Eps15 (epidermal growth factor receptor pathway substrate 15) - Rat Genome Database

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Gene: Eps15 (epidermal growth factor receptor pathway substrate 15) Ictidomys tridecemlineatus
Analyze
Symbol: Eps15
Name: epidermal growth factor receptor pathway substrate 15
RGD ID: 12726102
Description: ENCODES a protein that exhibits identical protein binding (ortholog); polyubiquitin modification-dependent protein binding (ortholog); ubiquitin binding (ortholog); INVOLVED IN clathrin coat assembly (ortholog); endocytic recycling (ortholog); Golgi to endosome transport (ortholog); PARTICIPATES IN clathrin-dependent synaptic vesicle endocytosis; Notch signaling pathway; FOUND IN aggresome (ortholog); AP-2 adaptor complex (ortholog); apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epidermal growth factor receptor pathway substrate 15, transcript variant X1; epidermal growth factor receptor pathway substrate 15, transcript variant X2; epidermal growth factor receptor substrate 15; epidermal growth factor receptor substrate 15-like; LOC110596890
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505865,928,976 - 66,023,422 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365229,438,929 - 9,486,781 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Eps15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505865,928,976 - 66,023,422 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365229,438,929 - 9,486,781 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38151,354,263 - 51,519,266 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl151,354,263 - 51,519,328 (-)EnsemblGRCh38hg38GRCh38
GRCh37151,819,935 - 51,984,938 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36151,592,523 - 51,757,583 (-)NCBINCBI36Build 36hg18NCBI36
Build 34151,531,955 - 51,697,016NCBI
Celera150,106,464 - 50,271,514 (-)NCBICelera
Cytogenetic Map1p32.3NCBI
HuRef149,937,536 - 50,064,736 (-)NCBIHuRef
CHM1_1151,937,379 - 52,102,411 (-)NCBICHM1_1
T2T-CHM13v2.0151,234,162 - 51,399,178 (-)NCBIT2T-CHM13v2.0
Eps15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394109,137,372 - 109,245,014 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4109,137,465 - 109,245,014 (+)EnsemblGRCm39 Ensembl
GRCm384109,280,175 - 109,387,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4109,280,268 - 109,387,817 (+)EnsemblGRCm38mm10GRCm38
MGSCv374108,952,880 - 109,060,422 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364108,778,235 - 108,883,626 (+)NCBIMGSCv36mm8
Celera4107,626,627 - 107,727,939 (+)NCBICelera
Cytogenetic Map4C7NCBI
cM Map451.29NCBI
Eps15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85129,274,487 - 129,374,856 (+)NCBIGRCr8
mRatBN7.25124,045,865 - 124,146,221 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5124,045,926 - 124,146,221 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5126,662,232 - 126,762,454 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05128,385,293 - 128,485,514 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05128,436,588 - 128,536,804 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05128,923,809 - 129,022,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5128,923,934 - 129,022,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05132,763,094 - 132,861,698 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45130,639,805 - 130,739,014 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15130,645,030 - 130,744,240 (+)NCBI
Celera5122,775,022 - 122,873,141 (+)NCBICelera
Cytogenetic Map5q34-q35NCBI
Eps15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554647,569,566 - 7,688,098 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554647,569,570 - 7,688,098 (+)NCBIChiLan1.0ChiLan1.0
EPS15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21175,347,708 - 175,512,679 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,488,255 - 174,653,230 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0150,598,692 - 50,763,585 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1152,097,387 - 52,223,533 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl152,097,387 - 52,223,533 (-)Ensemblpanpan1.1panPan2
EPS15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,834,285 - 9,895,755 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,787,260 - 9,893,540 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,904,456 - 10,047,227 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0159,877,844 - 10,020,742 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl159,877,855 - 10,020,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1159,689,665 - 9,832,450 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0159,778,543 - 9,921,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,794,994 - 9,938,012 (+)NCBIUU_Cfam_GSD_1.0
EPS15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6160,653,917 - 160,801,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16160,653,818 - 160,792,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26148,356,480 - 148,494,390 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPS15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12081,439,017 - 81,599,626 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2081,439,025 - 81,602,710 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603335,638,865 - 35,801,433 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eps15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248591,584,024 - 1,754,395 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005326085   ⟹   XP_005326142
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505865,928,976 - 65,976,014 (-)NCBI
SpeTri2.0NW_0049365229,440,263 - 9,486,781 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021726844   ⟹   XP_021582519
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505865,928,976 - 65,977,266 (-)NCBI
SpeTri2.0NW_0049365229,438,929 - 9,486,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040288661   ⟹   XP_040144595
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440505865,928,976 - 66,023,422 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005326142 (Get FASTA)   NCBI Sequence Viewer  
  XP_021582519 (Get FASTA)   NCBI Sequence Viewer  
  XP_040144595 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000023460.2
GenBank Protein KAG3283144 (Get FASTA)   NCBI Sequence Viewer  
  KAG3283145 (Get FASTA)   NCBI Sequence Viewer  
  KAG3283146 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_005326142   ⟸   XM_005326085
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_021582519   ⟸   XM_021726844
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040144595   ⟸   XM_040288661
- Peptide Label: isoform X1
Protein Domains
EF-hand   EH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000023598 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000024574.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  EH_dom UniProtKB/TrEMBL
  UIM_dom UniProtKB/TrEMBL
NCBI Gene Eps15 ENTREZGENE
PANTHER EH DOMAIN UniProtKB/TrEMBL
  EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE 15 UniProtKB/TrEMBL
Pfam EF-hand_4 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  PS50031 UniProtKB/TrEMBL
  UIM UniProtKB/TrEMBL
SMART EFh UniProtKB/TrEMBL
  SM00027 UniProtKB/TrEMBL
  UIM UniProtKB/TrEMBL
Superfamily-SCOP Myosin rod fragments UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
UniProt I3NGG3_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Eps15  epidermal growth factor receptor pathway substrate 15  LOC110596890  epidermal growth factor receptor substrate 15-like  Data merged from RGD:12968984 737654 PROVISIONAL