MS4A8 (membrane spanning 4-domains A8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MS4A8 (membrane spanning 4-domains A8) Homo sapiens
Analyze
Symbol: MS4A8
Name: membrane spanning 4-domains A8
RGD ID: 1319151
HGNC Page HGNC:13380
Description: Predicted to be involved in cell surface receptor signaling pathway. Located in plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 4SPAN4; CD20L5; four-span transmembrane protein 4; membrane-spanning 4-domains subfamily A member 8; membrane-spanning 4-domains subfamily A member 8B; membrane-spanning 4-domains, subfamily A, member 8; membrane-spanning 4-domains, subfamily A, member 8B; MS4A4; MS4A8B
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,699,612 - 60,715,807 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,699,585 - 60,715,807 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,467,085 - 60,483,280 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,223,623 - 60,239,860 (+)NCBINCBI36Build 36hg18NCBI36
Build 341160,223,622 - 60,239,858NCBI
Celera1157,831,254 - 57,847,490 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,813,422 - 56,829,655 (+)NCBIHuRef
CHM1_11160,333,125 - 60,349,358 (+)NCBICHM1_1
T2T-CHM13v2.01160,650,773 - 60,666,970 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,IDA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11245982   PMID:11401424   PMID:11486273   PMID:12477932   PMID:15489334   PMID:17207965   PMID:21873635   PMID:23348583   PMID:23874341  


Genomics

Comparative Map Data
MS4A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,699,612 - 60,715,807 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,699,585 - 60,715,807 (+)EnsemblGRCh38hg38GRCh38
GRCh371160,467,085 - 60,483,280 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361160,223,623 - 60,239,860 (+)NCBINCBI36Build 36hg18NCBI36
Build 341160,223,622 - 60,239,858NCBI
Celera1157,831,254 - 57,847,490 (+)NCBICelera
Cytogenetic Map11q12.2NCBI
HuRef1156,813,422 - 56,829,655 (+)NCBIHuRef
CHM1_11160,333,125 - 60,349,358 (+)NCBICHM1_1
T2T-CHM13v2.01160,650,773 - 60,666,970 (+)NCBIT2T-CHM13v2.0
Ms4a8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391911,044,835 - 11,058,467 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1911,044,835 - 11,058,466 (-)EnsemblGRCm39 Ensembl
GRCm381911,067,471 - 11,081,103 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1911,067,471 - 11,081,102 (-)EnsemblGRCm38mm10GRCm38
MGSCv371911,141,961 - 11,155,593 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361911,134,516 - 11,148,073 (-)NCBIMGSCv36mm8
Celera1911,758,959 - 11,772,928 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map197.62NCBI
Ms4a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81217,155,557 - 217,169,151 (-)NCBIGRCr8
mRatBN7.21207,730,665 - 207,744,260 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1207,730,665 - 207,744,324 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,105,502 - 216,119,101 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01223,165,601 - 223,179,274 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01215,859,903 - 215,873,498 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01227,136,154 - 227,149,748 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1227,136,154 - 227,149,748 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01234,203,005 - 234,216,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41213,583,486 - 213,597,080 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11213,741,912 - 213,785,366 (-)NCBI
Celera1205,215,300 - 205,228,872 (-)NCBICelera
Cytogenetic Map1q43NCBI
MS4A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2961,871,137 - 61,887,198 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11162,915,230 - 62,931,252 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01155,965,123 - 55,981,042 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11159,406,395 - 59,422,277 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1159,406,395 - 59,422,277 (+)Ensemblpanpan1.1panPan2
LOC102153191
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12150,497,486 - 50,504,173 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2149,936,895 - 49,944,920 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02151,668,967 - 51,677,011 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12150,716,461 - 50,724,482 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02150,815,733 - 50,821,947 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02151,438,692 - 51,446,753 (-)NCBIUU_Cfam_GSD_1.0
Ms4a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494712,146,900 - 12,157,540 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365812,261,090 - 2,271,213 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365812,260,960 - 2,270,127 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MS4A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl210,989,969 - 11,007,621 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1210,989,947 - 11,007,621 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MS4A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1113,125,146 - 13,140,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl113,123,461 - 13,140,309 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038110,480,437 - 110,495,367 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in MS4A8
