Hic2 (hypermethylated in cancer 2) - Rat Genome Database

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Gene: Hic2 (hypermethylated in cancer 2) Mus musculus
Analyze
Symbol: Hic2
Name: hypermethylated in cancer 2
RGD ID: 1313308
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in central nervous system; extraembryonic component; female reproductive system; heart; and urinary system. Orthologous to human HIC2 (HIC ZBTB transcriptional repressor 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA409108; hic-2; HRG2; HRG22; hypermethylated in cancer 2 protein; mKIAA1020
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,051,451 - 17,081,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,051,436 - 17,081,294 (+)EnsemblGRCm39 Ensembl
GRCm381617,233,587 - 17,263,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,233,572 - 17,263,430 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,233,680 - 17,263,523 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,147,150 - 17,176,993 (+)NCBIMGSCv36mm8
Celera1617,806,402 - 17,836,239 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.68NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleoplasm  (ISO)
nucleus  (IBA,ISO)
plasma membrane  (ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80.
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11173852   PMID:11217851   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14681479  
PMID:15489334   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18287559   PMID:18799693   PMID:20059953   PMID:21267068   PMID:21873635   PMID:23630078   PMID:24748541   PMID:26206133  
PMID:26584622   PMID:29061339   PMID:31127867   PMID:34351428  


Genomics

Comparative Map Data
Hic2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,051,451 - 17,081,294 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,051,436 - 17,081,294 (+)EnsemblGRCm39 Ensembl
GRCm381617,233,587 - 17,263,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1617,233,572 - 17,263,430 (+)EnsemblGRCm38mm10GRCm38
MGSCv371617,233,680 - 17,263,523 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361617,147,150 - 17,176,993 (+)NCBIMGSCv36mm8
Celera1617,806,402 - 17,836,239 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1610.68NCBI
HIC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,417,371 - 21,451,463 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,417,371 - 21,451,463 (+)EnsemblGRCh38hg38GRCh38
GRCh372221,771,660 - 21,805,752 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362220,101,693 - 20,135,752 (+)NCBINCBI36Build 36hg18NCBI36
Build 342220,096,246 - 20,130,302NCBI
Celera225,515,817 - 5,524,520 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef224,831,266 - 4,839,973 (+)NCBIHuRef
CHM1_12221,772,928 - 21,805,973 (+)NCBICHM1_1
T2T-CHM13v2.02221,896,880 - 21,930,996 (-)NCBIT2T-CHM13v2.0
Hic2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81197,241,308 - 97,294,429 (-)NCBIGRCr8
mRatBN7.21183,737,075 - 83,789,554 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1183,738,874 - 83,767,484 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1192,468,892 - 92,497,416 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,130,042 - 85,158,569 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,183,649 - 84,212,175 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,988,213 - 88,016,825 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,988,213 - 88,016,825 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,040,376 - 91,092,856 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41185,740,737 - 85,770,511 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11185,783,605 - 85,788,018 (-)NCBI
Celera1182,501,044 - 82,529,506 (-)NCBICelera
Cytogenetic Map11q23NCBI
Hic2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544217,626,190 - 17,643,455 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544217,610,042 - 17,643,381 (+)NCBIChiLan1.0ChiLan1.0
HIC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22331,035,190 - 31,070,717 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12233,584,202 - 33,619,723 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0223,603,972 - 3,639,341 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1377,445,100 - 77,453,976 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl377,445,100 - 77,454,473 (-)Ensemblpanpan1.1panPan2
HIC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12630,771,555 - 30,804,652 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2630,776,464 - 30,780,173 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2630,729,504 - 30,762,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02632,176,739 - 32,209,855 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2632,181,651 - 32,185,360 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12630,226,722 - 30,259,812 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02629,850,536 - 29,883,623 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02630,940,328 - 30,973,651 (-)NCBIUU_Cfam_GSD_1.0
Hic2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118140,525,714 - 140,551,694 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366192,205,464 - 2,214,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366192,205,106 - 2,214,199 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1450,365,851 - 50,368,634 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11450,347,575 - 50,373,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,799,713 - 53,821,429 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,584,633 - 4,622,519 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,613,833 - 4,617,835 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660852,378,628 - 2,413,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hic2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247471,067,927 - 1,092,757 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247471,065,864 - 1,096,164 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hic2
910 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2718
Count of miRNA genes:768
Interacting mature miRNAs:1091
Transcripts:ENSMUST00000090190, ENSMUST00000115698
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161477522320103513Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse

Markers in Region
RH124822  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381617,261,246 - 17,261,538UniSTSGRCm38
MGSCv371617,261,339 - 17,261,631UniSTSGRCm37
Celera1617,834,055 - 17,834,347UniSTS
Cytogenetic Map16B1UniSTS
RH125835  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381617,261,314 - 17,261,517UniSTSGRCm38
MGSCv371617,261,407 - 17,261,610UniSTSGRCm37
Celera1617,834,123 - 17,834,326UniSTS
Cytogenetic Map16B1UniSTS
Whitehead/MRC_RH1651.07UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000090190   ⟹   ENSMUSP00000087656
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,051,436 - 17,081,294 (+)Ensembl
GRCm38.p6 Ensembl1617,233,572 - 17,263,430 (+)Ensembl
RefSeq Acc Id: ENSMUST00000232082   ⟹   ENSMUSP00000156293
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1617,051,528 - 17,079,459 (+)Ensembl
GRCm38.p6 Ensembl1617,233,664 - 17,261,595 (+)Ensembl
RefSeq Acc Id: NM_178922   ⟹   NP_849253
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391617,051,451 - 17,081,294 (+)NCBI
GRCm381617,233,587 - 17,263,430 (+)NCBI
MGSCv371617,233,680 - 17,263,523 (+)RGD
Celera1617,806,402 - 17,836,239 (+)RGD
cM Map16 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_849253   ⟸   NM_178922
- UniProtKB: Q8BSZ9 (UniProtKB/Swiss-Prot),   Q5K036 (UniProtKB/Swiss-Prot),   Q3ULP4 (UniProtKB/Swiss-Prot),   Q3U030 (UniProtKB/Swiss-Prot),   Q8C3T5 (UniProtKB/Swiss-Prot),   Q9JLZ6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000087656   ⟸   ENSMUST00000090190
RefSeq Acc Id: ENSMUSP00000156293   ⟸   ENSMUST00000232082
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLZ6-F1-model_v2 AlphaFold Q9JLZ6 1-619 view protein structure

Promoters
RGD ID:6827124
Promoter ID:MM_KWN:20296
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000115698,   NM_178922
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361617,233,386 - 17,233,886 (+)MPROMDB
RGD ID:8685596
Promoter ID:EPDNEW_M20829
Type:multiple initiation site
Name:Hic2_1
Description:Mus musculus hypermethylated in cancer 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381617,233,575 - 17,233,635EPDNEW
RGD ID:6847311
Promoter ID:MM_ACW:19968
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:HIC2.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361617,258,796 - 17,259,296 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929869 AgrOrtholog
Ensembl Genes ENSMUSG00000050240 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000090190 ENTREZGENE
  ENSMUST00000090190.14 UniProtKB/Swiss-Prot
  ENSMUST00000232082.2 UniProtKB/Swiss-Prot
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:58180 UniProtKB/Swiss-Prot
MGD MGI:1929869 ENTREZGENE
NCBI Gene 58180 ENTREZGENE
PANTHER HYPERMETHYLATED IN CANCER 2 PROTEIN UniProtKB/Swiss-Prot
  ZINC FINGER PROTEIN UniProtKB/Swiss-Prot
Pfam BTB UniProtKB/Swiss-Prot
  zf-C2H2 UniProtKB/Swiss-Prot
PharmGKB HIC2 RGD
PhenoGen Hic2 PhenoGen
PROSITE BTB UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART BTB UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot
UniProt HIC2_MOUSE UniProtKB/Swiss-Prot
  Q3U030 ENTREZGENE
  Q3ULP4 ENTREZGENE
  Q5K036 ENTREZGENE
  Q8BSZ9 ENTREZGENE
  Q8C3T5 ENTREZGENE
  Q9JLZ6 ENTREZGENE
UniProt Secondary Q3U030 UniProtKB/Swiss-Prot
  Q3ULP4 UniProtKB/Swiss-Prot
  Q5K036 UniProtKB/Swiss-Prot
  Q8BSZ9 UniProtKB/Swiss-Prot
  Q8C3T5 UniProtKB/Swiss-Prot