Shc2 (SHC adaptor protein 2) - Rat Genome Database

Name: Shc2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Shc2 (SHC adaptor protein 2) Rattus norvegicus

Analyze

Symbol:

Shc2

Name:

SHC adaptor protein 2

RGD ID:

1307137

Description:

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. Orthologous to human SHC2 (SHC adaptor protein 2); PARTICIPATES IN chemokine mediated signaling pathway; chronic myeloid leukemia pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC314612; protein Sck; SH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHC-transforming protein 2; src homology 2 domain-containing transforming; src homology 2 domain-containing transforming protein C2; src homology 2 domain-containing-transforming protein C2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SHC2 (SHC adaptor protein 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Shc2 (SHC (Src homology 2 domain containing) transforming protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Shc2 (SHC adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SHC2 (SHC adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SHC2 (SHC adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Shc2 (SHC adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SHC2 (SHC adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103233559 (SHC-transforming protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Shc2 (SHC adaptor protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ITGAD (integrin subunit alpha D)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Shc2 (SHC (Src homology 2 domain containing) transforming protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SHC2 (SHC adaptor protein 2)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	shc2 (SHC (Src homology 2 domain containing) transforming protein 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	shc-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Shc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	shc2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,717,320 - 10,739,539 (+)	NCBI		GRCr8
mRatBN7.2	7	10,066,705 - 10,088,926 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	10,066,705 - 10,088,926 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,948,071 - 12,970,304 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,826,155 - 14,848,390 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,685,795 - 12,708,193 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,948,952 - 12,971,174 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,948,952 - 12,971,174 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	13,117,670 - 13,139,889 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,583,380 - 11,605,675 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,582,082 - 11,604,162 (+)	NCBI
Celera	7	8,239,277 - 8,261,491 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Butylbenzyl phthalate (EXP)

cadmium dichloride (EXP)

calcitriol (ISO)

choline (ISO)

cisplatin (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gentamycin (EXP)

L-methionine (ISO)

lead(0) (ISO)

Monobutylphthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

testosterone (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor protein tyrosine kinase signaling pathway (IBA)

intracellular signal transduction (IEA)

Cellular Component

plasma membrane (IBA)

Molecular Function

protein binding (ISO)

receptor tyrosine kinase binding (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine mediated signaling pathway (IEA)

chronic myeloid leukemia pathway (IEA)

epidermal growth factor/neuregulin signaling pathway (IEA)

glioma pathway (IEA)

insulin signaling pathway (IEA)

neurotrophic factor signaling pathway (IEA)

vascular endothelial growth factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment.	Jiang X, etal., Aging Cell 2003 Feb;2(1):47-57.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Shc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	10,717,320 - 10,739,539 (+)	NCBI		GRCr8
mRatBN7.2	7	10,066,705 - 10,088,926 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	10,066,705 - 10,088,926 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	12,948,071 - 12,970,304 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	14,826,155 - 14,848,390 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	12,685,795 - 12,708,193 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	12,948,952 - 12,971,174 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	12,948,952 - 12,971,174 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	13,117,670 - 13,139,889 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	11,583,380 - 11,605,675 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	11,582,082 - 11,604,162 (+)	NCBI
Celera	7	8,239,277 - 8,261,491 (+)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

SHC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	416,589 - 461,033 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	416,589 - 461,033 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	416,589 - 461,033 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	367,583 - 411,832 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	411,901 - 411,957	NCBI
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	185,638 - 230,388 (-)	NCBI		HuRef
CHM1_1	19	413,915 - 460,585 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	364,869 - 412,538 (-)	NCBI		T2T-CHM13v2.0

Shc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	79,453,768 - 79,473,752 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	79,453,885 - 79,473,752 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	79,617,934 - 79,637,918 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	79,618,051 - 79,637,918 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	79,080,679 - 79,100,663 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	79,021,033 - 79,040,990 (-)	NCBI		MGSCv36	mm8
Celera	10	80,631,300 - 80,651,284 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Shc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955495	7,216,806 - 7,236,056 (+)	NCBI	ChiLan1.0	ChiLan1.0