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_031457.1(MS4A8):c.586T>C (p.Phe196Leu) single nucleotide variant Malignant melanoma [RCV000069546] Chr11:60715072 [GRCh38]
Chr11:60482545 [GRCh37]
Chr11:60239121 [NCBI36]
Chr11:11q12.2		 not provided
NM_031457.1(MS4A8):c.693C>T (p.Ile231=) single nucleotide variant Malignant melanoma [RCV000069547] Chr11:60715354 [GRCh38]
Chr11:60482827 [GRCh37]
Chr11:60239403 [NCBI36]
Chr11:11q12.2		 not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
NM_031457.2(MS4A8):c.309C>G (p.Phe103Leu) single nucleotide variant Inborn genetic diseases [RCV003245541] Chr11:60703467 [GRCh38]
Chr11:60470940 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q12.1-12.3(chr11:58935215-62177656)x3 copy number gain not provided [RCV000683362] Chr11:58935215..62177656 [GRCh37]
Chr11:11q12.1-12.3		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_031457.2(MS4A8):c.487C>G (p.Pro163Ala) single nucleotide variant Inborn genetic diseases [RCV003274522] Chr11:60708734 [GRCh38]
Chr11:60476207 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11q12.2-12.3(chr11:60385382-62456278)x3 copy number gain not provided [RCV001006412] Chr11:60385382..62456278 [GRCh37]
Chr11:11q12.2-12.3		 uncertain significance
NC_000011.9:g.(?_59596957)_(68707199_?)dup duplication Familial temporal lobe epilepsy 8 [RCV001372442] Chr11:59596957..68707199 [GRCh37]
Chr11:11q12.1-13.3		 uncertain significance
NM_031457.2(MS4A8):c.265A>G (p.Ile89Val) single nucleotide variant Inborn genetic diseases [RCV003241597] Chr11:60703423 [GRCh38]
Chr11:60470896 [GRCh37]
Chr11:11q12.2		 uncertain significance
NC_000011.9:g.(?_58916346)_(64972349_?)dup duplication Leukocyte adhesion deficiency 3 [RCV003113394]|not provided [RCV003113393] Chr11:58916346..64972349 [GRCh37]
Chr11:11q12.1-13.1		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 11p11.2-q12.2(chr11:51581311-54891247)x3 copy number gain See cases [RCV002286338] Chr11:51581311..54891247 [GRCh37]
Chr11:11p11.2-q12.2		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_031457.2(MS4A8):c.635G>C (p.Cys212Ser) single nucleotide variant Inborn genetic diseases [RCV002906883] Chr11:60715121 [GRCh38]
Chr11:60482594 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.488C>G (p.Pro163Arg) single nucleotide variant Inborn genetic diseases [RCV002683547] Chr11:60708735 [GRCh38]
Chr11:60476208 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.367G>A (p.Val123Met) single nucleotide variant Inborn genetic diseases [RCV002869680] Chr11:60707012 [GRCh38]
Chr11:60474485 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.583G>C (p.Glu195Gln) single nucleotide variant Inborn genetic diseases [RCV002980333] Chr11:60715069 [GRCh38]
Chr11:60482542 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.697C>A (p.Pro233Thr) single nucleotide variant Inborn genetic diseases [RCV002954969] Chr11:60715358 [GRCh38]
Chr11:60482831 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.510C>G (p.Asp170Glu) single nucleotide variant Inborn genetic diseases [RCV002788547] Chr11:60708757 [GRCh38]
Chr11:60476230 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.349A>G (p.Ile117Val) single nucleotide variant Inborn genetic diseases [RCV002802268] Chr11:60706994 [GRCh38]
Chr11:60474467 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.356G>A (p.Gly119Glu) single nucleotide variant Inborn genetic diseases [RCV002714170] Chr11:60707001 [GRCh38]
Chr11:60474474 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.12G>T (p.Met4Ile) single nucleotide variant Inborn genetic diseases [RCV003256977] Chr11:60700872 [GRCh38]
Chr11:60468345 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.601G>C (p.Ala201Pro) single nucleotide variant Inborn genetic diseases [RCV003297816] Chr11:60715087 [GRCh38]
Chr11:60482560 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.647A>G (p.Asn216Ser) single nucleotide variant Inborn genetic diseases [RCV003266135] Chr11:60715133 [GRCh38]
Chr11:60482606 [GRCh37]
Chr11:11q12.2		 uncertain significance
NM_031457.2(MS4A8):c.327C>A (p.Phe109Leu) single nucleotide variant Inborn genetic diseases [RCV003369496] Chr11:60703485 [GRCh38]
Chr11:60470958 [GRCh37]
Chr11:11q12.2		 uncertain significance
GRCh37/hg19 11q12.2-13.5(chr11:59923608-76272324)x3 copy number gain not provided [RCV003484842] Chr11:59923608..76272324 [GRCh37]
Chr11:11q12.2-13.5		 pathogenic
GRCh37/hg19 11p11.12-q13.1(chr11:50398499-63924462)x3 copy number gain not specified [RCV003986918] Chr11:50398499..63924462 [GRCh37]
Chr11:11p11.12-q13.1		 likely pathogenic
GRCh37/hg19 11q12.1-13.3(chr11:56895955-69295402)x3 copy number gain not specified [RCV003986944] Chr11:56895955..69295402 [GRCh37]
Chr11:11q12.1-13.3		 likely pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1407
Count of miRNA genes:772
Interacting mature miRNAs:877
