316
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393106,294,719 - 106,313,517 (-)NCBI
GRCm383106,387,403 - 106,406,201 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_848499 (Get FASTA)   NCBI Sequence Viewer  
  XP_017175043 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH51070 (Get FASTA)   NCBI Sequence Viewer  
  EDL01868 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000029510
  ENSMUSP00000029510.8
Reference Protein Sequences
RefSeq Acc Id: NP_848499   ⟸   NM_178412
- UniProtKB: Q80W26 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017175043   ⟸   XM_017319554
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000029510   ⟸   ENSMUST00000029510
Protein Domains
GH18

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80W26-F1-model_v2 AlphaFold Q80W26 1-440 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2682303 AgrOrtholog
Ensembl Genes ENSMUSG00000027902 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000029510 ENTREZGENE
  ENSMUST00000029510.9 UniProtKB/TrEMBL
Gene3D-CATH 3.10.50.10 UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
InterPro Chitinase_II UniProtKB/TrEMBL
  Chitinase_insertion UniProtKB/TrEMBL
  Glyco_hydro18cat UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
KEGG Report mmu:229688 UniProtKB/TrEMBL
MGD MGI:2682303 ENTREZGENE
NCBI Gene 229688 ENTREZGENE
PANTHER CHITINASE UniProtKB/TrEMBL
  CHITINASE-LIKE 6 UniProtKB/TrEMBL
Pfam Glyco_hydro_18 UniProtKB/TrEMBL
PhenoGen Chil6 PhenoGen
PROSITE GH18_2 UniProtKB/TrEMBL
SMART Glyco_18 UniProtKB/TrEMBL
Superfamily-SCOP Glyco_hydro_cat UniProtKB/TrEMBL
  SSF54556 UniProtKB/TrEMBL
UniProt Q80W26 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-03 Chil6  chitinase-like 6  BC051070  cDNA sequence BC051070  Symbol and/or name change 5135510 APPROVED