TRIM44 (tripartite motif containing 44) - Rat Genome Database

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Gene: TRIM44 (tripartite motif containing 44) Homo sapiens
Analyze
Symbol: TRIM44
Name: tripartite motif containing 44
RGD ID: 1312571
HGNC Page HGNC:19016
Description: Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including negative regulation of protein K48-linked ubiquitination; positive regulation of defense response to virus by host; and positive regulation of signal transduction. Predicted to be active in cytoplasm. Implicated in aniridia.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AN3; DIPB; HSA249128; MC7; MGC3490; tripartite motif-containing 44; tripartite motif-containing protein 44
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381135,662,775 - 35,818,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1135,662,775 - 35,818,007 (+)EnsemblGRCh38hg38GRCh38
GRCh371135,684,323 - 35,839,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,640,929 - 35,786,351 (+)NCBINCBI36Build 36hg18NCBI36
Build 341135,640,928 - 35,786,333NCBI
Celera1135,831,618 - 35,978,179 (+)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1135,382,982 - 35,529,605 (+)NCBIHuRef
CHM1_11135,682,770 - 35,829,354 (+)NCBICHM1_1
T2T-CHM13v2.01135,801,539 - 35,956,748 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Cardiac-specific Trim44 knockout in rat attenuates isoproterenol-induced cardiac remodeling via inhibition of AKT/mTOR pathway. Jiang XY, etal., Dis Model Mech. 2023 May 1;16(5):dmm049444. doi: 10.1242/dmm.049444. Epub 2022 Aug 18.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10568747   PMID:11165382   PMID:11331580   PMID:12477932   PMID:14702039   PMID:15489334   PMID:16341674   PMID:16344560   PMID:16554811   PMID:17577209   PMID:18854154   PMID:19358823  
PMID:19490893   PMID:19875103   PMID:19953087   PMID:20379614   PMID:21145461   PMID:21832049   PMID:21873635   PMID:22862969   PMID:23460740   PMID:25345539   PMID:25416956   PMID:26186194  
PMID:26394807   PMID:27058415   PMID:27503909   PMID:27619678   PMID:27754579   PMID:28160462   PMID:28514442   PMID:28618928   PMID:28885545   PMID:28965013   PMID:29446253   PMID:29526558  
PMID:30089913   PMID:30098109   PMID:30383661   PMID:30539341   PMID:30792262   PMID:30922374   PMID:31253590   PMID:31605296   PMID:31873114   PMID:31883420   PMID:31929141   PMID:32222118  
PMID:32271433   PMID:32296183   PMID:32503466   PMID:33151473   PMID:33629295   PMID:33634427   PMID:33961781   PMID:34034495   PMID:34211088   PMID:34382902   PMID:34423728   PMID:34677810  
PMID:34988777   PMID:35541909   PMID:35563538   PMID:35633558   PMID:36512309   PMID:37070216   PMID:38691326  


Genomics

Comparative Map Data
TRIM44
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381135,662,775 - 35,818,007 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1135,662,775 - 35,818,007 (+)EnsemblGRCh38hg38GRCh38
GRCh371135,684,323 - 35,839,557 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,640,929 - 35,786,351 (+)NCBINCBI36Build 36hg18NCBI36
Build 341135,640,928 - 35,786,333NCBI
Celera1135,831,618 - 35,978,179 (+)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1135,382,982 - 35,529,605 (+)NCBIHuRef
CHM1_11135,682,770 - 35,829,354 (+)NCBICHM1_1
T2T-CHM13v2.01135,801,539 - 35,956,748 (+)NCBIT2T-CHM13v2.0
Trim44
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392102,130,464 - 102,231,541 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2102,130,464 - 102,238,173 (-)EnsemblGRCm39 Ensembl
GRCm382102,300,119 - 102,400,900 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2102,300,119 - 102,407,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv372102,140,276 - 102,241,057 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362102,100,958 - 102,201,739 (-)NCBIMGSCv36mm8
Celera2103,537,119 - 103,637,729 (-)NCBICelera
Cytogenetic Map2E2NCBI
cM Map254.13NCBI
Trim44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83109,048,643 - 109,183,821 (-)NCBIGRCr8
