BNIP2 (BCL2 interacting protein 2) - Rat Genome Database

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Gene: BNIP2 (BCL2 interacting protein 2) Homo sapiens
Analyze
Symbol: BNIP2
Name: BCL2 interacting protein 2
RGD ID: 1319009
HGNC Page HGNC:1083
Description: Predicted to enable GTPase activator activity and calcium ion binding activity. Predicted to be involved in apoptotic process. Predicted to act upstream of or within several processes, including blastocyst development; centrosome cycle; and positive regulation of intracellular signal transduction. Located in cytosol; nuclear envelope; and nucleolus.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; BCL2/adenovirus E1B 19kDa interacting protein 2; BNIP-2; NIP2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381559,659,146 - 59,689,320 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1559,659,146 - 59,689,339 (-)EnsemblGRCh38hg38GRCh38
GRCh371559,951,345 - 59,981,519 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361557,742,356 - 57,768,778 (-)NCBINCBI36Build 36hg18NCBI36
Build 341557,742,355 - 57,768,778NCBI
Celera1536,843,018 - 36,869,598 (-)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1536,777,017 - 36,803,599 (-)NCBIHuRef
CHM1_11560,073,017 - 60,099,603 (-)NCBICHM1_1
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Boyd JM, etal., Cell 1994 Oct 21;79(2):341-51.
2. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
3. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7478990   PMID:10381623   PMID:10551883   PMID:10799524   PMID:10954711   PMID:11741952   PMID:11744098   PMID:12477932   PMID:12901880   PMID:12944407   PMID:14702039   PMID:15489334  
PMID:15652341   PMID:15923648   PMID:16189514   PMID:17961507   PMID:20677014   PMID:20704564   PMID:20855536   PMID:21130087   PMID:21516116   PMID:21873635   PMID:22623531   PMID:22658674  
PMID:22863883   PMID:23414517   PMID:24623722   PMID:25378581   PMID:25416956   PMID:25472445   PMID:25659891   PMID:29467281   PMID:29997244   PMID:31515488   PMID:32296183   PMID:32789168  
PMID:34079125   PMID:34369648   PMID:34917906   PMID:35975420   PMID:37232246   PMID:37689310  


Genomics

Comparative Map Data
BNIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381559,659,146 - 59,689,320 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1559,659,146 - 59,689,339 (-)EnsemblGRCh38hg38GRCh38
GRCh371559,951,345 - 59,981,519 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361557,742,356 - 57,768,778 (-)NCBINCBI36Build 36hg18NCBI36
Build 341557,742,355 - 57,768,778NCBI
Celera1536,843,018 - 36,869,598 (-)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1536,777,017 - 36,803,599 (-)NCBIHuRef
CHM1_11560,073,017 - 60,099,603 (-)NCBICHM1_1
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBIT2T-CHM13v2.0
Bnip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39969,896,660 - 69,918,941 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl969,896,748 - 69,915,599 (+)EnsemblGRCm39 Ensembl
GRCm38969,989,438 - 70,011,659 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl969,989,466 - 70,008,317 (+)EnsemblGRCm38mm10GRCm38
MGSCv37969,837,308 - 69,856,124 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36969,788,665 - 69,807,481 (+)NCBIMGSCv36mm8
Celera967,205,929 - 67,224,771 (+)NCBICelera
Cytogenetic Map9DNCBI
cM Map939.15NCBI
Bnip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8879,521,375 - 79,539,148 (+)NCBIGRCr8
mRatBN7.2870,640,436 - 70,661,782 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl870,640,445 - 70,675,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx876,173,901 - 76,187,300 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0874,446,914 - 74,460,313 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0872,285,585 - 72,298,985 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0876,400,333 - 76,426,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl876,400,341 - 76,426,503 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0876,654,578 - 76,675,924 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4874,421,904 - 74,435,300 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1874,423,835 - 74,458,781 (+)NCBI
