Cdkn3 (cyclin dependent kinase inhibitor 3) - Rat Genome Database

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Gene: Cdkn3 (cyclin dependent kinase inhibitor 3) Mus musculus
Analyze
Symbol: Cdkn3
Name: cyclin dependent kinase inhibitor 3
RGD ID: 1317173
MGI Page MGI
Description: Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to act upstream of or within DNA damage response and regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in axial skeleton; cerebral cortex; cranium; hindlimb long bone; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410006H10Rik; CDK2-associated dual-specificity phosphatase; cyclin-dependent kinase inhibitor 3; K; KAP; kinase-associated phosphatase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,997,912 - 47,008,987 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,997,998 - 47,009,126 (+)EnsemblGRCm39 Ensembl
GRCm381446,760,461 - 46,771,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,760,541 - 46,771,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv371447,380,216 - 47,391,200 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361445,682,418 - 45,693,546 (+)NCBIMGSCv36mm8
Celera1442,925,363 - 42,936,240 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
(S)-colchicine  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzophenanthridine  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
bisphenol F  (EXP)
boron nitride  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP,ISO)
carmustine  (ISO)
chlordecone  (EXP)
chlorendic acid  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
cryptolepine  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
fipronil  (ISO)
folic acid  (EXP,ISO)
furan  (ISO)
gallic acid  (ISO)
genistein  (ISO)
geraniol  (ISO)
glafenine  (ISO)
glycidol  (ISO)
heptachlor  (ISO)
irinotecan  (ISO)
L-methionine  (EXP)
lead diacetate  (ISO)
levofloxacin  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
mirex  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nimesulide  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
palbociclib  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
pyrimidifen  (ISO)
quercetin  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thifluzamide  (ISO)
tioguanine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (EXP)
valdecoxib  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinoma. Dai W, etal., Mol Med Rep. 2016 Aug;14(2):1509-14. doi: 10.3892/mmr.2016.5410. Epub 2016 Jun 17.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Cyclin-dependent kinase-associated protein phosphatase is overexpressed in alcohol-related hepatocellular carcinoma and influences xenograft tumor growth. Lin WR, etal., Oncol Rep. 2013 Mar;29(3):903-10. doi: 10.3892/or.2012.2208. Epub 2012 Dec 24.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Cyclin-dependent kinase inhibitor 3 is overexpressed in hepatocellular carcinoma and promotes tumor cell proliferation. Xing C, etal., Biochem Biophys Res Commun. 2012 Mar 30;420(1):29-35. doi: 10.1016/j.bbrc.2012.02.107. Epub 2012 Feb 27.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15704002   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:23342106   PMID:24550317   PMID:26410627  
PMID:29196103   PMID:30635555   PMID:31352814   PMID:33681192   PMID:38355793  