mRatBN7.2388,593,619 - 88,729,085 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl388,592,719 - 88,729,188 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx392,174,688 - 92,232,227 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03100,773,706 - 100,831,243 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0398,593,249 - 98,650,810 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0391,968,781 - 92,242,138 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl392,183,556 - 92,242,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0398,626,537 - 98,894,480 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4387,458,183 - 87,594,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1387,354,610 - 87,490,757 (-)NCBI
Celera387,703,331 - 87,822,337 (-)NCBICelera
Cytogenetic Map3q32NCBI
Trim44
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542210,580,002 - 10,690,349 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542210,580,002 - 10,690,349 (-)NCBIChiLan1.0ChiLan1.0
TRIM44
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2937,881,633 - 38,111,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11137,886,297 - 38,116,016 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,633,985 - 35,782,260 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,508,589 - 35,656,684 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,508,083 - 35,656,684 (+)Ensemblpanpan1.1panPan2
TRIM44
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11832,242,830 - 32,351,540 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1832,247,146 - 32,351,648 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1831,849,489 - 31,958,122 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01832,853,137 - 32,961,804 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1832,853,874 - 32,962,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11832,414,167 - 32,522,742 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01831,999,405 - 32,108,058 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,644,829 - 32,753,492 (-)NCBIUU_Cfam_GSD_1.0
Trim44
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494729,315,842 - 29,424,036 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365332,437,641 - 2,548,837 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365332,440,241 - 2,548,831 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM44
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl225,276,859 - 25,378,448 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1225,275,193 - 25,378,738 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2227,638,106 - 27,737,932 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TRIM44
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,461,928 - 29,592,084 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,464,090 - 29,592,270 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038126,584,251 - 126,719,217 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Trim44
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476711,378,172 - 11,550,337 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476711,373,992 - 11,550,622 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TRIM44
18 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_017583.6(TRIM44):c.463G>A (p.Gly155Arg) single nucleotide variant Aniridia 3 [RCV000254593] Chr11:35663574 [GRCh38]
Chr11:35685122 [GRCh37]
Chr11:11p13		 pathogenic
GRCh38/hg38 11p13-12(chr11:35135480-37649168)x1 copy number loss See cases [RCV000051067] Chr11:35135480..37649168 [GRCh38]
Chr11:35157027..37670718 [GRCh37]
Chr11:35113603..37627294 [NCBI36]
Chr11:11p13-12		 uncertain significance
GRCh38/hg38 11p13-11.2(chr11:35663578-46959820)x1 copy number loss See cases [RCV000052679] Chr11:35663578..46959820 [GRCh38]
Chr11:35685126..46981371 [GRCh37]
Chr11:35641702..46937947 [NCBI36]
Chr11:11p13-11.2		 pathogenic
GRCh38/hg38 11p14.3-12(chr11:22550115-38199159)x1 copy number loss See cases [RCV000052648] Chr11:22550115..38199159 [GRCh38]
Chr11:22571661..38220709 [GRCh37]
