Habp4 (hyaluronic acid binding protein 4) - Rat Genome Database

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Gene: Habp4 (hyaluronic acid binding protein 4) Mus musculus
Analyze
Symbol: Habp4
Name: hyaluronic acid binding protein 4
RGD ID: 1315132
MGI Page MGI
Description: Predicted to enable RNA binding activity; SUMO binding activity; and hyaluronic acid binding activity. Predicted to be involved in PML body organization; cellular response to mechanical stimulus; and positive regulation of gene expression. Predicted to act upstream of or within hyaluronan metabolic process. Located in cytoplasm. Is active in synapse. Is expressed in central nervous system; ovary; retina; and white fat. Orthologous to human HABP4 (hyaluronan binding protein 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 4933413D03Rik; 4933428J01Rik; hyaluronic acid-binding protein 4 (intracellular); IHABP-4; IHABP4; intracellular hyaluronan-binding protein 4; intracellular hyaluronan-binding protein p57
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm3318   Gm7770  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,309,680 - 64,334,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1364,309,638 - 64,334,351 (+)EnsemblGRCm39 Ensembl
GRCm381364,161,866 - 64,186,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,161,824 - 64,186,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv371364,263,174 - 64,287,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361364,171,142 - 64,195,756 (+)NCBIMGSCv36mm8
Celera1365,825,382 - 65,849,877 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:6457647   PMID:8889548   PMID:10349636   PMID:10887182   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12537567   PMID:12652657   PMID:15489334   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:21267068   PMID:21873635   PMID:23894536   PMID:25211037   PMID:31040226   PMID:32325033   PMID:33245729  


Genomics

Comparative Map Data
Habp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,309,680 - 64,334,351 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1364,309,638 - 64,334,351 (+)EnsemblGRCm39 Ensembl
GRCm381364,161,866 - 64,186,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,161,824 - 64,186,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv371364,263,174 - 64,287,845 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361364,171,142 - 64,195,756 (+)NCBIMGSCv36mm8
Celera1365,825,382 - 65,849,877 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
HABP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38996,450,102 - 96,491,336 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl996,450,169 - 96,491,336 (+)EnsemblGRCh38hg38GRCh38
GRCh37999,212,451 - 99,253,618 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36998,252,235 - 98,293,439 (+)NCBINCBI36Build 36hg18NCBI36
Build 34996,292,041 - 96,332,342NCBI
Celera969,653,998 - 69,695,193 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef968,823,310 - 68,864,515 (+)NCBIHuRef
CHM1_1999,359,257 - 99,400,445 (+)NCBICHM1_1
T2T-CHM13v2.09108,621,878 - 108,663,114 (+)NCBIT2T-CHM13v2.0
Habp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr817940,672 - 963,358 (-)NCBIGRCr8
mRatBN7.217934,931 - 957,604 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17935,654 - 957,565 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17954,331 - 976,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,496,907 - 2,518,821 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017951,753 - 973,667 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0171,679,561 - 1,702,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,679,627 - 1,701,623 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,669,161 - 1,691,807 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,462,632 - 6,484,546 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1176,461,911 - 6,484,529 (-)NCBI
Celera171,559,641 - 1,581,556 (+)NCBICelera
Cytogenetic Map17p14NCBI
Habp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542223,450,251 - 23,475,984 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542223,449,175 - 23,475,919 (-)NCBIChiLan1.0ChiLan1.0
