Nek3 (NIMA (never in mitosis gene a)-related expressed kinase 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Nek3 (NIMA (never in mitosis gene a)-related expressed kinase 3) Mus musculus
Analyze
Symbol: Nek3
Name: NIMA (never in mitosis gene a)-related expressed kinase 3
RGD ID: 1316606
MGI Page MGI
Description: Predicted to enable ATP binding activity; metal ion binding activity; and protein serine/threonine kinase activity. Involved in establishment of cell polarity; neuron projection morphogenesis; and regulation of tubulin deacetylation. Predicted to be located in cell projection and cytoplasm. Is expressed in several structures, including brain; genitourinary system; intestine; and spleen. Orthologous to human NEK3 (NIMA related kinase 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: never in mitosis A-related kinase 3; NIMA-related expressed kinase 3; nimA-related protein kinase 3; serine/threonine-protein kinase Nek3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,618,299 - 22,657,009 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,618,299 - 22,656,451 (-)EnsemblGRCm39 Ensembl
GRCm38822,128,283 - 22,166,997 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,128,283 - 22,166,435 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,238,755 - 23,276,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,593,828 - 23,631,947 (-)NCBIMGSCv36mm8
Celera823,623,168 - 23,659,067 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, etal., Hum Mol Genet 2004 Oct 1;13(19):2263-78. Epub 2004 Aug 18.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10224116   PMID:10393247   PMID:11810268   PMID:12477932   PMID:14610273   PMID:15345747   PMID:19509051   PMID:21677750   PMID:30973865   PMID:38355793  