Chr11:22528237..38177285 [NCBI36]
Chr11:11p14.3-12		 pathogenic
GRCh38/hg38 11p13-12(chr11:35103218-38791492)x1 copy number loss See cases [RCV000053255] Chr11:35103218..38791492 [GRCh38]
Chr11:35124765..38813042 [GRCh37]
Chr11:35081341..38769618 [NCBI36]
Chr11:11p13-12		 uncertain significance
GRCh38/hg38 11p13-12(chr11:34161694-36799127)x3 copy number gain See cases [RCV000053617] Chr11:34161694..36799127 [GRCh38]
Chr11:34183241..36820677 [GRCh37]
Chr11:34139817..36777253 [NCBI36]
Chr11:11p13-12		 pathogenic
NM_017583.5(TRIM44):c.755G>T (p.Arg252Leu) single nucleotide variant Malignant melanoma [RCV000062202] Chr11:35725931 [GRCh38]
Chr11:35747479 [GRCh37]
Chr11:35704055 [NCBI36]
Chr11:11p13		 not provided
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11p13-12(chr11:34168931-36820798)x3 copy number gain See cases [RCV000142987] Chr11:34168931..36820798 [GRCh38]
Chr11:34190478..36842348 [GRCh37]
Chr11:34147054..36798924 [NCBI36]
Chr11:11p13-12		 uncertain significance
GRCh37/hg19 11p14.1-12(chr11:30615127-40606139)x1 copy number loss See cases [RCV000240268] Chr11:30615127..40606139 [GRCh37]
Chr11:11p14.1-12		 pathogenic
GRCh37/hg19 11p14.1-11.2(chr11:29238811-45494063)x1 copy number loss See cases [RCV000445800] Chr11:29238811..45494063 [GRCh37]
Chr11:11p14.1-11.2		 pathogenic
GRCh37/hg19 11p13-12(chr11:34189942-36857171)x3 copy number gain See cases [RCV000448252] Chr11:34189942..36857171 [GRCh37]
Chr11:11p13-12		 uncertain significance
GRCh37/hg19 11p13-12(chr11:32782607-36404823)x3 copy number gain See cases [RCV000448055] Chr11:32782607..36404823 [GRCh37]
Chr11:11p13-12		 uncertain significance
GRCh37/hg19 11p14.2-11.12(chr11:26574629-50508019)x3 copy number gain See cases [RCV000448603] Chr11:26574629..50508019 [GRCh37]
Chr11:11p14.2-11.12		 pathogenic
GRCh37/hg19 11p13-12(chr11:35126357-38814431)x1 copy number loss See cases [RCV000510326] Chr11:35126357..38814431 [GRCh37]
Chr11:11p13-12		 uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-12(chr11:230615-37698540)x3 copy number gain See cases [RCV000511561] Chr11:230615..37698540 [GRCh37]
Chr11:11p15.5-12		 pathogenic
GRCh37/hg19 11p14.1-12(chr11:27588560-41770792)x1 copy number loss See cases [RCV000511434] Chr11:27588560..41770792 [GRCh37]
Chr11:11p14.1-12		 pathogenic|uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p14.3-12(chr11:24469451-37524085)x1 copy number loss not provided [RCV000737457] Chr11:24469451..37524085 [GRCh37]
Chr11:11p14.3-12		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_017583.6(TRIM44):c.941A>G (p.Lys314Arg) single nucleotide variant not provided [RCV000881258] Chr11:35726117 [GRCh38]
Chr11:35747665 [GRCh37]
Chr11:11p13		 benign
NM_017583.6(TRIM44):c.552T>C (p.Leu184=) single nucleotide variant not provided [RCV000969064] Chr11:35663663 [GRCh38]
Chr11:35685211 [GRCh37]
Chr11:11p13		 benign
NM_017583.6(TRIM44):c.537T>C (p.Cys179=) single nucleotide variant not provided [RCV000976155] Chr11:35663648 [GRCh38]
Chr11:35685196 [GRCh37]
Chr11:11p13		 likely benign
NM_017583.6(TRIM44):c.579T>C (p.Asp193=) single nucleotide variant not provided [RCV000969065] Chr11:35663690 [GRCh38]
Chr11:35685238 [GRCh37]
Chr11:11p13		 benign
GRCh37/hg19 11p13(chr11:35782909-36024456)x3 copy number gain not provided [RCV001006403] Chr11:35782909..36024456 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.*23A>G single nucleotide variant Aniridia 3 [RCV001838947] Chr11:35806408 [GRCh38]
Chr11:35827958 [GRCh37]
Chr11:11p13		 benign
GRCh37/hg19 11p13-12(chr11:32782607-36404823) copy number gain not specified [RCV002052921] Chr11:32782607..36404823 [GRCh37]
Chr11:11p13-12		 uncertain significance
GRCh37/hg19 11p13-12(chr11:34189942-36857171) copy number gain not specified [RCV002052922] Chr11:34189942..36857171 [GRCh37]
Chr11:11p13-12		 uncertain significance
NM_017583.6(TRIM44):c.670-27G>C single nucleotide variant Aniridia 3 [RCV001838946] Chr11:35685232 [GRCh38]
Chr11:35706780 [GRCh37]
Chr11:11p13		 benign