Celera871,072,882 - 71,086,280 (-)NCBICelera
Cytogenetic Map8q24NCBI
Bnip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545015,157,226 - 15,180,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545015,157,411 - 15,180,069 (+)NCBIChiLan1.0ChiLan1.0
BNIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21648,923,635 - 48,955,642 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11553,106,285 - 53,138,308 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01538,628,798 - 38,659,161 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11556,933,697 - 56,964,197 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1556,933,697 - 56,964,044 (-)Ensemblpanpan1.1panPan2
BNIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13024,522,397 - 24,546,968 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3024,503,092 - 24,539,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3024,496,442 - 24,520,540 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03024,691,322 - 24,715,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3024,691,419 - 24,715,417 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13024,616,981 - 24,641,089 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03024,699,414 - 24,723,513 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03024,886,730 - 24,910,833 (-)NCBIUU_Cfam_GSD_1.0
Bnip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640102,807,285 - 102,827,361 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647120,652,601 - 20,675,325 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647120,655,415 - 20,675,351 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BNIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1112,344,228 - 112,370,404 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11112,272,883 - 112,370,404 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21124,261,168 - 124,283,937 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BNIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12623,821,350 - 23,846,130 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2623,821,499 - 23,855,741 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048117,479,543 - 117,507,302 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bnip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478112,468,711 - 12,488,360 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478112,468,675 - 12,497,130 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in BNIP2
20 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q21.3-22.2(chr15:57567950-63019415)x1 copy number loss See cases [RCV000051622] Chr15:57567950..63019415 [GRCh38]
Chr15:57860148..63311614 [GRCh37]
Chr15:55647440..61098667 [NCBI36]
Chr15:15q21.3-22.2		 pathogenic
GRCh38/hg38 15q21.3-22.2(chr15:57456076-61907285)x1 copy number loss See cases [RCV000050884] Chr15:57456076..61907285 [GRCh38]
Chr15:57748274..62199484 [GRCh37]
Chr15:55535566..59986776 [NCBI36]
Chr15:15q21.3-22.2		 pathogenic
GRCh38/hg38 15q22.2(chr15:59565894-59705977)x1 copy number loss See cases [RCV000135949] Chr15:59565894..59705977 [GRCh38]
Chr15:59858093..59998176 [GRCh37]
Chr15:57645385..57785468 [NCBI36]
Chr15:15q22.2		 uncertain significance
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:54713558-62769295)x1 copy number loss See cases [RCV000446622] Chr15:54713558..62769295 [GRCh37]
Chr15:15q21.3-22.2		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:58088503-62221756)x1 copy number loss See cases [RCV000510898] Chr15:58088503..62221756 [GRCh37]
Chr15:15q21.3-22.2		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
GRCh37/hg19 15q21.3-22.2(chr15:58441151-60270526)x3 copy number gain not provided [RCV000683699] Chr15:58441151..60270526 [GRCh37]
Chr15:15q21.3-22.2		 uncertain significance
GRCh37/hg19 15q22.2(chr15:59848471-60004707)x1 copy number loss not provided [RCV000751320] Chr15:59848471..60004707 [GRCh37]
Chr15:15q22.2		 benign