SHC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	4,723,555 - 4,787,947 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	3,967,330 - 4,025,675 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	19	367,348 - 405,054 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SHC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	58,001,442 - 58,023,201 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	57,804,227 - 57,825,834 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	58,744,465 - 58,766,097 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	20	57,798,377 - 57,819,985 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	58,278,093 - 58,299,887 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	58,481,722 - 58,503,345 (+)	NCBI		UU_Cfam_GSD_1.0

Shc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	217,725,930 - 217,743,083 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936588	91,700 - 109,784 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SHC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	77,812,379 - 77,844,032 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103233559
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	151,955 - 193,626 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666875	21,359 - 28,693 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Shc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624828	7,978,031 - 7,996,448 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Shc2
72 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	189
Count of miRNA genes:	139
Interacting mature miRNAs:	155
Transcripts:	ENSRNOT00000010714
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	27829089	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	31962314	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	31962314	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34000259	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	35342956	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	44782185	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	1	44822433	Rat
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	664270	26029351	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	3529280	48529280	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	5329019	50329019	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	7496499	52496499	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	7573985	52573985	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	9462246	58265113	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			2						57	6	26
Low	3	43	35	21	19	21	8	11	17	29	15	11	8
Below cutoff			20	20		20

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC097878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC115214	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000010714 ⟹ ENSRNOP00000010714

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	10,066,705 - 10,088,926 (+)	Ensembl
Rnor_6.0 Ensembl	7	12,948,952 - 12,971,174 (+)	Ensembl

RefSeq Acc Id:

NM_001108065 ⟹ NP_001101535

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	10,717,320 - 10,739,539 (+)	NCBI
mRatBN7.2	7	10,066,705 - 10,088,926 (+)	NCBI
Rnor_6.0	7	12,948,952 - 12,971,174 (+)	NCBI
Rnor_5.0	7	13,117,670 - 13,139,889 (+)	NCBI
RGSC_v3.4	7	11,583,380 - 11,605,675 (+)	RGD
Celera	7	8,239,277 - 8,261,491 (+)	RGD

Sequence:

show sequence

CATCACTCGGCGGGGAGGAGCGCACGGCTCCCGGCCAGGCTCAGCCGGGGTTCCTCGGCGGCCG
CGGCCATGACGCAGGGTCCCGGTGGCCGCGCGGCCCCCGAGCCCGAGGCGCCCACCACCTTCTG
CGCGCTGCTACCGCGCATGCCGCAGTGGAAGTTCGCGGCGCCCGGTAGCTTCCTGGGCCGCGGT
CCGGCGGCTGCGCGCGTGGCGGGGGCGGCAGAGGCGCAGCCCGAGCCTGGGGTCCCCGCGCTGG
CCGCCGTGCTGGGTGCCTGCGAACCGCGCTGTGCCGCGCCCTGTCCGCTACCAGCTCTCGGCCG
CTGCCGGGGCTCGGGGTCGCGGGGCGCGCGGGGAACTCCCGACGTCGCCGACGAGTGGGTGCGC
AAGGGCGGCTTCATTCACAAGCCCGCGCACGGCTGGCTGCACCCCGATGCGAGGGTCCTGGGGC
CCGGGGTCTCTTACATCGTTCGGTACATGGGCTGCATTGAGGTGCTCCGATCTATGCGCTCCCT
GGATTTCAACACCCGGACACAGGTGACGAGGGAAGCCATCAATCGGCTCCACGAGGCTGTGCCA
GGTGTCCGAGGCTCCTGGAAGAAGAAGGCCCCCAACAAGGCGCTGGCCTCCATCTTGGGGAAAA
GCAACCTGCGCTTCGCCGGCATGAGCATCTCAGTCAACATCTCTGTGGACGGCCTTAACTTGTC
AGTTCCCGCTACCCGTCAGATCATCGCCAACCATCACATGCAGTCTATTTCCTTCGCCTCCGGT
GGCGACACGGACATGACCGATTACGTGGCCTATGTGGCCAAGGACCCCATCAACCAGAGAGCCT
GCCACATCTTGGAATGCTGTGAGGGTCTCGCCCAGAGTGTCATCAGCACCGTGGGGCAAGCCTT
TGAGCTGCGCTTCAAGCAATACCTGCACAGTCCGCCCAAGGCTGTCGTGCCCCCTGAAAGGCTG
ACCGGGCTGGAGGAGTCGGCCTGGGGTGATGGTGAGGTTACTGCAGACCACGATTACTACAACA
GCATTCCAGGAAAGGAGCCACCCCTGGGCGGGCTGGTGGACTCCAGACTGGCTGTCACACAGCC
CTGTGCGCTGACAACACTTGGGGGCCTTGGACAGGGATTGTCACCTGCCTGGAGAGATGTCCGT
GGCTTGCCTTGGGACATGGGCCCCTCTGGAGCAGTCCCACCTGGGGATGGCTACGTGCAGGCAG
ATGCCCGAGGGCCACATGACTACGAGGAACACCTGTATGTCAACACCCAGGGCCTGGACGCTTT
GGAGCTTGAGGACACCTCCGAGACACCTCTGCAGCCTGAGGACAGCCCCAAGAAGGACCTGTTT
GACATGCGACCCTTTGAAGATGCCCTGAAGTTGCACGAGTGCTCCGTGGCAGCAGGCATTACTG
CAGCCTCACTCCCTCTGGAGGATCAGTGGCCCAGCCCCCCTACCCGCAGGGCCCCCATTGCACC
CACAGAGGAGCAACTGAGGCAGGAGCCCTGGTACCATGGACGAATGAGCCGTCGGGCTGCAGAG
AAGCTGCTTCGTGCCGATGGGGACTTCCTTGTGAGAGACAGCATCACCAACCCGGGGCAGTATG
TCCTCACAGGCATGCACGCGGGGCAGCCCAAGCACCTGCTGCTGGTGGACCCCGAGGGTGTGGT
ACGGACAAAAGATGTGCTGTTTGAGAGCATCAGCCACCTCATAGACTATCACCTGAAGAACGGG
TTGCCCATCGTGGCTGCCGAGAGTGAACTGCATCTGCGGGGAGTGGTCTCTCGGGAGCCATGAG
CCAGGTGACAGTCGTCAGCCCTTGCTGTGGCCCCGAGGGCTCAGCCTTTCTCTCAGACCCTGAA
GCCACGAGAACCAGAATGGTTACCACCTCTCCTTCCGCATGAGCCTCAGGAAGCCGCCTATTTC
CAGCTGCACTTGCTCAGCTGGCTGGGCCAGTGAGACAGAGTCAGGGTTCAAGCCCCTCGTCCCA
CCTGAGCCCCAACCCTGAACTTGGGTGAGGCCATATAAACCAAAGACAGACCGAGTCGCCTTTA
ACAAAGACATCCAAATGCAGGTCCCATGCCTCTGGTGCCCGGCGCGGGTAGAGACATCGGGCTG
TGTCCACAGAGTGACGTGGACGGCTCTGTGTGGGCAGGAGTAACATCCTGCCTTAGCAGGGCTC