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_017583.6(TRIM44):c.260A>G (p.Gln87Arg) single nucleotide variant not specified [RCV004141341] Chr11:35663371 [GRCh38]
Chr11:35684919 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.97T>G (p.Cys33Gly) single nucleotide variant not specified [RCV004111629] Chr11:35663208 [GRCh38]
Chr11:35684756 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.209C>T (p.Pro70Leu) single nucleotide variant not specified [RCV004084696] Chr11:35663320 [GRCh38]
Chr11:35684868 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.23C>T (p.Ala8Val) single nucleotide variant not specified [RCV004175089] Chr11:35663134 [GRCh38]
Chr11:35684682 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.992A>T (p.Asp331Val) single nucleotide variant not specified [RCV004228667] Chr11:35735430 [GRCh38]
Chr11:35756978 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.433A>G (p.Asn145Asp) single nucleotide variant not specified [RCV004146401] Chr11:35663544 [GRCh38]
Chr11:35685092 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.458C>T (p.Ala153Val) single nucleotide variant not specified [RCV004077106] Chr11:35663569 [GRCh38]
Chr11:35685117 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.289G>A (p.Glu97Lys) single nucleotide variant not specified [RCV004314961] Chr11:35663400 [GRCh38]
Chr11:35684948 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.467A>G (p.Glu156Gly) single nucleotide variant not specified [RCV004281081] Chr11:35663578 [GRCh38]
Chr11:35685126 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.222G>C (p.Glu74Asp) single nucleotide variant not specified [RCV004272975] Chr11:35663333 [GRCh38]
Chr11:35684881 [GRCh37]
Chr11:11p13		 likely benign
GRCh37/hg19 11p13(chr11:35516838-35724011)x3 copy number gain not provided [RCV003484836] Chr11:35516838..35724011 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.174C>T (p.Ala58=) single nucleotide variant TRIM44-related condition [RCV003907360] Chr11:35663285 [GRCh38]
Chr11:35684833 [GRCh37]
Chr11:11p13		 benign
NM_017583.6(TRIM44):c.669+7A>G single nucleotide variant TRIM44-related condition [RCV003941876] Chr11:35663787 [GRCh38]
Chr11:35685335 [GRCh37]
Chr11:11p13		 likely benign
NM_017583.6(TRIM44):c.124C>T (p.Arg42Cys) single nucleotide variant not specified [RCV004473885] Chr11:35663235 [GRCh38]
Chr11:35684783 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.155T>A (p.Phe52Tyr) single nucleotide variant not specified [RCV004473886] Chr11:35663266 [GRCh38]
Chr11:35684814 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.175G>C (p.Glu59Gln) single nucleotide variant not specified [RCV004473887] Chr11:35663286 [GRCh38]
Chr11:35684834 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.253G>T (p.Val85Leu) single nucleotide variant not specified [RCV004473890] Chr11:35663364 [GRCh38]
Chr11:35684912 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.418G>A (p.Glu140Lys) single nucleotide variant not specified [RCV004473891] Chr11:35663529 [GRCh38]
Chr11:35685077 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.208C>G (p.Pro70Ala) single nucleotide variant not specified [RCV004473888] Chr11:35663319 [GRCh38]
Chr11:35684867 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.227C>G (p.Ala76Gly) single nucleotide variant not specified [RCV004473889] Chr11:35663338 [GRCh38]
Chr11:35684886 [GRCh37]
Chr11:11p13		 uncertain significance
NM_017583.6(TRIM44):c.799C>G (p.Gln267Glu) single nucleotide variant not specified [RCV004473892] Chr11:35725975 [GRCh38]
Chr11:35747523 [GRCh37]
Chr11:11p13		 uncertain significance
GRCh37/hg19 11p13-12(chr11:31372721-38259316)x1 copy number loss not provided [RCV002472502] Chr11:31372721..38259316 [GRCh37]
Chr11:11p13-12		 pathogenic
GRCh37/hg19 11p13-12(chr11:34183318-36860753)x3 copy number gain not provided [RCV000845975] Chr11:34183318..36860753 [GRCh37]
Chr11:11p13-12		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:879
Count of miRNA genes:648
Interacting mature miRNAs:693
Transcripts:ENST00000299413, ENST00000532066