HABP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,960,697 - 43,002,100 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1942,963,075 - 43,004,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0967,545,866 - 67,587,270 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1995,640,088 - 95,708,956 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl995,668,184 - 95,707,653 (+)Ensemblpanpan1.1panPan2
HABP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1170,339,386 - 70,381,694 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl170,340,627 - 70,377,204 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha171,102,548 - 71,145,168 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0170,638,461 - 70,681,245 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl170,638,461 - 70,681,444 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1170,451,726 - 70,494,546 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0170,214,850 - 70,257,618 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0170,925,886 - 70,968,739 (-)NCBIUU_Cfam_GSD_1.0
Habp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049446,186,158 - 6,207,913 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936487402,701 - 424,399 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HABP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1025,598,175 - 25,636,046 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11025,599,413 - 25,636,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21029,514,408 - 29,538,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HABP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112106,645,715 - 106,685,444 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12106,643,424 - 106,685,417 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603895,044,457 - 95,084,354 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Habp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475318,047,970 - 18,078,150 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475318,048,042 - 18,077,322 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Habp4
1058 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:388
Count of miRNA genes:321
Interacting mature miRNAs:345
Transcripts:ENSMUST00000021929
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884393Humsd7_mhumerus midshaft diameter 7, 16 week (mouse)13395000076048119Mouse
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
4142009Pregq3_mpregnancy QTL 3 (mouse)Not determined132061551272385189Mouse
10755533Chol18_mcholesterol 18 (mouse)133096946764969467Mouse
10755517Chol15_mcholesterol 15 (mouse)133096946764969467Mouse
12738439Twq4_mtestis weight QTL 4 (mouse)133112911065129110Mouse
14696729Kidlq2_mkidney weight, left QTL 2 (mouse)133134473665344736Mouse
1301299Sluc23_msusceptibility to lung cancer 23 (mouse)Not determined133492194368922081Mouse
10412235Scgq5_mspontaneous crescentic glomerulonephritis QTL 5 (mouse)Not determined133606090896239162Mouse
1357587Pfat3_mpredicted fat percentage 3 (mouse)Not determined133610153070101640Mouse
1301734Acsns2_mAngiostrongylus costaricensis nematode susceptibility 2 (mouse)Not determined133610153070101640Mouse
1300561Heal7_mwound healing/regeneration 7 (mouse)Not determined133614482070144904Mouse
1300862Cfbw5_mcystic fibrosis body weight 5 (mouse)Not determined133872035872720517Mouse
1300985Bmd13_mbone mineral density 13 (mouse)Not determined133962924973629397Mouse
1302157Bwem2_mbody weight day 30 males 2 (mouse)Not determined133962924973629397Mouse
1301801Cpfd5_mcerebellum pattern fissures (mouse)Not determined133962924973629397Mouse
15039353Nmrs35_mNAFLD-associated magnetic resonance shift 35 (mouse)134058825374588253Mouse
1300668Pas10_mpulmonary adenoma susceptibility 10 (mouse)Not determined134148904275489158Mouse
4142331Bxs6_mBXSB/MpJ autoimmune nephritis 6 (mouse)Not determined4521044283744746Mouse
10412109Bxs7_mBXSB/MpJ autoimmune nephritis 7 (mouse)Not determined134521044283744746Mouse
26884396Humsd4_mhumerus midshaft diameter 4, 10 week (mouse)134785347673148119Mouse
4142372Moo2_mmodifier of Odc2 (mouse)Not determinedX5031841184318559Mouse
1301666Eae13_msusceptibility to experimental allergic encephalomyelitis 13 (mouse)Not determined135031841184318559Mouse
1300573Elsgp2_melevated serum gp70 2 (mouse)Not determined135061682884617027Mouse
14746975Manh74_mmandible shape 74 (mouse)135247726986477269Mouse
1302073Pgct1_mprimordial germ cell tumor locus 1 (mouse)Not determined135382078387820897Mouse