Genomics

Comparative Map Data
Cdkn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391446,997,912 - 47,008,987 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1446,997,998 - 47,009,126 (+)EnsemblGRCm39 Ensembl
GRCm381446,760,461 - 46,771,530 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1446,760,541 - 46,771,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv371447,380,216 - 47,391,200 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361445,682,418 - 45,693,546 (+)NCBIMGSCv36mm8
Celera1442,925,363 - 42,936,240 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.28NCBI
CDKN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381454,397,007 - 54,420,218 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1454,396,849 - 54,420,218 (+)EnsemblGRCh38hg38GRCh38
GRCh371454,863,725 - 54,886,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361453,933,476 - 53,956,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 341453,933,475 - 53,956,682NCBI
Celera1434,913,202 - 34,936,466 (+)NCBICelera
Cytogenetic Map14q22.2NCBI
HuRef1435,026,265 - 35,049,580 (+)NCBIHuRef
CHM1_11454,802,348 - 54,825,637 (+)NCBICHM1_1
T2T-CHM13v2.01448,602,154 - 48,625,376 (+)NCBIT2T-CHM13v2.0
Cdkn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,502,299 - 22,513,725 (+)NCBIGRCr8
mRatBN7.21520,022,522 - 20,033,948 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,022,664 - 20,033,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1522,803,376 - 22,814,712 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01523,761,370 - 23,772,706 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,011,622 - 22,022,961 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01523,553,171 - 23,564,538 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1523,553,128 - 23,564,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01527,496,654 - 27,508,025 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41522,617,409 - 22,624,922 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11522,633,120 - 22,644,448 (+)NCBI
Celera1520,421,091 - 20,428,602 (+)NCBICelera
Cytogenetic Map15p14NCBI
Cdkn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554099,015,353 - 9,031,050 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554099,015,220 - 9,030,983 (-)NCBIChiLan1.0ChiLan1.0
CDKN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21555,518,975 - 55,545,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11454,735,482 - 54,759,956 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01434,984,819 - 35,008,807 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,263,518 - 53,287,119 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,263,584 - 53,287,113 (+)Ensemblpanpan1.1panPan2
CDKN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,344,991 - 30,374,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl830,345,082 - 30,360,563 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha830,113,573 - 30,142,985 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0830,602,027 - 30,632,721 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl830,602,109 - 30,617,597 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,206,074 - 30,235,518 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,282,425 - 30,311,885 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0830,648,188 - 30,678,870 (+)NCBIUU_Cfam_GSD_1.0
Cdkn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,896,356 - 74,909,986 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936697670,785 - 683,996 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936697669,154 - 684,077 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDKN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1183,792,688 - 183,809,174 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11183,792,606 - 183,809,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,290,145 - 204,304,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDKN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12431,554,461 - 31,578,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2431,554,510 - 31,579,664 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605319,789,412 - 19,812,821 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdkn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,838,561 - 14,852,554 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,838,555 - 14,853,588 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdkn3
397 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:120
Count of miRNA genes:109
Interacting mature miRNAs:117
Transcripts:ENSMUST00000067426
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
27226752Femd4_mfemur midshaft diameter 4, 5 week (mouse)141376927347237457Mouse
1300544Hypn_mhyperinsulinemia (mouse)Not determined141516061649160765Mouse
1301372Sluc13_msusceptibility to lung cancer 13 (mouse)Not determined141882760452827726Mouse
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
14746973Manh76_mmandible shape 76 (mouse)142228721756287217Mouse
4142485Modor2_mmodifier of ocular retardation 2 (mouse)Not determined142492624858179769Mouse
13506929Recrq10_mrecombination rate in male meiosis QTL 10 (mouse)142792195761137449Mouse
10043886Cia49_mcollagen induced arthritis QTL 49 (mouse)Not determined142999699463997133Mouse
27226775Tibl7_mtibia length 7, 5 week (mouse)143032195748837457Mouse
27226744Metcl6_mmetatarsal-calcaneal length 6, 5 week (mouse)143032195752937457Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
1300909Ath13_matherosclerosis 13 (mouse)Not determined143033525064335381Mouse
1300998Cia17_mcollagen induced arthritis 17 (mouse)Not determined143033525064335381Mouse
27226737Metcl12_mmetatarsal-calcaneal length 12, 10 week (mouse)143322195759437449Mouse
27226727Tibl21_mtibia length 21, 16 week (mouse)143412195752937457Mouse
1300625Cosz2_mcocaine seizure 2 (mouse)Not determined143504579768785736Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse