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D11S4203  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,813,457 - 35,813,694UniSTSGRCh37
Build 361135,770,033 - 35,770,270RGDNCBI36
Celera1135,960,722 - 35,960,939RGD
Cytogenetic Map11p13UniSTS
HuRef1135,512,153 - 35,512,370UniSTS
Marshfield Genetic Map1145.94RGD
Marshfield Genetic Map1145.94UniSTS
Genethon Genetic Map1149.6UniSTS
deCODE Assembly Map1152.63UniSTS
Whitehead-YAC Contig Map11 UniSTS
SHGC-57397  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,830,930 - 35,831,079UniSTSGRCh37
Build 361135,787,506 - 35,787,655RGDNCBI36
Celera1135,978,179 - 35,978,328RGD
Cytogenetic Map11p13UniSTS
HuRef1135,529,605 - 35,529,754UniSTS
TNG Radiation Hybrid Map1116919.0UniSTS
WI-12351  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,829,640 - 35,829,765UniSTSGRCh37
Build 361135,786,216 - 35,786,341RGDNCBI36
Celera1135,976,884 - 35,977,009RGD
Cytogenetic Map11p13UniSTS
HuRef1135,528,309 - 35,528,434UniSTS
GeneMap99-GB4 RH Map11131.8UniSTS
Whitehead-RH Map11119.2UniSTS
NCBI RH Map11209.7UniSTS
SHGC-68523  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,711,302 - 35,711,522UniSTSGRCh37
Build 361135,667,878 - 35,668,098RGDNCBI36
Celera1135,858,567 - 35,858,787RGD
Cytogenetic Map11p13UniSTS
HuRef1135,409,935 - 35,410,155UniSTS
RH120541  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,693,616 - 35,693,934UniSTSGRCh37
Build 361135,650,192 - 35,650,510RGDNCBI36
Celera1135,840,881 - 35,841,199RGD
Cytogenetic Map11p13UniSTS
HuRef1135,392,249 - 35,392,567UniSTS
TNG Radiation Hybrid Map1116876.0UniSTS
SHGC-146955  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,750,473 - 35,750,750UniSTSGRCh37
Build 361135,707,049 - 35,707,326RGDNCBI36
Celera1135,897,732 - 35,898,009RGD
Cytogenetic Map11p13UniSTS
HuRef1135,449,163 - 35,449,440UniSTS
TNG Radiation Hybrid Map1116888.0UniSTS
D11S1201  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,689,636 - 35,689,802UniSTSGRCh37
Build 361135,646,212 - 35,646,378RGDNCBI36
Celera1135,836,901 - 35,837,067RGD
Cytogenetic Map11p13UniSTS
HuRef1135,388,265 - 35,388,431UniSTS
SHGC-154777  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,802,207 - 35,802,504UniSTSGRCh37
Build 361135,758,783 - 35,759,080RGDNCBI36
Celera1135,949,473 - 35,949,770RGD
Cytogenetic Map11p13UniSTS
HuRef1135,500,904 - 35,501,201UniSTS
TNG Radiation Hybrid Map1116903.0UniSTS
D11S981E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,828,852 - 35,828,949UniSTSGRCh37
GRCh371135,828,885 - 35,828,962UniSTSGRCh37
Build 361135,785,428 - 35,785,525RGDNCBI36
Celera1135,976,096 - 35,976,193RGD
Celera1135,976,129 - 35,976,206UniSTS
Cytogenetic Map11p13UniSTS
HuRef1135,527,554 - 35,527,631UniSTS
HuRef1135,527,521 - 35,527,618UniSTS
GeneMap99-GB4 RH Map11131.8UniSTS
NCBI RH Map11209.7UniSTS
RH64981  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,830,707 - 35,830,825UniSTSGRCh37
Build 361135,787,283 - 35,787,401RGDNCBI36
Celera1135,977,956 - 35,978,074RGD
Cytogenetic Map11p13UniSTS
HuRef1135,529,382 - 35,529,500UniSTS
GeneMap99-GB4 RH Map11131.82UniSTS
TRIM44_3837  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371135,829,137 - 35,829,913UniSTSGRCh37
Build 361135,785,713 - 35,786,489RGDNCBI36
Celera1135,976,381 - 35,977,162RGD
HuRef1135,527,806 - 35,528,588UniSTS
D11S981E  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1
Medium 2278 1568 1406 348 1172 214 3759 1317 3207 344 1359 1585 147 1194 2253 3
Low 158 1414 319 275 757 250 597 879 523 75 94 25 27 1 10 535 1 1