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q21.1-22.2(chr15:48000433-60747551)x3 copy number gain not provided [RCV000845891] Chr15:48000433..60747551 [GRCh37]
Chr15:15q21.1-22.2		 pathogenic
GRCh37/hg19 15q22.2(chr15:59862040-59970994)x3 copy number gain not provided [RCV000846654] Chr15:59862040..59970994 [GRCh37]
Chr15:15q22.2		 uncertain significance
GRCh37/hg19 15q22.2(chr15:59592936-60360150)x1 copy number loss not provided [RCV001006699] Chr15:59592936..60360150 [GRCh37]
Chr15:15q22.2		 uncertain significance
GRCh37/hg19 15q22.2(chr15:59926966-59984655)x1 copy number loss not provided [RCV001006700] Chr15:59926966..59984655 [GRCh37]
Chr15:15q22.2		 uncertain significance
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
GRCh37/hg19 15q21.1-22.2(chr15:48589845-63543438)x3 copy number gain not provided [RCV002472512] Chr15:48589845..63543438 [GRCh37]
Chr15:15q21.1-22.2		 pathogenic
NM_004330.4(BNIP2):c.-2G>C single nucleotide variant not specified [RCV004162364] Chr15:59682459 [GRCh38]
Chr15:59974658 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.-234G>A single nucleotide variant not specified [RCV004229847] Chr15:59689311 [GRCh38]
Chr15:59981510 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.-138G>A single nucleotide variant not specified [RCV004146587] Chr15:59689215 [GRCh38]
Chr15:59981414 [GRCh37]
Chr15:15q22.2		 likely benign
NM_004330.4(BNIP2):c.797C>T (p.Ser266Leu) single nucleotide variant not specified [RCV004172812] Chr15:59668988 [GRCh38]
Chr15:59961187 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.449A>G (p.Tyr150Cys) single nucleotide variant not specified [RCV004165653] Chr15:59677934 [GRCh38]
Chr15:59970133 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.713G>A (p.Arg238Gln) single nucleotide variant not specified [RCV004152838] Chr15:59669357 [GRCh38]
Chr15:59961556 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.71G>C (p.Ser24Thr) single nucleotide variant not specified [RCV004196136] Chr15:59680288 [GRCh38]
Chr15:59972487 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.440T>C (p.Ile147Thr) single nucleotide variant not specified [RCV004240840] Chr15:59677943 [GRCh38]
Chr15:59970142 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.157C>G (p.Leu53Val) single nucleotide variant not specified [RCV004116138] Chr15:59679730 [GRCh38]
Chr15:59971929 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.-150C>G single nucleotide variant not specified [RCV004203843] Chr15:59689227 [GRCh38]
Chr15:59981426 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.479A>T (p.Tyr160Phe) single nucleotide variant not specified [RCV004102150] Chr15:59672733 [GRCh38]
Chr15:59964932 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.791T>C (p.Ile264Thr) single nucleotide variant not specified [RCV004252081] Chr15:59669279 [GRCh38]
Chr15:59961478 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.-101C>G single nucleotide variant not specified [RCV004257050] Chr15:59689178 [GRCh38]
Chr15:59981377 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.638G>A (p.Gly213Asp) single nucleotide variant not specified [RCV004265543] Chr15:59671252 [GRCh38]
Chr15:59963451 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.94A>G (p.Ile32Val) single nucleotide variant not specified [RCV004284742] Chr15:59680265 [GRCh38]
Chr15:59972464 [GRCh37]
Chr15:15q22.2		 likely benign
NM_004330.4(BNIP2):c.392G>A (p.Arg131His) single nucleotide variant not specified [RCV004284204] Chr15:59677991 [GRCh38]
Chr15:59970190 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.68A>G (p.Asp23Gly) single nucleotide variant not specified [RCV004342861] Chr15:59680291 [GRCh38]
Chr15:59972490 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.769C>G (p.Leu257Val) single nucleotide variant not specified [RCV004348905] Chr15:59669301 [GRCh38]
Chr15:59961500 [GRCh37]
Chr15:15q22.2		 uncertain significance
GRCh37/hg19 15q21.3-22.2(chr15:54020810-62086530)x1 copy number loss not provided [RCV003483234] Chr15:54020810..62086530 [GRCh37]
Chr15:15q21.3-22.2		 pathogenic
NM_004330.4(BNIP2):c.859A>G (p.Met287Val) single nucleotide variant not specified [RCV004434003] Chr15:59668926 [GRCh38]