TGAGGACCTAGATGCACTGTTGCTTTTGGGGGTGATTAAGGTGCTTTTGAGTCTCAGATGCCTG
CTAGGGGAGTAGCCTGGGGCTCGCCTGGCGTGTAGGGCATCCAGGTGAGTAGGAGGCGGAGGAT
CCTCAGTGAGGTCTGGTGTCCAGTCAGCACCTCGCAGCTGTCGCCTGCCTGGACCTTCAACTGT
CATTAGACACAGGGTTGAGCGTGAGCCCGCTGTGCCTGCTAGGGACTCCCAGGTGGACAGCTGA
GGCTGGGGAAAGCCGTGTGGAGACCCTGGGCTGCAGCACAGTGGGCTAGATGGGTCTGTGGGGG
GTCTGATCTCCCCCAGCACCCCAGCCCCTGTATCCCAACAGTGAACAAGGCTCTGGTTTTACTC
CAAGATAAATGGGCCTCTCTCTTTGTTTGGTGTTTCCCCAGCCCCTTCTTGGAAATACTGTGGC
TTACCTCCTAGGGGCCCCACCTAGGGATTCCTGAACACGGGCCCCTGGGGAGGGCTGGGCTCCT
CTGTGTGGTTCTAGAGAAACATGTCAGGGATGGCATGGGAGCAAAAGCTTCCAGCTGCTCCAAA
CATGAGACACCATTAAAGTCAGAGTTACAGGTCACTTTGATGCCCTCTTCTTCCGAACACAGAA
AGGCCCAGAGTCCCATCCCCATGATCCCCACGGCCCACCCTTCCATCCCCCGTGGAAACTTACA
CGGTTTCTTTGGAAAGTCAGTTGTGTCAGGTGGTGTTTTAGCGGGACAGACGCATAAAGGAGTG
TTTTCCTGAAGCAGACACAGGTCAAAGGATGTTTTCCTTAGCATAGACGTGTGAAGAAATGTTT
CGACGAAGCTGACACAGATTAAAAAAAGTGTTTTTGTTAGAGCAAACATGTAAAAGGATGTATG
ATGTTAAAAAGGACCCAACAGACGGTGGACAATGTTAGATGATATTGTCGTTATTCGATGGTCA
CTGCTTGTCGTGACTTTATAAAACACACACACTAAAAATCTTCTGGTGGTGATCTGGCCGCTTT
CGCAGACCCAGTGCCATTGGCAGAGTGGTGTCAGCTGATTCAAACTCATGGAGGACACGTGATG
CTTGGGGAGAGTATAAATAGGACCCAATGGACGGTGACAGGCTTACGTAGCCAGCTTTGTAATC
CATCCCAGGGATCCAGTCTTAAGTCTTTGCTGATCTTAACTTCATTGAGAGGCACAGCAGAAGA
CTTTCTGTGGGGTCCCTGCTGGTCCTGTCACTCTGGCTGACTCGTGCTGATATGTCTGAGGCCT
GATTGTTAGGTCACACCACCGCTGCTGATTCCTGTTTGCTATCCTGGCACTGCTGAACTGGACT
GCTGGTGCATATCCTGACAACACAGATGGGAGTTGCTCTAAAGAACTCTTTCTAAACATGTCTC
CTTCCCCGGTACCCTAATAACATTTCTTTTCCACTTCTTCTGGTGGTTAGTGGGCAAGAAGAGA
GGTTAAAACATTTAGAAACACTTATTAAAAGTAGGTTTTAAAGGGGCTGGAGGGATGGCTCAGC
GGTGAAGAGCACTGACTGCTCTTCCAGAGGTCCTGAGTTCAAACCCCAGCAACCACATGGTGGC
TCACAACCATCTGTAATGGGATCTGACAGTCCTTCTGGTGTGTCTGAAGACAGCCACAGTGTAT
TCATATACATTAAATAAATAAATCAATCTTTAAGAAAGTTTTTTTTAAATCAGTCTACCCTACC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001101535	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL89416	(Get FASTA)	NCBI Sequence Viewer
	EDL89417	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010714
	ENSRNOP00000010714.5
	ENSRNOP00055045723
	ENSRNOP00060043321
	ENSRNOP00065027998
GenBank Protein	O70142	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001101535 ⟸ NM_001108065