Markers in Region
D14Mit141  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381446,759,537 - 46,759,676UniSTSGRCm38
MGSCv371447,379,212 - 47,379,351UniSTSGRCm37
Celera1442,924,371 - 42,924,496UniSTS
Cytogenetic Map14C1UniSTS
cM Map1415.0UniSTS
Whitehead Genetic1424.0UniSTS
Whitehead/MRC_RH14508.77UniSTS
Whitehead_YAC14 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000067426   ⟹   ENSMUSP00000070575
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,997,998 - 47,009,126 (+)Ensembl
GRCm38.p6 Ensembl1446,760,541 - 46,771,669 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226621
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,998,052 - 47,008,977 (+)Ensembl
GRCm38.p6 Ensembl1446,760,595 - 46,771,520 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227149   ⟹   ENSMUSP00000153781
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,998,012 - 47,006,306 (+)Ensembl
GRCm38.p6 Ensembl1446,760,555 - 46,768,849 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228106   ⟹   ENSMUSP00000154120
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1446,998,043 - 47,007,386 (+)Ensembl
GRCm38.p6 Ensembl1446,760,586 - 46,769,929 (+)Ensembl
RefSeq Acc Id: NM_001360041   ⟹   NP_001346970
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,997,998 - 47,008,978 (+)NCBI
GRCm381446,760,541 - 46,771,521 (+)NCBI
Sequence:
RefSeq Acc Id: NM_028222   ⟹   NP_082498
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,997,998 - 47,008,978 (+)NCBI
GRCm381446,760,541 - 46,771,521 (+)NCBI
MGSCv371447,380,216 - 47,391,200 (+)RGD
Celera1442,925,363 - 42,936,240 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519593   ⟹   XP_006519656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,997,924 - 47,008,987 (+)NCBI
GRCm381446,760,467 - 46,771,530 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006519594   ⟹   XP_006519657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,997,923 - 47,008,987 (+)NCBI
GRCm381446,760,465 - 46,771,530 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030248044   ⟹   XP_030103904
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,997,918 - 47,008,987 (+)NCBI
GRCm381446,760,461 - 46,771,530 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158855   ⟹   XP_036014748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391446,997,912 - 47,008,987 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082498   ⟸   NM_028222
- Peptide Label: isoform 2
- UniProtKB: Q9CWS3 (UniProtKB/Swiss-Prot),   Q810P3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006519657   ⟸   XM_006519594
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006519656   ⟸   XM_006519593
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030103904   ⟸   XM_030248044
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001346970   ⟸   NM_001360041
- Peptide Label: isoform 1
RefSeq Acc Id: ENSMUSP00000070575   ⟸   ENSMUST00000067426
RefSeq Acc Id: ENSMUSP00000154120   ⟸   ENSMUST00000228106
RefSeq Acc Id: ENSMUSP00000153781   ⟸   ENSMUST00000227149
RefSeq Acc Id: XP_036014748   ⟸   XM_036158855
- Peptide Label: isoform X1
- UniProtKB: A0A2I3BPS7 (UniProtKB/TrEMBL)
Protein Domains
CDKN3   Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q810P3-F1-model_v2 AlphaFold Q810P3 1-211 view protein structure

Promoters
RGD ID:8682054
Promoter ID:EPDNEW_M19057
Type:initiation region
Name:Cdkn3_1
Description:Mus musculus cyclin-dependent kinase inhibitor 3 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381446,760,620 - 46,760,680EPDNEW
RGD ID:6824763
Promoter ID:MM_KWN:16452
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:NM_028222,   UC007THE.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361447,379,976 - 47,380,476 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1919641 AgrOrtholog
Ensembl Genes ENSMUSG00000037628 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067426 ENTREZGENE
  ENSMUST00000067426.6 UniProtKB/Swiss-Prot
  ENSMUST00000226621 ENTREZGENE
  ENSMUST00000227149.2 UniProtKB/TrEMBL
  ENSMUST00000228106 ENTREZGENE
  ENSMUST00000228106.2 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CDK_inhib_3 UniProtKB/Swiss-Prot
  CDKN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
KEGG Report mmu:72391 UniProtKB/Swiss-Prot
MGD MGI:1919641 ENTREZGENE
NCBI Gene 72391 ENTREZGENE
PANTHER CYCLIN-DEPENDENT KINASE INHIBITOR 3-RELATED UniProtKB/Swiss-Prot
  TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE UniProtKB/Swiss-Prot
Pfam CDKN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdkn3 PhenoGen
PIRSF CDKN3 UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
SMART PTPc_motif UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BPS7 ENTREZGENE, UniProtKB/TrEMBL
  CDKN3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9CWS3 ENTREZGENE
UniProt Secondary Q9CWS3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-02 Cdkn3  cyclin dependent kinase inhibitor 3  Cdkn3  cyclin-dependent kinase inhibitor 3  Symbol and/or name change 5135510 APPROVED