Chr15:59961125 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.-129G>A single nucleotide variant not specified [RCV004434004] Chr15:59689206 [GRCh38]
Chr15:59981405 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.104C>A (p.Pro35Gln) single nucleotide variant not specified [RCV004434005] Chr15:59680255 [GRCh38]
Chr15:59972454 [GRCh37]
Chr15:15q22.2		 uncertain significance
NM_004330.4(BNIP2):c.203C>G (p.Ser68Cys) single nucleotide variant not specified [RCV004434006] Chr15:59679684 [GRCh38]
Chr15:59971883 [GRCh37]
Chr15:15q22.2		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR20Ahsa-miR-20a-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI21242194
MIR20Ahsa-miR-20a-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MIR20Ahsa-miR-20a-5pOncomiRDBexternal_infoNANA21242194

Predicted Target Of
Summary Value
Count of predictions:3067
Count of miRNA genes:1124
Interacting mature miRNAs:1408
Transcripts:ENST00000267859, ENST00000415213, ENST00000417312, ENST00000439052, ENST00000448414, ENST00000464390, ENST00000477543, ENST00000478981, ENST00000557987, ENST00000560458, ENST00000560776, ENST00000607373
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH65383  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,969,135 - 59,969,256UniSTSGRCh37
GRCh371468,060,547 - 68,060,670UniSTSGRCh37
Build 361467,130,300 - 67,130,423RGDNCBI36
Celera1536,857,092 - 36,857,213UniSTS
Celera1448,119,612 - 48,119,735RGD
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map15q22.2UniSTS
HuRef1536,791,090 - 36,791,211UniSTS
HuRef1448,230,286 - 48,230,409UniSTS
G59565  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,969,155 - 59,969,256UniSTSGRCh37
GRCh371468,060,547 - 68,060,650UniSTSGRCh37
Build 361467,130,300 - 67,130,403RGDNCBI36
Celera1448,119,612 - 48,119,715RGD
Celera1536,857,112 - 36,857,213UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map14q24.1UniSTS
HuRef1536,791,110 - 36,791,211UniSTS
HuRef1448,230,286 - 48,230,389UniSTS
TNG Radiation Hybrid Map1422803.0UniSTS
D15S703E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,955,393 - 59,955,545UniSTSGRCh37
Build 361557,742,685 - 57,742,837RGDNCBI36
Celera1536,843,350 - 36,843,502RGD
Cytogenetic Map15q22.2UniSTS
HuRef1536,777,349 - 36,777,501UniSTS
SHGC-154946  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,971,527 - 59,971,868UniSTSGRCh37
Build 361557,758,819 - 57,759,160RGDNCBI36
Celera1536,859,484 - 36,859,825RGD
Cytogenetic Map15q22.2UniSTS
HuRef1536,793,482 - 36,793,823UniSTS
TNG Radiation Hybrid Map1521070.0UniSTS
csnpbnip2-pcr1-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,981,185 - 59,981,559UniSTSGRCh37
Build 361557,768,477 - 57,768,851RGDNCBI36
Celera1536,869,141 - 36,869,515RGD
Cytogenetic Map15q22.2UniSTS
HuRef1536,803,142 - 36,803,516UniSTS
BNIP2_7248  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,955,035 - 59,955,694UniSTSGRCh37
Build 361557,742,327 - 57,742,986RGDNCBI36
Celera1536,842,992 - 36,843,651RGD
HuRef1536,776,991 - 36,777,650UniSTS
WI-7305  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,969,539 - 59,969,880UniSTSGRCh37
GRCh371468,056,435 - 68,056,778UniSTSGRCh37
Build 361467,126,188 - 67,126,531RGDNCBI36
Celera1448,115,500 - 48,115,843RGD
Celera1536,857,496 - 36,857,837UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map14q24.1UniSTS
HuRef1536,791,494 - 36,791,835UniSTS
HuRef1448,226,176 - 48,226,519UniSTS
Whitehead-YAC Contig Map15 UniSTS
SHGC-57103  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,969,129 - 59,969,315UniSTSGRCh37
GRCh371468,060,488 - 68,060,676UniSTSGRCh37
Build 361467,130,241 - 67,130,429RGDNCBI36
Celera1536,857,086 - 36,857,272UniSTS
Celera1448,119,553 - 48,119,741RGD
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map15q22.2UniSTS
HuRef1536,791,084 - 36,791,270UniSTS
HuRef1448,230,227 - 48,230,415UniSTS
D15S1347  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371559,956,089 - 59,956,230UniSTSGRCh37
Build 361557,743,381 - 57,743,522RGDNCBI36
Celera1536,844,046 - 36,844,187RGD
Cytogenetic Map15q22.2UniSTS