Genomics

Comparative Map Data
Nek3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39822,618,299 - 22,657,009 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl822,618,299 - 22,656,451 (-)EnsemblGRCm39 Ensembl
GRCm38822,128,283 - 22,166,997 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,128,283 - 22,166,435 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,238,755 - 23,276,907 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36823,593,828 - 23,631,947 (-)NCBIMGSCv36mm8
Celera823,623,168 - 23,659,067 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.07NCBI
NEK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381352,132,647 - 52,159,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1352,132,639 - 52,159,597 (-)EnsemblGRCh38hg38GRCh38
GRCh371352,706,783 - 52,733,732 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361351,604,780 - 51,631,997 (-)NCBINCBI36Build 36hg18NCBI36
Build 341351,604,779 - 51,631,511NCBI
Celera1333,755,426 - 33,782,643 (-)NCBICelera
Cytogenetic Map13q14.3NCBI
HuRef1333,494,915 - 33,522,031 (-)NCBIHuRef
CHM1_11352,674,859 - 52,702,079 (-)NCBICHM1_1
T2T-CHM13v2.01351,347,476 - 51,374,692 (-)NCBIT2T-CHM13v2.0
Nek3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,569,465 - 76,594,921 (+)NCBIGRCr8
mRatBN7.21669,867,020 - 69,892,477 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,867,047 - 69,892,508 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01674,781,371 - 74,806,567 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,785,281 - 74,806,149 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01674,412,402 - 74,437,059 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,524,839 - 74,547,785 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11674,525,103 - 74,569,327 (+)NCBI
Celera1667,751,672 - 67,777,870 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
Nek3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554315,378,896 - 5,412,221 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554315,382,992 - 5,412,206 (-)NCBIChiLan1.0ChiLan1.0
NEK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21453,564,420 - 53,592,624 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11352,208,697 - 52,236,903 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01333,261,186 - 33,288,316 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11352,003,518 - 52,030,538 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1352,003,518 - 52,030,212 (-)Ensemblpanpan1.1panPan2
NEK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.125118,558 - 130,901 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha25237,734 - 250,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.025221,349 - 233,911 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.125102,210 - 114,767 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.025116,905 - 129,452 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.025184,724 - 197,292 (-)NCBIUU_Cfam_GSD_1.0
Nek3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945161,356,381 - 161,383,259 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365654,840,894 - 4,863,301 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365654,840,416 - 4,863,349 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1115,772,844 - 15,798,420 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11115,772,578 - 15,798,424 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21116,097,410 - 16,123,551 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1330,018,641 - 30,048,787 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl330,018,635 - 30,045,216 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605713,765,557 - 13,795,721 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nek3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247481,944,152 - 1,977,187 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247481,939,806 - 1,976,484 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nek3
1339 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:480
Count of miRNA genes:156
Interacting mature miRNAs:173
Transcripts:ENSMUST00000033865, ENSMUST00000110730, ENSMUST00000151371, ENSMUST00000178324
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13432571Scvg1_msubcutaneous vessel growth QTL 1 (mouse)8124751082Mouse
11533914Mts5_mmammary tumor susceptibility 5 (mouse)8130447432Mouse
4140978Nilac5_mnicotine induced locomotor activity 5 (mouse)Not determined8131773288Mouse
27226756Femd2_mfemur midshaft diameter 2, 5 week (mouse)8495000035067154Mouse
1357525Pnhdlc3_mplasma non-HDL cholesterol 3 (mouse)Not determined8721249923753815Mouse
1301532Scc8_mcolon tumor susceptibility 8 (mouse)Not determined8721249935110107Mouse
1300906Ap8q_malcohol preference 8 QTL (mouse)Not determined8798418941984342Mouse
10412209Cypr7_mcytokine production 7 (mouse)Not determined8810320142103372Mouse
1301929Eae24_msusceptibility to experimental allergic encephalomyelitis 24 (mouse)Not determined8810320142103372Mouse
1301128Sluc20_msusceptibility to lung cancer 20 (mouse)Not determined8810320142103372Mouse
11532713Sluc42_msusceptibility to lung cancer 42 (mouse)81344721035321225Mouse
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81477316071498244Mouse
1301088Alcw6_malcohol withdrawal 6 (mouse)Not determined81550657249506729Mouse
1300912Daq19_mdirectional asymmetry QTL 19 (mouse)Not determined81550657249506729Mouse
1301298Pgia4_mproteoglycan induced arthritis 4 (mouse)Not determined81656937350569697Mouse
4142199Poats1_mpost-ovarectomy adrenal tumor susceptibility 1 (mouse)Not determined1708262628849467Mouse
1301550Fembrs2_mfemur breaking strength 2 (mouse)Not determined81832109752321225Mouse
1301160Eae14_msusceptibility to experimental allergic encephalomyelitis 14 (mouse)Not determined81945501853455150Mouse
1300603Cd8ts2_mCD8 T cell subset 2 (mouse)Not determined81945501853455150Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000033865   ⟹   ENSMUSP00000033865
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,618,299 - 22,656,428 (-)Ensembl
GRCm38.p6 Ensembl822,128,283 - 22,166,412 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110730   ⟹   ENSMUSP00000106358
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,618,299 - 22,656,451 (-)Ensembl
GRCm38.p6 Ensembl822,128,283 - 22,166,435 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151371
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,618,702 - 22,622,318 (-)Ensembl
GRCm38.p6 Ensembl822,128,686 - 22,132,302 (-)Ensembl
RefSeq Acc Id: ENSMUST00000178324   ⟹   ENSMUSP00000136876
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl822,618,302 - 22,652,510 (-)Ensembl
GRCm38.p6 Ensembl822,128,286 - 22,162,494 (-)Ensembl
RefSeq Acc Id: NM_001162947   ⟹   NP_001156419
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,618,299 - 22,656,442 (-)NCBI
GRCm38822,128,286 - 22,162,494 (-)NCBI
MGSCv37823,238,755 - 23,276,907 (-)RGD
Celera823,623,168 - 23,659,067 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001424203   ⟹   NP_001411132
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,618,299 - 22,656,442 (-)NCBI
RefSeq Acc Id: NM_011848   ⟹   NP_035978
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,618,299 - 22,656,442 (-)NCBI
GRCm38822,128,283 - 22,166,435 (-)NCBI
MGSCv37823,238,755 - 23,276,907 (-)RGD
Celera823,623,168 - 23,659,067 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_188143
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,618,299 - 22,656,442 (-)NCBI
RefSeq Acc Id: XR_378785
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39822,618,299 - 22,657,009 (-)NCBI
GRCm38822,128,283 - 22,166,997 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035978   ⟸   NM_011848
- Peptide Label: isoform 2
- UniProtKB: F8WGD4 (UniProtKB/TrEMBL),   Q99K72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001156419   ⟸   NM_001162947
- Peptide Label: isoform 1
- UniProtKB: E9QLM2 (UniProtKB/Swiss-Prot),   Q9Z0X9 (UniProtKB/Swiss-Prot),   Q9R0A5 (UniProtKB/Swiss-Prot),   Q99K72 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000136876   ⟸   ENSMUST00000178324
RefSeq Acc Id: ENSMUSP00000106358   ⟸   ENSMUST00000110730
RefSeq Acc Id: ENSMUSP00000033865   ⟸   ENSMUST00000033865
RefSeq Acc Id: NP_001411132   ⟸   NM_001424203
- Peptide Label: isoform 3
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R0A5-F1-model_v2 AlphaFold Q9R0A5 1-511 view protein structure

Promoters
RGD ID:8666655
Promoter ID:EPDNEW_M11358
Type:single initiation site
Name:Nek3_1
Description:Mus musculus NIMA -related expressed kinase 3 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38822,166,426 - 22,166,486EPDNEW
RGD ID:6843534
Promoter ID:MM_KWN:53912
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Liver,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000075436,   OTTMUST00000075437
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36823,276,366 - 23,276,866 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1344371 AgrOrtholog
Ensembl Genes ENSMUSG00000031478 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000033865 ENTREZGENE
  ENSMUST00000033865.16 UniProtKB/TrEMBL
  ENSMUST00000110730 ENTREZGENE
  ENSMUST00000110730.10 UniProtKB/Swiss-Prot
  ENSMUST00000178324.2 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:23954 UniProtKB/Swiss-Prot
MGD MGI:1344371 ENTREZGENE
NCBI Gene 23954 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE NEK3 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE NEK3 UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE NEK3 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE NEK3 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nek3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QLM2 ENTREZGENE
  F8WGD4 ENTREZGENE, UniProtKB/TrEMBL
  NEK3_MOUSE UniProtKB/Swiss-Prot
  Q99K72 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0A5 ENTREZGENE
  Q9Z0X9 ENTREZGENE
UniProt Secondary E9QLM2 UniProtKB/Swiss-Prot
  Q9Z0X9 UniProtKB/Swiss-Prot