Transcripts:ENST00000300226, ENST00000450141, ENST00000525458, ENST00000529752, ENST00000532816, ENST00000532953, ENST00000533354, ENST00000533691, ENST00000534316
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D11S3543  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,472,688 - 60,472,812UniSTSGRCh37
Build 361160,229,264 - 60,229,388RGDNCBI36
Celera1157,836,895 - 57,837,019RGD
Cytogenetic Map11q12.2UniSTS
HuRef1156,819,059 - 56,819,183UniSTS
WI-14145  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,483,124 - 60,483,249UniSTSGRCh37
Build 361160,239,700 - 60,239,825RGDNCBI36
Celera1157,847,330 - 57,847,455RGD
Cytogenetic Map11q12.2UniSTS
HuRef1156,829,495 - 56,829,620UniSTS
GeneMap99-GB4 RH Map11221.13UniSTS
Whitehead-RH Map11296.9UniSTS
AFM350wa9  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371160,472,265 - 60,472,501UniSTSGRCh37
Build 361160,228,841 - 60,229,077RGDNCBI36
Celera1157,836,472 - 57,836,708RGD
Cytogenetic Map11q12.2UniSTS
HuRef1156,818,640 - 56,818,872UniSTS
Whitehead-RH Map11293.2UniSTS
Whitehead-YAC Contig Map11 UniSTS
NCBI RH Map11446.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 437 1 149 4 127 5 2 2 147 53 272
Low 522 17 197 125 89 32 319 331 584 17 714 312 94 5 315
Below cutoff 618 865 510 193 503 133 1406 846 1705 116 366 389 62 336 1025 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000300226   ⟹   ENSP00000300226
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,612 - 60,715,807 (+)Ensembl
RefSeq Acc Id: ENST00000450141
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,694 - 60,708,863 (+)Ensembl
RefSeq Acc Id: ENST00000525458   ⟹   ENSP00000433200
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,700,916 - 60,712,027 (+)Ensembl
RefSeq Acc Id: ENST00000529752   ⟹   ENSP00000436857
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,703 - 60,715,386 (+)Ensembl
RefSeq Acc Id: ENST00000532816   ⟹   ENSP00000435567
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,747 - 60,703,486 (+)Ensembl
RefSeq Acc Id: ENST00000532953
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,586 - 60,709,219 (+)Ensembl
RefSeq Acc Id: ENST00000533354
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,657 - 60,709,065 (+)Ensembl
RefSeq Acc Id: ENST00000533691
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,585 - 60,709,206 (+)Ensembl
RefSeq Acc Id: ENST00000534316
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1160,699,755 - 60,701,527 (+)Ensembl
RefSeq Acc Id: NM_031457   ⟹   NP_113645
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,699,612 - 60,715,807 (+)NCBI
GRCh371160,467,046 - 60,483,284 (+)NCBI
Build 361160,223,623 - 60,239,860 (+)NCBI Archive
Celera1157,831,254 - 57,847,490 (+)RGD
HuRef1156,813,422 - 56,829,655 (+)RGD
CHM1_11160,333,125 - 60,349,358 (+)NCBI
T2T-CHM13v2.01160,650,773 - 60,666,970 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_113645   ⟸   NM_031457
- UniProtKB: Q8TCA5 (UniProtKB/Swiss-Prot),   Q9BY19 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000435567   ⟸   ENST00000532816
RefSeq Acc Id: ENSP00000300226   ⟸   ENST00000300226
RefSeq Acc Id: ENSP00000433200   ⟸   ENST00000525458
RefSeq Acc Id: ENSP00000436857   ⟸   ENST00000529752

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BY19-F1-model_v2 AlphaFold Q9BY19 1-250 view protein structure

Promoters
RGD ID:7220483
Promoter ID:EPDNEW_H15987
Type:initiation region
Name:MS4A8_1
Description:membrane spanning 4-domains A8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381160,699,612 - 60,699,672EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13380 AgrOrtholog
COSMIC MS4A8 COSMIC
Ensembl Genes ENSG00000166959 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000300226 ENTREZGENE
  ENST00000300226.7 UniProtKB/Swiss-Prot
  ENST00000525458.1 UniProtKB/TrEMBL
  ENST00000529752.5 UniProtKB/TrEMBL
  ENST00000532816.1 UniProtKB/TrEMBL
GTEx ENSG00000166959 GTEx
HGNC ID HGNC:13380 ENTREZGENE
Human Proteome Map MS4A8 Human Proteome Map
InterPro CD20-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MS4A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:83661 UniProtKB/Swiss-Prot
NCBI Gene 83661 ENTREZGENE
OMIM 606549 OMIM
PANTHER MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MEMBER 8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CD20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA31126 PharmGKB
UniProt E9PJN8_HUMAN UniProtKB/TrEMBL
  E9PQE1_HUMAN UniProtKB/TrEMBL
  H0YD94_HUMAN UniProtKB/TrEMBL
  M4A8_HUMAN UniProtKB/Swiss-Prot
  Q8TCA5 ENTREZGENE
  Q9BY19 ENTREZGENE
UniProt Secondary Q8TCA5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-26 MS4A8  membrane spanning 4-domains A8  MS4A8  membrane-spanning 4-domains subfamily A member 8  Symbol and/or name change 5135510 APPROVED
2016-01-19 MS4A8  membrane-spanning 4-domains subfamily A member 8  MS4A8  membrane-spanning 4-domains, subfamily A, member 8  Symbol and/or name change 5135510 APPROVED
2013-03-12 MS4A8  membrane-spanning 4-domains, subfamily A, member 8  MS4A8B  membrane-spanning 4-domains, subfamily A, member 8B  Symbol and/or name change 5135510 APPROVED