HuRef1536,778,045 - 36,778,186UniSTS
Stanford-G3 RH Map151814.0UniSTS
NCBI RH Map15321.6UniSTS
GeneMap99-G3 RH Map151814.0UniSTS
STS-U15173  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.2UniSTS
GeneMap99-GB4 RH Map15212.3UniSTS
NCBI RH Map15315.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2342 2420 1553 483 1705 326 4229 1859 1780 287 1416 1594 174 1 1203 2670 6 2
Low 97 571 173 141 246 139 128 338 1954 132 44 19 1 1 118
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001368061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC092755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI914901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK125533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK299628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY268590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG257875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX378770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC378237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC425485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000267859   ⟹   ENSP00000267859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,659,146 - 59,689,534 (-)Ensembl
RefSeq Acc Id: ENST00000415213   ⟹   ENSP00000412767
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,663,757 - 59,688,926 (-)Ensembl
RefSeq Acc Id: ENST00000417312
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,678,049 - 59,689,320 (-)Ensembl
RefSeq Acc Id: ENST00000439052   ⟹   ENSP00000393644
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,662,856 - 59,689,330 (-)Ensembl
RefSeq Acc Id: ENST00000448414   ⟹   ENSP00000398364
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,669,289 - 59,680,296 (-)Ensembl
RefSeq Acc Id: ENST00000464390
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,671,181 - 59,678,640 (-)Ensembl
RefSeq Acc Id: ENST00000477543
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,679,256 - 59,689,309 (-)Ensembl
RefSeq Acc Id: ENST00000478981
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,662,893 - 59,668,949 (-)Ensembl
RefSeq Acc Id: ENST00000557987
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,678,572 - 59,682,502 (-)Ensembl
RefSeq Acc Id: ENST00000560458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,677,813 - 59,689,339 (-)Ensembl
RefSeq Acc Id: ENST00000560776
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,668,755 - 59,669,362 (-)Ensembl
RefSeq Acc Id: ENST00000607373   ⟹   ENSP00000475320
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,659,146 - 59,689,320 (-)Ensembl
RefSeq Acc Id: ENST00000612191   ⟹   ENSP00000479818
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1559,662,865 - 59,689,443 (-)Ensembl
RefSeq Acc Id: NM_001320674   ⟹   NP_001307603
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,689,320 (-)NCBI
CHM1_11560,069,301 - 60,099,694 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001320675   ⟹   NP_001307604
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,688,926 (-)NCBI
CHM1_11560,069,301 - 60,099,086 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,490,644 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368057   ⟹   NP_001354986
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,689,320 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368058   ⟹   NP_001354987
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,689,320 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368059   ⟹   NP_001354988
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,689,320 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368060   ⟹   NP_001354989
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,689,320 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001368061   ⟹   NP_001354990
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,689,320 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBI
Sequence:
RefSeq Acc Id: NM_004330   ⟹   NP_004321
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,659,146 - 59,689,320 (-)NCBI
GRCh371559,951,345 - 59,981,728 (-)NCBI