- UniProtKB:

O70142 (UniProtKB/Swiss-Prot), A6K8Z6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTQGPGGRAAPEPEAPTTFCALLPRMPQWKFAAPGSFLGRGPAAARVAGAAEAQPEPGVPALAA
VLGACEPRCAAPCPLPALGRCRGSGSRGARGTPDVADEWVRKGGFIHKPAHGWLHPDARVLGPG
VSYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASILGKSN
LRFAGMSISVNISVDGLNLSVPATRQIIANHHMQSISFASGGDTDMTDYVAYVAKDPINQRACH
ILECCEGLAQSVISTVGQAFELRFKQYLHSPPKAVVPPERLTGLEESAWGDGEVTADHDYYNSI
PGKEPPLGGLVDSRLAVTQPCALTTLGGLGQGLSPAWRDVRGLPWDMGPSGAVPPGDGYVQADA
RGPHDYEEHLYVNTQGLDALELEDTSETPLQPEDSPKKDLFDMRPFEDALKLHECSVAAGITAA
SLPLEDQWPSPPTRRAPIAPTEEQLRQEPWYHGRMSRRAAEKLLRADGDFLVRDSITNPGQYVL
TGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDYHLKNGLPIVAAESELHLRGVVSREP

hide sequence

RefSeq Acc Id:

ENSRNOP00000010714 ⟸ ENSRNOT00000010714

Protein Domains

PID SH2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O70142-F1-model_v2	AlphaFold	O70142	1-573	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695057

Promoter ID:

EPDNEW_R5581

Type:

initiation region

Name:

Shc2_1

Description:

SHC adaptor protein 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	12,948,998 - 12,949,058	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307137	AgrOrtholog
BioCyc Gene	G2FUF-34876	BioCyc
Ensembl Genes	ENSRNOG00000008030	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055032016	UniProtKB/Swiss-Prot
	ENSRNOG00060029984	UniProtKB/Swiss-Prot
	ENSRNOG00065020589	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010714	ENTREZGENE
	ENSRNOT00000010714.6	UniProtKB/Swiss-Prot
	ENSRNOT00055055385	UniProtKB/Swiss-Prot
	ENSRNOT00060052088	UniProtKB/Swiss-Prot
	ENSRNOT00065034858	UniProtKB/Swiss-Prot
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot
	3.30.505.10	UniProtKB/Swiss-Prot
	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	UniProtKB/TrEMBL
	SH2 domain	UniProtKB/TrEMBL
InterPro	PH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PID_Shc-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTB/PI_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SHC_SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:314612	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	314612	ENTREZGENE
PANTHER	PTHR10337:SF5	UniProtKB/Swiss-Prot
	SHC TRANSFORMING PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SHC-TRANSFORMING PROTEIN 2	UniProtKB/TrEMBL
Pfam	PID	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Shc2	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SHCPIDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PID	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008030	RatGTEx
	ENSRNOG00055032016	RatGTEx
	ENSRNOG00060029984	RatGTEx
	ENSRNOG00065020589	RatGTEx
SMART	PTB	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH2 domain	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt	A6K8Z6	ENTREZGENE, UniProtKB/TrEMBL
	O70142	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-20	Shc2	SHC adaptor protein 2	Shc2	SHC (Src homology 2 domain containing) transforming protein 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-04	Shc2	SHC (Src homology 2 domain containing) transforming protein 2	Shc2	src homology 2 domain-containing transforming protein C2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Shc2	src homology 2 domain-containing transforming protein C2	Shc2_predicted	src homology 2 domain-containing transforming protein C2 (predicted)	'predicted' is removed	2292626	APPROVED
2007-04-24	Shc2_predicted	src homology 2 domain-containing transforming protein C2 (predicted)	Shc2	src homology 2 domain-containing transforming protein C2	Data merged from RGD:69347	737654	APPROVED
2005-01-12	Shc2_predicted	src homology 2 domain-containing transforming protein C2 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-06-10	Shc2	src homology 2 domain-containing transforming protein C2			Name updated	70584	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)