1357563Bmch6_mbone mechanical trait 6 (mouse)Not determined135538498089385140Mouse
4142314Tailaq3_mtail length adjusted QTL 3 (mouse)Not determined55720354112431103Mouse
4140959W10q17_mweight 10 weeks QTL 17 (mouse)Not determined55720354112431103Mouse
4141992W6q16_mweight 6 weeks QTL 16 (mouse)Not determined55720354112431103Mouse
4142241Tailq3_mtail length QTL 3 (mouse)Not determined55720354112431103Mouse
1558850Sgp3_mserum gp70 production 3 (mouse)Not determined135647045676971314Mouse
10402414Sgp5_mserum gp70 production 5 (mouse)Not determined1356470456105422186Mouse
1357553Cia28_mcollagen induced arthritis 28 (mouse)Not determined135662924996239162Mouse
10412163Wra1_mwheel running activity 1 (mouse)Not determined135913260093132738Mouse
1300941Skl6_mskeletal size (tail length) 6 (mouse)Not determined136425082198250945Mouse
1301949Skull20_mskull morphology 20 (mouse)Not determined136425082198250945Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021929   ⟹   ENSMUSP00000021929
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1364,309,683 - 64,334,351 (+)Ensembl
GRCm38.p6 Ensembl1364,161,869 - 64,186,537 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1364,310,060 - 64,311,432 (+)Ensembl
GRCm38.p6 Ensembl1364,162,246 - 64,163,618 (+)Ensembl
RefSeq Acc Id: ENSMUST00000221904   ⟹   ENSMUSP00000152612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1364,309,638 - 64,334,351 (+)Ensembl
GRCm38.p6 Ensembl1364,161,824 - 64,186,537 (+)Ensembl
RefSeq Acc Id: ENSMUST00000222806
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1364,321,914 - 64,330,397 (+)Ensembl
GRCm38.p6 Ensembl1364,174,100 - 64,182,583 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223328
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1364,310,060 - 64,320,610 (+)Ensembl
GRCm38.p6 Ensembl1364,162,246 - 64,172,796 (+)Ensembl
RefSeq Acc Id: ENSMUST00000223377
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1364,332,317 - 64,333,658 (+)Ensembl
GRCm38.p6 Ensembl1364,184,503 - 64,185,844 (+)Ensembl
RefSeq Acc Id: NM_019986   ⟹   NP_064370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391364,309,680 - 64,334,351 (+)NCBI
GRCm381364,161,866 - 64,186,537 (+)ENTREZGENE
MGSCv371364,263,174 - 64,287,845 (+)RGD
Celera1365,825,382 - 65,849,877 (+)RGD
cM Map13 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_064370   ⟸   NM_019986
- UniProtKB: Q9D450 (UniProtKB/Swiss-Prot),   Q3UNH8 (UniProtKB/Swiss-Prot),   Q9JKS5 (UniProtKB/Swiss-Prot),   E9QKB2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021929   ⟸   ENSMUST00000021929
RefSeq Acc Id: ENSMUSP00000152612   ⟸   ENSMUST00000221904
Protein Domains
Hyaluronan/mRNA-binding protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKS5-F1-model_v2 AlphaFold Q9JKS5 1-411 view protein structure

Promoters
RGD ID:8680636
Promoter ID:EPDNEW_M18349
Type:initiation region
Name:Habp4_1
Description:Mus musculus hyaluronic acid binding protein 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381364,161,870 - 64,161,930EPDNEW
RGD ID:6824006
Promoter ID:MM_KWN:14471
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_019986,   UC007QYL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361364,262,831 - 64,263,331 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891713 AgrOrtholog
Ensembl Genes ENSMUSG00000021476 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000021929 ENTREZGENE
  ENSMUST00000021929.10 UniProtKB/TrEMBL
  ENSMUST00000221904.2 UniProtKB/TrEMBL
InterPro HABP4/SERBP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HABP4_PAIRBP1-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IHABP4_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56541 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1891713 ENTREZGENE
NCBI Gene 56541 ENTREZGENE
PANTHER INTRACELLULAR HYALURONAN-BINDING PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HABP4_PAI-RBP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IHABP4_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Habp4 PhenoGen
SMART HABP4_PAI-RBP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VNT1_MOUSE UniProtKB/TrEMBL
  A7MAY6_MOUSE UniProtKB/TrEMBL
  E9QKB2 ENTREZGENE, UniProtKB/TrEMBL
  HABP4_MOUSE UniProtKB/Swiss-Prot
  Q3UJC1_MOUSE UniProtKB/TrEMBL
  Q3UNH8 ENTREZGENE
  Q9D450 ENTREZGENE
  Q9JKS5 ENTREZGENE
UniProt Secondary Q3UNH8 UniProtKB/Swiss-Prot
  Q9D450 UniProtKB/Swiss-Prot