Build 361557,742,356 - 57,768,778 (-)NCBI Archive
HuRef1536,777,017 - 36,803,599 (-)ENTREZGENE
CHM1_11560,069,301 - 60,099,694 (-)NCBI
T2T-CHM13v2.01557,460,850 - 57,491,038 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_004321   ⟸   NM_004330
- Peptide Label: isoform 2
- UniProtKB: Q12982 (UniProtKB/Swiss-Prot),   B4DS94 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307603   ⟸   NM_001320674
- Peptide Label: isoform 1
- UniProtKB: H7C096 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001307604   ⟸   NM_001320675
- Peptide Label: isoform 2
- UniProtKB: Q12982 (UniProtKB/Swiss-Prot),   B4DS94 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001354989   ⟸   NM_001368060
- Peptide Label: isoform 7
RefSeq Acc Id: NP_001354987   ⟸   NM_001368058
- Peptide Label: isoform 5
RefSeq Acc Id: NP_001354988   ⟸   NM_001368059
- Peptide Label: isoform 6
RefSeq Acc Id: NP_001354986   ⟸   NM_001368057
- Peptide Label: isoform 4
RefSeq Acc Id: NP_001354990   ⟸   NM_001368061
- Peptide Label: isoform 8
RefSeq Acc Id: ENSP00000267859   ⟸   ENST00000267859
RefSeq Acc Id: ENSP00000393644   ⟸   ENST00000439052
RefSeq Acc Id: ENSP00000412767   ⟸   ENST00000415213
RefSeq Acc Id: ENSP00000479818   ⟸   ENST00000612191
RefSeq Acc Id: ENSP00000398364   ⟸   ENST00000448414
RefSeq Acc Id: ENSP00000475320   ⟸   ENST00000607373
Protein Domains
CRAL-TRIO

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q12982-F1-model_v2 AlphaFold Q12982 1-314 view protein structure

Promoters
RGD ID:6792125
Promoter ID:HG_KWN:21557
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000328348
Position:
Human AssemblyChrPosition (strand)Source
Build 361557,760,381 - 57,760,881 (-)MPROMDB
RGD ID:6792124
Promoter ID:HG_KWN:21558
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000409352,   OTTHUMT00000328346,   OTTHUMT00000328347
Position:
Human AssemblyChrPosition (strand)Source
Build 361557,768,551 - 57,769,051 (-)MPROMDB
RGD ID:7229697
Promoter ID:EPDNEW_H20594
Type:initiation region
Name:BNIP2_2
Description:BCL2 interacting protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20595  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,689,152 - 59,689,212EPDNEW
RGD ID:7229705
Promoter ID:EPDNEW_H20595
Type:initiation region
Name:BNIP2_1
Description:BCL2 interacting protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20594  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381559,689,320 - 59,689,380EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1083 AgrOrtholog
COSMIC BNIP2 COSMIC
Ensembl Genes ENSG00000140299 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000415213 ENTREZGENE
  ENST00000415213.7 UniProtKB/Swiss-Prot
  ENST00000439052 ENTREZGENE
  ENST00000439052.6 UniProtKB/TrEMBL
  ENST00000448414.5 UniProtKB/TrEMBL
  ENST00000607373 ENTREZGENE
  ENST00000607373.6 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.525.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000140299 GTEx
HGNC ID HGNC:1083 ENTREZGENE
Human Proteome Map BNIP2 Human Proteome Map
InterPro Bcl2-/adenovirus-E1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL-TRIO_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:663 UniProtKB/Swiss-Prot
NCBI Gene 663 ENTREZGENE
OMIM 603292 OMIM
PANTHER BCL2/ADENOVIRUS E1B 19 KDA PROTEIN-INTERACTING PROTEIN 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BNIP - RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BNIP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRAL_TRIO_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25393 PharmGKB
PROSITE CRAL_TRIO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SEC14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52087 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B4DS94 ENTREZGENE
  BNIP2_HUMAN UniProtKB/Swiss-Prot
  H7C096 ENTREZGENE, UniProtKB/TrEMBL
  H7C142_HUMAN UniProtKB/TrEMBL
  Q12982 ENTREZGENE
UniProt Secondary B4DS94 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-28 BNIP2  BCL2 interacting protein 2    BCL2/adenovirus E1B 19kDa interacting protein 2  Symbol and/or name change 5135510 APPROVED