Below cutoff 2 7 11 1 3 4 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_052784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006718254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054369171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC026970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ249128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK021823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL138812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI222592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI550863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM787577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ014398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA445350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX788887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX871447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA128342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA131915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA158251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA208113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF510371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000299413   ⟹   ENSP00000299413
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1135,662,775 - 35,818,007 (+)Ensembl
RefSeq Acc Id: ENST00000532066
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1135,724,256 - 35,806,621 (+)Ensembl
RefSeq Acc Id: NM_017583   ⟹   NP_060053
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381135,662,775 - 35,818,007 (+)NCBI
GRCh371135,684,353 - 35,830,930 (+)RGD
Build 361135,640,929 - 35,786,351 (+)NCBI Archive
Celera1135,831,618 - 35,978,179 (+)RGD
HuRef1135,382,982 - 35,529,605 (+)ENTREZGENE
CHM1_11135,682,717 - 35,831,027 (+)NCBI
T2T-CHM13v2.01135,801,539 - 35,956,748 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006718254   ⟹   XP_006718317
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381135,662,775 - 35,818,007 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054369171   ⟹   XP_054225146
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01135,801,539 - 35,956,748 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_060053   ⟸   NM_017583
- UniProtKB: Q96QY2 (UniProtKB/Swiss-Prot),   D3DR14 (UniProtKB/Swiss-Prot),   Q9UGK0 (UniProtKB/Swiss-Prot),   Q96DX7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006718317   ⟸   XM_006718254
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000299413   ⟸   ENST00000299413
RefSeq Acc Id: XP_054225146   ⟸   XM_054369171
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q96DX7-F1-model_v2 AlphaFold Q96DX7 1-344 view protein structure

Promoters
RGD ID:6789477
Promoter ID:HG_KWN:12633
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_017583
Position:
Human AssemblyChrPosition (strand)Source
Build 361135,640,781 - 35,641,281 (+)MPROMDB
RGD ID:7220069
Promoter ID:EPDNEW_H15781
Type:initiation region
Name:TRIM44_1
Description:tripartite motif containing 44
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381135,662,880 - 35,662,940EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:19016 AgrOrtholog
COSMIC TRIM44 COSMIC
Ensembl Genes ENSG00000166326 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000299413 ENTREZGENE
  ENST00000299413.7 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.830.40 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
GTEx ENSG00000166326 GTEx
HGNC ID HGNC:19016 ENTREZGENE
Human Proteome Map TRIM44 Human Proteome Map
InterPro Znf_B-box UniProtKB/Swiss-Prot
KEGG Report hsa:54765 UniProtKB/Swiss-Prot
NCBI Gene 54765 ENTREZGENE
OMIM 612298 OMIM
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/Swiss-Prot
  TRIPARTITE MOTIF-CONTAINING PROTEIN 44 UniProtKB/Swiss-Prot
Pfam zf-B_box UniProtKB/Swiss-Prot
PharmGKB PA134906584 PharmGKB
PROSITE ZF_BBOX UniProtKB/Swiss-Prot
SMART BBOX UniProtKB/Swiss-Prot
Superfamily-SCOP B-box zinc-binding domain UniProtKB/Swiss-Prot
UniProt D3DR14 ENTREZGENE
  Q96DX7 ENTREZGENE
  Q96QY2 ENTREZGENE
  Q9UGK0 ENTREZGENE
  TRI44_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary D3DR14 UniProtKB/Swiss-Prot
  Q96QY2 UniProtKB/Swiss-Prot
  Q9UGK0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-01 TRIM44  tripartite motif containing 44  TRIM44  tripartite motif containing 44  Symbol and/or name change 5135510 APPROVED
2011-07-27 TRIM44  tripartite motif containing 44  TRIM44  tripartite motif-containing 44  Symbol and/or name change 5135510 APPROVED